{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:41:50Z","timestamp":1785472910994,"version":"3.56.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010042","name":"Special Fund for Agro-scientific Research in the Public Interest","doi-asserted-by":"crossref","award":["201203085"],"award-info":[{"award-number":["201203085"]}],"id":[{"id":"10.13039\/501100010042","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31402345"],"award-info":[{"award-number":["31402345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.etap.2016.07.015","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T22:27:52Z","timestamp":1469658472000},"page":"188-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Effects of inducers of cytochrome P450s on enrofloxacin N -deethylation in crucian carp Carassius auratus gibelio"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-8739","authenticated-orcid":false,"given":"Guihong","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2016.07.015_bib0005","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.chemosphere.2012.09.023","article-title":"Effluent from drug manufacturing affects cytochrome P450 1 regulation and function in fish","volume":"90","author":"Beijer","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2016.07.015_bib0010","series-title":"Antibiotic Drug Use in US Aquaculture","author":"Benbrook","year":"2002"},{"key":"10.1016\/j.etap.2016.07.015_bib0015","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.2174\/1389200214666131118234935","article-title":"Enrofloxacin: pharmacokinetics and metabolism in domestic animal species","volume":"14","author":"Cadenas","year":"2013","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.etap.2016.07.015_bib0020","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-2885.1996.tb00079.x","article-title":"The disposition of five therapeutically important antimicrobial agents in llamas","volume":"19","author":"Christensen","year":"1996","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.etap.2016.07.015_bib0025","first-page":"35","article-title":"Pharmacoknetics of enroflxacin and its metabolite ciprofloxacin in Fenneropenaeus chinensi","volume":"28","author":"Fang","year":"2004","journal-title":"J. Fisher. China"},{"key":"10.1016\/j.etap.2016.07.015_bib0030","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.aquaculture.2007.08.049","article-title":"Pharmacokinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in Scylla serrata following oral gavage at two salinities","volume":"2","author":"Fang","year":"2007","journal-title":"Aquaculture"},{"key":"10.1016\/j.etap.2016.07.015_bib0035","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2885.2005.00684.x","article-title":"Enrofloxacin pharmacokinetics in the European Cuttlefish Sepia officinalis, after a single iv injection and bath administration","volume":"28","author":"Gore","year":"2005","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.etap.2016.07.015_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11270-015-2429-z","article-title":"Certain phase I and II enzymes as toxicity biomarker: an overview","volume":"226","author":"Hassan","year":"2015","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.etap.2016.07.015_bib0045","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.aquatox.2007.11.006","article-title":"Ketoconazole, an antifungal imidazole, increases the sensitivity of rainbow trout to 17\u03b1-ethynylestradiol exposure","volume":"86","author":"Hasselberg","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.etap.2016.07.015_bib0050","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.3390\/s7112599","article-title":"Biochemical markers for assessing aquatic contamination","volume":"7","author":"Havelkov\u00e1","year":"2007","journal-title":"Sensors"},{"key":"10.1016\/j.etap.2016.07.015_bib0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0044-8486(99)00253-7","article-title":"Pharmacokinetics of enrofloxacin in the seabass (Dicentrarchus labrax)","volume":"182","author":"Intorrea","year":"2000","journal-title":"Aquaculture"},{"key":"10.1016\/j.etap.2016.07.015_bib0060","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2885.1993.tb00212.x","article-title":"Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and oral administration of enrofloxacin in dogs","volume":"16","author":"K\u00fcng","year":"1993","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.etap.2016.07.015_bib0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.marpolbul.2008.01.005","article-title":"Molecular cloning and beta-naphthoflavone-induced expression of a cytochrome P450 1A (CYP1A) gene from an anadromous river pufferfish, Takifugu obscurus","volume":"57","author":"Kim","year":"2008","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.etap.2016.07.015_bib0070","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0305-0491(99)00080-2","article-title":"Cytochrome P450 1A-dependent enzyme activities in the liver of dab (Limanda limanda): kinetics: seasonal changes and detection limits","volume":"123","author":"Langea","year":"1999","journal-title":"Comp. Biochem. Physiol. B: Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.etap.2016.07.015_bib0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cbpc.2007.07.003","article-title":"Effects of mammalian CYP3A inducers on CYP3A-related enzyme activities in grass carp (Ctenopharyngodon idellus): possible implications for the establishment of a fish CYP3A induction model","volume":"147","author":"Li","year":"2008","journal-title":"Comp. Biochem. Physiol. Toxicol. Pharmacol. C"},{"issue":"5","key":"10.1016\/j.etap.2016.07.015_bib0080","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/jvp.12115","article-title":"Accumulation and elimination of enrofloxacin and its metabolite ciprofloxacin in the ridgetail white prawn Exopalaemon carinicauda following medicated feed and bath administration","volume":"37","author":"Liang","year":"2014","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.etap.2016.07.015_bib0085","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.2042-3306.1997.tb03143.x","article-title":"Pharmacokinetics of enrofloxacin in horses after single intravenous and intramuscular administration","volume":"29","author":"Liisa","year":"1997","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.etap.2016.07.015_bib0090","first-page":"314","article-title":"Enzymatic on deethlation metabolism of enrofloxacin in grass carp hepatocyte","volume":"17","author":"Lin","year":"2003","journal-title":"High Technol. Lett."},{"key":"10.1016\/j.etap.2016.07.015_bib0095","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1439-0442.1996.tb00465.x","article-title":"Disposition of enrofloxacin (Baytril@) into the udder after intravenous and intra-arterial injections into dairy cow","volume":"43","author":"Malbe","year":"1996","journal-title":"J. Vet. Med. Series A"},{"key":"10.1016\/j.etap.2016.07.015_bib0100","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1517\/17425255.2.6.875","article-title":"Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction","volume":"2","author":"Marcella","year":"2006","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.etap.2016.07.015_bib0105","series-title":"Fish Disease: Diagnosis and Treatment","first-page":"536","author":"Noga","year":"2010"},{"key":"10.1016\/j.etap.2016.07.015_bib0110","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0166-445X(97)00069-6","article-title":"Biotransformation enzymes and their induction by \u03b2\u2013naphtoflavone in adult sea bass (Dicentrarchus labrax)","volume":"41","author":"Novi","year":"1998","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.etap.2016.07.015_bib0115","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2885.2000.00295.x","article-title":"Effects of endotoxin induced fever and probenecid on disposition of enrofloxacin and its metabolite ciprofloxacin after intravascular administration of enrofloxacin in goats","volume":"23","author":"Rao","year":"2000","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.etap.2016.07.015_bib0120","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ddtec.2004.10.008","article-title":"Metabolic screening in vitro: metabolic stability, CYP inhibition and induction","volume":"1","author":"Riley","year":"2004","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.etap.2016.07.015_bib0125","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0044-8486(03)00455-1","article-title":"The disposition of enrofloxacin in seabream (Sparus aurata L.) after single intravenous injection or from medicated feed administration","volume":"232","author":"Rocca","year":"2004","journal-title":"Aquaculture"},{"key":"10.1016\/j.etap.2016.07.015_bib0130","first-page":"45","article-title":"Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intracoelomic administration in Tortoises (Testudo hermanni)","volume":"70","author":"Salvadori","year":"2015","journal-title":"Isr. J. Vet. Med."},{"key":"10.1016\/j.etap.2016.07.015_bib0135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1051\/vetres:2001120","article-title":"Use of antimicrobials in veterinary medicine and mechanisms of resistance","volume":"32","author":"Schwarz","year":"2001","journal-title":"Vet. Res."},{"key":"10.1016\/j.etap.2016.07.015_bib0140","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1124\/dmd.112.049940","article-title":"Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug\u2013drug interactions","volume":"41","author":"Shirasaka","year":"2013","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"10.1016\/j.etap.2016.07.015_bib0145","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0166-445X(00)00085-0","article-title":"Cytochrome P450 enzymes in aquatic invertebrates: recent advances and future directions","volume":"48","author":"Snyder","year":"2000","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.etap.2016.07.015_bib0150","first-page":"623","article-title":"High-affinity nitrosamine dealkylase system in rat liver microsomes and its induction by fasting","volume":"43","author":"Tu","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.etap.2016.07.015_bib0155","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0166-445X(02)00064-4","article-title":"Inhibition of cytochrome P450 enzymes by enrofloxacin in the sea bass (Dicentrarchus labrax)","volume":"62","author":"Vaccaroa","year":"2003","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.etap.2016.07.015_bib0160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1365-2761.2001.00269.x","article-title":"Occurrence of thelohanellosis caused by Thelohanellus wuhanensis (Myxosporea) in juvenile allogynogenetic silver crucian carp Carassius auratus gibelio (Bloch), with an observation on the efficacy of fumagillin as a therapeutant","volume":"24","author":"Wang","year":"2001","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.etap.2016.07.015_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquaculture.2005.10.030","article-title":"Residues of enrofloxacin, furazolidone and metabolites in Nile tilapia (Oreochromis niloticus)","volume":"254","author":"Xu","year":"2006","journal-title":"Aquaculture"},{"key":"10.1016\/j.etap.2016.07.015_bib0170","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.etap.2009.11.008","article-title":"Effects of fish cytochromes P450 inducers and inhibitors on difloxacin N-demethylation in kidney of Chinese idle (Ctenopharyngodon idellus)","volume":"29","author":"Yu","year":"2010","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2016.07.015_bib0175","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.cbpc.2011.07.005","article-title":"Inhibition of CYP450 1A and 3A by berberine in crucian carp Carassius auratus gibelio","volume":"154","author":"Zhou","year":"2011","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668916301934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668916301934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T02:12:04Z","timestamp":1589681524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668916301934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":35,"alternative-id":["S1382668916301934"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2016.07.015","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of inducers of cytochrome P450s on enrofloxacin N-deethylation in crucian carp Carassius auratus gibelio","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2016.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}