{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:35:23Z","timestamp":1792697723035,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.etap.2023.104252","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T00:56:11Z","timestamp":1692492971000},"page":"104252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Effects of glyphosate-based herbicides and glyphosate exposure on sex hormones and the reproductive system: From epidemiological evidence to mechanistic insights"],"prefix":"10.1016","volume":"102","author":[{"given":"Preechaya","family":"Tajai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dumnoensun","family":"Pruksakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn C.","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-0087","authenticated-orcid":false,"given":"Krekwit","family":"Shinlapawittayatorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2023.104252_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3109\/15376516.2014.989349","article-title":"Combined effects of repeated administration of Bretmont Wipeout (glyphosate) and Ultrazin (atrazine) on testosterone, oxidative stress and sperm quality of Wistar rats","volume":"25","author":"Abarikwu","year":"2015","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.etap.2023.104252_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mce.2018.12.007","article-title":"Neonatal exposure to a glyphosate-based herbicide alters the histofunctional differentiation of the ovaries and uterus in lambs","volume":"482","author":"Alarc\u00f3n","year":"2019","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.etap.2023.104252_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114874","article-title":"Neonatal exposure to a glyphosate-based herbicide alters the uterine differentiation of prepubertal ewe lambs","volume":"265","author":"Alarc\u00f3n","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2023.104252_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.fct.2018.05.011","article-title":"Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats","volume":"118","author":"Altamirano","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137358","article-title":"Postnatal exposure to a glyphosate-based herbicide interferes with the development and growth of the mammary gland of pre-pubertal Ewe lambs","volume":"313","author":"Altamirano","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2023.104252_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.627210","article-title":"Controversies on endocrine and reproductive effects of glyphosate and glyphosate-based herbicides: a mini-review","volume":"12","author":"de Ara\u00fajo-Ramos","year":"2021","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.etap.2023.104252_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1021\/tx800218n","article-title":"Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells","volume":"22","author":"Benachour","year":"2009","journal-title":"Chem. Res Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00244-006-0154-8","article-title":"Time- and dose-dependent effects of roundup on human embryonic and placental cells","volume":"53","author":"Benachour","year":"2007","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12302-016-0070-0","article-title":"Trends in glyphosate herbicide use in the United States and globally","volume":"28","author":"Benbrook","year":"2016","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.etap.2023.104252_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12718","article-title":"Melatonin rescues the reproductive toxicity of low-dose glyphosate-based herbicide during mouse oocyte maturation via the GPER signaling pathway","volume":"70","author":"Cao","year":"2021","journal-title":"J. Pineal Res"},{"key":"10.1016\/j.etap.2023.104252_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.etap.2014.05.007","article-title":"An acute exposure to glyphosate-based herbicide alters aromatase levels in testis and sperm nuclear quality","volume":"38","author":"Cassault-Meyer","year":"2014","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.etap.2023.104252_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tiv.2011.12.009","article-title":"A glyphosate-based herbicide induces necrosis and apoptosis in mature rat testicular cells in vitro, and testosterone decrease at lower levels","volume":"26","author":"Clair","year":"2012","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.etap.2023.104252_bib13","first-page":"19","article-title":"Comparison of the Toxicological Effects of Pesticides in Non-Tumorigenic MCF-12A and Tumorigenic MCF-7 Human Breast Cells","author":"Coppola","year":"2022","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.etap.2023.104252_bib14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.acthis.2016.05.009","article-title":"Effect of glyphosate on reproductive organs in male rat","volume":"118","author":"Dai","year":"2016","journal-title":"Acta Histochem"},{"key":"10.1016\/j.etap.2023.104252_bib15","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00204-006-0170-5","article-title":"Pre- and postnatal toxicity of the commercial glyphosate formulation in Wistar rats","volume":"81","author":"Dallegrave","year":"2007","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113300","article-title":"The association between urinary glyphosate and aminomethyl phosphonic acid with biomarkers of oxidative stress among pregnant women in the PROTECT birth cohort study","volume":"233","author":"Eaton","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.etap.2023.104252_bib17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.reprotox.2020.11.011","article-title":"Herbicides glyphosate and glufosinate ammonium negatively affect human sperm mitochondria respiration efficiency","volume":"99","author":"Ferramosca","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/toxsci\/kfs121","article-title":"BLTK1 murine Leydig cells: a novel steroidogenic model for evaluating the effects of reproductive and developmental toxicants","volume":"127","author":"Forgacs","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2023.104252_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115596","article-title":"Effects of glyphosate-based herbicide-contaminated diets on reproductive organ toxicity and hypothalamic-pituitary-ovarian axis hormones in weaned piglets","volume":"272","author":"Fu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2023.104252_bib20","article-title":"Exposure risk and environmental impacts of glyphosate: Highlights on the toxicity of herbicide co-formulants","volume":"4","author":"Gandhi","year":"2021","journal-title":"Environ. Chall."},{"key":"10.1016\/j.etap.2023.104252_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115116","article-title":"Ovarian mitochondrial and oxidative stress proteins are altered by glyphosate exposure in mice","volume":"402","author":"Ganesan","year":"2020","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.etap.2023.104252_bib22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.reprotox.2020.06.011","article-title":"Absence of glyphosate-induced effects on ovarian folliculogenesis and steroidogenesis","volume":"96","author":"Ganesan","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib23","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tox.2009.06.006","article-title":"Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines","volume":"262","author":"Gasnier","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2023.104252_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110841","article-title":"Glyphosate induces epithelial mesenchymal transition-related changes in human endometrial Ishikawa cells via estrogen receptor pathway","volume":"510","author":"Gastiazoro","year":"2020","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.etap.2023.104252_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.137796","article-title":"Urine glyphosate exposure and serum sex hormone disruption within the 2013-2014 National Health and Nutrition Examination survey (NHANES)","volume":"316","author":"Geier","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2023.104252_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12940-022-00906-3","article-title":"Glyphosate exposure in early pregnancy and reduced fetal growth: a prospective observational study of high-risk pregnancies","volume":"21","author":"Gerona","year":"2022","journal-title":"Environ. Health"},{"key":"10.1016\/j.etap.2023.104252_bib27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12940-018-0435-5","article-title":"The evidence of human exposure to glyphosate: a review","volume":"18","author":"Gillezeau","year":"2019","journal-title":"Environ. Health"},{"key":"10.1016\/j.etap.2023.104252_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2018.11.005","article-title":"Male mammary gland development and methylation status of estrogen receptor alpha in Wistar rats are modified by the developmental exposure to a glyphosate-based herbicide","volume":"481","author":"Gomez","year":"2019","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.etap.2023.104252_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152477","article-title":"Exposure to a Glyphosate-based Herbicide Alters the Expression of Key Regulators of Mammary Gland Development on Pre-pubertal Male Rats","volume":"439","author":"Gomez","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2023.104252_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.615678","article-title":"Low Doses of Glyphosate\/Roundup Alter Blood-Testis Barrier Integrity in Juvenile Rats","volume":"12","author":"Gorga","year":"2021","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.etap.2023.104252_bib31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tox.2016.06.004","article-title":"Neonatal exposure to a glyphosate based herbicide alters the development of the rat uterus","volume":"376","author":"Guerrero Schimpf","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2023.104252_bib32","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-18-0207","article-title":"Glyphosate-based herbicide enhances the uterine sensitivity to estradiol in rats","author":"Guerrero Schimpf","year":"2018","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.etap.2023.104252_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/13813455.2017.1352606","article-title":"Subchronic exposure to kalach 360 SL-induced endocrine disruption and ovary damage in female rats","volume":"124","author":"Hamdaoui","year":"2018","journal-title":"Arch. Physiol. Biochem"},{"key":"10.1016\/j.etap.2023.104252_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110934","article-title":"Are glyphosate and glyphosate-based herbicides endocrine disruptors that alter female fertility?","volume":"518","author":"Ingaramo","year":"2020","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.etap.2023.104252_bib35","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1530\/REP-16-0171","article-title":"Effects of neonatal exposure to a glyphosate-based herbicide on female rat reproduction","volume":"152","author":"Ingaramo","year":"2016","journal-title":"Reproduction"},{"key":"10.1016\/j.etap.2023.104252_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110832","article-title":"Acute uterine effects and long-term reproductive alterations in postnatally exposed female rats to a mixture of commercial formulations of endosulfan and glyphosate","volume":"134","author":"Ingaramo","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.reprotox.2018.09.008","article-title":"Exposure to a glyphosate-based herbicide formulation, but not glyphosate alone, has only minor effects on adult rat testis","volume":"82","author":"Johansson","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib38","doi-asserted-by":"crossref","first-page":"6372","DOI":"10.1038\/s41598-019-42860-0","article-title":"Assessment of glyphosate induced epigenetic transgenerational inheritance of pathologies and sperm epimutations: generational toxicology","volume":"9","author":"Kubsad","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.etap.2023.104252_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117002","article-title":"Maternal urinary levels of glyphosate during pregnancy and anogenital distance in newborns in a US multicenter pregnancy cohort","volume":"280","author":"Lesseur","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2023.104252_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111811","article-title":"Urinary glyphosate concentration in pregnant women in relation to length of gestation","volume":"203","author":"Lesseur","year":"2022","journal-title":"Environ. Res"},{"key":"10.1016\/j.etap.2023.104252_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.107038","article-title":"Glyphosate damages blood-testis barrier via NOX1-triggered oxidative stress in rats: Long-term exposure as a potential risk for male reproductive health","volume":"159","author":"Liu","year":"2022","journal-title":"Environ. Int"},{"key":"10.1016\/j.etap.2023.104252_bib42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.mce.2018.10.022","article-title":"Epigenetic disruption of estrogen receptor alpha is induced by a glyphosate-based herbicide in the preimplantation uterus of rats","volume":"480","author":"Lorenz","year":"2019","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.etap.2023.104252_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111560","article-title":"Perinatal exposure to glyphosate or a glyphosate-based formulation disrupts hormonal and uterine milieu during the receptive state in rats","volume":"143","author":"Lorenz","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120314","article-title":"Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig cells","volume":"314","author":"Lu","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2023.104252_bib45","doi-asserted-by":"crossref","first-page":"47001","DOI":"10.1289\/EHP10174","article-title":"Association of Glyphosate Exposure with Blood DNA Methylation in a Cross-Sectional Study of Postmenopausal Women","volume":"130","author":"Lucia","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2023.104252_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12940-019-0453-y","article-title":"The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system","volume":"18","author":"Manservisi","year":"2019","journal-title":"Environ. Health"},{"key":"10.1016\/j.etap.2023.104252_bib47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.fct.2017.07.025","article-title":"Evaluation of estrogen receptor alpha activation by glyphosate-based herbicide constituents","volume":"108","author":"Mesnage","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib48","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1007\/s00204-018-2236-6","article-title":"Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats","volume":"92","author":"Milesi","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.672532","article-title":"Glyphosate Herbicide: Reproductive Outcomes and Multigenerational Effects","volume":"12","author":"Milesi","year":"2021","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.etap.2023.104252_bib50","doi-asserted-by":"crossref","first-page":"62030","DOI":"10.1007\/s11356-021-16145-x","article-title":"A systematic review and meta-analysis of the impacts of glyphosate on the reproductive hormones","volume":"29","author":"Mohammadi","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.etap.2023.104252_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128619","article-title":"Glyphosate and the key characteristics of an endocrine disruptor: A review","volume":"270","author":"Mu\u00f1oz","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2023.104252_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137201","article-title":"Glyphosate mimics 17\u03b2-estradiol effects promoting estrogen receptor alpha activity in breast cancer cells","volume":"313","author":"Mu\u00f1oz","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2023.104252_bib53","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/vms3.443","article-title":"Growth performance and reproductive function impairment of glyphosate-based herbicide in male guinea pig (Cavia porcellus)","volume":"7","author":"Mutwedu","year":"2021","journal-title":"Vet. Med Sci."},{"key":"10.1016\/j.etap.2023.104252_bib54","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.fct.2016.12.030","article-title":"Prepubertal subchronic exposure to soy milk and glyphosate leads to endocrine disruption","volume":"100","author":"Nardi","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12940-018-0367-0","article-title":"Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study","volume":"17","author":"Parvez","year":"2018","journal-title":"Environ. Health"},{"key":"10.1016\/j.etap.2023.104252_bib56","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.chemosphere.2017.09.007","article-title":"Influence of a Roundup formulation on glyphosate effects on steroidogenesis and proliferation of bovine granulosa cells in vitro","volume":"188","author":"Perego","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2023.104252_bib57","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/jat.3417","article-title":"Evidence for direct effects of glyphosate on ovarian function: glyphosate influences steroidogenesis and proliferation of bovine granulosa but not theca cells in vitro","volume":"37","author":"Perego","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib58","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/toxsci\/kfz039","article-title":"Perinatal exposure to glyphosate and a glyphosate-based herbicide affect spermatogenesis in mice","volume":"169","author":"Pham","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2023.104252_bib59","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.envpol.2018.09.049","article-title":"Effects of glyphosate on the ovarian function of pregnant mice, the secretion of hormones and the sex ratio of their fetuses","volume":"243","author":"Ren","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2023.104252_bib60","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1289\/ehp.7728","article-title":"Differential effects of glyphosate and roundup on human placental cells and aromatase","volume":"113","author":"Richard","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2023.104252_bib61","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00204-011-0788-9","article-title":"Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression","volume":"86","author":"Romano","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib62","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00204-009-0494-z","article-title":"Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology","volume":"84","author":"Romano","year":"2010","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib63","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.3390\/cells10113079","article-title":"Review: mechanisms of glyphosate and glyphosate-based herbicides action in female and male fertility in humans and animal models","volume":"10","author":"Serra","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.etap.2023.104252_bib64","doi-asserted-by":"crossref","first-page":"57011","DOI":"10.1289\/EHP7295","article-title":"Prenatal Exposure to Glyphosate and Its Environmental Degradate, Aminomethylphosphonic Acid (AMPA), and Preterm Birth: A Nested Case-Control Study in the PROTECT Cohort (Puerto Rico)","volume":"129","author":"Silver","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2023.104252_bib65","doi-asserted-by":"crossref","first-page":"12007","DOI":"10.1038\/s41598-020-68813-6","article-title":"Glyphosate and its formulation Roundup impair pig oocyte maturation","volume":"10","author":"Spinaci","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.etap.2023.104252_bib66","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.fct.2018.06.014","article-title":"Glyphosate induces growth of estrogen receptor alpha positive cholangiocarcinoma cells via non-genomic estrogen receptor\/ERK1\/2 signaling pathway","volume":"118","author":"Sritana","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib67","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1017\/S2040174419000382","article-title":"Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring","volume":"11","author":"Teleken","year":"2020","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.etap.2023.104252_bib68","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.fct.2013.05.057","article-title":"Glyphosate induces human breast cancer cells growth via estrogen receptors","volume":"59","author":"Thongprakaisang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib69","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/tox.22316","article-title":"Effects of a glyphosate-based herbicide on the uterus of adult ovariectomized rats","volume":"32","author":"Varayoud","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.etap.2023.104252_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.113949","article-title":"The endoplasmic reticulum stress and related signal pathway mediated the glyphosate-induced testosterone synthesis inhibition in TM3 cells","volume":"260","author":"Xia","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2023.104252_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.110658","article-title":"Glyphosate-based herbicide induces hyperplastic ducts in the mammary gland of aging Wistar rats","volume":"501","author":"Zanardi","year":"2020","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.etap.2023.104252_bib72","first-page":"17","article-title":"Molecular basis for endocrine disruption by pesticides targeting aromatase and estrogen receptor","author":"Zhang","year":"2020","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.etap.2023.104252_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147323","article-title":"Glyphosate exposure attenuates testosterone synthesis via NR1D1 inhibition of StAR expression in mouse Leydig cells","volume":"785","author":"Zhao","year":"2021","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668923001941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668923001941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T09:59:43Z","timestamp":1761299983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668923001941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":73,"alternative-id":["S1382668923001941"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2023.104252","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of glyphosate-based herbicides and glyphosate exposure on sex hormones and the reproductive system: From epidemiological evidence to mechanistic insights","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2023.104252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104252"}}