{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:53:50Z","timestamp":1782489230154,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.etap.2021.103605","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T06:01:26Z","timestamp":1612332086000},"page":"103605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy"],"prefix":"10.1016","volume":"84","author":[{"given":"Rong","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2021.103605_bib0005","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/stem.3038","article-title":"C-met signaling is essential for mouse adult liver progenitor cells expansion after transforming growth factor-beta-induced epithelial-mesenchymal transition and regulates cell phenotypic switch","volume":"37","author":"Almale","year":"2019","journal-title":"Stem Cells"},{"key":"10.1016\/j.etap.2021.103605_bib0010","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1523\/JNEUROSCI.1348-17.2017","article-title":"Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity","volume":"38","author":"Bai","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.etap.2021.103605_bib0015","doi-asserted-by":"crossref","first-page":"F160","DOI":"10.1152\/ajprenal.90567.2008","article-title":"Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death","volume":"296","author":"Bouvier","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.etap.2021.103605_bib0020","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1038\/s41419-017-0017-4","article-title":"circHIPK2-mediated sigma-1R promotes endoplasmic reticulum stress in human pulmonary fibroblasts exposed to silica","volume":"8","author":"Cao","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.etap.2021.103605_bib0025","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000452547","article-title":"Role of MCPIP1 in the endothelial-mesenchymal transition induced by silica","volume":"40","author":"Chao","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.etap.2021.103605_bib0030","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.4049\/jimmunol.1800124","article-title":"Epidermal growth factor (EGF) autocrine activation of human platelets promotes EGF receptor-dependent oral squamous cell carcinoma invasion, migration, and epithelial mesenchymal transition","volume":"201","author":"Chen","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.etap.2021.103605_bib0035","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1667\/RR13625.1","article-title":"Transforming growth factor alpha is a critical mediator of radiation lung injury","volume":"182","author":"Chung","year":"2014","journal-title":"Radiat. Res."},{"key":"10.1016\/j.etap.2021.103605_bib0040","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nature16063","article-title":"FGF signalling regulates bone growth through autophagy","volume":"528","author":"Cinque","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.etap.2021.103605_bib0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061299","article-title":"ER stress is involved in Epithelial-To-Mesenchymal transition of alveolar epithelial cells exposed to a hypoxic microenvironment","volume":"20","author":"Delbrel","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.etap.2021.103605_bib0050","article-title":"Current understanding of fibrosis in genetic cardiomyopathies","author":"Eijgenraam","year":"2019","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.etap.2021.103605_bib0055","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41419-018-0432-1","article-title":"circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1","volume":"9","author":"Fang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.etap.2021.103605_bib0060","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00063198-200003000-00010","article-title":"Pathology and pathophysiology of pneumoconiosis","volume":"6","author":"Fujimura","year":"2000","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.etap.2021.103605_bib0065","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature16187","article-title":"Autophagy maintains stemness by preventing senescence","volume":"529","author":"Garcia-Prat","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.etap.2021.103605_bib0070","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41586-019-1006-9","article-title":"Autophagy induction via STING trafficking is a primordial function of the cGAS pathway","volume":"567","author":"Gui","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.etap.2021.103605_bib0075","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1183\/09059180.00001012","article-title":"Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis","volume":"21","author":"Gunther","year":"2012","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.etap.2021.103605_bib0080","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41419-019-1820-x","article-title":"Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis","volume":"10","author":"Hill","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.etap.2021.103605_bib0085","first-page":"192","article-title":"Identification of differentially expressed circular RNAs during TGF-ss1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells","volume":"19","author":"Huang","year":"2018","journal-title":"Anatol. J. Cardiol."},{"key":"10.1016\/j.etap.2021.103605_bib0090","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.toxlet.2019.02.014","article-title":"The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition","volume":"307","author":"Jiang","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.etap.2021.103605_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.07.005","article-title":"SPIO nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by SiO2","volume":"383","author":"Jiang","year":"2019","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.etap.2021.103605_bib0100","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.3389\/fimmu.2018.01309","article-title":"Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins","volume":"9","author":"Li","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.etap.2021.103605_bib0105","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fcell.2019.00245","article-title":"The chromatin remodeler Brg1 integrates ROS production and endothelial-mesenchymal transition to promote liver fibrosis in mice","volume":"7","author":"Li","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.etap.2021.103605_bib0110","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jdiacomp.2016.01.009","article-title":"Advanced oxidation protein products induce endothelial-to-mesenchymal transition in human renal glomerular endothelial cells through induction of endoplasmic reticulum stress","volume":"30","author":"Liang","year":"2016","journal-title":"J. Diab. Compl."},{"key":"10.1016\/j.etap.2021.103605_bib0115","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12989-016-0167-z","article-title":"Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy","volume":"13","author":"Liu","year":"2016","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.etap.2021.103605_bib0120","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bcp.2019.06.021","article-title":"Endothelial-to-mesenchymal transition: pathogenesis and therapeutic targets for chronic pulmonary and vascular diseases","volume":"168","author":"Lu","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.etap.2021.103605_bib0125","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S2213-2600(19)30078-5","article-title":"The lancet respiratory. The world is failing on silicosis","volume":"7","author":"M","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.etap.2021.103605_bib0130","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3389\/fimmu.2018.00874","article-title":"Silicosis and silica-induced autoimmunity in the diversity outbred mouse","volume":"9","author":"Mayeux","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.etap.2021.103605_bib0135","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1164\/ajrccm.157.5.9707141","article-title":"Mechanisms in the pathogenesis of asbestosis and silicosis","volume":"157","author":"Mossman","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.etap.2021.103605_bib0140","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.ajpath.2011.06.001","article-title":"Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders","volume":"179","author":"Piera-Velazquez","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.etap.2021.103605_bib0145","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8361945","article-title":"Endothelial-to-Mesenchymal transition (EndoMT): roles in Tumorigenesis, metastatic extravasation and therapy resistance","volume":"2019","author":"Platel","year":"2019","journal-title":"J. Oncol."},{"key":"10.1016\/j.etap.2021.103605_bib0150","doi-asserted-by":"crossref","first-page":"10753","DOI":"10.1096\/fj.201900351R","article-title":"Renal progenitor cells revert LPS-induced endothelial-to-mesenchymal transition by secreting CXCL6, SAA4, and BPIFA2 antiseptic peptides","volume":"33","author":"Sallustio","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.etap.2021.103605_bib0155","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1074\/jbc.M114.604603","article-title":"The essential autophagy gene ATG7 modulates organ fibrosis via regulation of endothelial-to-mesenchymal transition","volume":"290","author":"Singh","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2021.103605_bib0160","doi-asserted-by":"crossref","DOI":"10.3390\/cells8030234","article-title":"Selected aspects of chemoresistance mechanisms in colorectal Carcinoma-A focus on epithelial-to-Mesenchymal transition, autophagy, and apoptosis","volume":"8","author":"Skarkova","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.etap.2021.103605_bib0165","article-title":"Calcitriol attenuates doxorubicin-induced cardiac dysfunction and inhibits endothelial-to-Mesenchymal transition in mice","volume":"8","author":"Tsai","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.etap.2021.103605_bib0170","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.196584","article-title":"Retraction: ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells","volume":"129","author":"Ulianich","year":"2016","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.etap.2021.103605_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090965","article-title":"Exogenous hydrogen sulfide (H2S) protects alveolar growth in experimental O2-induced neonatal lung injury","volume":"9","author":"Vadivel","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2021.103605_bib0180","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2174\/157488810790442813","article-title":"Signaling mechanism(s) of reactive oxygen species in epithelial-mesenchymal transition reminiscent of cancer stem cells in tumor progression","volume":"5","author":"Wang","year":"2010","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.etap.2021.103605_bib0185","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/toxsci\/kfw029","article-title":"MCPIP1 regulates alveolar macrophage apoptosis and pulmonary fibroblast activation after in vitro exposure to silica","volume":"151","author":"Wang","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2021.103605_bib0190","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1096\/fj.201701118R","article-title":"Silica-induced initiation of circular ZC3H4 RNA\/ZC3H4 pathway promotes the pulmonary macrophage activation","volume":"32","author":"Yang","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.etap.2021.103605_bib0195","article-title":"Silica-induced initiation of circular ZC3H4 RNA\/ZC3H4 pathway promotes the pulmonary macrophage activation","author":"Yang","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.etap.2021.103605_bib0200","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/toxsci\/kfy221","article-title":"The CDR1as\/miR-7\/TGFBR2 Axis Modulates EMT in silica-induced pulmonary fibrosis","volume":"166","author":"Yao","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2021.103605_bib0205","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/s41418-018-0175-7","article-title":"Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis","volume":"26","author":"Yao","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.etap.2021.103605_bib0210","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.lfs.2015.11.025","article-title":"Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway","volume":"144","author":"Ying","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.etap.2021.103605_bib0215","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijcard.2018.07.148","article-title":"Inhibition of HMGB1 ameliorates cardiac fibrosis through regulation of endothelial-to-mesenchymal transition","volume":"274","author":"Zhang","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.etap.2021.103605_bib0220","doi-asserted-by":"crossref","first-page":"575","DOI":"10.7150\/thno.21648","article-title":"circRNA mediates silica-induced macrophage activation via HECTD1\/ZC3H12A-Dependent ubiquitination","volume":"8","author":"Zhou","year":"2018","journal-title":"Theranostics"}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668921000247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668921000247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T09:46:05Z","timestamp":1761299165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668921000247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":44,"alternative-id":["S1382668921000247"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2021.103605","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2021.103605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103605"}}