{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:03:11Z","timestamp":1774382591744,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.etap.2024.104591","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T08:15:58Z","timestamp":1732090558000},"page":"104591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Synbiotics, a promising approach for alleviating exacerbated allergic airway immune responses in offspring of a preclinical murine pollution model"],"prefix":"10.1016","volume":"112","author":[{"given":"Ali","family":"Dehghani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Garssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini","family":"Styla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thea","family":"Leusink-Muis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Van Ark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Folkerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Van Bergenhenegouwen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Braber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.etap.2024.104591_bib1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1080\/10408398.2017.1414030","article-title":"Non-digestible carbohydrates in infant formula as substitution for human milk oligosaccharide functions: Effects on microbiota and gut maturation","volume":"59","author":"Akkerman","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"40","key":"10.1016\/j.etap.2024.104591_bib2","doi-asserted-by":"crossref","first-page":"34583","DOI":"10.1074\/jbc.M111.248138","article-title":"Physiology of consumption of human milk oligosaccharides by infant gut-associated bifidobacteria","volume":"286","author":"Asakuma","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2024.104591_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111009","article-title":"Revolutionizing lung health: exploring the latest breakthroughs and future prospects of synbiotic nanostructures in lung diseases","volume":"395","author":"Bani Saeid","year":"2024","journal-title":"Chem. -Biol. Interact."},{"issue":"1","key":"10.1016\/j.etap.2024.104591_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2020.100494","article-title":"First evaluation of a symbiotic food supplement in an allergen exposure chamber in birch pollen allergic patients","volume":"14","author":"Bergmann","year":"2021","journal-title":"World Allergy Organ J."},{"issue":"4","key":"10.1016\/j.etap.2024.104591_bib5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/ACI.0000000000000922","article-title":"New approaches in childhood asthma treatment","volume":"23","author":"Castagnoli","year":"2023","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"issue":"7","key":"10.1016\/j.etap.2024.104591_bib6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1471-0528.2011.02941.x","article-title":"Effects of environmental tobacco smoke on perinatal outcomes: a retrospective cohort study","volume":"118","author":"Crane","year":"2011","journal-title":"Bjog"},{"issue":"4","key":"10.1016\/j.etap.2024.104591_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/nu12040946","article-title":"The Relationship between the infant gut microbiota and allergy. the role of bifidobacterium breve and prebiotic oligosaccharides in the activation of anti-allergic mechanisms in early life","volume":"12","author":"Cukrowska","year":"2020","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.etap.2024.104591_bib8","article-title":"Environmental influences on childhood asthma: allergens","volume":"34","author":"Custovic","year":"2023","journal-title":"Pedia Allergy Immunol."},{"issue":"4","key":"10.1016\/j.etap.2024.104591_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.aller.2018.12.009","article-title":"Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma","volume":"47","author":"Demirci","year":"2019","journal-title":"Allergol. Immunopathol. (Madr."},{"issue":"12","key":"10.1016\/j.etap.2024.104591_bib10","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.imbio.2017.08.002","article-title":"Humoral immune responses during asthma and influenza co-morbidity in mice","volume":"222","author":"Doorley","year":"2017","journal-title":"Immunobiology"},{"issue":"1","key":"10.1016\/j.etap.2024.104591_bib11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12989-017-0212-6","article-title":"Prenatal tobacco smoke exposure predisposes offspring mice to exacerbated allergic airway inflammation associated with altered innate effector function","volume":"14","author":"Ferrini","year":"2017","journal-title":"Part Fibre Toxicol."},{"issue":"1-2","key":"10.1016\/j.etap.2024.104591_bib12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000484897","article-title":"Fecal microbiome and food allergy in pediatric atopic dermatitis: a cross-sectional pilot study","volume":"175","author":"Fieten","year":"2018","journal-title":"Int Arch. Allergy Immunol."},{"issue":"10","key":"10.1016\/j.etap.2024.104591_bib13","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nm.4176","article-title":"Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation","volume":"22","author":"Fujimura","year":"2016","journal-title":"Nat. Med"},{"issue":"1","key":"10.1016\/j.etap.2024.104591_bib14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1465-9921-14-110","article-title":"Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-\/- mice","volume":"14","author":"Gabehart","year":"2013","journal-title":"Respir. Res"},{"issue":"2","key":"10.1016\/j.etap.2024.104591_bib15","doi-asserted-by":"crossref","first-page":"2291164","DOI":"10.1080\/19490976.2023.2291164","article-title":"Bifidobacterium mechanisms of immune modulation and tolerance","volume":"15","author":"Gavzy","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.etap.2024.104591_bib16","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.3389\/fimmu.2020.01092","article-title":"Crude turmeric extract improves the suppressive effects of lactobacillus rhamnosus GG on allergic inflammation in a murine model of house dust mite-induced asthma","volume":"11","author":"Ghiamati Yazdi","year":"2020","journal-title":"Front Immunol."},{"issue":"2","key":"10.1016\/j.etap.2024.104591_bib17","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00035.2017","article-title":"Transgenerational transmission of asthma risk after exposure to environmental particles during pregnancy","volume":"313","author":"Gregory","year":"2017","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.etap.2024.104591_bib18","doi-asserted-by":"crossref","DOI":"10.31661\/gmj.v8i0.1350","article-title":"Synbiotics and treatment of asthma: a double-blinded, randomized, placebo-controlled clinical trial","volume":"8","author":"Hassanzad","year":"2019","journal-title":"Galen. Med J."},{"issue":"10","key":"10.1016\/j.etap.2024.104591_bib19","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1002\/ppul.24961","article-title":"The association between secondhand smoke and childhood asthma: a systematic review and meta-analysis","volume":"55","author":"He","year":"2020","journal-title":"Pedia Pulmonol."},{"key":"10.1016\/j.etap.2024.104591_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105189","article-title":"Why do some asthma patients respond poorly to glucocorticoid therapy?","volume":"160","author":"Henderson","year":"2020","journal-title":"Pharm. Res"},{"issue":"15","key":"10.1016\/j.etap.2024.104591_bib21","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1016\/j.cell.2021.05.030","article-title":"Bifidobacteria-mediated immune system imprinting early in life","volume":"184","author":"Henrick","year":"2021","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.etap.2024.104591_bib22","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1164\/rccm.201504-0658OC","article-title":"Prenatal particulate air pollution and asthma onset in urban children. identifying sensitive windows and sex differences","volume":"192","author":"Hsu","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med"},{"issue":"4","key":"10.1016\/j.etap.2024.104591_bib23","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.fertnstert.2008.07.1781","article-title":"Effects of cigarette smoke on fertilization and embryo development in vivo","volume":"92","author":"Huang","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.etap.2024.104591_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.797376","article-title":"Prenatal and postnatal cigarette smoke exposure is associated with increased risk of exacerbated allergic airway immune responses: a preclinical mouse model","volume":"12","author":"Janbazacyabar","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.etap.2024.104591_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119066","article-title":"Probiotics, prebiotics, and synbiotics to prevent or combat air pollution consequences: The gut-lung axis","volume":"302","author":"Keulers","year":"2022","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.etap.2024.104591_bib26","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3920\/BM2017.0110","article-title":"A synbiotic mixture of scGOS\/lcFOS and bifidobacterium breve M-16V increases faecal Bifidobacterium in healthy young children","volume":"9","author":"Kosuwon","year":"2018","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.etap.2024.104591_bib27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3389\/fmicb.2013.00263","article-title":"Pathology of asthma","volume":"4","author":"Kudo","year":"2013","journal-title":"Front Microbiol"},{"issue":"2","key":"10.1016\/j.etap.2024.104591_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12016-018-8712-1","article-title":"Understanding asthma phenotypes, endotypes, and mechanisms of disease","volume":"56","author":"Kuruvilla","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.etap.2024.104591_bib29","doi-asserted-by":"crossref","first-page":"1216674","DOI":"10.3389\/fmicb.2023.1216674","article-title":"Probiotics: mechanism of action, health benefits and their application in food industries","volume":"14","author":"Latif","year":"2023","journal-title":"Front Microbiol"},{"issue":"5","key":"10.1016\/j.etap.2024.104591_bib30","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.jaci.2017.07.017","article-title":"Prenatal fine particulate exposure and early childhood asthma: effect of maternal stress and fetal sex","volume":"141","author":"Lee","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.etap.2024.104591_bib31","doi-asserted-by":"crossref","first-page":"31775","DOI":"10.1038\/srep31775","article-title":"Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity","volume":"6","author":"Levin","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.etap.2024.104591_bib32","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ebiom.2019.07.048","article-title":"Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial","volume":"46","author":"McLoughlin","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.etap.2024.104591_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111180","article-title":"Thirdhand smoke associations with the gut microbiomes of infants admitted to a neonatal intensive care unit: An observational study","volume":"197","author":"Northrup","year":"2021","journal-title":"Environ. Res."},{"issue":"4","key":"10.1016\/j.etap.2024.104591_bib34","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1165\/rcmb.2016-0307TR","article-title":"Transforming growth factor \u03b21 function in airway remodeling and hyperresponsiveness. the missing link?","volume":"56","author":"Ojiaku","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"8","key":"10.1016\/j.etap.2024.104591_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/nu15081815","article-title":"Role of akkermansia in human diseases: from causation to therapeutic properties","volume":"15","author":"Pellegrino","year":"2023","journal-title":"Nutrients"},{"issue":"18","key":"10.1016\/j.etap.2024.104591_bib36","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.3390\/app9183918","article-title":"Combined model for IAQ assessment: part 1\u2014morphology of the model and selection of substantial air quality impact sub-models","volume":"9","author":"Piasecki","year":"2019","journal-title":"Appl. Sci."},{"key":"10.1016\/j.etap.2024.104591_bib37","article-title":"Asthma prevention and recent advances in management","volume":"9","author":"Ple\u0219ca","year":"2024","journal-title":"Glob. Pediatr."},{"key":"10.1016\/j.etap.2024.104591_bib38","unstructured":"REPORT, G.M. 2022 GINA Report, Global Strategy for Asthma Management and Prevention. 2023; Available from: https:\/\/ginasthma.org\/gina-reports\/."},{"issue":"4","key":"10.1016\/j.etap.2024.104591_bib39","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbadis.2014.01.005","article-title":"The combination of Bifidobacterium breve with non-digestible oligosaccharides suppresses airway inflammation in a murine model for chronic asthma","volume":"1842","author":"Sagar","year":"2014","journal-title":"Biochim Biophys. Acta"},{"issue":"4","key":"10.1016\/j.etap.2024.104591_bib40","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/all.15666","article-title":"Decoding the genetic and epigenetic basis of asthma","volume":"78","author":"Stikker","year":"2023","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.etap.2024.104591_bib41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1398-9995.2010.02454.x","article-title":"Synbiotics reduce allergen-induced T-helper 2 response and improve peak expiratory flow in allergic asthmatics","volume":"66","author":"van de Pol","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.etap.2024.104591_bib42","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-015-0171-0","article-title":"Dietary galacto-oligosaccharides prevent airway eosinophilia and hyperresponsiveness in a murine house dust mite-induced asthma model","volume":"16","author":"Verheijden","year":"2015","journal-title":"Respir. Res."},{"key":"10.1016\/j.etap.2024.104591_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02419","article-title":"The combination therapy of dietary galacto-oligosaccharides with budesonide reduces pulmonary Th2 driving mediators and mast cell degranulation in a murine model of house dust mite induced asthma","volume":"9","author":"Verheijden","year":"2018","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.etap.2024.104591_bib44","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.intimp.2007.07.024","article-title":"Dietary supplementation with specific oligosaccharide mixtures decreases parameters of allergic asthma in mice","volume":"7","author":"Vos","year":"2007","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.etap.2024.104591_bib45","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fcell.2020.00038","article-title":"Why do intrauterine exposure to air pollution and cigarette smoke increase the risk of asthma?","volume":"8","author":"Wang","year":"2020","journal-title":"Front Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.etap.2024.104591_bib46","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.1038\/s41598-018-24574-x","article-title":"A 4-week model of house dust mite (HDM) induced allergic airways inflammation with airway remodeling","volume":"8","author":"Woo","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.etap.2024.104591_bib47","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fgene.2019.00471","article-title":"Paternal tobacco smoke correlated to offspring asthma and prenatal epigenetic programming","volume":"10","author":"Wu","year":"2019","journal-title":"Front Genet"},{"issue":"3","key":"10.1016\/j.etap.2024.104591_bib48","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1177\/039463201002300306","article-title":"Dietary supplementation with fructooligosaccharides attenuates airway inflammation related to house dust mite allergen in mice","volume":"23","author":"Yasuda","year":"2010","journal-title":"Int J. Immunopathol. Pharm."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138266892400231X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138266892400231X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T03:54:32Z","timestamp":1733543672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138266892400231X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":48,"alternative-id":["S138266892400231X"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2024.104591","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synbiotics, a promising approach for alleviating exacerbated allergic airway immune responses in offspring of a preclinical murine pollution model","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2024.104591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104591"}}