{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:01:58Z","timestamp":1773878518666,"version":"3.50.1"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018227","name":"National Research Foundation of Ukraine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008690","name":"National Research Foundation of Ukraine","doi-asserted-by":"publisher","award":["2021.01\/0061"],"award-info":[{"award-number":["2021.01\/0061"]}],"id":[{"id":"10.13039\/501100008690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.etap.2025.104881","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:17:27Z","timestamp":1764202647000},"page":"104881","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mutual oral administration of wood\/plastic smoke PM and heavy metals Pb2+\/Cd2+: General toxicity effects and ACE2 expression in rats"],"prefix":"10.1016","volume":"121","author":[{"given":"Nataliya","family":"Dziubenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna","family":"Byelinska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisa","family":"Dovbynchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arsen","family":"Ishchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoriia","family":"Velmyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariia","family":"Korbush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Paliienko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliia","family":"Kalynovska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Krisanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Pozdnyakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6533-1420","authenticated-orcid":false,"given":"Tatiana","family":"Borisova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganna","family":"Tolstanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2025.104881_bib1","unstructured":"Alemu, H.Y., Atomsa, A., Sahlemariam, Z., 2006. LECTURE NOTES For Medical Laboratory Students \u3008https:\/\/www.cartercenter.org\/resources\/pdfs\/health\/ephti\/library\/lecture_notes\/med_lab_tech_students\/LN_Hematology_MLT_final.pdf\u3009. https:\/\/doi.org\/https:\/\/www.cartercenter.org\/resources\/pdfs\/health\/ephti\/library\/lecture_notes\/med_lab_tech_students\/ln_hematology_mlt_final.pdf."},{"key":"10.1016\/j.etap.2025.104881_bib2","first-page":"339","article-title":"Levels of trace elements in the serum and erythrocytes and some parameters of erythrocyte heme metabolism (FEP, ALA-D, ALA-U) in copper foundry workers","volume":"4","author":"Antonowicz","year":"1991","journal-title":"Pol. J. Occup. Med. Environ. Health"},{"key":"10.1016\/j.etap.2025.104881_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cellimm.2013.01.002","article-title":"Intracellular localization of myeloperoxidase in murine peritoneal B-lymphocytes and macrophages","volume":"281","author":"de Araujo","year":"2013","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.etap.2025.104881_bib4","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3233\/JAD-200282","article-title":"Heavy metals exposure and Alzheimer\u2019s disease and related dementias","volume":"76","author":"Bakulski","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.etap.2025.104881_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.643972","article-title":"Toxic mechanisms of five heavy metals: mercury, lead, chromium, cadmium, and arsenic","volume":"12","author":"Balali-Mood","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.etap.2025.104881_bib6","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2019.12.034","article-title":"Mechanisms, evaluation, and management of chronic constipation","volume":"158","author":"Bharucha","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2025.104881_bib7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.15407\/fz60.04.040","article-title":"[Hematological effects of the protein kinase inhibitor maleimide derivative in dimethylhydrazin E-induced colorectal carcinogenesis of rats]","volume":"60","author":"Bielins\u2019ka","year":"2014","journal-title":"Fiziol. Zh."},{"key":"10.1016\/j.etap.2025.104881_bib8","doi-asserted-by":"crossref","first-page":"40371","DOI":"10.1007\/s11356-020-11183-3","article-title":"Air pollution particulate matter as a potential carrier of SARS-CoV-2 to the nervous system and\/or neurological symptom enhancer: arguments in favor","volume":"28","author":"Borisova","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.etap.2025.104881_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114502","article-title":"Plastic smoke aerosol: nano-sized particle distribution, absorption\/fluorescent properties, dysregulation of oxidative processes and synaptic transmission in rat brain nerve terminals","volume":"263","author":"Borysov","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2025.104881_bib10","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.3390\/w14213432","article-title":"A Review on cadmium and lead contamination: sources, fate, mechanism, health effects and remediation methods","volume":"14","author":"Bouida","year":"2022","journal-title":"Water"},{"key":"10.1016\/j.etap.2025.104881_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04691","article-title":"Heavy metal pollution in the environment and their toxicological effects on humans","volume":"6","author":"Briffa","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.etap.2025.104881_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.15407\/fz61.04.071","article-title":"Morphofunctional state of blood cells after chronic exposure of the protein kinases inhibitor maleimide derivative","volume":"61","author":"Byelinska","year":"2015","journal-title":"Fiziol. Zh."},{"key":"10.1016\/j.etap.2025.104881_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116329","article-title":"Acute respiratory response to individual particle exposure (PM1.0, PM2.5 and PM10) in the elderly with and without chronic respiratory diseases","volume":"271","author":"Chen","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2025.104881_bib14","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev-pharmtox-010818-021031","article-title":"Metals and mechanisms of carcinogenesis","volume":"59","author":"Chen","year":"2019","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.etap.2025.104881_bib15","article-title":"Traffic-related PM2.5 exposure and its cardiovascular effects among healthy commuters in Taipei, Taiwan","volume":"7","author":"Chuang","year":"2020","journal-title":"Atmos. Environ. X"},{"key":"10.1016\/j.etap.2025.104881_bib16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0076-6879(74)31050-6","article-title":"Isolation of synaptosomal and synaptic plasma membrane fractions","volume":"31","author":"Cotman","year":"1974","journal-title":"Methods Enzym."},{"key":"10.1016\/j.etap.2025.104881_bib17","doi-asserted-by":"crossref","first-page":"R373","DOI":"10.1152\/ajpregu.00292.2006","article-title":"Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system","volume":"292","author":"Doobay","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.etap.2025.104881_bib18","doi-asserted-by":"crossref","first-page":"7312","DOI":"10.1007\/s11356-022-22710-9","article-title":"Gastrointestinal health: changes of intestinal mucosa and microbiota in patients with ulcerative colitis and irritable bowel syndrome from PM2.5-polluted regions of Ukraine","volume":"30","author":"Dorofeyev","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.etap.2025.104881_bib19","unstructured":"Digital Pathology Archives, n.d. Digital Pathology Archives - IHC WORLD [WWW Document]. URL \u3008https:\/\/ihcworld.com\/category\/digital-pathology\/\u3009 (Accessed 7.10.24)."},{"key":"10.1016\/j.etap.2025.104881_bib20","unstructured":"EPA, 2025. Managing Air Quality - Multi-Pollutant Planning and Control [WWW Document]. URL \u3008https:\/\/www.epa.gov\/air-quality-management-process\/managing-air-quality-multi-pollutant-planning-and-control#multi\u3009] (accessed 3.12.25)."},{"key":"10.1016\/j.etap.2025.104881_bib21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1161\/CIRCRESAHA.107.169110","article-title":"Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation","volume":"102","author":"Feng","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.etap.2025.104881_bib22","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.2460\/ajvr.1981.42.09.1630","article-title":"Erythrocyte protoporphyrin in experimental chronic lead poisoning in calves","volume":"42","author":"George","year":"1981","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.etap.2025.104881_bib23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0006-2944(80)90068-X","article-title":"Red blood cell protoporphyrin accumulation in experimental lead poisoning","volume":"23","author":"Hart","year":"1980","journal-title":"Biochem. Med."},{"key":"10.1016\/j.etap.2025.104881_bib24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature11228","article-title":"ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation","volume":"487","author":"Hashimoto","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.etap.2025.104881_bib25","unstructured":"Health Effects Institute Annual Report 2022., n.d. Insights that Endure: Investing in Science for Lasting Impact [WWW Document]. URL https:\/\/www.healtheffects.org\/annual-report-2022 (accessed 7.10.24)."},{"key":"10.1016\/j.etap.2025.104881_bib26","unstructured":"Health Effects Institute State of Global Air 2020, n.d. Air quality and health in cities: A State of Global Air report [WWW Document]. URL \u3008https:\/\/www.c40knowledgehub.org\/s\/article\/Air-quality-and-health-in-cities-A-State-of-Global-Air-report?language=en_US\u3009 (accessed 7.10.24)."},{"key":"10.1016\/j.etap.2025.104881_bib27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1756-0500-3-133","article-title":"Relation between anemia and blood levels of lead, copper, zinc and iron among children","volume":"3","author":"Hegazy","year":"2010","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.etap.2025.104881_bib28","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.jaci.2020.12.634","article-title":"Combined exposure to heavy metals in PM2.5 and pediatric asthma","volume":"147","author":"Hsieh","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.etap.2025.104881_bib29","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1179\/oeh.2007.13.2.202","article-title":"Cadmium-induced cancers in animals and in humans","volume":"13","author":"Huff","year":"2007","journal-title":"Int. J. Occup. Environ. Health"},{"key":"10.1016\/j.etap.2025.104881_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127453","article-title":"Atmospheric particulate matter and potentially hazardous compounds around residential\/road side soil in an urban area","volume":"259","author":"Islam","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2025.104881_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.135027","article-title":"An overview on atmospheric carbonaceous particulate matter into carbon nanomaterials: A new approach for air pollution mitigation","volume":"303","author":"Islam","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2025.104881_bib32","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10653-015-9720-1","article-title":"Air pollution and public health: emerging hazards and improved understanding of risk","volume":"37","author":"Kelly","year":"2015","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.etap.2025.104881_bib33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.15430\/JCP.2017.22.1.6","article-title":"Predictive and prognostic biomarkers of respiratory diseases due to particulate matter exposure","volume":"22","author":"Kim","year":"2017","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.etap.2025.104881_bib34","first-page":"22","article-title":"Intestinal barrier integrity under effect of particulate matter from cottonwood combustion","volume":"93","author":"Korbush","year":"2023","journal-title":"Bull. Taras Shevchenko Natl. Univ. Kyiv. Ser. Biol."},{"key":"10.1016\/j.etap.2025.104881_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0252799","article-title":"Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients","volume":"16","author":"Kragstrup","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.etap.2025.104881_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.115009","article-title":"Synergistic neurological threat from \u0421u and wood smoke particulate matter","volume":"193","author":"Krisanova","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2025.104881_bib37","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nm1267","article-title":"A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury","volume":"11","author":"Kuba","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.etap.2025.104881_bib38","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1007\/s11010-021-04144-y","article-title":"Suppression of systemic inflammation and signs of acute and chronic cholangitis by multi-kinase inhibitor 1-(4-Cl-benzyl)-3-chloro-4-(CF3-phenylamino)-1H-pyrrole-2,5-dione","volume":"476","author":"Kuznietsova","year":"2021","journal-title":"Mol. Cell. Biochem"},{"key":"10.1016\/j.etap.2025.104881_bib39","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1186\/s12889-023-15614-x","article-title":"Interaction between blood cadmium and lead concentration and physical activity on hypertension from the Korean national health and nutrition examination survey in 2008\u20132013","volume":"23","author":"Kwon","year":"2023","journal-title":"BMC Public Health"},{"key":"10.1016\/j.etap.2025.104881_bib40","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018692","article-title":"Lead and cadmium as cardiovascular risk factors: the burden of proof has been met","volume":"10","author":"Lamas","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.etap.2025.104881_bib41","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(17)32345-0","article-title":"The Lancet Commission on pollution and health","volume":"391","author":"Landrigan","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.etap.2025.104881_bib42","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0003-2697(86)90432-X","article-title":"Artificial reductant enhancement of the Lowry method for protein determination","volume":"155","author":"Larson","year":"1986","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.etap.2025.104881_bib43","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1073\/pnas.0405193102","article-title":"Myeloperoxidase mediates neutrophil activation by association with CD11b\/CD18 integrins","volume":"102","author":"Lau","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.etap.2025.104881_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn5164","article-title":"Childhood lead exposure is associated with lower cognitive functioning at older ages","volume":"8","author":"Lee","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.etap.2025.104881_bib45","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature15371","article-title":"The contribution of outdoor air pollution sources to premature mortality on a global scale","volume":"525","author":"Lelieveld","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.etap.2025.104881_bib46","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1289\/ehp.7533","article-title":"Air pollution-associated changes in lung function among asthmatic children in Detroit","volume":"113","author":"Lewis","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2025.104881_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103832","article-title":"PM2.5 deregulated microRNA and inflammatory microenvironment in lung injury","volume":"91","author":"Liu","year":"2022","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.etap.2025.104881_bib48","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.envpol.2013.06.009","article-title":"Carbon black vs. black carbon and other airborne materials containing elemental carbon: Physical and chemical distinctions","volume":"181","author":"Long","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2025.104881_bib49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.33573\/ujoh2016.01.031","article-title":"Disorders of iron metabolism in lead exposure (clinical and experimental studies)","volume":"2016","author":"Lubyanova","year":"2016","journal-title":"Ukr. J. Occup. Heal"},{"key":"10.1016\/j.etap.2025.104881_bib50","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.immuni.2018.04.021","article-title":"TRPV4 channel signaling in macrophages promotes gastrointestinal motility via direct effects on smooth muscle cells","volume":"49","author":"Luo","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.etap.2025.104881_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124251","article-title":"The effect of P2X7 on cadmium-induced osteoporosis in mice","volume":"405","author":"Ma","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.etap.2025.104881_bib52","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1476-5381.2010.00873.x","article-title":"Guidelines for reporting experiments involving animals: the ARRIVE guidelines","volume":"160","author":"McGrath","year":"2010","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.etap.2025.104881_bib53","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.envint.2018.11.001","article-title":"Association of long-term PM2.5 exposure with traditional and novel lipid measures related to cardiovascular disease risk","volume":"122","author":"McGuinn","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.etap.2025.104881_bib54","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41467-022-28060-x","article-title":"The mouse metallomic landscape of aging and metabolism","volume":"13","author":"Morel","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.etap.2025.104881_bib55","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ijid.2020.11.184","article-title":"A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patient","volume":"103","author":"Nagy","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.etap.2025.104881_bib56","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/bcpt.13179","article-title":"Impact of chronic lead exposure on liver and kidney function and haematologic parameters","volume":"124","author":"Nakhaee","year":"2019","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.etap.2025.104881_bib57","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1166\/jnn.2009.GR02","article-title":"Nanoparticles and the brain: cause for concern?","volume":"9","author":"Oberd\u00f6rster","year":"2009","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.etap.2025.104881_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s44273-024-00037-w","article-title":"PM2.5 and heavy metals in urban and agro-industrial areas: health risk assessment considerations","volume":"18","author":"Park","year":"2024","journal-title":"Asian J. Atmos. Environ."},{"key":"10.1016\/j.etap.2025.104881_bib59","doi-asserted-by":"crossref","first-page":"2003730","DOI":"10.1183\/13993003.03730-2020","article-title":"Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: Implications for COVID-19 pathogenesis and consequences","volume":"57","author":"Patel","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.etap.2025.104881_bib60","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1053\/j.gastro.2018.08.063","article-title":"Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018","volume":"156","author":"Peery","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etap.2025.104881_bib61","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1289\/ehp.1103639","article-title":"Lung cancer and cardiovascular disease mortality associated with ambient air pollution and cigarette smoke: Shape of the exposure-response relationships","volume":"119","author":"Pope","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2025.104881_bib62","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3390\/atmos12040425","article-title":"Particulate Matter and Associated Metals: A Link with Neurotoxicity and Mental Health","volume":"12","author":"Potter","year":"2021","journal-title":"Atmosphere"},{"key":"10.1016\/j.etap.2025.104881_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114449","article-title":"Multipollutant reciprocal neurological hazard from smoke particulate matter and heavy metals cadmium and lead in brain nerve terminals","volume":"185","author":"Pozdnyakova","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2025.104881_bib64","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3390\/ijerph14060564","article-title":"Evaluation of the dietary intake of cadmium, lead and mercury and its relationship with bone health among postmenopausal women in Spain","volume":"14","author":"Puerto-Parejo","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.etap.2025.104881_bib65","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1128\/IAI.00814-08","article-title":"Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL\/6 mice","volume":"77","author":"Rhee","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.etap.2025.104881_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.110722","article-title":"Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung","volume":"195","author":"Sagawa","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.etap.2025.104881_bib67","article-title":"Poisoned in their homes - red blood cell abnormalities in lead-exposed residents of a Pakistani industrial zone","author":"Shah","year":"2023","journal-title":"medRxiv 2023"},{"key":"10.1016\/j.etap.2025.104881_bib68","series-title":"Disease-related malnutrition: an evidence-based approach to treatment","author":"Stratton","year":"2003"},{"key":"10.1016\/j.etap.2025.104881_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2020.126472","article-title":"Morpho-functional alterations in lymphocytes and erythrocytes of Japanese quail due to prolonged in vivo exposure to heavy metal complexes","volume":"59","author":"Suljevi\u0107","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.etap.2025.104881_bib70","doi-asserted-by":"crossref","first-page":"38315","DOI":"10.1007\/s11356-022-18741-x","article-title":"A comparative study of wood sawdust and plastic smoke particulate matter with a focus on spectroscopic, fluorescent, oxidative, and neuroactive properties","volume":"29","author":"Tarasenko","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.etap.2025.104881_bib71","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s12031-010-9351-z","article-title":"Cholesterol depletion from the plasma membrane impairs proton and glutamate storage in synaptic vesicles of nerve terminals","volume":"41","author":"Tarasenko","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.etap.2025.104881_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92979-2","article-title":"Increased colonic expression of ACE2 associates with poor prognosis in Crohn\u2019s disease","volume":"11","author":"Toyonaga","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.etap.2025.104881_bib73","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41561-018-0181-x","article-title":"New light on black carbon","volume":"11","author":"Tranvik","year":"2018","journal-title":"Nat. Geosci."},{"key":"10.1016\/j.etap.2025.104881_bib74","series-title":"The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications","first-page":"185","article-title":"ACE2 cell biology, regulation, and physiological functions","author":"Turner","year":"2015"},{"key":"10.1016\/j.etap.2025.104881_bib75","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/10590500802494538","article-title":"Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms","volume":"26","author":"Valavandis","year":"2008","journal-title":"J. Environ. Sci. Heal. Part C."},{"key":"10.1016\/j.etap.2025.104881_bib76","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.chest.2017.07.034","article-title":"Exposure to ambient particulate matter is associated with accelerated functional decline in idiopathic pulmonary fibrosis","volume":"153","author":"Winterbottom","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.etap.2025.104881_bib77","unstructured":"World Health Organisation, 2007. Health risks of heavy metals from long-range transboundary air pollution [WWW Document]. URL \u3008https:\/\/www.who.int\/europe\/publications\/i\/item\/EUR-06-5067592\u3009 (accessed 11.16.23)."},{"key":"10.1016\/j.etap.2025.104881_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132190","article-title":"Association between lead and cadmium co-exposure and systemic immune inflammation in residents living near a mining and smelting area in NW China","volume":"287","author":"Zhang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2025.104881_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139145","article-title":"Respiratory exposure to PM2.5 soluble extract disrupts mucosal barrier function and promotes the development of experimental asthma","volume":"730","author":"Zhao","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.etap.2025.104881_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122457","article-title":"Long-term effect of personal PM2.5 exposure on lung function: a panel study in China","volume":"393","author":"Zhou","year":"2020","journal-title":"J. Hazard. Mater."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138266892500256X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138266892500256X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:24:57Z","timestamp":1773854697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138266892500256X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":80,"alternative-id":["S138266892500256X"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2025.104881","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutual oral administration of wood\/plastic smoke PM and heavy metals Pb2+\/Cd2+: General toxicity effects and ACE2 expression in rats","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2025.104881","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104881"}}