{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:03:17Z","timestamp":1790010197125,"version":"4.0.1"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination of Higher Education Personnel Improvement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.etap.2025.104757","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T18:43:33Z","timestamp":1752605013000},"page":"104757","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effects of bisphenol A alternatives (BPS and BPAF) on zebrafish (Danio rerio) spermatogenesis ex vivo: meiosis damage and transcriptional deregulation of genes related to spermatogenic processes and epigenetic regulation"],"prefix":"10.1016","volume":"117","author":[{"given":"Daniel Fernandes da","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira","family":"da Silva Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Marino","family":"Borali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Marques","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Habibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-5076","authenticated-orcid":false,"given":"Rafael Henrique","family":"N\u00f3brega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.etap.2025.104757_bib1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1530\/JME-17-0177","article-title":"Estrogen-induced inhibition of spermatogenesis in zebrafish is largely reversed by androgen","volume":"60","author":"Assis","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.etap.2025.104757_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111372","article-title":"Interrenal development and function in zebrafish","volume":"535","author":"Bacila","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"issue":"4","key":"10.1016\/j.etap.2025.104757_bib3","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1111\/raq.12563","article-title":"Testicular development and spermatogenesis in fish: Insights into molecular aspects and regulation of gene expression by different exogenous factors","volume":"13","author":"Bhat","year":"2021","journal-title":"Rev. Aquac."},{"issue":"2","key":"10.1016\/j.etap.2025.104757_bib4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/10408444.2019.1701986","article-title":"Substitution of bisphenol A: a review of the carcinogenicity, reproductive toxicity, and endocrine disruption potential of alternative substances","volume":"50","author":"Braver-Sewradj","year":"2020","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.etap.2025.104757_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.113980","article-title":"Evaluation of the effects of low concentrations of bisphenol AF on gonadal development using the Xenopus laevis model: a finding of testicular differentiation inhibition coupled with feminization","volume":"260","author":"Cai","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2025.104757_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fcell.2018.00050","article-title":"A decade of exploring the mammalian sperm epigenome: paternal epigenetic and transgenerational inheritance","volume":"6","author":"Champroux","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.etap.2025.104757_bib7","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/acs.est.5b05387","article-title":"Bisphenol analogues other than BPA: environmental occurrence, human exposure, and toxicity: a review","volume":"50","author":"Chen","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.etap.2025.104757_bib8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/tox.22539","article-title":"In silico binding of 4, 4\u2032-bisphenols predicts in vitro estrogenic and antiandrogenic activity","volume":"33","author":"Conroy-Ben","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.etap.2025.104757_bib9","article-title":"A83-01 and DMH1 effects in the zebrafish spermatogonial niche: unraveling the roles of TGF-\u03b2 and BMP signaling in the Fsh-mediated spermatogonial fate","volume":"897","author":"Costa","year":"2024","journal-title":"Gene"},{"key":"10.1016\/j.etap.2025.104757_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.mce.2016.08.033","article-title":"Expression profiling identifies Sertoli and Leydig cell genes as Fsh targets in adult zebrafish testis","volume":"437","author":"Crespo","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"8","key":"10.1016\/j.etap.2025.104757_bib11","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/jemt.20697","article-title":"Spermatozoal RNAs: what about their functions?","volume":"72","author":"Dadoune","year":"2009","journal-title":"Microsc. Res. Tech."},{"issue":"11","key":"10.1016\/j.etap.2025.104757_bib12","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1002\/jat.4170","article-title":"Oxidative stress-mediated apoptosis is involved in bisphenol S-induced reproductive toxicity in male C57BL\/6 mice","volume":"41","author":"Dai","year":"2021","journal-title":"J. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.etap.2025.104757_bib13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1530\/REP-08-0055","article-title":"Functional characterization and expression analysis of the androgen receptor in zebrafish (Danio rerio) testis","volume":"136","author":"De Waal","year":"2008","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.etap.2025.104757_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1677\/JOE-09-0050","article-title":"Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis","volume":"202","author":"De Waal","year":"2009","journal-title":"J. Endocrinol."},{"issue":"37","key":"10.1016\/j.etap.2025.104757_bib15","doi-asserted-by":"crossref","first-page":"14930","DOI":"10.1073\/pnas.1203574109","article-title":"Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes","volume":"109","author":"Delfosse","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.etap.2025.104757_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fertnstert.2014.11.005","article-title":"A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound","volume":"103","author":"Eladak","year":"2015","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.etap.2025.104757_bib17","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/10643389.2019.1629802","article-title":"A critical review on remediation of bisphenol S (BPS) contaminated water: efficacy and mechanisms","volume":"50","author":"Fang","year":"2020","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.etap.2025.104757_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.toxlet.2012.03.802","article-title":"Bisphenol AF may cause testosterone reduction by directly affecting testis function in adult male rats","volume":"211","author":"Feng","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.etap.2025.104757_bib19","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s12010-020-03247-4","article-title":"Removal of bisphenol A and its potential substitutes by biodegradation","volume":"191","author":"Frankowski","year":"2020","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"5","key":"10.1016\/j.etap.2025.104757_bib20","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1210\/en.2009-1227","article-title":"Studies in zebrafish reveal unusual cellular expression patterns of gonadotropin receptor messenger ribonucleic acids in the testis and unexpected functional differentiation of the gonadotropins","volume":"151","author":"Garc\u00eda-Lopez","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.etap.2025.104757_bib21","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.envpol.2019.01.127","article-title":"Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes","volume":"248","author":"Gonz\u00e1lez-Rojo","year":"2019","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.etap.2025.104757_bib22","doi-asserted-by":"crossref","first-page":"dvw002","DOI":"10.1093\/eep\/dvw002","article-title":"Developmental origins of epigenetic transgenerational inheritance","volume":"2","author":"Hanson","year":"2016","journal-title":"Environ. epigenetics"},{"key":"10.1016\/j.etap.2025.104757_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113142","article-title":"Transgenerational effects of parental bisphenol S exposure on zebrafish (Danio rerio) reproduction","volume":"165","author":"Hao","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2025.104757_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112210","article-title":"BPA and BPA alternatives BPS, BPAF, and TMBPF, induce cytotoxicity and apoptosis in rat and human stem cells","volume":"216","author":"Harnett","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"12","key":"10.1016\/j.etap.2025.104757_bib25","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1078\/0171-9335-00123","article-title":"Regulated hyperacetylation of core histones during mouse spermatogenesis: involvement of histone-deacetylases","volume":"79","author":"Hazzouri","year":"2000","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.etap.2025.104757_bib26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.scitotenv.2019.05.486","article-title":"Genotoxic activity of bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF and their mixtures in human hepatocellular carcinoma (HepG2) cells","volume":"687","author":"Hercog","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.etap.2025.104757_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.aquaculture.2016.03.007","article-title":"Paternal contribution to development: sperm genetic damage and repair in fish","volume":"472","author":"Herr\u00e1ez","year":"2017","journal-title":"Aquaculture"},{"issue":"3","key":"10.1016\/j.etap.2025.104757_bib28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1530\/JOE-12-0509","article-title":"Cyp17a1 and Cyp19a1 in the zebrafish testis are differentially affected by oestradiol","volume":"216","author":"Hinfray","year":"2013","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.etap.2025.104757_bib29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.toxrep.2017.12.013","article-title":"Bisphenol A (BPA) the mighty and the mutagenic","volume":"5","author":"Jalal","year":"2018","journal-title":"Toxicol. Rep."},{"issue":"15","key":"10.1016\/j.etap.2025.104757_bib30","doi-asserted-by":"crossref","first-page":"8793","DOI":"10.1021\/es400329t","article-title":"Effects of bisphenol S exposure on endocrine functions and reproduction of zebrafish","volume":"47","author":"Ji","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.etap.2025.104757_bib31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrg2045","article-title":"Environmental epigenomics and disease susceptibility","volume":"8","author":"Jirtle","year":"2007","journal-title":"Nat. Rev. Genet."},{"issue":"5","key":"10.1016\/j.etap.2025.104757_bib32","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1073\/pnas.1417731112","article-title":"Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish","volume":"112","author":"Kinch","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.etap.2025.104757_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/toxsci\/kfi074","article-title":"Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds","volume":"84","author":"Kitamura","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.etap.2025.104757_bib34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chemosphere.2017.07.004","article-title":"Bisphenol A disrupts steroidogenesis and induces a sex hormone imbalance through c-Jun phosphorylation in Leydig cells","volume":"185","author":"Lan","year":"2017","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.etap.2025.104757_bib35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1095\/biolreprod.109.076299","article-title":"Histological and stereological evaluation of zebrafish (Danio rerio) spermatogenesis with an emphasis on spermatogonial generations","volume":"81","author":"Leal","year":"2009","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.etap.2025.104757_bib36","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ygcen.2009.03.003","article-title":"Zebrafish primary testis tissue culture: an approach to study testis function ex vivo","volume":"162","author":"Leal","year":"2009","journal-title":"Gen. Comp. Endocrinol."},{"issue":"4","key":"10.1016\/j.etap.2025.104757_bib37","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.3390\/app11041837","article-title":"Systematic review of exposure to bisphenol A alternatives and its effects on reproduction and thyroid endocrine system in zebrafish","volume":"11","author":"Lee","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.etap.2025.104757_bib38","article-title":"Bisphenol A attenuates testosterone production in Leydig cells via the inhibition of NR1D1 signaling","volume":"263","author":"Li","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2025.104757_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116394","article-title":"Plasticizer contamination in the urine and hair of preschool children, airborne particles in kindergartens, and drinking water in Hong Kong","volume":"271","author":"Li","year":"2021","journal-title":"Environ. Pollut."},{"issue":"7","key":"10.1016\/j.etap.2025.104757_bib40","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1289\/ehp.1104689","article-title":"Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor \u03b1 and \u03b2 in vitro","volume":"120","author":"Li","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.etap.2025.104757_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/toxsci\/kfw178","article-title":"High-content analysis provides mechanistic insights into the testicular toxicity of bisphenol A and selected analogues in mouse spermatogonial cells","volume":"155","author":"Liang","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"12","key":"10.1016\/j.etap.2025.104757_bib42","doi-asserted-by":"crossref","first-page":"6515","DOI":"10.1021\/es300876n","article-title":"Bisphenol S, a new bisphenol analogue, in paper products and currency bills and its association with bisphenol A residues","volume":"46","author":"Liao","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2025.104757_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2021.108826","article-title":"An in vitro investigation of endocrine disrupting potentials of ten bisphenol analogues","volume":"169","author":"Lin","year":"2021","journal-title":"Steroids"},{"key":"10.1016\/j.etap.2025.104757_bib44","first-page":"269","article-title":"EDCs: focus on male fish reproductive alterations","author":"Lo Nostro","year":"2023","journal-title":"Environ. Contam. Endocr. Health [S. L. ]"},{"key":"10.1016\/j.etap.2025.104757_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138560","article-title":"Bisphenols in water: occurrence, effects, and mitigation strategies","author":"Loganathan","year":"2023","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.etap.2025.104757_bib46","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.3390\/ijms22042125","article-title":"Paternal inheritance of bisphenol A cardiotoxic effects: the implications of sperm epigenome","volume":"22","author":"Lomb\u00f3","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.etap.2025.104757_bib47","doi-asserted-by":"crossref","first-page":"18029","DOI":"10.1038\/s41598-019-54368-8","article-title":"Genetic and epigenetic alterations induced by bisphenol A exposure during different periods of spermatogenesis: from spermatozoa to the progeny","volume":"9","author":"Lomb\u00f3","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.etap.2025.104757_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.mce.2006.04.033","article-title":"Endocrine disruptors and reproductive health: the case of bisphenol-A","volume":"254","author":"Maffini","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"issue":"9","key":"10.1016\/j.etap.2025.104757_bib49","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1289\/ehp.0901819","article-title":"Bisphenol AF is a full agonist for the estrogen receptor ER\u03b1 but a highly specific antagonist for ER\u03b2","volume":"118","author":"Matsushima","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"9","key":"10.1016\/j.etap.2025.104757_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184306","article-title":"Atrazine induced epigenetic transgenerational inheritance of disease, lean phenotype and sperm epimutation pathology biomarkers","volume":"12","author":"McBirney","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.etap.2025.104757_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114634","article-title":"Exposure to bisphenol A alternatives bisphenol AF and fluorene-9-bisphenol induces gonadal injuries in male zebrafish","volume":"253","author":"Meng","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.etap.2025.104757_bib52","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/humupd\/dml037","article-title":"Towards a better understanding of RNA carriage by ejaculate spermatozoa","volume":"12","author":"Miller","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.etap.2025.104757_bib53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1023\/B:FISH.0000030522.71779.47","article-title":"Molecular control mechanisms of fish spermatogenesis","volume":"28","author":"Miura","year":"2003","journal-title":"Fish. Physiol. Biochem."},{"issue":"13","key":"10.1016\/j.etap.2025.104757_bib54","doi-asserted-by":"crossref","first-page":"5774","DOI":"10.1073\/pnas.88.13.5774","article-title":"Hormonal induction of all stages of spermatogenesis in vitro in the male Japanese eel (Anguilla japonica)","volume":"88","author":"Miura","year":"1991","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.etap.2025.104757_bib55","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4093\/dmj.2019.0027","article-title":"Concern about the safety of bisphenol A substitutes","volume":"43","author":"Moon","year":"2019","journal-title":"Diabetes Metab. J."},{"issue":"11","key":"10.1016\/j.etap.2025.104757_bib56","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1210\/en.2013-1308","article-title":"Thyroid hormone stimulates the proliferation of Sertoli cells and single type A spermatogonia in adult zebrafish (Danio rerio) testis","volume":"154","author":"Morais","year":"2013","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.etap.2025.104757_bib57","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1021\/acs.est.7b06255","article-title":"Developmental effects and estrogenicity of bisphenol A alternatives in a zebrafish embryo model","volume":"52","author":"Mu","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2025.104757_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106078","article-title":"A comprehensive review of the neurobehavioral effects of bisphenol S and the mechanisms of action: new insights from in vitro and in vivo models","volume":"145","author":"Naderi","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.etap.2025.104757_bib59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.aquatox.2014.01.009","article-title":"Developmental exposure of zebrafish (Danio rerio) to bisphenol-S impairs subsequent reproduction potential and hormonal balance in adults","volume":"148","author":"Naderi","year":"2014","journal-title":"Aquat. toxicol."},{"issue":"10","key":"10.1016\/j.etap.2025.104757_bib60","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1210\/en.2015-1157","article-title":"Fsh stimulates spermatogonial proliferation and differentiation in zebrafish via Igf3","volume":"156","author":"N\u00f3brega","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.etap.2025.104757_bib61","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.chemosphere.2019.03.177","article-title":"Neurotoxicity of BPA, BPS, and BPB for the hippocampal cell line (HT-22): An implication for the replacement of BPA in plastics","volume":"226","author":"Pang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2025.104757_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.113102","article-title":"Sex-specific effects of bisphenol S with tissue-specific responsiveness in adult zebrafish: The antiandrogenic and antiestrogenic effects","volume":"229","author":"Park","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.etap.2025.104757_bib63","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/toxsci\/kfz173","article-title":"Characterization of estrogenic and androgenic activities for bisphenol A-like chemicals (BPs): in vitro estrogen and androgen receptors transcriptional activation, gene regulation, and binding profiles","volume":"172","author":"Pelch","year":"2019","journal-title":"Toxicol. Sci."},{"issue":"12","key":"10.1016\/j.etap.2025.104757_bib64","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.2174\/1568026611313120002","article-title":"CYP17A1: a biochemistry, chemistry, and clinical review","volume":"13","author":"Porubek","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.etap.2025.104757_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124303","article-title":"The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms","volume":"406","author":"Qiu","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.etap.2025.104757_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.emcon.2023.100296","article-title":"Unveiling the next generation of bisphenol analogs and their impact on human health using in vitro methods","author":"Rifa","year":"2024","journal-title":"Emerg. Contam."},{"issue":"7","key":"10.1016\/j.etap.2025.104757_bib67","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1289\/ehp.1408989","article-title":"Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes","volume":"123","author":"Rochester","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2025.104757_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.865948","article-title":"Thyroid hormones deficiency impairs male germ cell development: a cross talk between hypothalamic-Pituitary-thyroid, and\u2014gonadal axes in Zebrafish","volume":"10","author":"Rodrigues","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.etap.2025.104757_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001034","article-title":"Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis","volume":"6","author":"Rodriguez-Mari","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.etap.2025.104757_bib70","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tox.2015.01.003","article-title":"Structural bisphenol analogues differentially target steroidogenesis in murine MA-10 Leydig cells as well as the glucocorticoid receptor","volume":"329","author":"Roelofs","year":"2015","journal-title":"Toxicology"},{"issue":"1-2","key":"10.1016\/j.etap.2025.104757_bib71","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2011.05.002","article-title":"Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects","volume":"127","author":"Rubin","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"7","key":"10.1016\/j.etap.2025.104757_bib72","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/dvdy.22661","article-title":"Isolation and cytogenetic characterization of zebrafish meiotic prophase I mutants","volume":"240","author":"Saito","year":"2011","journal-title":"Dev. Dyn."},{"issue":"1","key":"10.1016\/j.etap.2025.104757_bib73","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/humupd\/dmab034","article-title":"All you need to know about sperm RNAs","volume":"28","author":"Santiago","year":"2022","journal-title":"Hum. Reprod. Update"},{"issue":"3","key":"10.1016\/j.etap.2025.104757_bib74","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ygcen.2009.02.013","article-title":"Spermatogenesis in fish","volume":"165","author":"Schulz","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"issue":"11","key":"10.1016\/j.etap.2025.104757_bib75","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.3390\/biomedicines9111744","article-title":"Bisphenol a and its analogues deteriorate the hormones physiological function of the male reproductive system: a mini-review","volume":"9","author":"Shamhari","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.etap.2025.104757_bib76","doi-asserted-by":"crossref","unstructured":"Sharma, R., Agarwal, A., 2011. Spermatogenesis Overv. Sperm chromatin Biol. Clin. Appl. male Infertil. Assist. Reprod.1944.","DOI":"10.1007\/978-1-4419-6857-9_2"},{"key":"10.1016\/j.etap.2025.104757_bib77","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.chemosphere.2015.01.060","article-title":"Long-term effects of bisphenol AF (BPAF) on hormonal balance and genes of hypothalamus-pituitary-gonad axis and liver of zebrafish (Danio rerio), and the impact on offspring","volume":"128","author":"Shi","year":"2015","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.etap.2025.104757_bib78","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1039\/c8tx00064f","article-title":"The state of bisphenol research in the lesser developed countries of the EU: a mini-review","volume":"7","author":"Thoene","year":"2018","journal-title":"Toxicol. Res."},{"issue":"3-5","key":"10.1016\/j.etap.2025.104757_bib79","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0960-0760(03)00347-9","article-title":"Analysis of zebrafish cyp19 promoters","volume":"86","author":"Tong","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.etap.2025.104757_bib80","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3390\/biom10030429","article-title":"Cortisol directly stimulates spermatogonial differentiation, meiosis, and spermiogenesis in zebrafish (Danio rerio) testicular explants","volume":"10","author":"Tovo-Neto","year":"2020","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.etap.2025.104757_bib81","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/1541-4337.13113","article-title":"Endocrine modulating chemicals in food packaging: a review of phthalates and bisphenols","volume":"22","author":"Tumu","year":"2023","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"1","key":"10.1016\/j.etap.2025.104757_bib82","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.stemcr.2014.10.011","article-title":"Early depletion of primordial germ cells in zebrafish promotes testis formation","volume":"4","author":"Tzung","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.etap.2025.104757_bib83","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.chemosphere.2018.06.089","article-title":"Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: comparative in vitro and in vivo studies on the sperms and testicular tissues of rats","volume":"209","author":"Ullah","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2025.104757_bib84","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.fct.2018.08.024","article-title":"Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: a focus on the possible hormonal mode of action","volume":"121","author":"Ullah","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.etap.2025.104757_bib85","article-title":"Non-monotonic dose responses in studies of endocrine disrupting chemicals: bisphenol a as a case study","volume":"12","author":"Vandenberg","year":"2014","journal-title":"DoseResponse"},{"issue":"1","key":"10.1016\/j.etap.2025.104757_bib86","doi-asserted-by":"crossref","first-page":"11770","DOI":"10.1038\/s41598-017-11995-3","article-title":"Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca2+ entry in mouse pancreatic \u03b2-cells","volume":"7","author":"Villar-Pazos","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.etap.2025.104757_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124410","article-title":"Bisphenol AF compromises blood-testis barrier integrity and sperm quality in mice","volume":"237","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2025.104757_bib88","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.scitotenv.2017.09.194","article-title":"Occurrence of bisphenol S in the environment and implications for human exposure: A short review","volume":"615","author":"Wu","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.etap.2025.104757_bib89","doi-asserted-by":"crossref","first-page":"10606","DOI":"10.18632\/oncotarget.7218","article-title":"Neonatal bisphenol A exposure induces meiotic arrest and apoptosis of spermatogenic cells","volume":"7","author":"Xie","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.etap.2025.104757_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115030","article-title":"Prenatal exposure to bisphenol AF induced male offspring reproductive dysfunction by triggering testicular innate and adaptive immune responses","volume":"259","author":"Xue","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.etap.2025.104757_bib91","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.watres.2018.10.018","article-title":"Comparative study on ferrate oxidation of BPS and BPAF: Kinetics, reaction mechanism, and the improvement on their biodegradability","volume":"148","author":"Yang","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.etap.2025.104757_bib92","doi-asserted-by":"crossref","first-page":"1044318","DOI":"10.3389\/fendo.2023.1044318","article-title":"Identification of fish spermatogenic cells through high-throughput immunofluorescence against testis with an antibody set","volume":"14","author":"Ye","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.etap.2025.104757_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2023.105589","article-title":"High-content analysis of testicular toxicity of BPA and its selected analogs in mouse spermatogonial, Sertoli cells, and Leydig cells revealed BPAF induced unique multinucleation phenotype associated with the increased DNA synthesis","volume":"89","author":"Yin","year":"2023","journal-title":"Toxicol. Vitr."},{"issue":"1-2","key":"10.1016\/j.etap.2025.104757_bib94","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.mce.2014.05.013","article-title":"Characterization of two paralogous StAR genes in a teleost, Nile tilapia (Oreochromis niloticus)","volume":"392","author":"Yu","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.etap.2025.104757_bib95","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.seppur.2013.05.036","article-title":"High efficiency removal and recovery of an endocrine disrupting compound\u2013bisphenol AF from wastewaters","volume":"116","author":"Zhang","year":"2013","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.etap.2025.104757_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153714","article-title":"Intergenerational toxic effects of parental exposure to bisphenol AF on offspring and epigenetic modulations in zebrafish","volume":"823","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668925001322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668925001322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:13:28Z","timestamp":1790007208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668925001322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":96,"alternative-id":["S1382668925001322"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2025.104757","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of bisphenol A alternatives (BPS and BPAF) on zebrafish (Danio rerio) spermatogenesis ex vivo: meiosis damage and transcriptional deregulation of genes related to spermatogenic processes and epigenetic regulation","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2025.104757","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104757"}}