{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:09:09Z","timestamp":1790896149612,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFD0801300"],"award-info":[{"award-number":["2017YFD0801300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1803304"],"award-info":[{"award-number":["2018YFC1803304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.etap.2021.103751","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:36:08Z","timestamp":1633480568000},"page":"103751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Disrupted metabolic pathways and potential human diseases induced by bisphenol S"],"prefix":"10.1016","volume":"88","author":[{"given":"Haiyan","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2021.103751_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103373","article-title":"Bisphenol A-induced metabolic disorders: from exposure to mechanism of action","volume":"77","author":"Akash","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2021.103751_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yhbeh.2018.05.009","article-title":"Introduction to the special issue on endocrine disrupting chemicals and behavior","volume":"101","author":"Barrett","year":"2018","journal-title":"Horm. Behav."},{"key":"10.1016\/j.etap.2021.103751_bib0015","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1210\/en.2015-1872","article-title":"Bisphenol S induces adipogenesis in primary human preadipocytes from female donors","volume":"157","author":"Boucher","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.etap.2021.103751_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128009","article-title":"Transgenerational effects on intestinal inflammation status in mice perinatally exposed to bisphenol S","volume":"262","author":"Brulport","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2021.103751_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2016.00112","article-title":"Estrogenic effects of several BPA analogs in the developing zebrafish brain","volume":"10","author":"Cano-Nicolau","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.etap.2021.103751_bib0030","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.envres.2015.07.001","article-title":"Bisphenol A, bisphenol F and bisphenol S affect differently 5\u03b1-reductase expression and dopamine-serotonin systems in the prefrontal cortex of juvenile female rats","volume":"142","author":"Castro","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.etap.2021.103751_bib0035","first-page":"516","article-title":"Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy\/lactation and their daughters","volume":"158","author":"Catanese","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.etap.2021.103751_bib0040","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/acs.est.5b05387","article-title":"Bisphenol analogues other than BPA: environmental occurrence, human exposure, and toxicity - a review","volume":"50","author":"Chen","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2021.103751_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1006223","article-title":"Exposure to the BPA-substitute bisphenol S causes unique alterations of germline function","volume":"12","author":"Chen","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.etap.2021.103751_bib0050","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.envpol.2018.09.093","article-title":"Association of urinary concentrations of bisphenols with type 2 diabetes mellitus: a case-control study *, **","volume":"243","author":"Duan","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2021.103751_bib0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fertnstert.2014.11.005","article-title":"A new chapter in the bisphenol a story: Bisphenol S and bisphenol F are not safe alternatives to this compound","volume":"103","author":"Eladak","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.etap.2021.103751_bib0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.chemosphere.2015.12.081","article-title":"Chemosphere effects of bisphenol analogues on steroidogenic gene expression and hormone synthesis in H295R cells","volume":"147","author":"Feng","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2021.103751_bib0065","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.tiv.2015.03.014","article-title":"Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S","volume":"29","author":"Fic","year":"2015","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.etap.2021.103751_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103387","article-title":"Chronic exposure of bisphenol A impairs carbohydrate and lipid metabolism by altering corresponding enzymatic and metabolic pathways","volume":"78","author":"Haq","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2021.103751_bib0075","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.taap.2014.07.025","article-title":"Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study","volume":"280","author":"H\u00e9li\u00e8s-toussaint","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2021.103751_bib0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2016.05.023","article-title":"Obesogen effects after perinatal exposure of 4,4\u2032-sulfonyldiphenol (Bisphenol S) in C57BL\/6 mice","volume":"357\u2013358","author":"Ivry Del Moral","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2021.103751_bib0085","doi-asserted-by":"crossref","first-page":"8793","DOI":"10.1021\/es400329t","article-title":"Effects of bisphenol S exposure on endocrine functions and reproduction of zebrafish","volume":"47","author":"Ji","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2021.103751_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0196425","article-title":"Comparative analysis of distinctive transcriptome profiles with biochemical evidence in bisphenol S- and benzo[a]pyrene-exposed liver tissues of the olive flounder Paralichthys olivaceus","volume":"13","author":"Jung","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2021.103751_bib0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/toxsci\/kfx133","article-title":"Lifelong exposure of C57bl\/6n male mice to bisphenol A or bisphenol S reduces recovery from a myocardial infarction","volume":"159","author":"Kasneci","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2021.103751_bib0100","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1073\/pnas.1417731112","article-title":"Low-dose exposure to bisphenol a and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish","volume":"112","author":"Kinch","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.etap.2021.103751_bib0105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.reprotox.2018.03.003","article-title":"Low dose bisphenol S or ethinyl estradiol exposures during the perinatal period alter female mouse mammary gland development","volume":"78","author":"Kolla","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.etap.2021.103751_bib0110","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ecoenv.2017.04.009","article-title":"In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays","volume":"142","author":"Le Fol","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.etap.2021.103751_bib0115","doi-asserted-by":"crossref","first-page":"6617","DOI":"10.1021\/acs.est.8b00776","article-title":"Thyroid disruption by bisphenol S analogues via thyroid hormone receptor \u03b2: in vitro, in vivo, and molecular dynamics simulation study","volume":"52","author":"Lu","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2021.103751_bib0120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tiv.2017.02.018","article-title":"Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study)","volume":"41","author":"Ma\u0107czak","year":"2017","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.etap.2021.103751_bib0125","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chemosphere.2018.08.076","article-title":"Chemosphere Effects of perinatal exposure to BPA and its alternatives (BPS, BPF and BPAF) on hepatic lipid and glucose homeostasis in female mice adolescent offspring","volume":"212","author":"Meng","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2021.103751_bib0130","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.envpol.2019.01.116","article-title":"Effects of perinatal exposure to BPA, BPF and BPAF on liver function in male mouse offspring involving in oxidative damage and metabolic disorder","volume":"247","author":"Meng","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2021.103751_bib0135","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.aquatox.2014.01.009","article-title":"Developmental exposure of zebrafish (Danio rerio) to bisphenol-S impairs subsequent reproduction potential and hormonal balance in adults","volume":"148","author":"Naderi","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.etap.2021.103751_bib0140","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.reprotox.2017.06.134","article-title":"Effects of bisphenol A analogues on reproductive functions in mice","volume":"73","author":"Shi","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.etap.2021.103751_bib0145","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/toxsci\/kfy061","article-title":"Prenatal exposure to bisphenol A analogues on male reproductive functions in mice","volume":"163","author":"Shi","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2021.103751_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2018.09.006","article-title":"Cellular, transcriptomic and methylome effects of individual and combined exposure to BPA, BPF, BPS on mouse spermatocyte GC-2 cell line","volume":"359","author":"Sidorkiewicz","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2021.103751_bib0155","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.chemosphere.2016.02.125","article-title":"Effect of bisphenol S exposure on male reproductive system of rats: A histological and biochemical study","volume":"152","author":"Ullah","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2021.103751_bib0160","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.chemosphere.2018.06.089","article-title":"Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: comparative in vitro and in vivo studies on the sperms and testicular tissues of rats","volume":"209","author":"Ullah","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2021.103751_bib0165","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.chemosphere.2018.01.163","article-title":"Bisphenol S induces obesogenic effects through deregulating lipid metabolism in zebrafish (Danio rerio) larvae","volume":"199","author":"Wang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2021.103751_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121737","article-title":"Bisphenol A degradation pathway and associated metabolic networks in Escherichia coli harboring the gene encoding CYP450","volume":"388","author":"Wang","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.etap.2021.103751_bib0175","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.envpol.2018.09.042","article-title":"Transgenerational thyroid endocrine disruption induced by bisphenol S affects the early development of zebrafish offspring","volume":"243","author":"Wei","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2021.103751_bib0180","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jphotobiol.2016.12.020","article-title":"Exploring the effect of bisphenol S on sludge hydrolysis and mechanism of the interaction between bisphenol S and \u03b1 -Amylase through spectrophotometric methods","volume":"167","author":"Yang","year":"2017","journal-title":"J. Photochem. Photobiol. B, Biol."},{"key":"10.1016\/j.etap.2021.103751_bib0185","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.chemosphere.2018.09.133","article-title":"Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish","volume":"213","author":"Yang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2021.103751_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-00570-5","article-title":"Bisphenol S negatively affects the meotic maturation of pig oocytes","volume":"7","author":"\u017dalmanov\u00e1","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.etap.2021.103751_bib0195","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yrtph.2017.11.018","article-title":"Subchronic bisphenol S exposure affects liver function in mice involving oxidative damage","volume":"92","author":"Zhang","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2021.103751_bib0200","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.scitotenv.2017.03.035","article-title":"Bisphenol S exposure modulate macrophage phenotype as defined by cytokines profiling, global metabolomics and lipidomics analysis","volume":"592","author":"Zhao","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.etap.2021.103751_bib0205","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ecoenv.2017.09.048","article-title":"Bisphenol S exposure impairs glucose homeostasis in male zebrafish (Danio rerio)","volume":"147","author":"Zhao","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668921001691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668921001691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T09:49:28Z","timestamp":1761299368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668921001691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":41,"alternative-id":["S1382668921001691"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2021.103751","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disrupted metabolic pathways and potential human diseases induced by bisphenol S","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2021.103751","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103751"}}