{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:02:37Z","timestamp":1787583757107,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":267,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.etap.2023.104076","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T02:26:33Z","timestamp":1675736793000},"page":"104076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Environmental pesticide exposure and the risk of irritable bowel syndrome: A case-control study"],"prefix":"10.1016","volume":"98","author":[{"given":"Lola","family":"Rueda-Ruzafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Requena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ropero-Padilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Alarc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2023.104076_bib1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ntt.2018.04.002","article-title":"Glyphosate based-herbicide exposure affects gut microbiota, anxiety and depression-like behaviors in mice","volume":"67","author":"Aitbali","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.etap.2023.104076_bib2","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.3892\/mmr.2015.3808","article-title":"Molecular and cellular mechanisms of tight junction dysfunction in the irritable bowel syndrome","volume":"12","author":"Cheng","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.etap.2023.104076_bib3","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1289\/ehp.1306534","article-title":"Exercise attenuates PCB-induced changes in the mouse gut microbiome","volume":"121","author":"Choi","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2023.104076_bib4","article-title":"Increased gut permeability and bacterial translocation after chronic chlorpyrifos exposure in rats","volume":"9","author":"Condette","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2023.104076_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/nu7010017","article-title":"The impact of diet and lifestyle on gut microbiota and human health","volume":"7","author":"Conlon","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.etap.2023.104076_bib6","series-title":"Cartograf\u00eda de invernaderos en Almer\u00eda","author":"Consejer\u00eda de Agricultura Pesca y Desarrollo Rural","year":"2017"},{"key":"10.1016\/j.etap.2023.104076_bib7","first-page":"133","article-title":"Newly identified vitamin K-producing bacteria isolated from the neonatal faecal flora","volume":"18","author":"Cooke","year":"2009","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.etap.2023.104076_bib8","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/MCG.0000000000000924","article-title":"Postinfection irritable bowel syndrome: the links between gastroenteritis, inflammation, the microbiome, and functional disease","volume":"51","author":"Downs","year":"2017","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.etap.2023.104076_bib9","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/carcin\/bgg147","article-title":"DNA adduct formation and oxidative stress in colon and liver of Big Blue rats after dietary exposure to diesel particles","volume":"24","author":"Dybdahl","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.etap.2023.104076_bib10","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nri2394","article-title":"The X-files in immunity: sex-based differences predispose immune responses","volume":"8","author":"Fish","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.etap.2023.104076_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1289\/EHP202","article-title":"Sex-specific effects of organophosphate diazinon on the gut microbiome and its metabolic functions","volume":"125","author":"Gao","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2023.104076_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1021\/acs.chemrestox.8b00179","article-title":"The carbamate aldicarb altered the gut microbiome, metabolome and lipidome of C57BL\/6J mice","volume":"32","author":"Gao","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.etap.2023.104076_bib13","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.lfs.2015.10.013","article-title":"Occupational pesticide exposure and adverse health effects at the clinical, hematological and biochemical level","volume":"145","author":"Garc\u00eda-Garc\u00eda","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.etap.2023.104076_bib14","doi-asserted-by":"crossref","first-page":"932","DOI":"10.5009\/gnl15588","article-title":"Irritable bowel syndrome, particularly the constipation-predominant form, involves an increase in Methanobrevibacter smithii, which is associated with higher methane production","volume":"10","author":"Ghoshal","year":"2016","journal-title":"Gut Liver"},{"key":"10.1016\/j.etap.2023.104076_bib15","article-title":"Big sales, no carrots: assessment of pesticide policy in Spain","volume":"141","author":"Gonz\u00e1lez","year":"2021","journal-title":"Crop Prot."},{"key":"10.1016\/j.etap.2023.104076_bib16","unstructured":"International Labour Organization, 2019. Encuesta de Poblaci\u00f3n Activa 2019."},{"key":"10.1016\/j.etap.2023.104076_bib17","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1136\/gutjnl-2011-301501","article-title":"An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota","volume":"61","author":"Jeffery","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.etap.2023.104076_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.chemosphere.2016.06.105","article-title":"Oral imazalil exposure induces gut microbiota dysbiosis and colonic inflammation in mice","volume":"160","author":"Jin","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2023.104076_bib19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/toxsci\/kfx227","article-title":"Insights into a possible influence on gut microbiota and intestinal barrier function during chronic exposure of mice to imazalil","volume":"162","author":"Jin","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2023.104076_bib20","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/toxsci\/kfv115","article-title":"Oral exposure of mice to carbendazim induces hepatic lipid metabolism disorder and gut microbiota dysbiosis","volume":"147","author":"Jin","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2023.104076_bib21","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1007\/s11356-012-1283-4","article-title":"Impact of chronic exposure to low doses of chlorpyrifos on the intestinal microbiota in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and in the rat","volume":"20","author":"Joly","year":"2013","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.etap.2023.104076_bib22","doi-asserted-by":"crossref","first-page":"472","DOI":"10.5009\/gnl.2011.5.4.472","article-title":"The effects of lifestyle modification on symptoms and quality of life in patients with irritable bowel syndrome: a prospective observational study","volume":"5","author":"Kang","year":"2011","journal-title":"Gut Liver"},{"key":"10.1016\/j.etap.2023.104076_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047669","article-title":"Non-specific abdominal pain and air pollution: a novel association","volume":"7","author":"Kaplan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2023.104076_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3349\/ymj.2010.51.1.45","article-title":"Increased immunoendocrine cells in intestinal mucosa of postinfectious irritable bowel syndrome patients 3 years after acute Shigella infection - an observation in a small case control study","volume":"51","author":"Kim","year":"2010","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.etap.2023.104076_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062220","article-title":"Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome","volume":"8","author":"Kish","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2023.104076_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-019-0635-4","article-title":"Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance through impacting gut and gut microbiota","volume":"7","author":"Liang","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.etap.2023.104076_bib27","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2007.01.046","article-title":"Immune activation in patients with irritable bowel syndrome","volume":"132","author":"Liebregts","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2023.104076_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110130","article-title":"Acute oral methylmercury exposure perturbs the gut microbiome and alters gut-brain axis related metabolites in rats","volume":"190","author":"Lin","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.etap.2023.104076_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12302-019-0206-0","article-title":"Pesticide contamination and associated risk factors at public playgrounds near intensively managed apple and wine orchards","volume":"31","author":"Linhart","year":"2019","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.etap.2023.104076_bib30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.toxrep.2017.12.005","article-title":"Sex-dependent impact of Roundup on the rat gut microbiome","volume":"5","author":"Lozano","year":"2018","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.etap.2023.104076_bib31","doi-asserted-by":"crossref","DOI":"10.1289\/EHP2877","article-title":"Metabolic effects of a chronic dietary exposure to a low-dose pesticide cocktail in mice: sexual dimorphism and role of the constitutive androstane receptor","volume":"126","author":"Lukowicz","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2023.104076_bib32","doi-asserted-by":"crossref","first-page":"11371","DOI":"10.3748\/wjg.v21.i40.11371","article-title":"Role of environmental pollution in irritable bowel syndrome","volume":"21","author":"Marynowski","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.etap.2023.104076_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12876-021-01693-w","article-title":"Gut microbiota composition and functional prediction in diarrhea-predominant irritable bowel syndrome","volume":"21","author":"Mei","year":"2021","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.etap.2023.104076_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-022-00860-0","article-title":"Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins","volume":"21","author":"Mesnage","year":"2022","journal-title":"Environ. Health"},{"key":"10.1016\/j.etap.2023.104076_bib35","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3390\/nu11061279","article-title":"Irregular dietary habits with a high intake of cereals and sweets are associated with more severe gastrointestinal symptoms in IBS patients","volume":"11","author":"Nilholm","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.etap.2023.104076_bib36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.intimp.2006.08.015","article-title":"Anti-inflammatory effects of short chain fatty acids in IFN-gamma-stimulated RAW 264.7 murine macrophage cells: involvement of NF-kappaB and ERK signaling pathways","volume":"7","author":"Park","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.etap.2023.104076_bib37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.taap.2011.05.006","article-title":"Association between environmental exposure to pesticides and neurodegenerative diseases","volume":"256","author":"Parr\u00f3n","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.etap.2023.104076_bib38","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/ajg.2012.414","article-title":"Relationship between patterns of alcohol consumption and gastrointestinal symptoms among patients with irritable bowel syndrome","volume":"108","author":"Reding","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.etap.2023.104076_bib39","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3390\/ijerph13111088","article-title":"Changes in composition and function of human intestinal microbiota exposed to chlorpyrifos in oil as assessed by the SHIME\u00ae model","volume":"13","author":"Reygner","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.etap.2023.104076_bib40","article-title":"Survey of glyphosate residues in honey, corn and soy products","volume":"05","author":"Rubio","year":"2014","journal-title":"J. Environ. Anal. Toxicol."},{"key":"10.1016\/j.etap.2023.104076_bib41","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1001\/jama.294.23.3003","article-title":"Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model","volume":"294","author":"Sun","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.etap.2023.104076_bib42","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/1751-2980.12988","article-title":"Sex\u2010based differences in fecal short\u2010chain fatty acid and gut microbiota in irritable bowel syndrome patients","volume":"22","author":"Sun","year":"2021","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.etap.2023.104076_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114129","article-title":"Glyphosate exposure induces inflammatory responses in the small intestine and alters gut microbial composition in rats","volume":"261","author":"Tang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2023.104076_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijerph18031112","article-title":"Agriculture development, pesticide application and its impact on the environment","volume":"18","author":"Tudi","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.etap.2023.104076_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000426","article-title":"Functional roles of B-vitamins in the gut and gut microbiome","volume":"64","author":"Uebanso","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.etap.2023.104076_bib46","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1136\/gutjnl-2013-305690","article-title":"Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism","volume":"63","author":"Vanuytsel","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.etap.2023.104076_bib47","first-page":"17","article-title":"Use of broad-spectrum antibiotics and the development of irritable bowel syndrome","volume":"111","author":"Villarreal","year":"2012","journal-title":"Wmj"},{"key":"10.1016\/j.etap.2023.104076_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005374","article-title":"SeXX matters in infectious disease pathogenesis","volume":"12","author":"vom Steeg","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.etap.2023.104076_bib49","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ni0901-777","article-title":"Sex differences in autoimmune disease","volume":"2","author":"Whitacre","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.etap.2023.104076_bib50","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.chom.2013.09.012","article-title":"Microbial modulation of energy availability in the colon regulates intestinal transit","volume":"14","author":"Wichmann","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.etap.2023.104076_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112476","article-title":"Imidacloprid increases intestinal permeability by disrupting tight junctions","volume":"222","author":"Zhao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668923000170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668923000170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T09:52:48Z","timestamp":1761299568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668923000170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":51,"alternative-id":["S1382668923000170"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2023.104076","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmental pesticide exposure and the risk of irritable bowel syndrome: A case-control study","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2023.104076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104076"}}