{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:56:18Z","timestamp":1769633778636,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81322053 and"],"award-info":[{"award-number":["81322053 and"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573679"],"award-info":[{"award-number":["81573679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.etap.2016.07.002","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T22:07:15Z","timestamp":1467929235000},"page":"80-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NF\u03baB, Egr1, Nrf2, MAPKs and PI3K signals"],"prefix":"10.1016","volume":"46","author":[{"given":"Zhiyong","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2016.07.002_bib0005","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1210\/jcem.87.3.8462","article-title":"Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations","volume":"87","author":"Aljada","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.etap.2016.07.002_bib0010","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.3140380","article-title":"I Kappa B: a specific inhibitor of the NF-kappa B transcription factor","volume":"242","author":"Baeuerle","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.etap.2016.07.002_bib0015","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/00313029400169601","article-title":"Actinomycin D associated hepatic veno-occlusive disease-a report of 2 cases","volume":"26","author":"Barclay","year":"1994","journal-title":"Pathology"},{"key":"10.1016\/j.etap.2016.07.002_bib0020","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1042\/CS20110065","article-title":"Role of toll-like receptors in liver health and disease","volume":"121","author":"Broering","year":"2011","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.etap.2016.07.002_bib0025","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/bjh.13215","article-title":"How I manage sinusoidal obstruction syndrome after haematopoietic cell transplantation","volume":"168","author":"Carreras","year":"2015","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.etap.2016.07.002_bib0030","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1440-1746.2011.06661.x","article-title":"Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Gynura segetum","volume":"26","author":"Chen","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.etap.2016.07.002_bib0035","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.3748\/wjg.v13.i10.1628","article-title":"Gynura root induces hepatic veno-occlusive disease: a case report and review of the literature","volume":"13","author":"Dai","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.etap.2016.07.002_bib0040","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/hep.510290615","article-title":"Characterization of a reproducible rat model of hepatic veno-occlusive disease","volume":"29","author":"DeLeve","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.etap.2016.07.002_bib0045","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/hep.22772","article-title":"Vascular disorders of the liver","volume":"49","author":"DeLeve","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.etap.2016.07.002_bib0050","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0016-5085(03)01056-4","article-title":"Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition","volume":"125","author":"Deleve","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2016.07.002_bib0055","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.bcp.2006.07.010","article-title":"Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity","volume":"72","author":"Doyle","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.etap.2016.07.002_bib0060","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/toxsci\/kfg222","article-title":"Basement membrane and matrix metalloproteinases in monocrotaline- induced liver injury","volume":"76","author":"Hanumegowda","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2016.07.002_bib0065","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.jnutbio.2013.05.007","article-title":"Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism","volume":"24","author":"Ji","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.etap.2016.07.002_bib0070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/1024533031000084231","article-title":"Role of plasminogen activator inhibitor-1 (PAI-1) levels in the diagnosis of BMT-associated hepatic veno-occlusive disease and monitoring of subsequent therapy with defibrotide (DF)","volume":"8","author":"Kaleelrahman","year":"2003","journal-title":"Hematology"},{"key":"10.1016\/j.etap.2016.07.002_bib0075","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.freeradbiomed.2009.07.035","article-title":"Nrf2:INrf2 (Keap1) signaling in oxidative stress","volume":"47","author":"Kaspar","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.etap.2016.07.002_bib0080","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s40261-014-0242-x","article-title":"Defibrotide: a review of its use in severe hepatic veno-occlusive disease following haematopoietic stem cell transplantation","volume":"34","author":"Keating","year":"2014","journal-title":"Clin. Drug Invest."},{"key":"10.1016\/j.etap.2016.07.002_bib0085","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/583494","article-title":"Chlorogenic and caftaric acids in liver toxicity and oxidative stress induced by methamphetamine","volume":"2014","author":"Koriem","year":"2014","journal-title":"J. Toxicol."},{"key":"10.1016\/j.etap.2016.07.002_bib0090","doi-asserted-by":"crossref","DOI":"10.1136\/jcp.29.9.788","article-title":"A case of veno-occlusive disease of the liver in Britain associated with herbal tea consumption","volume":"29","author":"McGee","year":"1976","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.etap.2016.07.002_bib0095","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0140-6736(76)90726-1","article-title":"An outbreak of hepatic veno-occlusive disease in north-western Afghanistan","volume":"2","author":"Mohabbat","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.etap.2016.07.002_bib0100","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2012.07.004","article-title":"Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9","volume":"57","author":"Nakamura","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.etap.2016.07.002_bib0105","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jss.2014.08.052","article-title":"Regorafenib suppresses sinusoidal obstruction syndrome in rats","volume":"193","author":"Okuno","year":"2015","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.etap.2016.07.002_bib0110","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/sj.bmt.1700760","article-title":"Changes in hemostatic parameters in hepatic veno-occlusive disease following bone marrow transplantation","volume":"19","author":"Park","year":"1997","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.etap.2016.07.002_bib0115","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12013-011-9215-3","article-title":"Therapeutic sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats by inhibiting matrix metalloproteinase-9","volume":"61","author":"Periasamy","year":"2011","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.etap.2016.07.002_bib0120","doi-asserted-by":"crossref","first-page":"146S","DOI":"10.1097\/01.alc.0000189286.81943.51","article-title":"Ethanol-induced liver injury: potential roles for Egr-1","volume":"29","author":"Pritchard","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.etap.2016.07.002_bib0125","doi-asserted-by":"crossref","first-page":"G1124","DOI":"10.1152\/ajpgi.00325.2007","article-title":"Early growth response-1 contributes to galactosamine\/lipopolysaccharide-induced actue liver injury","volume":"293","author":"Pritchard","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.etap.2016.07.002_bib0130","doi-asserted-by":"crossref","first-page":"G1124","DOI":"10.1152\/ajpgi.00544.2010","article-title":"Early growth response (EGR)-1 is required for timely cell-cycle entry and progression in hepatocytes after acute carbon tetrachloride exposure in mice","volume":"300","author":"Pritchard","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.etap.2016.07.002_bib0135","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/01926230701584163","article-title":"Role of neutrophils in the pathogenesis of acute inflammatory liver injury","volume":"35","author":"Ramaiah","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.etap.2016.07.002_bib0140","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1016\/j.bbmt.2012.10.023","article-title":"Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: novel insights to pathogenesis, current status of treatment, and future directions","volume":"19","author":"Richardson","year":"2013","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.etap.2016.07.002_bib0145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/10428199909093722","article-title":"The relevance of plasminogen activator inhibitor 1 (PAI-1) as a marker for the diagnosis of hepatic veno-occlusive disease in patients after bone marrow transplantation","volume":"33","author":"Salat","year":"1999","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.etap.2016.07.002_bib0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3350\/cmh.2014.20.1.81","article-title":"Sinusoidal obstruction syndrome after oxaliplatin-based chemotherapy","volume":"20","author":"Seo","year":"2014","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.etap.2016.07.002_bib0155","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ejphar.2009.09.026","article-title":"Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats","volume":"623","author":"Shi","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.etap.2016.07.002_bib0160","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/jcp.10178","article-title":"Regulation of life and death by the zinc finger transcription factor Egr-1","volume":"193","author":"Thiel","year":"2002","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.etap.2016.07.002_bib0165","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/biof.5520170128","article-title":"Redox signaling and the MAP kinase pathways","volume":"17","author":"Torres","year":"2003","journal-title":"Biofactors"},{"key":"10.1016\/j.etap.2016.07.002_bib0170","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.4161\/cc.21572","article-title":"Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K","volume":"11","author":"Troutman","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.etap.2016.07.002_bib0175","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1080\/10408398.2011.576319","article-title":"An outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities","volume":"53","author":"Upadhyay","year":"2013","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.etap.2016.07.002_bib0180","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/1751-2980.12112","article-title":"Tusanqi and hepatic sinusoidal syndrome","volume":"15","author":"Wang","year":"2014","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.etap.2016.07.002_bib0185","doi-asserted-by":"crossref","first-page":"e942","DOI":"10.1097\/MD.0000000000000942","article-title":"Tusanqi-related sinusoidal obstruction syndrome in China: a systematic review of the Literatures","volume":"94","author":"Wang","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.etap.2016.07.002_bib0190","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0140-6736(01)00020-4","article-title":"Senecio disease, or cirrhosis of the liver due to senecio poisoning","volume":"196","author":"Willmot","year":"1920","journal-title":"Lancet"},{"key":"10.1016\/j.etap.2016.07.002_bib0195","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ijbiomac.2010.02.010","article-title":"Chemical characterization of lyceum barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice","volume":"46","author":"Wu","year":"2010","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.etap.2016.07.002_bib0200","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00011-010-0199-z","article-title":"Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice","volume":"59","author":"Xu","year":"2010","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.etap.2016.07.002_bib0205","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.jhep.2008.11.022","article-title":"Receptor for advanced glycation end product (RAGE)- dependent modulation of early growth response-1 in hepatic ischemia\/reperfusion injury","volume":"50","author":"Zeng","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.etap.2016.07.002_bib0210","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cbi.2015.05.023","article-title":"The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation","volume":"238","author":"Zheng","year":"2015","journal-title":"Chem. Biol. Interact."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668916301703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668916301703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T17:52:54Z","timestamp":1536601974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668916301703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":42,"alternative-id":["S1382668916301703"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2016.07.002","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NF\u03baB, Egr1, Nrf2, MAPKs and PI3K signals","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2016.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}