{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:22:54Z","timestamp":1790796174451,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o Amparo \u00e0 Pesquisa do Estado do Piau\u00ed"},{"name":"Universidade Federal do Piau\u00ed UFPI"},{"name":"UNINOVAFAPI University Center"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.etap.2020.103470","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T10:29:21Z","timestamp":1597573761000},"page":"103470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["preADMET analysis and clinical aspects of dogs treated with the Organotellurium compound RF07: A possible control for canine visceral leishmaniasis?"],"prefix":"10.1016","volume":"80","author":[{"given":"Adriana Maria","family":"Viana Nunes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"das Chagas Pereira de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia Alves","family":"Filgueiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oct\u00e1vio Augusto","family":"de Carvalho Maia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo L.O.R.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-6548","authenticated-orcid":false,"given":"Sindy V.A.","family":"Rodezno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Luiz Martins","family":"Maia Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A\u00e9cio","family":"de Amorim Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora Cavalcante","family":"Braz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9778-3667","authenticated-orcid":false,"given":"Anderson Nogueira","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2020.103470_bib0005","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.fct.2008.04.010","article-title":"Bcl-2 expression and apoptosis induction in human HL60 leukaemic cells treated with a novel organotellurium(IV) compound RT-04","volume":"46","author":"Abondanza","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2020.103470_bib0010","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.tvjl.2013.08.024","article-title":"Leishmaniasis causes oxidative stress and alteration of oxidative metabolism and viability of neutrophils in dogs","volume":"198","author":"Almeida","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.etap.2020.103470_bib0015","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1073\/pnas.69.11.3128","article-title":"Carcinogens as frameshift mutagens: metabolites and derivatives of 2-Acetylaminofluorene and other aromatic amine carcinogens","volume":"69","author":"Ames","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.etap.2020.103470_bib0020","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1023\/A:1023090929302","article-title":"Distribution and relationships between clinical and biopathological parameters in canine leishmaniasis","volume":"18","author":"Amusategui","year":"2003","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.etap.2020.103470_bib0025","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/infdis\/154.6.1003","article-title":"New perspectives on a subclinical form of visceral leishmaniasis","volume":"154","author":"Badaro","year":"1986","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.etap.2020.103470_bib0030","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/clind\/24.4.684","article-title":"Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years","volume":"24","author":"Berman","year":"1997","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.etap.2020.103470_bib0035","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.0306-5251.2001.01548.x","article-title":"Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs","volume":"53","author":"Bertilsson","year":"2002","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.etap.2020.103470_bib0040","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/infdis\/165.3.535","article-title":"Immunologic markers of clinical evolution in children recently infected with Leishmania donovani chagasi","volume":"165","author":"Carvalho","year":"1992","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.etap.2020.103470_bib0045","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.bmcl.2004.11.012","article-title":"Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B. Bioorg","volume":"15","author":"Cunha","year":"2005","journal-title":"Med. Chem. Lett."},{"key":"10.1016\/j.etap.2020.103470_bib0050","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1515\/BC.2009.125","article-title":"Irreversible inhibition of human cathepsins B, L, S and K by hypervalent tellurium compounds","volume":"390","author":"Cunha","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.etap.2020.103470_bib0055","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.bjid.2013.11.013","article-title":"Kidney involvement in leishmaniasis--a review","volume":"18","author":"da Silva Junior","year":"2014","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.etap.2020.103470_bib0060","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0022-3565(24)29199-0","article-title":"Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos","volume":"299","author":"Dai","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.etap.2020.103470_bib0065","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3389\/fphar.2014.00203","article-title":"Early identification of hERG liability in drug discovery programs by automated patch clamp","volume":"5","author":"Danker","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.etap.2020.103470_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005150","article-title":"Epidemiologic correlates of mortality among symptomatic visceral leishmaniasis cases: findings from situation assessment in high endemic foci in India","volume":"10","author":"Das","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.etap.2020.103470_bib0075","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1590\/S0037-86822012000100006","article-title":"Clinical and laboratory alterations in dogs naturally infected by Leishmania chagasi","volume":"45","author":"de Freitas","year":"2012","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.etap.2020.103470_bib0080","article-title":"Clinical and laboratory alterations in dogs naturally infected by Leishmania chagasi","author":"de Freitas","year":"2012","journal-title":"Rev. da Soc. Bras. Med. Trop."},{"key":"10.1016\/j.etap.2020.103470_bib0085","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41586-018-0327-4","article-title":"Challenges and recent progress in drug discovery for tropical diseases","volume":"559","author":"De Rycker","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.etap.2020.103470_bib0090","article-title":"In vitro and in vivo activity of a palladacycle complex on leishmania (Leishmania) amazonensis","volume":"6","author":"de S. Paladi","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.etap.2020.103470_bib0095","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.2174\/138161209788682479","article-title":"Drug-like property concepts in pharmaceutical design","volume":"15","author":"Di","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.etap.2020.103470_bib0100","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1590\/0037-8682-0120-2016","article-title":"Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis","volume":"49","author":"Duarte","year":"2016","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.etap.2020.103470_bib0105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.parint.2015.09.006","article-title":"Hypervalent organotellurium compounds as inhibitors of P. Falciparum calcium-dependent cysteine proteases","volume":"65","author":"El Chamy Maluf","year":"2016","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.etap.2020.103470_bib0110","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1124\/dmd.107.019265","article-title":"CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles","volume":"36","author":"Foti","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.etap.2020.103470_bib0115","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1357-2725(98)00113-7","article-title":"Binding of tellurium to hepatocellular selenoproteins during incubation with inorganic tellurite: consequences for the activity of selenium-dependent glutathione peroxidase","volume":"31","author":"Garberg","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.etap.2020.103470_bib0120","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1590\/S1415-790X2004000300011","article-title":"Leishmaniose visceral no Brasil: quadro atual, desafios e perspectivas","volume":"7","author":"Gontijo","year":"2004","journal-title":"Rev. Bras. Epidemiol."},{"key":"10.1016\/j.etap.2020.103470_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0185438","article-title":"Field trial of efficacy of the Leish-tec\u00ae vaccine against canine leishmaniasis caused by Leishmania infantum in an endemic area with high transmission rates","volume":"12","author":"Grimaldi","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2020.103470_bib0130","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.autrev.2014.08.003","article-title":"The effect of the novel tellurium compound AS101 on autoimmune diseases","volume":"13","author":"Halpert","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.etap.2020.103470_bib0135","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41597-020-0451-5","article-title":"An interactive database of Leishmania species distribution in the Americas","volume":"7","author":"Herrera","year":"2020","journal-title":"Sci. Data"},{"key":"10.1016\/j.etap.2020.103470_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jim.2015.03.017","article-title":"Vaccines for visceral leishmaniasis: a review","volume":"422","author":"Jain","year":"2015","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.etap.2020.103470_bib0145","doi-asserted-by":"crossref","DOI":"10.1038\/nrd2445","article-title":"The influence of drug-like concepts on decision-making in medicinal chemistry","author":"Leeson","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.etap.2020.103470_bib0150","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3347\/kjp.2009.47.3.213","article-title":"A novel organotellurium compound (RT-01) as a new antileishmanial agent","volume":"47","author":"Lima","year":"2009","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/j.etap.2020.103470_bib0155","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1186\/s13071-019-3723-1","article-title":"Assessment of histological liver alterations in dogs naturally infected with Leishmania infantum","volume":"12","author":"Lima","year":"2019","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.etap.2020.103470_bib0160","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ridd.2009.08.005","article-title":"Serum glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) levels in children and adolescents with intellectual disabilities","volume":"31","author":"Lin","year":"2010","journal-title":"Res. Dev. Disabil."},{"key":"10.1016\/j.etap.2020.103470_bib0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1056-8719(00)00107-6","article-title":"Drug-like properties and the causes of poor solubility and poor permeability","volume":"44","author":"Lipinski","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.etap.2020.103470_bib0170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s004300100076","article-title":"Leishmania infection and virulence","volume":"190","author":"Matlashewski","year":"2001","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.etap.2020.103470_bib0175","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s41182-016-0011-z","article-title":"Decentralized control of human visceral leishmaniasis in endemic urban areas of Brazil: a literature review","volume":"44","author":"Menon","year":"2016","journal-title":"Trop. Med. Health"},{"key":"10.1016\/j.etap.2020.103470_bib0180","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1365-3164.2009.00824.x","article-title":"Multicentric, controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosis","volume":"20","author":"Miro","year":"2009","journal-title":"Vet. Dermatol."},{"key":"10.1016\/j.etap.2020.103470_bib0185","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ijpharm.2011.02.023","article-title":"Mathematical models of skin permeability: an overview","volume":"418","author":"Mitragotri","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.etap.2020.103470_bib0190","first-page":"34","article-title":"Leishmaniosis canina","volume":"6","author":"Nieto","year":"2005","journal-title":"Terap\u00e9utica. Inf. Vet."},{"key":"10.1016\/j.etap.2020.103470_bib0195","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jmgm.2016.03.001","article-title":"Docking and ADMET prediction of few GSK-3 inhibitors divulges 6-bromoindirubin-3-oxime as a potential inhibitor","volume":"65","author":"Nisha","year":"2016","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.etap.2020.103470_bib0200","first-page":"8","article-title":"A randomised, double-blind, controlled efficacy trial of the LiESP\/QA-21 vaccine in na\u00efve dogs exposed to Two Leishmania infantum transmission seasons","author":"Oliva","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.etap.2020.103470_bib0205","doi-asserted-by":"crossref","first-page":"7990","DOI":"10.1038\/s41598-020-64820-9","article-title":"Immunity to vector saliva is compromised by short sand fly seasons in endemic regions with temperate climates","volume":"10","author":"Oliveira","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.etap.2020.103470_bib0210","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1023\/A:1008130001697","article-title":"Property distribution of drug-related chemical databases","volume":"14","author":"Oprea","year":"2000","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.etap.2020.103470_bib0215","first-page":"1","article-title":"Plant-derived compounds in treatment of leishmaniasis","volume":"16","author":"Oryan","year":"2015","journal-title":"Iran. J. Vet. Res."},{"key":"10.1016\/j.etap.2020.103470_bib0220","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.apjtm.2016.06.021","article-title":"Worldwide risk factors in leishmaniasis","volume":"9","author":"Oryan","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.etap.2020.103470_bib0225","doi-asserted-by":"crossref","DOI":"10.1002\/0471140856.tx0110s39","article-title":"Use of medaka in toxicity testing","author":"Padilla","year":"2009","journal-title":"Curr. Protoc. Toxicol."},{"key":"10.1016\/j.etap.2020.103470_bib0230","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/vcp.12413","article-title":"Laboratory tests for diagnosing and monitoring canine leishmaniasis","volume":"45","author":"Paltrinieri","year":"2016","journal-title":"Vet. Clin. Pathol."},{"key":"10.1016\/j.etap.2020.103470_bib0235","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/jmf.2010.0018","article-title":"Natural products from Garcinia brasiliensis as Leishmania protease inhibitors","volume":"14","author":"Pereira","year":"2011","journal-title":"J. Med. Food"},{"key":"10.1016\/j.etap.2020.103470_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0004614","article-title":"Recombinant forms of leishmania amazonensis Excreted\/Secreted promastigote surface antigen (PSA) induce protective immune responses in dogs","volume":"10","author":"Petitdidier","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.etap.2020.103470_bib0245","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.rvsc.2019.08.028","article-title":"Neutrophil-to-lymphocyte ratio, nucleated red blood cells and erythrocyte abnormalities in canine systemic inflammatory response syndrome","volume":"126","author":"Pierini","year":"2019","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.etap.2020.103470_bib0250","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1023\/A:1015810312465","article-title":"Predicting skin permeability","volume":"9","author":"Potts","year":"1992","journal-title":"Pharm. Res."},{"key":"10.1016\/j.etap.2020.103470_bib0255","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1383-5718(97)00196-4","article-title":"Chemicals mutagenic in Salmonella typhimurium strain TA1535 but not in TA100","volume":"412","author":"Prival","year":"1998","journal-title":"Mutat. Res."},{"key":"10.1016\/j.etap.2020.103470_bib0260","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/835910","article-title":"Natural products: insights into leishmaniasis inflammatory response","volume":"2015","author":"Rodrigues","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.etap.2020.103470_bib0265","article-title":"In vitro and in vivo activity of an organic tellurium compound on Leishmania (Leishmania) chagasi","volume":"7","author":"Salerno Pimentel","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2020.103470_bib0270","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1590\/S0103-84782006000600023","article-title":"Laboratorial accompaniment of kidney funtion of health dogs experimentally treated with therapeutic dosages of amphotericin B","volume":"36","author":"Santin","year":"2006","journal-title":"Cienc. Rural"},{"key":"10.1016\/j.etap.2020.103470_bib0275","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12539-013-0200-y","article-title":"In silico molecular docking, preclinical evaluation of spiroindimicins A-D, lynamicin A and D isolated from deep marine sea derived Streptomyces sp. SCSIO 03032","volume":"6","author":"Saurav","year":"2014","journal-title":"Interdiscip. Sci."},{"key":"10.1016\/j.etap.2020.103470_bib0280","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri.2016.72","article-title":"Cutaneous leishmaniasis: immune responses in protection and pathogenesis","volume":"16","author":"Scott","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.etap.2020.103470_bib0285","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1939-1676.1993.tb03163.x","article-title":"Endemic visceral leishmaniasis in a dog from Texas","volume":"7","author":"Sellon","year":"1993","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.etap.2020.103470_bib0290","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/med.2610130504","article-title":"Transdermal drug delivery by passive diffusion and iontophoresis: a review","volume":"13","author":"Singh","year":"1993","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.etap.2020.103470_bib0295","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12941-016-0170-0","article-title":"Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites","volume":"15","author":"Tariq","year":"2016","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.etap.2020.103470_bib0300","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.prevetmed.2016.08.006","article-title":"Correlations between peripheral parasite load and common clinical and laboratory alterations in dogs with visceral leishmaniasis","volume":"132","author":"Torrecilha","year":"2016","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.etap.2020.103470_bib0305","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/ptr.5710","article-title":"Plants as antileishmanial agents: current scenario","volume":"30","author":"Ullah","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.etap.2020.103470_bib0310","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/FPC.0b013e3283349e84","article-title":"Cytochrome P450 2C9-CYP2C9","volume":"20","author":"Van Booven","year":"2010","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.etap.2020.103470_bib0315","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"335","author":"von Elm","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.etap.2020.103470_bib0320","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.jacc.2013.02.058","article-title":"The P-glycoprotein transport system and cardiovascular drugs","volume":"61","author":"Wessler","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.etap.2020.103470_bib0325","first-page":"1931","article-title":"Acute toxicity data: a comprehensive comparison of results of fish, Daphnia,and algae tests with new substances notified in the European Union","volume":"19","author":"Weyers","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.etap.2020.103470_bib0330","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0006-2952(97)00517-0","article-title":"Antioxidative properties of organotellurium compounds in cell systems","volume":"55","author":"Wieslander","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.etap.2020.103470_bib0335","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12011-017-1006-2","article-title":"Tracing tellurium and its nanostructures in biology","volume":"180","author":"Zare","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.etap.2020.103470_bib0340","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1021\/om980738d","article-title":"Addition reaction of p-Methoxyphenyltellurium trichloride to 3-Hydroxy alkynes","volume":"18","author":"Zeni","year":"1999","journal-title":"Organometallics"},{"key":"10.1016\/j.etap.2020.103470_bib0345","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1038\/s41467-020-17154-z","article-title":"A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.etap.2020.103470_bib0350","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/jps.1031","article-title":"Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors","volume":"90","author":"Zhao","year":"2001","journal-title":"J. Pharm. Sci."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668920301460?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668920301460?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T09:45:12Z","timestamp":1761299112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668920301460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":70,"alternative-id":["S1382668920301460"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2020.103470","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"preADMET analysis and clinical aspects of dogs treated with the Organotellurium compound RF07: A possible control for canine visceral leishmaniasis?","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2020.103470","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103470"}}