{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:09:09Z","timestamp":1778796549681,"version":"3.51.4"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004728","name":"VIT University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009530","name":"Jawaharlal Institute Of Postgraduate Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.etap.2019.103269","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T11:42:02Z","timestamp":1569238922000},"page":"103269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Sulphated polysaccharide from Sargassum myriocystum confers protection against gentamicin-induced nephrotoxicity in adult zebrafish"],"prefix":"10.1016","volume":"72","author":[{"given":"Durairaj","family":"Vaishnu Devi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3796-5589","authenticated-orcid":false,"given":"Pragasam","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2019.103269_bib0005","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5455\/njppp.2013.3.14-20","article-title":"A study of oxidative stress in gentamicin induced nephrotoxicity and effect of antioxidant vitamin C in wistar rats","volume":"3","author":"Acharya","year":"2013","journal-title":"J. Physiol. Pharm. Pharmacol."},{"key":"10.1016\/j.etap.2019.103269_bib0010","doi-asserted-by":"crossref","first-page":"996","DOI":"10.3109\/0886022X.2016.1165120","article-title":"Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction","volume":"38","author":"Adil","year":"2016","journal-title":"Ren. Fail."},{"key":"10.1016\/j.etap.2019.103269_bib0015","doi-asserted-by":"crossref","DOI":"10.1111\/j.1742-7843.2011.00728.x","article-title":"Experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research","author":"Ali","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.etap.2019.103269_bib0020","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0308-8146(03)00278-4","article-title":"Free-radical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies","volume":"84","author":"Amarowicz","year":"2004","journal-title":"Food Chem."},{"key":"10.1016\/j.etap.2019.103269_bib0025","doi-asserted-by":"crossref","DOI":"10.1177\/1470320308098343","article-title":"Experimental models for nephropathy","author":"Balakumar","year":"2008","journal-title":"JRAAS - J. Renin-Angiotensin-Aldosterone Syst."},{"key":"10.1016\/j.etap.2019.103269_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/polym8050188","article-title":"Repair effect of seaweed polysaccharides with different contents of sulfate group and molecular weights on damaged HK-2 cells","volume":"8","author":"Bhadja","year":"2016","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.etap.2019.103269_bib0035","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4103\/0973-8398.154698","article-title":"Structural characterization and pharmaceutical properties of porphyran","volume":"9","author":"Bhatia","year":"2015","journal-title":"Asian J. Pharm."},{"key":"10.1016\/j.etap.2019.103269_bib0040","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.carres.2003.10.028","article-title":"A highly regular fraction of a fucoidan from the brown seaweed Fucus distichus L","volume":"339","author":"Bilan","year":"2004","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.etap.2019.103269_bib0045","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0008-6215(02)00053-8","article-title":"Structure of a fucoidan from the brown seaweed Fucus evanescens C","volume":"337","author":"Bilan","year":"2002","journal-title":"Ag. Carbohydr. Res."},{"key":"10.1016\/j.etap.2019.103269_bib0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/abio.1993.1198","article-title":"Size-dependent separation of proteoglycans by electrophoresis in gels of pure agarose","volume":"210","author":"Bj\u00f6rnsson","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.etap.2019.103269_bib0055","first-page":"137","article-title":"Fucoidan improves the renal blood flow in the early stage of renal ischemia\/reperfusion injury in the rat","volume":"52","author":"Bojakowski","year":"2001","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.etap.2019.103269_bib0060","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.etap.2019.103269_bib0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/08923973.2012.707211","article-title":"Antiinflammatory and antinociceptive effects in mice of a sulfated polysaccharide fraction extracted from the marine red algae Gracilaria caudata","volume":"35","author":"Chaves","year":"2013","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.etap.2019.103269_bib0070","doi-asserted-by":"crossref","DOI":"10.1007\/s40139-015-0080-4","article-title":"Zebrafish models of kidney damage and repair","author":"Cirio","year":"2015","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.etap.2019.103269_bib0075","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.biopha.2009.03.005","article-title":"Biological activities of sulfated polysaccharides from tropical seaweeds","volume":"64","author":"Costa","year":"2010","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.etap.2019.103269_bib0080","doi-asserted-by":"crossref","DOI":"10.3390\/md13052967","article-title":"Marine polysaccharides from algae with potential biomedical applications","author":"De Jesus Raposo","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.etap.2019.103269_bib0085","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3390\/toxins7010097","article-title":"Nephroprotective role of resveratrol and ursolic acid in aristolochic acid intoxicated zebrafish","volume":"7","author":"Ding","year":"2015","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.etap.2019.103269_bib0090","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0021-9258(18)57178-7","article-title":"A specific color reaction of methylpentoses and a spectrophotometric micromethod for their determination","volume":"175","author":"Dische","year":"1948","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2019.103269_bib0095","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1042\/bj0840106","article-title":"A note on the determination of the ester sulphate content of sulphated polysaccharides","volume":"84","author":"Dodgson","year":"1962","journal-title":"Biochem. J."},{"key":"10.1016\/j.etap.2019.103269_bib0100","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.carbpol.2012.07.075","article-title":"A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects","volume":"91","author":"Dore","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.etap.2019.103269_bib0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0008-6215(01)00149-5","article-title":"Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum","volume":"333","author":"Duarte","year":"2001","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.etap.2019.103269_bib0110","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"Dubois","year":"1956","journal-title":"Anal. Chem."},{"key":"10.1016\/j.etap.2019.103269_bib0115","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.etap.2019.103269_bib0120","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/abio.1995.0014","article-title":"Microplate superoxide dismutase assay employing a nonenzymatic superoxide generator","volume":"232","author":"Ewing","year":"1995","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.etap.2019.103269_bib0125","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/glycob\/cwm139","article-title":"A preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladum","volume":"18","author":"Farias","year":"2008","journal-title":"Glycobiology"},{"key":"10.1016\/j.etap.2019.103269_bib0130","series-title":"Probit Analysis","author":"Finney","year":"1971"},{"key":"10.1016\/j.etap.2019.103269_bib0135","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.foodchem.2014.08.016","article-title":"Structural characterisation, physicochemical properties and antioxidant activity of polysaccharide from Lilium lancifolium Thunb","volume":"169","author":"Gao","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.etap.2019.103269_bib0140","doi-asserted-by":"crossref","DOI":"10.3791\/2839","article-title":"Dissection of the adult zebrafish kidney","author":"Gerlach","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.etap.2019.103269_bib0145","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00204-006-0157-2","article-title":"Comparative effects of selective and non-selective nitric oxide synthase inhibition in gentamicin-induced rat nephrotoxicity","volume":"81","author":"Ghaznavi","year":"2007","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.etap.2019.103269_bib0150","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1177\/175114371301400313","article-title":"Survey on the use of gentamicin and vancomycin in adult intensive care units 1A02","volume":"14","author":"Gopal","year":"2013","journal-title":"J. Intensive Care Soc."},{"key":"10.1016\/j.etap.2019.103269_bib0155","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-017-2063-1","article-title":"Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations","author":"Gorgulho","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.etap.2019.103269_bib0160","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.etap.2019.103269_bib0165","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijbiomac.2015.03.030","article-title":"Antioxidant and antitumor activities in vitro of polysaccharides from E. sipunculoides","volume":"78","author":"He","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.etap.2019.103269_bib0170","doi-asserted-by":"crossref","DOI":"10.1152\/ajprenal.00386.2004","article-title":"Acute renal failure in zebrafish: a novel system to study a complex disease","author":"Hentschel","year":"2005","journal-title":"Am. J. Physiol. Physiol."},{"key":"10.1016\/j.etap.2019.103269_bib0175","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfi110","article-title":"Zebrafish as a model vertebrate for investigating chemical toxicity","author":"Hill","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2019.103269_bib0180","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00134-015-3934-7","article-title":"Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study","volume":"41","author":"Hoste","year":"2015","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.etap.2019.103269_bib0185","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.molimm.2013.01.013","article-title":"Kidney injury molecule-1 and osteopontin: new markers for prediction of early kidney transplant rejection","volume":"54","author":"Jin","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.etap.2019.103269_bib0190","doi-asserted-by":"crossref","DOI":"10.19071\/jp.2015.v7.2921","article-title":"Antioxidant and antimitotic activities of sulfated polysaccharide from marine brown algae Padina tetrastromatica","volume":"7","author":"Jose","year":"2015","journal-title":"J. Phytol."},{"key":"10.1016\/j.etap.2019.103269_bib0195","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1742-7843.2007.00081.x","article-title":"Sulphated polysaccharides: new insight in the prevention of cyclosporine A-induced glomerular injury","volume":"101","author":"Josephine","year":"2007","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.etap.2019.103269_bib0200","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11010-005-9081-7","article-title":"Evaluating the effect of sulphated polysaccharides on cyclosporine A induced oxidative renal injury","volume":"287","author":"Josephine","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.etap.2019.103269_bib0205","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0008-6215(95)00412-2","article-title":"FTIR and laser-Raman spectra of oligosaccharides in water: characterization of the glycosidic bond","volume":"284","author":"Ka\u010dur\u00e1kov\u00e1","year":"1996","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.etap.2019.103269_bib0210","doi-asserted-by":"crossref","DOI":"10.3791\/51912","article-title":"Kidney regeneration in adult zebrafish by gentamicin induced injury","author":"Kamei","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.etap.2019.103269_bib0215","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tox.2005.07.007","article-title":"Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats","volume":"215","author":"Karahan","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2019.103269_bib0220","first-page":"28","article-title":"Effect of benzene on the enzymes of carbohydrate metabolism, brush border membrane (BBM) and oxidative stress in kidney and other rat tissues","volume":"1","author":"Khan","year":"2009","journal-title":"Biol. Med."},{"key":"10.1016\/j.etap.2019.103269_bib0225","doi-asserted-by":"crossref","DOI":"10.4490\/ALGAE.2007.22.3.247","article-title":"Purification and anticoagulant activity of a fucoidan from korean undaria pinnatifida sporophyll","author":"Kim","year":"2007","journal-title":"Algae"},{"key":"10.1016\/j.etap.2019.103269_bib0230","doi-asserted-by":"crossref","DOI":"10.3791\/2126","article-title":"Intraperitoneal injection into adult zebrafish","author":"Kinkel","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.etap.2019.103269_bib0235","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1021\/tx00030a017","article-title":"Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide","volume":"5","author":"Koppenol","year":"1992","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.etap.2019.103269_bib0240","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3390\/molecules13081671","article-title":"Fucoidan: structure and bioactivity","volume":"13","author":"Li","year":"2008","journal-title":"Molecules"},{"key":"10.1016\/j.etap.2019.103269_bib0245","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.etap.2019.103269_bib0250","doi-asserted-by":"crossref","DOI":"10.1038\/ki.2010.337","article-title":"New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view","author":"Lopez-Novoa","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.etap.2019.103269_bib0255","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0891-5849(03)00312-5","article-title":"Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage","volume":"35","author":"Maldonado","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.etap.2019.103269_bib0260","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.ejphar.2011.08.037","article-title":"Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats","volume":"670","author":"Manikandan","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.etap.2019.103269_bib0265","doi-asserted-by":"crossref","DOI":"10.3923\/pjbs.2014.402.407","article-title":"In vitro antioxidant properties of fucoidan fractions from Sargassum tenerrimum","author":"Marudhupandi","year":"2014","journal-title":"Pak. J. Biol. Sci."},{"key":"10.1016\/j.etap.2019.103269_bib0270","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/547636","article-title":"Atlas of cellular dynamics during zebrafish adult kidney regeneration","volume":"2015","author":"McCampbell","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.etap.2019.103269_bib0275","doi-asserted-by":"crossref","DOI":"10.1007\/s40139-015-0082-2","article-title":"Zebrafish renal pathology: emerging models of acute kidney injury","author":"McKee","year":"2015","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.etap.2019.103269_bib0280","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1111\/j.1523-1755.2004.00927.x","article-title":"Spectrum of acute renal failure in the intensive care unit: the PICARD experience","volume":"66","author":"Mehta","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.etap.2019.103269_bib0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2011.09.001","article-title":"Seaweeds: a sustainable functional food for complementary and alternative therapy","author":"Mohamed","year":"2012","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.etap.2019.103269_bib0290","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ki.2010.11","article-title":"Metformin prevents experimental gentamicin-induced nephropathyby a mitochondria-dependent pathway","volume":"77","author":"Morales","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.etap.2019.103269_bib0295","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.clnu.2013.05.005","article-title":"Ascorbic acid reduces gentamicin-induced nephrotoxicity in rats through the control of reactive oxygen species","volume":"33","author":"Moreira","year":"2014","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.etap.2019.103269_bib0300","series-title":"Fish Acute Tox. OECD TG 1\u201318","author":"OECD-203","year":"1992"},{"key":"10.1016\/j.etap.2019.103269_bib0305","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.etap.2019.103269_bib0310","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.msec.2010.05.002","article-title":"Degradation of sulfated polysaccharide extracted from algal Laminaria japonica and its modulation on calcium oxalate crystallization","volume":"30","author":"Ouyang","year":"2010","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.etap.2019.103269_bib0315","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1021\/jf302619c","article-title":"Structural characterization of an arabinogalactan-protein from the fruits of lycium ruthenicum","volume":"60","author":"Peng","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.etap.2019.103269_bib0320","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.carbpol.2010.06.048","article-title":"Structural characterization of polysaccharides from Hyriopsis cumingii","volume":"82","author":"Qiao","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.etap.2019.103269_bib0325","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/toxsci\/kfq267","article-title":"An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin","volume":"119","author":"Quiros","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2019.103269_bib0330","article-title":"Guidance on the housing and care of Zebrafish (Danio rerio), research animals department, science group","author":"Reed","year":"2011","journal-title":"RSPCA"},{"key":"10.1016\/j.etap.2019.103269_bib0335","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.phytochem.2010.05.021","article-title":"Structural characterization of laminaran and galactofucan extracted from the brown seaweed Saccharina longicruris","volume":"71","author":"Rioux","year":"2010","journal-title":"Phytochemistry"},{"key":"10.1016\/j.etap.2019.103269_bib0340","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/j.1529-8817.2009.00699.x","article-title":"Seasonal variability of physicochemical and rheological properties of ulvan in two ulva species (chlorophyta) from the Brittany coast1","volume":"45","author":"Robic","year":"2009","journal-title":"J. Phycol."},{"key":"10.1016\/j.etap.2019.103269_bib0345","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.taap.2014.02.022","article-title":"Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection","volume":"277","author":"Sahu","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2019.103269_bib0350","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21081085","article-title":"Immunomodulatory and antioxidant effects of polysaccharides from Gynostemma pentaphyllum Makino in immunosuppressed mice","volume":"21","author":"Shang","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.etap.2019.103269_bib0355","article-title":"Diagnostic value of urinary kidney injury molecule 1 for acute kidney injury: a meta-analysis","volume":"9","author":"Shao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2019.103269_bib0360","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jams.2012.03.002","article-title":"In vitro antioxidant and free radical scavenging activity of nardostachys jatamansi DC","volume":"5","author":"Sharma","year":"2012","journal-title":"J. Acupunct. Meridian Stud."},{"key":"10.1016\/j.etap.2019.103269_bib0365","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijbiomac.2016.06.100","article-title":"Bioactivities, isolation and purification methods of polysaccharides from natural products: a review","volume":"92","author":"Shi","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.etap.2019.103269_bib0370","series-title":"Extraction and Purification of Sulfated Polysaccharide from Brown Algae and Its Efficacy in Preventing Blood Clotting","author":"Sigamani","year":"2017"},{"key":"10.1016\/j.etap.2019.103269_bib0375","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10811-009-9438-5","article-title":"Monthly changes in the content and monosaccharide composition of fucoidan from Undaria pinnatifida (Laminariales, Phaeophyta)","volume":"22","author":"Skriptsova","year":"2010","journal-title":"J. Appl. Phycol."},{"key":"10.1016\/j.etap.2019.103269_bib0380","first-page":"62","article-title":"The state of the art of the zebrafish model for toxicology and toxicologic pathology research\u2014advantages and current limitations","volume":"31","author":"Spitsbergen","year":"2003","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.etap.2019.103269_bib0385","doi-asserted-by":"crossref","DOI":"10.1172\/JCI11830","article-title":"NF-\u03baB: a key role in inflammatory diseases","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.etap.2019.103269_bib0390","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jep.2011.12.022","article-title":"Effect and mechanism of fucoidan derivatives from Laminaria japonica in experimental adenine-induced chronic kidney disease","volume":"139","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.etap.2019.103269_bib0395","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijbiomac.2007.10.003","article-title":"Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica","volume":"42","author":"Wang","year":"2008","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.etap.2019.103269_bib0400","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijbiomac.2008.11.010","article-title":"Synthesized phosphorylated and aminated derivatives of fucoidan and their potential antioxidant activity in vitro","volume":"44","author":"Wang","year":"2009","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.etap.2019.103269_bib0405","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ijbiomac.2011.08.026","article-title":"International Journal of Biological Macromolecules in vitro antioxidant activities of sulfated polysaccharide fractions extracted from Corallina officinalis","volume":"49","author":"Yang","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.etap.2019.103269_bib0410","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.foodchem.2008.04.012","article-title":"Purification, antitumor and antioxidant activities in vitro of polysaccharides from the brown seaweed Sargassum pallidum","volume":"111","author":"Ye","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.etap.2019.103269_bib0415","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.carbpol.2016.08.092","article-title":"Isolation, purification, characterization and immunostimulatory activity of polysaccharides derived from American ginseng","volume":"156","author":"Yu","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.etap.2019.103269_bib0420","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1055\/s-2003-40634","article-title":"Effects of fucoidan on chronic renal failure in rats","volume":"69","author":"Zhang","year":"2003","journal-title":"Planta Med."},{"key":"10.1016\/j.etap.2019.103269_bib0425","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1025137728525","article-title":"Antioxidant activities of sulfated polysaccharide fractions from Porphyra haitanesis","volume":"15","author":"Zhang","year":"2003","journal-title":"J. Appl. Phycol."},{"key":"10.1016\/j.etap.2019.103269_bib0430","doi-asserted-by":"crossref","DOI":"10.1038\/ki.2010.20","article-title":"Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria","author":"Zorov","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.etap.2019.103269_bib0435","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.carbpol.2010.01.038","article-title":"Structure characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L","volume":"80","author":"Zou","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.etap.2019.103269_bib0440","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-0981(03)00244-2","article-title":"Water-soluble polysaccharides of some far-eastern brown seaweeds. Distribution, structure, and their dependence on the developmental conditions","volume":"294","author":"Zvyagintseva","year":"2003","journal-title":"J. Exp. Mar. Bio. Ecol."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668919301437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668919301437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T09:43:57Z","timestamp":1761299037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668919301437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":88,"alternative-id":["S1382668919301437"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2019.103269","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sulphated polysaccharide from Sargassum myriocystum confers protection against gentamicin-induced nephrotoxicity in adult zebrafish","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2019.103269","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103269"}}