{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:45:53Z","timestamp":1787312753154,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.etap.2016.05.031","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T06:34:42Z","timestamp":1464849282000},"page":"158-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide"],"prefix":"10.1016","volume":"45","author":[{"given":"Amr A.","family":"Fouad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem O.","family":"Qutub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid N.","family":"Al-Melhim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2016.05.031_bib0005","doi-asserted-by":"crossref","first-page":"10158","DOI":"10.3748\/wjg.v20.i29.10158","article-title":"Cytoprotective effects of amifostine: ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats","volume":"20","author":"Akbulut","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.etap.2016.05.031_bib0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cbi.2015.02.016","article-title":"Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats","volume":"232","author":"Cuce","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.etap.2016.05.031_bib0015","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/cdd.2009.180","article-title":"Neuronal caspase-3 signaling: not only cell death","volume":"17","author":"D\u2019Amelio","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.etap.2016.05.031_bib0020","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2165\/00003495-199142050-00005","article-title":"Cyclophosphamide toxicity. Characterising and avoiding the problem","volume":"42","author":"Fraiser","year":"1991","journal-title":"Drugs"},{"key":"10.1016\/j.etap.2016.05.031_bib0025","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00432-014-1665-8","article-title":"Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines","volume":"140","author":"Germoush","year":"2014","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.etap.2016.05.031_bib0030","first-page":"149","article-title":"Hepatotoxicity of cyclophosphamide in man: pharmacokinetic analysis","volume":"61","author":"Honjo","year":"1988","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.etap.2016.05.031_bib0035","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1039\/C5FO00053J","article-title":"The anti-infective activity of punicalagin against Salmonella enterica subsp. enterica serovar typhimurium in mice","volume":"6","author":"Li","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.etap.2016.05.031_bib0040","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.2042-7158.1998.tb07141.x","article-title":"Antioxidant and hepatoprotective activity of punicalagin and punicalin on carbon tetrachloride-induced liver damage in rats","volume":"50","author":"Lin","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.etap.2016.05.031_bib0045","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/ptr.816","article-title":"Antioxidant and hepatoprotective effects of punicalagin and punicalin on acetaminophen-induced liver damage in rats","volume":"15","author":"Lin","year":"2001","journal-title":"Phytother. Res."},{"key":"10.1016\/j.etap.2016.05.031_bib0050","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-\u03baB in the liver-linking injury, fibrosis and hepatocellular carcinoma","volume":"8","author":"Luedde","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.etap.2016.05.031_bib0055","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1139\/cjpp-2014-0204","article-title":"Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPAR\u03b3 and abrogation of oxidative stress and inflammation","volume":"92","author":"Mahmoud","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.etap.2016.05.031_bib0060","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cbi.2015.02.021","article-title":"Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: role of NF\u03baB\/MAPK pathway","volume":"231","author":"Nafees","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.etap.2016.05.031_bib0065","article-title":"Potential role of punicalagin against oxidative stress induced testicular damage","author":"Rao","year":"2016","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.etap.2016.05.031_bib0070","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1515\/DMDI.2002.19.2.67","article-title":"Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats","volume":"19","author":"Stankiewicz","year":"2002","journal-title":"Drug Metabol. Drug Interact."},{"key":"10.1016\/j.etap.2016.05.031_bib0075","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1097\/01.MP.0000097367.56816.5E","article-title":"Potential role of bcl-2 and bax mRNA and protein expression in chronic hepatitis type B and C: a clinicopathologic study","volume":"16","author":"Tsamandas","year":"2003","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.etap.2016.05.031_bib0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11010-014-2321-y","article-title":"Punicalagin attenuated cerebral ischemia-reperfusion insult via inhibition of proinflammatory cytokines, up-regulation of Bcl-2, down-regulation of Bax, and caspase-3","volume":"402","author":"Yaidikar","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.etap.2016.05.031_bib0085","doi-asserted-by":"crossref","first-page":"17536","DOI":"10.1038\/srep17536","article-title":"Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid","volume":"5","author":"Zhu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.etap.2016.05.031_bib0090","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1089\/ars.2013.5538","article-title":"Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin","volume":"21","author":"Zou","year":"2014","journal-title":"Antioxid. Redox Signal."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668916301326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668916301326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T09:51:01Z","timestamp":1536659461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668916301326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":18,"alternative-id":["S1382668916301326"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2016.05.031","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2016.05.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}