{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:47:09Z","timestamp":1792457229571,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2016R1A2B4006269"],"award-info":[{"award-number":["2016R1A2B4006269"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2011-0006527"],"award-info":[{"award-number":["2011-0006527"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.etap.2017.03.011","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T17:48:48Z","timestamp":1490032128000},"page":"99-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["18\u03b2-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model"],"prefix":"10.1016","volume":"52","author":[{"given":"Seung-Hyung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-hee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Cheol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.etap.2017.03.011_bib0005","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1080\/0886022X.2016.1216722","article-title":"18\u03b2-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2\/ARE\/HO-1 pathway and endogenous antioxidants","volume":"38","author":"Abd El-Twab","year":"2016","journal-title":"Ren. Fail."},{"issue":"3","key":"10.1016\/j.etap.2017.03.011_bib0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1179\/135100005X57346","article-title":"Inhibitory effect of 18beta-glycyrrhetinic acid on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in mice","volume":"10","author":"Agarwal","year":"2005","journal-title":"Redox Rep."},{"key":"10.1016\/j.etap.2017.03.011_bib0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.intimp.2016.03.003","article-title":"Airway oxidative stress causes vascular and hepatic inflammation via upregulation of IL-17A in a murine model of allergic asthma","volume":"34","author":"Al-Harbi","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.etap.2017.03.011_bib0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nri2254","article-title":"Immunology of asthma and chronic obstructive pulmonary disease","volume":"8","author":"Barnes","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"1\u20133","key":"10.1016\/j.etap.2017.03.011_bib0025","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejphar.2005.12.048","article-title":"Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation","volume":"533","author":"Belvisi","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.etap.2017.03.011_bib0030","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1056\/NEJM200102013440507","article-title":"Asthma","volume":"344","author":"Busse","year":"2001","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.etap.2017.03.011_bib0035","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0022-1759(03)00200-X","article-title":"T-bet\/GATA-3 ratio as a measure of the Th1\/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3","volume":"278","author":"Chakir","year":"2003","journal-title":"J. Immunol. Methods"},{"issue":"19","key":"10.1016\/j.etap.2017.03.011_bib0040","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1074\/jbc.M210429200","article-title":"Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine\/autocrine loop","volume":"278","author":"Chen","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"301","key":"10.1016\/j.etap.2017.03.011_bib0045","doi-asserted-by":"crossref","first-page":"301ra129","DOI":"10.1126\/scitranslmed.aab3142","article-title":"TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma","volume":"7","author":"Choy","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.etap.2017.03.011_bib0050","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev.iy.08.040190.003203","article-title":"Fc epsilon RII\/CD23: the low affinity receptor for IgE","volume":"8","author":"Conrad","year":"1990","journal-title":"Annu. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.etap.2017.03.011_bib0055","doi-asserted-by":"crossref","first-page":"9101","DOI":"10.3390\/molecules19079101","article-title":"Bioactive profiles, antioxidant activities, nitrite scavenging capacities and protective effects on H2O2-injured PC12 cells of Glycyrrhiza glabra L. leaf and root extracts","volume":"19","author":"Dong","year":"2014","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.etap.2017.03.011_bib0060","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1172\/JCI8124","article-title":"Airway remodeling in asthma","volume":"104","author":"Elias","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.etap.2017.03.011_bib0065","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.4049\/jimmunol.1102699","article-title":"Allergen-specific CTL require perforin expression to suppress allergic airway inflammation","volume":"188","author":"Enomoto","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.etap.2017.03.011_bib0070","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.4049\/jimmunol.141.7.2335","article-title":"IL-4 is required to generate and sustain in vivo IgE responses","volume":"141","author":"Finkelman","year":"1988","journal-title":"J. Immunol."},{"issue":"5553","key":"10.1016\/j.etap.2017.03.011_bib0075","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.1065544","article-title":"Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet","volume":"295","author":"Finotto","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.etap.2017.03.011_bib0080","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.4049\/jimmunol.174.12.7716","article-title":"IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13","volume":"174","author":"Fish","year":"2005","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.etap.2017.03.011_bib0085","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jep.2013.05.022","article-title":"18\u03b2-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells","volume":"148","author":"Fu","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.etap.2017.03.011_bib0090","doi-asserted-by":"crossref","first-page":"172","DOI":"10.5507\/bp.2013.043","article-title":"STAT6 \u2013 polymorphisms, haplotypes and epistasis in relation to atopy and asthma","volume":"157","author":"Godava","year":"2013","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech. Repub."},{"issue":"11","key":"10.1016\/j.etap.2017.03.011_bib0095","doi-asserted-by":"crossref","first-page":"10556","DOI":"10.1074\/jbc.M411673200","article-title":"Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes","volume":"280","author":"Gumpricht","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1-2","key":"10.1016\/j.etap.2017.03.011_bib0100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jim.2007.07.019","article-title":"A new approach for analyzing cellular infiltration during allergic airway inflammation","volume":"328","author":"Hoffmann","year":"2007","journal-title":"J. Immunol. Methods"},{"issue":"25","key":"10.1016\/j.etap.2017.03.011_bib0105","doi-asserted-by":"crossref","first-page":"17003","DOI":"10.1074\/jbc.M801286200","article-title":"Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat","volume":"283","author":"Ichiyama","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.etap.2017.03.011_bib0110","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.etap.2017.03.011_bib0115","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.tiv.2014.02.015","article-title":"18\u03b2-Glycyrrhetinic acid suppresses TNF-\u03b1 induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-\u03baB pathway","volume":"28","author":"Jayasooriya","year":"2014","journal-title":"Toxicol. In Vitro"},{"issue":"1\u20133","key":"10.1016\/j.etap.2017.03.011_bib0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejphar.2008.12.057","article-title":"Antihyperglycemic effect of 18 beta-glycyrrhetinic acid aglycone of glycyrrhizin, on streptozotocin-diabetic rats","volume":"606","author":"Kalaiarasi","year":"2009","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.etap.2017.03.011_bib0125","doi-asserted-by":"crossref","first-page":"e74761","DOI":"10.1371\/journal.pone.0074761","article-title":"In silico and in vivo anti-malarial studies of 18\u03b2 glycyrrhetinic acid from Glycyrrhiza glabra","volume":"8","author":"Kalani","year":"2013","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.etap.2017.03.011_bib0130","doi-asserted-by":"crossref","first-page":"8623","DOI":"10.1021\/jf101841r","article-title":"Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K\/Akt\/GSK3beta signaling and glucocorticoid receptor activation","volume":"58","author":"Kao","year":"2010","journal-title":"J. Agric. Food Chem."},{"issue":"11","key":"10.1016\/j.etap.2017.03.011_bib0135","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.4049\/jimmunol.167.11.6497","article-title":"Tumor-specific Tc1, but not Tc2, cells deliver protective antitumor immunity","volume":"167","author":"Kemp","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.etap.2017.03.011_bib0140","first-page":"485402","article-title":"Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma","author":"Kim","year":"2011","journal-title":"Mediators Inflamm."},{"issue":"3","key":"10.1016\/j.etap.2017.03.011_bib0145","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/08923973.2013.768636","article-title":"18\u03b2-Glycyrrhetinic acid from licorice root impairs dendritic cells maturation and Th1 immune responses","volume":"35","author":"Kim","year":"2013","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"3","key":"10.1016\/j.etap.2017.03.011_bib0150","doi-asserted-by":"crossref","first-page":"e91146","DOI":"10.1371\/journal.pone.0091146","article-title":"Reactive oxygen species prevent imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.etap.2017.03.011_bib0155","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.intimp.2013.12.009","article-title":"Oleanolic acid suppresses ovalbumin-induced airway inflammation and Th2-mediated allergic asthma by modulating the transcription factors T-bet, GATA-3, ROR\u03b3t and Foxp3 in asthmatic mice","volume":"18","author":"Kim","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.etap.2017.03.011_bib0160","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nm734","article-title":"Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma","volume":"8","author":"Kuperman","year":"2002","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.etap.2017.03.011_bib0165","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/ni.1926","article-title":"Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma","volume":"11","author":"Lajoie","year":"2010","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.etap.2017.03.011_bib0170","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1378\/chest.06-2434","article-title":"Regulatory T cells in allergy and asthma","volume":"132","author":"Larch\u00e9","year":"2007","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.etap.2017.03.011_bib0175","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bcp.2012.05.005","article-title":"Role of NADPH oxidase\/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases","volume":"84","author":"Lee","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.etap.2017.03.011_bib0180","doi-asserted-by":"crossref","first-page":"5248","DOI":"10.4049\/jimmunol.177.8.5248","article-title":"Modulation of airway remodeling and airway inflammation by peroxisome proliferator-activated receptor gamma in a murine model of toluene diisocyanate-induced asthma","volume":"177","author":"Lee","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.etap.2017.03.011_bib0185","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cmi.2009.49","article-title":"Inhibition of NF-kappaB expression and allergen-induced airway inflammation in a mouse allergic asthma model by andrographolide","volume":"6","author":"Li","year":"2009","journal-title":"Cell Mol. Immunol."},{"issue":"5","key":"10.1016\/j.etap.2017.03.011_bib0190","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3177\/jnsv.61.375","article-title":"Glycyrrhiza glabra L. extract inhibits LPS-induced inflammation in RAW macrophages","volume":"61","author":"Li","year":"2015","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"issue":"6","key":"10.1016\/j.etap.2017.03.011_bib0195","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12263-015-0491-1","article-title":"18\u03b2-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPAR\u03b3 and Nrf2 upregulation","volume":"10","author":"Mahmoud","year":"2015","journal-title":"Genes Nutr."},{"issue":"11","key":"10.1016\/j.etap.2017.03.011_bib0200","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1002\/eji.201242433","article-title":"STAT6-dependent and \u2212independent mechanisms in Th2 polarization","volume":"42","author":"Maier","year":"2012","journal-title":"Eur. J. Immunol."},{"issue":"12","key":"10.1016\/j.etap.2017.03.011_bib0205","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1371\/journal.pbio.0050329","article-title":"GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells","volume":"5","author":"Mantel","year":"2007","journal-title":"PLoS Biol."},{"issue":"9","key":"10.1016\/j.etap.2017.03.011_bib0210","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1084\/jem.193.9.1087","article-title":"Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation","volume":"193","author":"Mathew","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.etap.2017.03.011_bib0215","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1073\/pnas.90.8.3735","article-title":"Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function","volume":"90","author":"McKenzie","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.etap.2017.03.011_bib0220","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1084\/jem.20080193","article-title":"In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure","volume":"205","author":"Meiler","year":"2008","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.etap.2017.03.011_bib0225","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.phrs.2008.05.012","article-title":"Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice","volume":"58","author":"Menegazzi","year":"2008","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.etap.2017.03.011_bib0230","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nm1081","article-title":"Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness","volume":"10","author":"Miyahara","year":"2004","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.etap.2017.03.011_bib0235","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1183\/09031936.95.08071091","article-title":"Treatment of steroid-dependent bronchial asthma with cyclosporin","volume":"8","author":"Nizankowska","year":"1995","journal-title":"Eur. Respir. J."},{"issue":"13","key":"10.1016\/j.etap.2017.03.011_bib0240","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.4161\/cc.7.13.6234","article-title":"KLF13 influences multiple stages of both B and T cell development","volume":"7","author":"Outram","year":"2008","journal-title":"ABBV Cell Cycle"},{"issue":"8","key":"10.1016\/j.etap.2017.03.011_bib0245","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s10072-014-1685-9","article-title":"The beneficial effects of 18\u03b2-glycyrrhetinic acid following oxidative and neuronal damage in brain tissue caused by global cerebral ischemia\/reperfusion in a C57BL\/J6 mouse model","volume":"35","author":"Oztanir","year":"2014","journal-title":"Neurol. Sci."},{"issue":"1","key":"10.1016\/j.etap.2017.03.011_bib0250","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF02980047","article-title":"Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-d-glucuronide","volume":"27","author":"Park","year":"2004","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.etap.2017.03.011_bib0255","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1067\/mai.2001.118600","article-title":"IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism","volume":"108","author":"Pope","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5\u20136","key":"10.1016\/j.etap.2017.03.011_bib0260","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00508-011-0103-z","article-title":"Effects of 18\u03b2-Glycyrrhetinic acid in hTNFtg mice \u2013 a model of rheumatoid arthritis","volume":"124","author":"Puchner","year":"2012","journal-title":"Wien. Klin. Wochenschr."},{"issue":"9","key":"10.1016\/j.etap.2017.03.011_bib0265","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.intimp.2006.04.020","article-title":"Glycyrrhizin alleviates experimental allergic asthma in mice","volume":"6","author":"Ram","year":"2006","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.etap.2017.03.011_bib0270","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00011-013-0700-6","article-title":"Linking GATA-3 and interleukin-13: implications in asthma","volume":"63","author":"Rayees","year":"2014","journal-title":"Inflamm. Res."},{"issue":"3","key":"10.1016\/j.etap.2017.03.011_bib0275","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/s-2007-967126","article-title":"In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components","volume":"73","author":"Shin","year":"2007","journal-title":"Planta Med."},{"key":"10.1016\/j.etap.2017.03.011_bib0280","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/sj.jhh.1001215","article-title":"Liquorice-induced rise in blood pressure: a linear dose\u2013response relationship","volume":"15","author":"Sigurjonsdottir","year":"2001","journal-title":"J. Hum. Hypertens."},{"issue":"7","key":"10.1016\/j.etap.2017.03.011_bib0285","first-page":"1209","article-title":"Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: a repertoire of Glycyrrhiza glabra flavonoid antioxidants","volume":"54","author":"Singh","year":"2016","journal-title":"Pharm. Biol."},{"issue":"4","key":"10.1016\/j.etap.2017.03.011_bib0290","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0278-6915(93)90080-I","article-title":"Glycyrrhizic acid in liquorice?evaluation of health hazard","volume":"31","author":"St\u00f8rmer","year":"1993","journal-title":"Food Chem. Toxicol."},{"issue":"11","key":"10.1016\/j.etap.2017.03.011_bib0295","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.vaccine.2005.10.040","article-title":"Immunological adjuvant effect of Glycyrrhiza uralensis saponins on the immune responses to ovalbumin in mice","volume":"24","author":"Sun","year":"2006","journal-title":"Vaccine"},{"issue":"9342","key":"10.1016\/j.etap.2017.03.011_bib0300","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0140-6736(02)11312-2","article-title":"Asthma","volume":"360","author":"Tattersfield","year":"2002","journal-title":"Lancet"},{"issue":"6608","key":"10.1016\/j.etap.2017.03.011_bib0305","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/384474a0","article-title":"Transcription factor GATA-3 is required for development of the T-cell lineage","volume":"384","author":"Ting","year":"1996","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.etap.2017.03.011_bib0310","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.4049\/jimmunol.175.2.1161","article-title":"18 Beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kappa B","volume":"175","author":"Ukil","year":"2005","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.etap.2017.03.011_bib0315","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1365-2222.2010.03640.x","article-title":"FoxP3, GATA-3 and T-bet expression in elderly asthma","volume":"41","author":"Vale-Pereira","year":"2011","journal-title":"Clin. Exp. Allergy"},{"issue":"3","key":"10.1016\/j.etap.2017.03.011_bib0320","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jep.2013.09.055","article-title":"Liquorice, a unique guide drug of traditional Chinese medicine: a review of its role in drug interactions","volume":"150","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.etap.2017.03.011_bib0325","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4049\/jimmunol.170.1.394","article-title":"CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice","volume":"170","author":"Xu","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.etap.2017.03.011_bib0330","doi-asserted-by":"crossref","first-page":"2526174","DOI":"10.1155\/2016\/2526174","article-title":"Oxidative stress and Treg and Th17 dysfunction in systemic lupus erythematosus","volume":"2016","author":"Yang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668917300765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668917300765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T18:46:10Z","timestamp":1692729970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668917300765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":66,"alternative-id":["S1382668917300765"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2017.03.011","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"18\u03b2-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2017.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}