{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:08:32Z","timestamp":1772791712451,"version":"3.50.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002923","name":"National Scientific and Technical Research Council","doi-asserted-by":"publisher","award":["PIP2021-162"],"award-info":[{"award-number":["PIP2021-162"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2020-0642"],"award-info":[{"award-number":["PICT 2020-0642"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT A 2021-027"],"award-info":[{"award-number":["PICT A 2021-027"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2020-1061"],"award-info":[{"award-number":["PICT 2020-1061"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.etap.2025.104775","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T06:41:06Z","timestamp":1753339266000},"page":"104775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Analysis of the effects of Glyphosate and Roundup on Sertoli cell proliferation"],"prefix":"10.1016","volume":"118","author":[{"given":"Cecilia Lucia","family":"Centola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Ercilia","family":"Dasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostina","family":"Gorga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Marcelo","family":"Rindone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Noel","family":"Galardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda","family":"Riera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0313-7075","authenticated-orcid":false,"given":"Silvina Beatriz","family":"Meroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2025.104775_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mce.2018.12.007","article-title":"Neonatal exposure to a glyphosate-based herbicide alters the histofunctional differentiation of the ovaries and uterus in lambs","volume":"482","author":"Alarc\u00f3n","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.etap.2025.104775_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1021\/tx800218n","article-title":"Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells","volume":"22","author":"Benachour","year":"2009","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.etap.2025.104775_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12302-016-0070-0","article-title":"Trends in glyphosate herbicide use in the United States and globally","volume":"28","author":"Benbrook","year":"2016","journal-title":"Environ. Sci. Eur."},{"issue":"1","key":"10.1016\/j.etap.2025.104775_bib4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-5793(83)80888-6","article-title":"Kinetics of 5-enolpyruvylshikimate-3-phosphate synthase inhibition by glyphosate","volume":"154","author":"Boocock","year":"1983","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.etap.2025.104775_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.etap.2007.08.011","article-title":"The effect of sub-acute and sub-chronic exposure of rats to the glyphosate-based herbicide Roundup","volume":"25","author":"Ca\u011flar","year":"2008","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2025.104775_bib6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.etap.2017.07.015","article-title":"Effects of glyphosate exposure on sperm concentration in rodents: A systematic review and meta-analysis","volume":"55","author":"Cai","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"6854","key":"10.1016\/j.etap.2025.104775_bib7","first-page":"609","article-title":"Evidence for decreasing quality of semen during past 50 years","volume":"305","author":"Carlsen","year":"1992","journal-title":"BMJ (Clin. Res. Ed. )"},{"issue":"1","key":"10.1016\/j.etap.2025.104775_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.etap.2014.05.007","article-title":"An acute exposure to glyphosate-based herbicide alters aromatase levels in testis and sperm nuclear quality","volume":"38","author":"Cassault-Meyer","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.etap.2025.104775_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120801","article-title":"In vitro study of glyphosate effects on thyroid cells","volume":"317","author":"Coperchini","year":"2023","journal-title":"Environ. Pollut. (Barking Essex 1987)"},{"key":"10.1016\/j.etap.2025.104775_bib10","article-title":"Alternation between toxic and proliferative effects of Roundup\u00ae on human thyroid cells at different concentrations","volume":"13","author":"Dal' B\u00f3","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"9","key":"10.1016\/j.etap.2025.104775_bib11","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00204-006-0170-5","article-title":"Pre- and postnatal toxicity of the commercial glyphosate formulation in Wistar rats","volume":"81","author":"Dallegrave","year":"2007","journal-title":"Arch. Toxicol."},{"issue":"3","key":"10.1016\/j.etap.2025.104775_bib12","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/ijerph13030264","article-title":"Co-Formulants in Glyphosate-Based Herbicides Disrupt Aromatase Activity in Human Cells below Toxic Levels","volume":"13","author":"Defarge","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"2","key":"10.1016\/j.etap.2025.104775_bib13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1530\/REP-19-0127","article-title":"Prepubertal PTU treatment in rat increases Sertoli cell number and sperm production","volume":"158","author":"Figueiredo","year":"2019","journal-title":"Reprod. (Camb. Engl. )"},{"key":"10.1016\/j.etap.2025.104775_bib14","doi-asserted-by":"crossref","unstructured":"Franz, J.E., Mao, M.K., & Sikorski, J.A. (1997). Glyphosate: a unique global herbicide. American Chemical Society, Washington, DC. https:\/\/doi.org\/10.1016\/S0176-1617(99)80221-1.","DOI":"10.1016\/S0176-1617(99)80221-1"},{"issue":"3","key":"10.1016\/j.etap.2025.104775_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tox.2009.06.006","article-title":"Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines","volume":"262","author":"Gasnier","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2025.104775_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152477","article-title":"Exposure to a Glyphosate-based Herbicide Alters the Expression of Key Regulators of Mammary Gland Development on Pre-pubertal Male Rats","volume":"439","author":"Gomez","year":"2020","journal-title":"Toxicology"},{"issue":"4","key":"10.1016\/j.etap.2025.104775_bib17","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bbrc.2018.05.206","article-title":"HIF involvement in the regulation of rat Sertoli cell proliferation by FSH","volume":"502","author":"Gorga","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.etap.2025.104775_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104682","article-title":"In vitro effects of glyphosate and Roundup on Sertoli cell physiology","volume":"62","author":"Gorga","year":"2020","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.etap.2025.104775_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.615678","article-title":"Low Doses of Glyphosate\/Roundup Alter Blood-Testis Barrier Integrity in Juvenile Rats","volume":"12","author":"Gorga","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.etap.2025.104775_bib20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tox.2016.06.004","article-title":"Neonatal exposure to a glyphosate based herbicide alters the development of the rat uterus","volume":"376","author":"Guerrero Schimpf","year":"2017","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.etap.2025.104775_bib21","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1210\/endo.133.2.8344214","article-title":"High neonatal triiodothyronine levels reduce the period of Sertoli cell proliferation and accelerate tubular lumen formation in the rat testis, and increase serum inhibin levels","volume":"133","author":"van Haaster","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.etap.2025.104775_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109306","article-title":"Adjuvant contributes Roundup's unexpected effects on A549 cells","volume":"184","author":"Hao","year":"2020","journal-title":"Environ. Res."},{"issue":"23","key":"10.1016\/j.etap.2025.104775_bib23","doi-asserted-by":"crossref","first-page":"19267","DOI":"10.1007\/s11356-017-9438-y","article-title":"Effects of low doses of glyphosate on DNA damage, cell proliferation and oxidative stress in the HepG2 cell line","volume":"24","author":"Ka\u0161uba","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"1","key":"10.1016\/j.etap.2025.104775_bib24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1292\/jvms.63.5","article-title":"Effects of exposure of lactating female rats to polychlorinated biphenyls (Pcbs) on testis weight, sperm production and sertoli cell numbers in the adult male offspring","volume":"63","author":"Kim","year":"2001","journal-title":"J. Vet. Med. Sci."},{"issue":"2","key":"10.1016\/j.etap.2025.104775_bib25","first-page":"210","article-title":"Detection of Glyphosate Residues in Animals and Humans","volume":"4","author":"Kr\u00fcger","year":"2014","journal-title":"Environ. Anal. Toxicol."},{"issue":"6","key":"10.1016\/j.etap.2025.104775_bib26","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/humupd\/dmx022","article-title":"Temporal trends in sperm count: a systematic review and meta-regression analysis","volume":"23","author":"Levine","year":"2017","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.etap.2025.104775_bib27","first-page":"635","article-title":"Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis","volume":"7","author":"Li","year":"2013","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.etap.2025.104775_bib28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.toxlet.2018.07.001","article-title":"Fluorochloridone perturbs blood-testis barrier\/Sertoli cell barrier function through Arp3-mediated F-actin disruption","volume":"295","author":"Liu","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.etap.2025.104775_bib29","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1006\/rtph.1995.1049","article-title":"A review of the acceptable daily intakes of pesticides assessed by WHO","volume":"21","author":"Lu","year":"1995","journal-title":"Regulatory toxicology pharmacology RTP"},{"key":"10.1016\/j.etap.2025.104775_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115112","article-title":"Exposure to environmental concentrations of glyphosate induces cardiotoxicity through cellular senescence and reduced cell proliferation capacity","volume":"261","author":"Lu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.etap.2025.104775_bib31","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00204-015-1492-y","article-title":"Perfluorooctanoic acid disrupts the blood-testis barrier and activates the TNF\u03b1\/p38 MAPK signaling pathway in vivo and in vitro","volume":"90","author":"Lu","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.etap.2025.104775_bib32","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.tiv.2012.04.017","article-title":"A commercial formulation of glyphosate inhibits proliferation and differentiation to adipocytes and induces apoptosis in 3T3-L1 fibroblasts","volume":"26","author":"Martini","year":"2012","journal-title":"Toxicology vitro international journal published association BIBRA"},{"issue":"1","key":"10.1016\/j.etap.2025.104775_bib33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1095\/biolreprod54.1.36","article-title":"Neonatal exposure of rats to recombinant follicle stimulating hormone increases adult Sertoli and spermatogenic cell numbers","volume":"54","author":"Meachem","year":"1996","journal-title":"Biol. Reprod."},{"issue":"2-3","key":"10.1016\/j.etap.2025.104775_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.tox.2012.09.006","article-title":"Ethoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity","volume":"313","author":"Mesnage","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2025.104775_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/179691","article-title":"Major pesticides are more toxic to human cells than their declared active principles","volume":"2014","author":"Mesnage","year":"2014","journal-title":"BioMed. Res. Int."},{"issue":"Pt A","key":"10.1016\/j.etap.2025.104775_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.fct.2017.07.025","article-title":"Evaluation of estrogen receptor alpha activation by glyphosate-based herbicide constituents","volume":"108","author":"Mesnage","year":"2017","journal-title":"Food chemical toxicology international journal published British Industrial Biological Research Association"},{"key":"10.1016\/j.etap.2025.104775_bib37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.fct.2019.03.053","article-title":"Insight into the confusion over surfactant co-formulants in glyphosate-based herbicides","volume":"128","author":"Mesnage","year":"2019","journal-title":"Food chemical toxicology international journal published British Industrial Biological Research Association"},{"key":"10.1016\/j.etap.2025.104775_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137201","article-title":"Glyphosate mimics 17\u03b2-estradiol effects promoting estrogen receptor alpha activity in breast cancer cells","volume":"313","author":"Mu\u00f1oz","year":"2023","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.etap.2025.104775_bib39","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/ar.1092030408","article-title":"Proliferation of Sertoli cells in fetal and postnatal rats: a quantitative autoradiographic study","volume":"203","author":"Orth","year":"1982","journal-title":"Anat. Rec."},{"issue":"3","key":"10.1016\/j.etap.2025.104775_bib40","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/endo-122-3-787","article-title":"Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development","volume":"122","author":"Orth","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.etap.2025.104775_bib41","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.chemosphere.2017.09.007","article-title":"Influence of a Roundup formulation on glyphosate effects on steroidogenesis and proliferation of bovine granulosa cells in vitro","volume":"188","author":"Perego","year":"2017","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.etap.2025.104775_bib42","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/toxsci\/kfz039","article-title":"Perinatal Exposure to Glyphosate and a Glyphosate-Based Herbicide Affect Spermatogenesis in Mice","volume":"169","author":"Pham","year":"2019","journal-title":"Toxicological sciences official journal Society Toxicology"},{"key":"10.1016\/j.etap.2025.104775_bib43","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ygcen.2015.08.011","article-title":"FSH and bFGF regulate the expression of genes involved in Sertoli cell energetic metabolism","volume":"222","author":"Regueira","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"issue":"8","key":"10.1016\/j.etap.2025.104775_bib44","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/jat.3122","article-title":"Sertoli cell as a model in male reproductive toxicology: Advantages and disadvantages","volume":"35","author":"Reis","year":"2015","journal-title":"Journal applied toxicology JAT"},{"key":"10.1016\/j.etap.2025.104775_bib45","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000069300","article-title":"Regulation of spermatogenesis","volume":"5","author":"Rey","year":"2003","journal-title":"Endocr. Dev."},{"key":"10.1016\/j.etap.2025.104775_bib46","series-title":"Puberty: Physiology and Abnormalities","first-page":"23","article-title":"Hormonal Changes in Childhood and Puberty","author":"Rey","year":"2016"},{"issue":"6","key":"10.1016\/j.etap.2025.104775_bib47","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1289\/ehp.7728","article-title":"Differential effects of glyphosate and roundup on human placental cells and aromatase","volume":"113","author":"Richard","year":"2005","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.etap.2025.104775_bib48","doi-asserted-by":"crossref","first-page":"E914","DOI":"10.1152\/ajpendo.00477.2011","article-title":"Signal transduction pathways in FSH regulation of rat Sertoli cell proliferation","volume":"302","author":"Riera","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.etap.2025.104775_bib49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1530\/REP-18-0233","article-title":"Metformin counteracts the effects of FSH on rat Sertoli cell proliferation","volume":"156","author":"Rindone","year":"2018","journal-title":"Reprod. (Camb. Engl. )"},{"issue":"3","key":"10.1016\/j.etap.2025.104775_bib50","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/andr.12957","article-title":"Postnatal metformin treatment alters rat Sertoli cell proliferation and daily sperm production","volume":"9","author":"Rindone","year":"2021","journal-title":"Andrology"},{"issue":"4","key":"10.1016\/j.etap.2025.104775_bib51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00204-009-0494-z","article-title":"Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology","volume":"84","author":"Romano","year":"2010","journal-title":"Arch. Toxicol."},{"issue":"11","key":"10.1016\/j.etap.2025.104775_bib52","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.3390\/cells10113079","article-title":"Review: Mechanisms of Glyphosate and Glyphosate-Based Herbicides Action in Female and Male Fertility in Humans and Animal Models","volume":"10","author":"Serra","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.etap.2025.104775_bib53","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1530\/rep.0.1250769","article-title":"Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood","volume":"125","author":"Sharpe","year":"2003","journal-title":"Reprod. (Camb. Engl. )"},{"key":"10.1016\/j.etap.2025.104775_bib54","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.fct.2018.06.014","article-title":"Glyphosate induces growth of estrogen receptor alpha positive cholangiocarcinoma cells via non-genomic estrogen receptor\/ERK1\/2 signaling pathway","volume":"118","author":"Sritana","year":"2018","journal-title":"Food chemical toxicology international journal published British Industrial Biological Research Association"},{"issue":"10","key":"10.1016\/j.etap.2025.104775_bib55","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1289\/ehp.00108961","article-title":"The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996","volume":"108","author":"Swan","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"2 Pt 1","key":"10.1016\/j.etap.2025.104775_bib56","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/rtph.1999.1371","article-title":"Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans","volume":"31","author":"Williams","year":"2000","journal-title":"Regulatory toxicology pharmacology RTP"},{"issue":"4","key":"10.1016\/j.etap.2025.104775_bib57","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/03601239509372951","article-title":"Toxic effects of carbofuran and glyphosate on semen characteristics in rabbits","volume":"30","author":"Yousef","year":"1995","journal-title":"J. Environ. Sci. Health Part. B Pestic. Food Contam. Agric. Wastes"}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668925001504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668925001504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:14:25Z","timestamp":1772781265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668925001504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":57,"alternative-id":["S1382668925001504"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2025.104775","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of the effects of Glyphosate and Roundup on Sertoli cell proliferation","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2025.104775","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104775"}}