{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:26:44Z","timestamp":1776947204138,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.etap.2018.01.011","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T17:51:11Z","timestamp":1517507471000},"page":"212-219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Protective role of nebivolol in cadmium-induced hepatotoxicity via downregulation of oxidative stress, apoptosis and inflammatory pathways"],"prefix":"10.1016","volume":"58","author":[{"given":"Marwa M.M.","family":"Refaie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maram","family":"El-Hussieny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagwa M.","family":"Zenhom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.etap.2018.01.011_bib0005","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1177\/0960327111429136","article-title":"Toxicity of cadmium and protective effect of bee honey, vitamins C and B complex","volume":"32","author":"Abdelaziz","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"issue":"7","key":"10.1016\/j.etap.2018.01.011_bib0010","doi-asserted-by":"crossref","first-page":"e68418","DOI":"10.1371\/journal.pone.0068418","article-title":"Chronic cadmium treatment promotes oxidative stress and endothelial damage in isolated rat aorta","volume":"12","author":"Almenara","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2018.01.011_bib0015","first-page":"001","article-title":"Liver and cadmium toxicity","volume":"S5","author":"Arroyo","year":"2012","journal-title":"J. Drug Metab. Toxicol."},{"issue":"2","key":"10.1016\/j.etap.2018.01.011_bib0020","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12011-015-0491-4","article-title":"Genetic and histopathological responses to cadmium toxicity in rabbit\u2019s kidney and liver: protection by ginger (Zingiber officinale)","volume":"170","author":"Baiomy","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.etap.2018.01.011_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/394652","article-title":"Cadmium toxicity and treatment","volume":"2013","author":"Bernhoft","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.etap.2018.01.011_bib0030","doi-asserted-by":"crossref","first-page":"e12389","DOI":"10.1111\/jpi.12389","article-title":"Melatonin alleviates cadmium-inducedliver injury by inhibiting the TXNIP-NLRP3inflammasome","volume":"62","author":"Cao","year":"2017","journal-title":"J. Pineal Res."},{"issue":"4","key":"10.1016\/j.etap.2018.01.011_bib0035","doi-asserted-by":"crossref","first-page":"580","DOI":"10.3109\/1547691X.2016.1142488","article-title":"Nebivolol prevents indomethacin-induced gastric ulcer in rats","volume":"13","author":"El-Ashmawy","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.etap.2018.01.011_bib0040","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3390\/ijms18050957","article-title":"Protective effect of fragariaananassa crude extract on cadmium-induced lipid peroxidation, antioxidant enzymes suppression, and apoptosis in rat testes","volume":"18","author":"Elmallah","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.etap.2018.01.011_bib0045","first-page":"7898","article-title":"Lyciumbarbarum extract provides effective protection against paracetamol induced acute hepatotoxicity in rats","volume":"8","author":"Gunduz","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.etap.2018.01.011_bib0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1750-9378-8-9","article-title":"Immunohistochemical expression of COX2 and iNOS in bladder cancer and its association with urinary schistosomiasis among sudanese patients","volume":"8","author":"Hassan","year":"2013","journal-title":"Infect. Agents Cancer"},{"issue":"11\u201312","key":"10.1016\/j.etap.2018.01.011_bib0055","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.lfs.2011.12.001","article-title":"NebivololregulateseNOS and iNOSexpressions and alleviatesoxidativestress in cerebralischemia\/reperfusioninjury in rats","volume":"90","author":"Heeba","year":"2012","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.etap.2018.01.011_bib0060","doi-asserted-by":"crossref","DOI":"10.19080\/IJCSMB.2016.01.555553","article-title":"Effects of cadmium toxicity on bio-distribution of trace elements in normal and protein malnourished rats","volume":"1","author":"Husain","year":"2016","journal-title":"Int. J. Cell Sci. Mol. Biol."},{"key":"10.1016\/j.etap.2018.01.011_bib0065","series-title":"Monographs-Cadmium","author":"International Agency for Research on Cancer (IARC)","year":"1993"},{"key":"10.1016\/j.etap.2018.01.011_bib0070","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/jcp.54.5.356","volume":"54","author":"Koracevic","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.etap.2018.01.011_bib0075","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3390\/nu6031194","article-title":"Curcumin protects against cadmium-induced vascular dysfunction, hypertension and tissue cadmium accumulation in mice","volume":"6","author":"Kukongviriyapan","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.etap.2018.01.011_bib0080","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-017-0868-3","article-title":"Impact of oral cadmium intoxication on levels of different essential trace elements and oxidative stress measures in mice: a response to dose","author":"Kumar","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.etap.2018.01.011_bib0085","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4103\/2356-8097.195889","article-title":"Protective effects of nebivolol on acetic acid-induced ulcerative colitis in rats","volume":"22","author":"Labiba","year":"2016","journal-title":"Kasr Al Ainy Med. J."},{"issue":"2","key":"10.1016\/j.etap.2018.01.011_bib0090","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/jcb.22980","article-title":"Preventive effect of phytoglycoprotein (27 kDa) on inflammatory factors at liver injury in cadmium chloride-exposed ICR mice","volume":"112","author":"Lee","year":"2011","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.etap.2018.01.011_bib0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.coph.2013.01.006","article-title":"Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease","volume":"13","author":"Li","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"issue":"2","key":"10.1016\/j.etap.2018.01.011_bib0100","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1248\/cpb.31.605","article-title":"Properties of thiobarbituric acid-reactive materials obtained from lipid peroxide and tissue homogenate","volume":"31","author":"Mihara","year":"1983","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.etap.2018.01.011_bib0105","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1079\/BJN20051450","article-title":"Changes in arterial blood pressure caused in hypertensive rats by long-term intake of milk fermented by enterococcus faecaliscect 5728","volume":"93","author":"Miguel","year":"2005","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.etap.2018.01.011_bib0110","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/bcpt.12538","article-title":"Nebivolol ameliorates cisplatin induced nephrotoxicity in rats","volume":"118","author":"Morsy","year":"2016","journal-title":"Basic. Clin. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.etap.2018.01.011_bib0115","first-page":"86","article-title":"Nebivolol and chrysin protect the liver against ischemia\/reperfusion-induced injury in rats","volume":"4","author":"Mizar","year":"2015","journal-title":"J. Basic Appl. Sci."},{"key":"10.1016\/j.etap.2018.01.011_bib0120","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.3390\/ijms14036116","article-title":"Cadmium-induced pathologies: where is the oxidative balance lost (or not)?","volume":"14","author":"Nair","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.etap.2018.01.011_bib0125","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the reaction of reduced phenazinemethosulfate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophs. Res. Commun."},{"key":"10.1016\/j.etap.2018.01.011_bib0130","first-page":"475","volume":"59","author":"Olszowski","year":"2012"},{"key":"10.1016\/j.etap.2018.01.011_bib0135","article-title":"Effects of carvedilol compared to nebivolol on insulin resistance and lipid profile in patients with essential hypertension","author":"Ozy\u0131ld\u0131z","year":"2016","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.etap.2018.01.011_bib0140","first-page":"9507563","article-title":"Possible protective effect of diacerein on doxorubicin-induced nephrotoxicity in rats","author":"Refaie","year":"2016","journal-title":"J. Toxicol."},{"issue":"2","key":"10.1016\/j.etap.2018.01.011_bib0145","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/fcp.12253","article-title":"Different effects of selective b1-adrenoceptor antagonists, nebivolol or atenolol in acetaminophen-induced hepatotoxicity of rats","volume":"31","author":"Rofaeil","year":"2017","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.etap.2018.01.011_bib0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13010088","article-title":"Cadmium chloride induces DNA damage and apoptosis of human liver carcinoma cells via oxidative stress","volume":"13","author":"Skipper","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.etap.2018.01.011_bib0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.asjsur.2015.12.005","article-title":"Effect of nebivolol on liver regeneration in an experimental 70% partial hepatectomy model","volume":"40","author":"Sumer","year":"2017","journal-title":"Asian J. Surg."},{"issue":"4","key":"10.1016\/j.etap.2018.01.011_bib0160","doi-asserted-by":"crossref","first-page":"537","DOI":"10.14202\/vetworld.2015.537-540","article-title":"Hepatoprotective activity of moringaoleiferaagainst cadmium toxicity in rats","volume":"8","author":"Toppo","year":"2015","journal-title":"Vet. World"},{"key":"10.1016\/j.etap.2018.01.011_bib0165","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/08941939.2015.1031923","article-title":"Nebivolol ameliorates hepatic ischemia\/reperfusion injury on liver but not on distant organs","volume":"28","author":"Ulger","year":"2015","journal-title":"J. Invest. Surg."},{"issue":"5","key":"10.1016\/j.etap.2018.01.011_bib0170","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2144\/000112776","article-title":"Twenty-five years of quantitative PCR for gene expression analysis","volume":"44","author":"VanGuilder","year":"2008","journal-title":"Biotechniques"},{"issue":"6","key":"10.1016\/j.etap.2018.01.011_bib0175","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S1995-7645(12)60074-1","article-title":"Antihyperlipidemiceffect of melothriamaderaspatana leaf extracts on DOCA-salt induced hypertensive rats","volume":"5","author":"Veeramani","year":"2012","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.etap.2018.01.011_bib0180","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1014471714058","article-title":"Proliferation- and apoptosis-related proteins in intracranial ependymomas: an immunohistochemical analysis","volume":"56","author":"Verstegen","year":"2002","journal-title":"J. Neurooncol."},{"issue":"2","key":"10.1016\/j.etap.2018.01.011_bib0185","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.yrtph.2015.10.007","article-title":"The potential protective effect of green, black, red and white tea infusions against adverse effect of cadmium and lead during chronic exposure - A rat model study","volume":"73","author":"Winiarska-Mieczan","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2018.01.011_bib0190","first-page":"479","volume":"11","author":"Yaz\u0131han","year":"2011"},{"key":"10.1016\/j.etap.2018.01.011_bib0195","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.7150\/ijms.6308","article-title":"Cadmium induced cell apoptosis, DNA damage, decreased DNA repair capacity, and genomic instability during malignant transformation of human bronchial epithelial cells","volume":"10","author":"Zhou","year":"2013","journal-title":"Int. J. Med. Sci."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668918300188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668918300188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T04:30:50Z","timestamp":1570681850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668918300188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":39,"alternative-id":["S1382668918300188"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2018.01.011","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective role of nebivolol in cadmium-induced hepatotoxicity via downregulation of oxidative stress, apoptosis and inflammatory pathways","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2018.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}