{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:09:31Z","timestamp":1778609371819,"version":"3.51.4"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019187","name":"HORIZON EUROPE Widening Participation and Strengthening the European Research Area","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019187","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["UID\/50006 + LA\/P\/0094\/2020"],"award-info":[{"award-number":["UID\/50006 + LA\/P\/0094\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.etap.2025.104832","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T06:26:18Z","timestamp":1759299978000},"page":"104832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Can bystander effects of metals in Daphnia magna be mediated by DNA methylation?"],"prefix":"10.1016","volume":"119","author":[{"given":"Guilherme","family":"Jeremias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Louren\u00e7o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano V.M.","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Van Nieuwerburgh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando J.M.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Asselman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana L.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2025.104832_bib1","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/gbe\/evw069","article-title":"Gene body methylation patterns in Daphnia are associated with gene family size","volume":"8","author":"Asselman","year":"2016","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.etap.2025.104832_bib2","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/etc.2887","article-title":"Global cytosine methylation in Daphnia magna depends on genotype, environment, and their interaction","volume":"34","author":"Asselman","year":"2015","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.etap.2025.104832_bib3","series-title":"Report E 729-80","article-title":"Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians","author":"ASTM","year":"1980"},{"key":"10.1016\/j.etap.2025.104832_bib4","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.febslet.2010.10.042","article-title":"The role of deubiquitinating enzymes in chromatin regulation","volume":"585","author":"Atanassov","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.etap.2025.104832_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.12688\/wellcomeopenres.15552.1","article-title":"A simple ATAC-seq protocol for population epigenetics","volume":"5","author":"Augusto","year":"2020","journal-title":"Wellcome Open Res."},{"key":"10.1016\/j.etap.2025.104832_bib6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature05913","article-title":"Perceptions of epigenetics","volume":"447","author":"Bird","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.etap.2025.104832_bib7","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41586-019-1411-0","article-title":"Advances in epigenetics link genetics to the environment and disease","volume":"571","author":"Cavalli","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.etap.2025.104832_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.aquatox.2019.02.016","article-title":"Variation in transcriptional responses to copper exposure across Daphnia pulex lineages","volume":"210","author":"Chain","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.etap.2025.104832_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5620\/eht.e2018015","article-title":"Epigenetic profiling to environmental stressors in model and non-model organisms: ecotoxicology perspective","volume":"33","author":"Chatterjee","year":"2018","journal-title":"Environ. Health Toxicol."},{"key":"10.1016\/j.etap.2025.104832_bib10","doi-asserted-by":"crossref","first-page":"14605","DOI":"10.1021\/acs.est.5b03988","article-title":"Novel cadmium responsive MicroRNAs in Daphnia pulex","volume":"49","author":"Chen","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2025.104832_bib11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO;2-Q","article-title":"Ubiquitin-mediated proteolysis: biological regulation via destruction","volume":"22","author":"Ciechanover","year":"2000","journal-title":"BioEssays"},{"key":"10.1016\/j.etap.2025.104832_bib12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0140-6736(18)31268-6","article-title":"Principles of DNA methylation and their implications for biology and Medicine","volume":"392","author":"Dor","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.etap.2025.104832_bib13","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1021\/acs.est.5b05973","article-title":"Cyanobacteria affect fitness and genetic structure of experimental Daphnia populations","volume":"50","author":"Drug\u0103","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2025.104832_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13227-022-00199-0","article-title":"Daphnia as a versatile model system in ecology and evolution","volume":"13","author":"Ebert","year":"2022","journal-title":"EvoDevo"},{"key":"10.1016\/j.etap.2025.104832_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201700148","article-title":"Epigenetic and transcriptional variability shape phenotypic plasticity","volume":"40","author":"Ecker","year":"2018","journal-title":"BioEssays"},{"key":"10.1016\/j.etap.2025.104832_bib16","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.3390\/cancers13092005","article-title":"The context-dependent impact of integrin-associated cd151 and other tetraspanins on cancer development and progression: a class of versatile mediators of cellular function and signaling, tumorigenesis and metastasis","volume":"13","author":"Erfani","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.etap.2025.104832_bib17","doi-asserted-by":"crossref","first-page":"20734","DOI":"10.1074\/jbc.R115.656462","article-title":"The AlkB family of Fe(II)\/\u03b1-ketoglutarate-dependent dioxygenases: repairing nucleic acid alkylation damage and beyond","volume":"290","author":"Fedeles","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2025.104832_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104303","article-title":"Environmentally induced DNA methylation is inherited across generations in an aquatic keystone species","volume":"25","author":"Feiner","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.etap.2025.104832_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122972","article-title":"Inter-species bystander effect: eisenia fetida and Enchytraeus albidus exposed to uranium and cadmium","volume":"399","author":"Fernandes","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"11","key":"10.1016\/j.etap.2025.104832_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/15287394.2022.2034688","article-title":"Rapid communication: effects of cadmium exposure on the growth-related genes of Daphnia magna","volume":"85","author":"Fern\u00e1ndez","year":"2022","journal-title":"J. Toxicol. Environ. Health Part A"},{"key":"10.1016\/j.etap.2025.104832_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev-biochem-052110-120012","article-title":"Ubiquitin and proteasomes in transcription","volume":"81","author":"Geng","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.etap.2025.104832_bib22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mrgentox.2017.03.001","article-title":"Induction of cytotoxic and genotoxic damage following exposure of V79 cells to cadmium chloride","volume":"816\u2013817","author":"Gobrecht","year":"2017","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.etap.2025.104832_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129303","article-title":"Integrating transcriptome and physiological analysis to reveal the essential responses of Daphnia magna to antimony trioxide nanoparticle","volume":"437","author":"Gu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.etap.2025.104832_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2012-13-10-r83","article-title":"BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions","volume":"13","author":"Hansen","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.etap.2025.104832_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12964-020-00607-9","article-title":"Eukaryotic translation initiation factors as promising targets in cancer therapy","volume":"18","author":"Hao","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.etap.2025.104832_bib26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/evl3.273","article-title":"Pollution induces epigenetic effects that are stably transmitted across multiple generations","volume":"6","author":"Harney","year":"2022","journal-title":"Evol. Lett."},{"key":"10.1016\/j.etap.2025.104832_bib27","first-page":"8","article-title":"Daphnia as an emerging epigenetic model organism","volume":"2012","author":"Harris","year":"2012","journal-title":"Genet. Res. Int."},{"key":"10.1016\/j.etap.2025.104832_bib28","first-page":"8","article-title":"Daphnia as an emerging epigenetic model organism","volume":"2012","author":"Harris","year":"2012","journal-title":"Genet. Res. Int."},{"key":"10.1016\/j.etap.2025.104832_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2023.130386","article-title":"Epigenetic modifications in radiation-induced non-targeted effects and their clinical significance","volume":"1867","author":"He","year":"2023","journal-title":"Biochim. Et. Biophys. Acta Gen. Subj."},{"issue":"1","key":"10.1016\/j.etap.2025.104832_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/icb\/icu025","article-title":"Patterns of DNA methylation in animals: an ecotoxicological perspective","volume":"54","author":"Head","year":"2014","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.etap.2025.104832_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12864-019-5578-4","article-title":"Genome-wide methylation is modified by caloric restriction in Daphnia magna","volume":"20","author":"Hearn","year":"2019","journal-title":"BMC Genom."},{"key":"10.1016\/j.etap.2025.104832_bib32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13072-020-00379-z","article-title":"DNA methylation differs extensively between strains of the same geographical origin and changes with age in Daphnia magna","volume":"14","author":"Hearn","year":"2021","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.etap.2025.104832_bib33","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1667\/RR15489.1","article-title":"The Radiation-Induced bystander effect (RIBE) and its connections with the hallmarks of cancer","volume":"192","author":"Heeran","year":"2019","journal-title":"Radiat. Res."},{"key":"10.1016\/j.etap.2025.104832_bib34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/1471-2148-10-306","article-title":"The evolution of vertebrate tetraspanins: gene loss, retention, and massive positive selection after whole genome duplications","volume":"10","author":"Huang","year":"2010","journal-title":"BMC Evolut. Biol."},{"key":"10.1016\/j.etap.2025.104832_bib35","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1021\/acs.est.8b03225","article-title":"Transgenerational inheritance of DNA hypomethylation in Daphnia magna in response to salinity stress","volume":"52","author":"Jeremias","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2025.104832_bib36","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1111\/mec.14727","article-title":"Synthesizing the role of epigenetics in the response and adaptation of species to climate change in freshwater ecosystems","volume":"27","author":"Jeremias","year":"2018","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.etap.2025.104832_bib37","series-title":"Epigenetics, Development, Ecology and Evolution","first-page":"5","article-title":"Epigenetic regulation: the cross-talk among development, adaptive strategies, and microevolutionary change","author":"Jeremias","year":"2022"},{"key":"10.1016\/j.etap.2025.104832_bib38","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/brv.12589","article-title":"Prospects for incorporation of epigenetic biomarkers in human health and environmental risk assessment of chemicals","volume":"95","author":"Jeremias","year":"2020","journal-title":"Biol. Rev."},{"key":"10.1016\/j.etap.2025.104832_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124517","article-title":"New insights on the effects of ionic liquid structural changes at the gene expression level: molecular mechanisms of toxicity in Daphnia magna","volume":"409","author":"Jeremias","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.etap.2025.104832_bib40","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2023.2296275","article-title":"History of exposure to copper influences transgenerational gene expression responses in Daphnia magna","volume":"19","author":"Jeremias","year":"2024","journal-title":"Epigenetics"},{"key":"10.1016\/j.etap.2025.104832_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.136231","article-title":"Multigenerational DNA methylation responses to copper exposure in Daphnia: potential targets for epigenetic biomarkers?","volume":"308","author":"Jeremias","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2025.104832_bib42","article-title":"Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin","author":"Jiang","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.etap.2025.104832_bib43","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/molbev\/msv345","article-title":"Evolutionary transition of promoter and gene body DNA methylation across Invertebrate\u2013vertebrate boundary","volume":"33","author":"Keller","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.etap.2025.104832_bib44","doi-asserted-by":"crossref","first-page":"12261","DOI":"10.3390\/ijms160612261","article-title":"Ecotoxicogenomic approaches for understanding molecular mechanisms of environmental chemical toxicity using aquatic invertebrate, Daphnia model organism","volume":"16","author":"Kim","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.etap.2025.104832_bib45","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1093\/carcin\/bgm053","article-title":"Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo","volume":"28","author":"Koturbash","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.etap.2025.104832_bib46","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/em.20361","article-title":"Epigenetic changes and nontargeted radiation Effects-Is there a link?","volume":"49","author":"Kovalchuk","year":"2008","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.etap.2025.104832_bib47","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","article-title":"Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications","volume":"27","author":"Krueger","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.etap.2025.104832_bib48","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3389\/fgene.2018.00640","article-title":"Epigenetics of modified DNA bases: 5-methylcytosine and beyond","volume":"9","author":"Kumar","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.etap.2025.104832_bib49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12864-019-6415-5","article-title":"A comprehensive epigenomic analysis of phenotypically distinguishable, genetically identical female and Male Daphnia pulex","volume":"21","author":"Kvist","year":"2020","journal-title":"BMC Genom."},{"key":"10.1016\/j.etap.2025.104832_bib50","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1093\/gbe\/evy155","article-title":"Pattern of DNA methylation in Daphnia: evolutionary perspective","volume":"10","author":"Kvist","year":"2018","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.etap.2025.104832_bib51","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1890\/03-0286","article-title":"Inducible defenses in multipredator environments: cyclomorphosis in Daphnia cucullata","volume":"85","author":"Laforsch","year":"2004","journal-title":"Ecology"},{"key":"10.1016\/j.etap.2025.104832_bib52","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1080\/09553002.2023.2188977","article-title":"Investigation of presence and impact of radiation-induced bystander effect in acheta domesticus","volume":"99","author":"Li","year":"2023","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.etap.2025.104832_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/eep\/dvz016","article-title":"Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-azacytidine","volume":"5","author":"Lindeman","year":"2019","journal-title":"Environ. Epigenetics"},{"key":"10.1016\/j.etap.2025.104832_bib54","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13072-025-00580-y","article-title":"Genome-wide DNA methylation patterns in Daphnia magna are not significantly associated with age","volume":"18","author":"Liu","year":"2025","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.etap.2025.104832_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125215","article-title":"Evaluating the hazardous impact of ionic liquids \u2013 challenges and opportunities","volume":"412","author":"Magina","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.etap.2025.104832_bib56","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/iub.2276","article-title":"Human and Arabidopsis alpha-ketoglutarate-dependent dioxygenase homolog proteins\u2014New players in important regulatory processes","volume":"72","author":"Marcinkowski","year":"2020","journal-title":"IUBMB Life"},{"key":"10.1016\/j.etap.2025.104832_bib57","doi-asserted-by":"crossref","first-page":"10591","DOI":"10.1021\/acs.est.3c00499","article-title":"DNA adductomics for the biological effect assessment of contaminant exposure in marine sediments","volume":"57","author":"Martella","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2025.104832_bib58","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tig.2022.03.010","article-title":"DNA methylation: a historical perspective","volume":"38","author":"Mattei","year":"2022","journal-title":"Trends Genet."},{"key":"10.1016\/j.etap.2025.104832_bib59","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1080\/09553002.2018.1434323","article-title":"Intercellular communication of DNA damage and oxidative status underpin bystander effects","volume":"94","author":"Mladenov","year":"2018","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.etap.2025.104832_bib60","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41416-018-0192-9","article-title":"Exosome-packaged mir-1246 contributes to bystander dna damage by targeting lig4","volume":"119","author":"Mo","year":"2018","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.etap.2025.104832_bib61","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1534\/g3.117.300447","article-title":"Zinc detoxification: a functional genomics and transcriptomics analysis in Drosophila melanogaster cultured cells","volume":"8","author":"Mohr","year":"2018","journal-title":"G3 Genes Genomes Genetics"},{"key":"10.1016\/j.etap.2025.104832_bib62","doi-asserted-by":"crossref","first-page":"fnu058","DOI":"10.1093\/femsle\/fnu058","article-title":"Rescue of fish exposed to a lethal dose of pathogen, by signals from sublethally exposed survivors","volume":"362","author":"Mothersill","year":"2015","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.etap.2025.104832_bib63","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1021\/es061099y","article-title":"Communication of radiation-induced stress or bystander signals between fish in vivo","volume":"40","author":"Mothersill","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2025.104832_bib64","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/09553002.2017.1398436","article-title":"History of bystander effects research 1905-present; What\u2019s in a name?","volume":"94","author":"Mothersill","year":"2018","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.etap.2025.104832_bib65","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1667\/0033-7587(2001)155[0759:RIBEPH]2.0.CO;2","article-title":"Radiation-induced bystander effects: past history and future directions","volume":"155","author":"Mothersill","year":"2001","journal-title":"Radiat. Res."},{"key":"10.1016\/j.etap.2025.104832_bib66","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fgene.2012.00074","article-title":"Are epigenetic mechanisms involved in radiation-induced bystander effects","volume":"3","author":"Mothersill","year":"2012","journal-title":"Front. Genet."},{"key":"10.1016\/j.etap.2025.104832_bib67","unstructured":"OECD. 2004. OECD guideline for testing of chemicals 202 - Daphnia sp., acute immobilisation test. Paris."},{"key":"10.1016\/j.etap.2025.104832_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2016.30","article-title":"Daphnia magna transcriptome by RNA-Seq across 12 environmental stressors","volume":"3","author":"Orsini","year":"2016","journal-title":"Sci. Data"},{"key":"10.1016\/j.etap.2025.104832_bib69","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/bioinformatics\/btw026","article-title":"Differential methylation analysis for BS-seq data under general experimental design","volume":"32","author":"Park","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.etap.2025.104832_bib70","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1186\/s12864-024-10701-8","article-title":"Exploring the sublethal impacts of cu and zn on Daphnia magna: a transcriptomic perspective","volume":"25","author":"Paylar","year":"2024","journal-title":"BMC Genom."},{"key":"10.1016\/j.etap.2025.104832_bib71","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1038\/s41598-020-63456-z","article-title":"Kairomone-like activity of bile and bile components: a step towards revealing the chemical nature of fish kairomone","volume":"10","author":"Pijanowska","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.etap.2025.104832_bib72","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1073\/pnas.1713901115","article-title":"Chemical encoding of risk perception and predator detection among estuarine invertebrates","volume":"115","author":"Poulin","year":"2018","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"10.1016\/j.etap.2025.104832_bib73","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1021\/es0615573","article-title":"Daphnia magna ecotoxicogenomics provides mechanistic insights into metal toxicity","volume":"41","author":"Poynton","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2025.104832_bib74","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10534-007-9118-3","article-title":"Genotoxicity and mutagenicity of iron and copper in mice","volume":"21","author":"Pr\u00e1","year":"2008","journal-title":"BioMetals"},{"issue":"2","key":"10.1016\/j.etap.2025.104832_bib75","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1534\/genetics.116.193334","article-title":"Promoter architecture and Sex-Specific gene expression in Daphnia pulex","volume":"204","author":"Raborn","year":"2016","journal-title":"Genetics"},{"key":"10.1016\/j.etap.2025.104832_bib76","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.aquatox.2018.03.007","article-title":"RIBE at an inter-organismic level: a study on genotoxic effects in Daphnia magna exposed to waterborne uranium and a uranium mine effluent","volume":"198","author":"Reis","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.etap.2025.104832_bib77","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1042\/BST0390501","article-title":"The complexity of tetraspanins","volume":"39","author":"Rubinstein","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.etap.2025.104832_bib78","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/1471-2164-8-477","article-title":"Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins","volume":"8","author":"Shaw","year":"2007","journal-title":"BMC Genom."},{"key":"10.1016\/j.etap.2025.104832_bib79","doi-asserted-by":"crossref","first-page":"838","DOI":"10.4161\/epi.6.7.16537","article-title":"Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability","volume":"6","author":"Skinner","year":"2011","journal-title":"Epigenetics"},{"key":"10.1016\/j.etap.2025.104832_bib80","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.envres.2015.11.019","article-title":"Irradiation of rainbow trout at early life stages results in trans-generational effects including the induction of a bystander effect in non-irradiated fish","volume":"145","author":"Smith","year":"2016","journal-title":"Environ. Res."},{"issue":"3","key":"10.1016\/j.etap.2025.104832_bib81","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.aquatox.2007.04.010","article-title":"Molecular responses during cadmium-induced stress in Daphnia magna: integration of differential gene expression with higher-level effects","volume":"83","author":"Soetaert","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.etap.2025.104832_bib82","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3390\/genes12060819","article-title":"The crossroads between RAS and RHO signaling pathways in cellular transformation, motility and contraction","volume":"12","author":"Soriano","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.etap.2025.104832_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131026","article-title":"Ecotoxicological epigenetics in invertebrates: emerging tool for the evaluation of present and past pollution burden","volume":"282","author":"\u0160rut","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2025.104832_bib84","series-title":"Handbook of phycological Methods-Culture methods and growth measurements","author":"Stein","year":"1973"},{"key":"10.1016\/j.etap.2025.104832_bib85","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12864-020-06831-4","article-title":"Alternative splicing is highly variable among Daphnia pulex lineages in response to acute copper exposure","volume":"21","author":"Suresh","year":"2020","journal-title":"BMC Genom."},{"key":"10.1016\/j.etap.2025.104832_bib86","unstructured":"Team R.C. 2019. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available from: \u3008www.R-project.org\/\u3009."},{"issue":"34","key":"10.1016\/j.etap.2025.104832_bib87","article-title":"Tetraspanins Function as Regulators of Cellular Signaling","volume":"5","author":"Termini","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.etap.2025.104832_bib88","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1021\/acs.est.7b05695","article-title":"Transgenerational DNA methylation changes in Daphnia magna exposed to chronic \u03b3 irradiation","volume":"52","author":"Trijau","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2025.104832_bib89","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mrrev.2017.05.003","article-title":"Significance and nature of bystander responses induced by various agents","volume":"773","author":"Verma","year":"2017","journal-title":"Mutat. Res."},{"key":"10.1016\/j.etap.2025.104832_bib90","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3010342","article-title":"Radiation-Induced normal tissue damage: oxidative stress and epigenetic mechanisms","volume":"2019","author":"Wei","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.etap.2025.104832_bib91","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/s41589-018-0164-7","article-title":"Identification of Chaoborus kairomone chemicals that induce defences in Daphnia","volume":"14","author":"Weiss","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.etap.2025.104832_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/ijmpcero.2016.51001","article-title":"Radiation induced bystander effect: from in vitro studies to clinical application","volume":"5","author":"Widel","year":"2016","journal-title":"Int. J. Med. Phys. Clin. Eng. Radiat. Oncol."},{"key":"10.1016\/j.etap.2025.104832_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115659","article-title":"Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development","volume":"143","author":"van Wijnen","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.etap.2025.104832_bib94","doi-asserted-by":"crossref","first-page":"20150274","DOI":"10.1098\/rstb.2015.0274","article-title":"The effects of climatic fluctuations and extreme events on running water ecosystems","volume":"371","author":"Woodward","year":"2016","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.etap.2025.104832_bib95","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1667\/RR13909.1","article-title":"Radiation-Induced epigenetic bystander effects demonstrated in arabidopsis thaliana","volume":"183","author":"Xu","year":"2015","journal-title":"Radiat. Res."},{"key":"10.1016\/j.etap.2025.104832_bib96","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.exphem.2016.02.006","article-title":"Tetraspanins: spanning from solid tumors to hematologic malignancies","volume":"44","author":"Yang","year":"2016","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.etap.2025.104832_bib97","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1021\/acs.chemrestox.6b00265","article-title":"Occurrence, biological consequences, and human health relevance of oxidative Stress-Induced DNA damage","volume":"29","author":"Yu","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.etap.2025.104832_bib98","doi-asserted-by":"crossref","DOI":"10.1111\/imb.12865","article-title":"Functional characterisation of fe (II) and 2OG-dependent dioxygenase TcALKBH4 in the red flour beetle, tribolium castaneum","author":"Yu","year":"2023","journal-title":"Insect Mol. Biol.113."},{"issue":"3","key":"10.1016\/j.etap.2025.104832_bib99","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nmeth.3152","article-title":"Coverage recommendations for methylation analysis by whole-genome bisulfite sequencing","volume":"12","author":"Ziller","year":"2015","journal-title":"Nat. Methods"}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668925002078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668925002078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:28:30Z","timestamp":1778606910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668925002078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":99,"alternative-id":["S1382668925002078"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2025.104832","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Can bystander effects of metals in Daphnia magna be mediated by DNA methylation?","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2025.104832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104832"}}