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Pharm."},{"key":"10.1016\/j.etap.2025.104714_bib61","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jsat.2019.10.005","article-title":"Association between methamphetamine use and retention among patients with opioid use disorders treated with buprenorphine","volume":"109","author":"Tsui","year":"2020","journal-title":"J. Subst. Abus. Treat."},{"key":"10.1016\/j.etap.2025.104714_bib62","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0166-2236(94)90110-4","article-title":"An opiate-receptor gene family reunion","volume":"14","author":"Uhl","year":"1994","journal-title":"Trends Neurosci."},{"issue":"3","key":"10.1016\/j.etap.2025.104714_bib63","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11920-002-0024-7","article-title":"Stimulant-induced psychosis and schizophrenia: the role of sensitization","volume":"4","author":"Ujike","year":"2002","journal-title":"Curr. 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Lett."},{"issue":"5","key":"10.1016\/j.etap.2025.104714_bib71","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/sj.mp.4002035","article-title":"The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk","volume":"13","author":"Zhang","year":"2008","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.etap.2025.104714_bib72","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1046\/j.1471-4159.2000.740472.x","article-title":"An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression","volume":"74","author":"Zimprich","year":"2000","journal-title":"J. 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