{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:24:01Z","timestamp":1773840241524,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973603"],"award-info":[{"award-number":["30973603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Main Cultivate Object of Program for the Top Science"},{"name":"Technology Innovation Teams of Higher Learning Institutions of Shanxi"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.etap.2017.01.012","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T04:31:32Z","timestamp":1487910692000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Hepatotoxicity and proteomic mechanism of Di- n -butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT) in vivo"],"prefix":"10.1016","volume":"51","author":[{"given":"Li","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-ran","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-lan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-shan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2017.01.012_bib0005","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1042\/bj20020320","article-title":"Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1 Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice","volume":"365","author":"Chanas","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.etap.2017.01.012_bib0010","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.ica.2007.07.036","article-title":"The interaction of hydroxymandelate synthase with the 4-hydroxyphenylpyruvate dioxygenase inhibitor: NTBC","volume":"361","author":"Conrad","year":"2008","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.etap.2017.01.012_bib0015","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ygyno.2004.03.018","article-title":"Eukaryotic initiation factor 5A-1 (eIF5A-1) as a diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva","volume":"94","author":"Cracchiolo","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.etap.2017.01.012_bib0020","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1093\/carcin\/bgg122","article-title":"Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTM2 by butyrate","volume":"24","author":"Ebert","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.etap.2017.01.012_bib0025","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1203\/00006450-198301000-00005","article-title":"Chronic tyrosinemia associated with 4-hydroxyphenylpyruvate dioxygenase deficiency with acute intermittent ataxia and without visceral and bone involvement","volume":"17","author":"Giardini","year":"1983","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.etap.2017.01.012_bib0030","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s00726-011-1042-8","article-title":"Translationalcontrol of eIF5a in various diseases","volume":"42","author":"Kaiser","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.etap.2017.01.012_bib0035","first-page":"1","article-title":"Mechanisms by which the antitumor compound di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) induces apoptosis and the mitochondrial-mediated signaling pathway in human cancer SGC-7901 cells","volume":"9999","author":"Li","year":"2010","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.etap.2017.01.012_bib0040","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jinorgbio.2013.12.002","article-title":"Diorganotin(IV) derivatives of substituted N-hydroxybenzamides withselective cytotoxicity in vitro and potent antitumor activity in vivo","volume":"133","author":"Li","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.etap.2017.01.012_bib0045","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1074\/mcp.M800109-MCP200","article-title":"Comparative studies of early liver dysfunction in senescence-accelerated mouse using mitochondrial proteomics approaches","volume":"7","author":"Liu","year":"2008","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.etap.2017.01.012_bib0050","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.abb.2004.08.015","article-title":"4-Hydroxyphenylpyruvate dioxygenase","volume":"433","author":"Moran","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.etap.2017.01.012_bib0055","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.ica.2014.05.007","article-title":"Medicinal properties of organotin compounds and theirlimitationscaused by toxicity","volume":"423","author":"Niu","year":"2014","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.etap.2017.01.012_bib0060","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.tiv.2012.12.002","article-title":"Toxicity of organotin compounds: shared and unshared biochemical targets and mechanisms in animal cells","volume":"27","author":"Pagliarani","year":"2013","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.etap.2017.01.012_bib0065","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1016\/j.jorganchem.2005.12.025","article-title":"Biological activity studies on organotin(IV)n+ complexes and parent compounds","volume":"691","author":"Pellerito","year":"2006","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.etap.2017.01.012_bib0070","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1289\/ehp.730461","article-title":"Organotin compounds: industrial applications and biological investigation","volume":"4","author":"Piver","year":"1973","journal-title":"Environ. Health. Perspect."},{"key":"10.1016\/j.etap.2017.01.012_bib0075","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1093\/toxsci\/kfr115","article-title":"Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and-independent regulations","volume":"122","author":"Singh","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2017.01.012_bib0080","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.toxlet.2012.06.008","article-title":"Oxidative stress in di-n-butyl-di-(4-chlorobenzohydroxamato)tin (IV)-induced hepatotoxicity determined by proteomic profiles","volume":"213","author":"Tang","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.etap.2017.01.012_bib0085","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.yexcr.2006.09.030","article-title":"Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor \u03b1 signaling","volume":"313","author":"Taylor","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.etap.2017.01.012_bib0090","doi-asserted-by":"publisher","first-page":"10994","DOI":"10.3390\/molecules170910994","article-title":"Inhibition of cytochrome P450 3A in rat liver by the diorganotin (IV) compound di-n-butyl-di-(4-chlorobenzohydroxamato)tin (IV) and its probable mechanism","volume":"17","author":"Zhang","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.etap.2017.01.012_bib0095","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s11010-007-9647-7","article-title":"Reduced expression of GSTM2 and increased oxidative stress in spontaneously hypertensive rat","volume":"309","author":"Zhou","year":"2008","journal-title":"Mol. Cell Biochem."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668917300200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668917300200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T22:52:23Z","timestamp":1536015143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668917300200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":19,"alternative-id":["S1382668917300200"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2017.01.012","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatotoxicity and proteomic mechanism of Di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT) in vivo","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2017.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}