{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T05:20:12Z","timestamp":1793769612089,"version":"4.6.1"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2024YFD2402204"],"award-info":[{"award-number":["2024YFD2402204"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473592"],"award-info":[{"award-number":["82473592"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.etap.2026.105032","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:20:48Z","timestamp":1777584048000},"page":"105032","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cardio-Vessel Organoids (CVO) generated from pluripotent stem cell for modelling the cardiovascular system in vitro and revealing the cardiovascular toxicity of drugs"],"prefix":"10.1016","volume":"124","author":[{"given":"Yue","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hange","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.etap.2026.105032_bib1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.stemcr.2017.01.025","article-title":"Notch inhibition enhances cardiac reprogramming by increasing MEF2C transcriptional activity","volume":"8","author":"Abad","year":"2017","journal-title":"Stem Cell Rep."},{"issue":"10","key":"10.1016\/j.etap.2026.105032_bib2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3390\/ph14100970","article-title":"Anticancer drug-induced cardiotoxicity: insights and pharmacogenetics","volume":"14","author":"Adhikari","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.etap.2026.105032_bib3","unstructured":"Administration F. a D. FDA Modernization Act 2.0. U.S. Government Publishing Office. 2022."},{"issue":"9","key":"10.1016\/j.etap.2026.105032_bib4","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.3390\/ijms23095255","article-title":"Towards understanding the gene-specific roles of GATA factors in heart development: does GATA4 lead the way?","volume":"23","author":"Afouda","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.etap.2026.105032_bib5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/15376516.2023.2238069","article-title":"Modulatory effect of amifostine (WR-1065) against genotoxicity and oxidative stress induced by methotrexate in human umbilical vein endothelial cells (HUVECs)","volume":"33","author":"Aghajanshakeri","year":"2023","journal-title":"Toxicol. Mech. Method"},{"issue":"6","key":"10.1016\/j.etap.2026.105032_bib6","article-title":"Protective Effect of Pycnogenol against Methotrexate-Induced Hepatic, Renal, and Cardiac Toxicity: An In Vivo Study","volume":"15","author":"Al-Abkal","year":"2022","journal-title":"Pharm. (Basel)"},{"key":"10.1016\/j.etap.2026.105032_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1694060","article-title":"Protective effects of avenanthramide-C against cisplatin-induced cardiotoxicity in rats by attenuating oxidative stress, inflammatory cytokines, and modulating p62-Keap1-Nrf2 pathway","volume":"16","author":"Aldubayan","year":"2025","journal-title":"Front Pharm."},{"issue":"10","key":"10.1016\/j.etap.2026.105032_bib8","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/ptr.6152","article-title":"Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention","volume":"32","author":"Allawadhi","year":"2018","journal-title":"Phytother. Res"},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib9","article-title":"Cardioprotective, anti-inflammatory, and antioxidative outcome of costus against bleomycin-induced cardiotoxicity in rat model","volume":"23","author":"Alrashdi","year":"2025","journal-title":"J. Genet Eng. Biotechn"},{"key":"10.1016\/j.etap.2026.105032_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1394557","article-title":"modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis","volume":"15","author":"Anajirih","year":"2024","journal-title":"Front Pharm."},{"key":"10.1016\/j.etap.2026.105032_bib11","article-title":"Changes in vascular identity during vascular remodeling","volume":"6","author":"Aoyagi","year":"2025","journal-title":"Jvs-Vasc. Sci."},{"issue":"4","key":"10.1016\/j.etap.2026.105032_bib12","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3892\/or.2013.2279","article-title":"Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: A retrospective evaluation","volume":"29","author":"Astolfi","year":"2013","journal-title":"Oncol. Rep."},{"issue":"7","key":"10.1016\/j.etap.2026.105032_bib13","first-page":"552","article-title":"Adverse reactions of Amiodarone","volume":"16","author":"Biancatelli","year":"2019","journal-title":"J. Geriatr. Cardiol."},{"issue":"2","key":"10.1016\/j.etap.2026.105032_bib14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.taap.2005.04.028","article-title":"Biomarkers of drug-induced vascular injury","volume":"207","author":"Brott","year":"2005","journal-title":"Toxicol. Appl. Pharm."},{"issue":"3","key":"10.1016\/j.etap.2026.105032_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jaccao.2020.06.004","article-title":"Comprehensive Characterization of the Vascular Effects of Cisplatin-Based Chemotherapy in Patients With Testicular Cancer","volume":"2","author":"Cameron","year":"2020","journal-title":"JACC CardioOncol"},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cells15010007","article-title":"Human Cardiac Organoids: Advances and Prospects from Construction to Preclinical Drug Evaluation","volume":"15","author":"Chen","year":"2025","journal-title":"Cells"},{"issue":"34","key":"10.1016\/j.etap.2026.105032_bib17","doi-asserted-by":"crossref","first-page":"54274","DOI":"10.18632\/oncotarget.11026","article-title":"Cardiac fibrosis in mouse expressing DsRed tetramers involves chronic autophagy and proteasome degradation insufficiency","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.etap.2026.105032_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.900751","article-title":"Dexamethasone Alleviates Myocardial Injury in a Rat Model of Acute Myocardial Infarction Supported by Venoarterial Extracorporeal Membrane Oxygenation","volume":"10","author":"Cheng","year":"2022","journal-title":"Front Public Health"},{"issue":"3","key":"10.1016\/j.etap.2026.105032_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091877","article-title":"Isoproterenol induces vascular oxidative stress and endothelial dysfunction via a Gi\u03b1-coupled \u03b22-adrenoceptor signaling pathway","volume":"9","author":"Davel","year":"2014","journal-title":"Plos One"},{"issue":"16","key":"10.1016\/j.etap.2026.105032_bib20","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1001\/jama.2022.4983","article-title":"Aspirin Use to Prevent Cardiovascular Disease US Preventive Services Task Force Recommendation Statement","volume":"327","author":"Davidson","year":"2022","journal-title":"Jama-J. Am. Med Assoc."},{"key":"10.1016\/j.etap.2026.105032_bib21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.phrs.2015.04.012","article-title":"Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions","volume":"97","author":"Della Latta","year":"2015","journal-title":"Pharm. Res"},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41421-020-00233-2","article-title":"Plasma membrane integrity in health and disease: significance and therapeutic potential","volume":"7","author":"Dias","year":"2021","journal-title":"Cell Discov."},{"issue":"2","key":"10.1016\/j.etap.2026.105032_bib23","first-page":"187","article-title":"Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor","volume":"17","author":"Didagelos","year":"2013","journal-title":"Hippokratia"},{"issue":"21","key":"10.1016\/j.etap.2026.105032_bib24","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1161\/CIRCULATIONAHA.116.026099","article-title":"M. Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy","volume":"137","author":"Diguet","year":"2018","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.etap.2026.105032_bib25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00392-007-0633-6","article-title":"Usefulness of myocardial performance index and biochemical markers for early detection of anthracycline-induced cardiotoxicity in adults","volume":"97","author":"Dodos","year":"2008","journal-title":"Clin. Res Cardiol."},{"issue":"13","key":"10.1016\/j.etap.2026.105032_bib26","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.3390\/ijms23137227","article-title":"Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity","volume":"23","author":"Domingo","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.etap.2026.105032_bib27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tox.2016.10.001","article-title":"An integrative view of cisplatin-induced renal and cardiac toxicities: Molecular mechanisms, current treatment challenges and potential protective measures","volume":"371","author":"Dugbartey","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.etap.2026.105032_bib28","unstructured":"(Fda) U.S.F. a D.A. FDA Announcement on the Use of Organoids and Alternative Models for Monoclonal Antibody Therapies. U.S. Department of Health and Human Services. 2025."},{"issue":"6","key":"10.1016\/j.etap.2026.105032_bib29","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases: role in redox signaling, vascular function, and diseases","volume":"15","author":"Fukai","year":"2011","journal-title":"Antioxid. Redox Signal"},{"issue":"2","key":"10.1016\/j.etap.2026.105032_bib30","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10787-023-01169-1","article-title":"The effects of vitamin C on respiratory, allergic and immunological diseases: an experimental and clinical-based review","volume":"31","author":"Ghalibaf","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"9","key":"10.1016\/j.etap.2026.105032_bib31","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3390\/pharmaceutics13091324","article-title":"Bleomycin Concentration in Patients' Plasma and Tumors after Electrochemotherapy. A Study from InspECT Group","volume":"13","author":"Groselj","year":"2021","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.etap.2026.105032_bib32","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s40256-020-00401-5","article-title":"Amiodarone: a comprehensive guide for clinicians","volume":"20","author":"Hamilton","year":"2020","journal-title":"Am. J. Cardiovasc Drugs"},{"issue":"8","key":"10.1016\/j.etap.2026.105032_bib33","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fphar.2017.00196","article-title":"Characterization of cardiovascular alterations induced by different chronic cisplatin treatments","volume":"8","author":"Herrad\u00f3n","year":"2017","journal-title":"Front Pharm."},{"issue":"6","key":"10.1016\/j.etap.2026.105032_bib34","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/00005344-200412000-00001","article-title":"Effects of high- and low-dose amiodarone on mortality left ventricular remodeling, and hemodynamics in rats with experimental myocardial infarction","volume":"44","author":"Hu","year":"2004","journal-title":"J. Cardiovasc Pharm."},{"issue":"4","key":"10.1016\/j.etap.2026.105032_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/cells12040636","article-title":"Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen","volume":"12","author":"Huang","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61554-w","article-title":"Improving human cardiac organoid design using transcriptomics","volume":"14","author":"Hyams","year":"2024","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.etap.2026.105032_bib37","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1136\/jme.2003.004515","article-title":"Applying a research ethics committee approach to a medical practice controversy: the case of the selective COX-2 inhibitor rofecoxib","volume":"30","author":"James","year":"2004","journal-title":"J. Med Ethics"},{"issue":"7","key":"10.1016\/j.etap.2026.105032_bib38","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1039\/D2FO00298A","article-title":"Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway","volume":"13","author":"Jia","year":"2022","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib39","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/s41598-018-37909-5","article-title":"Pancreatic adenocarcinomas with mature blood vessels have better overall survival","volume":"9","author":"Katsuta","year":"2019","journal-title":"Sci. Rep. -Uk"},{"issue":"4","key":"10.1016\/j.etap.2026.105032_bib40","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.stem.2022.03.012","article-title":"Progress in multicellular human cardiac organoids for clinical applications","volume":"29","author":"Kim","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib41","article-title":"Impact of overnight 1 mg dexamethasone on vascular function in patients with nonfunctioning adrenal adenomas","volume":"13","author":"Kishimoto","year":"2023","journal-title":"Sci. Rep. -Uk"},{"key":"10.1016\/j.etap.2026.105032_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116676","article-title":"Amiodarone but not propafenone impairs bioenergetics and autophagy of human myocardial cells","volume":"477","author":"Kraj\u010dov\u00e1","year":"2023","journal-title":"Toxicol. Appl. Pharm."},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib43","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1186\/s12864-024-10967-y","article-title":"Mechanism of vitamin C alleviating the immunotoxicity of 17\u03b1-methyltestosterone in Carassius auratus","volume":"25","author":"Li","year":"2024","journal-title":"BMC Genom."},{"issue":"5","key":"10.1016\/j.etap.2026.105032_bib44","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41401-020-0496-1","article-title":"Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes","volume":"42","author":"Liu","year":"2021","journal-title":"Acta Pharm. Sin."},{"issue":"8","key":"10.1016\/j.etap.2026.105032_bib45","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41423-025-01310-w","article-title":"NF-\u03baB in inflammation and cancer","volume":"22","author":"Mao","year":"2025","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.etap.2026.105032_bib46","unstructured":"Mcintire E., Barr K.A., Gonzales N.M., Allen O.L., Gilad Y. Guided Differentiation of Pluripotent Stem Cells into Heterogeneously Differentiating Cultures of Cardiac Cells. bioRxiv, 2025."},{"issue":"40","key":"10.1016\/j.etap.2026.105032_bib47","doi-asserted-by":"crossref","first-page":"E8372","DOI":"10.1073\/pnas.1707316114","article-title":"Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest","volume":"114","author":"Mills","year":"2017","journal-title":"P Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.etap.2026.105032_bib48","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/med.21476","article-title":"Cardiotox T-O. Comprehensive review of cardiovascular toxicity of drugs and related agents","volume":"38","author":"Mladenka","year":"2018","journal-title":"Med Res Rev."},{"issue":"12","key":"10.1016\/j.etap.2026.105032_bib49","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3390\/antiox9121227","article-title":"Vitamin C and Cardiovascular Disease: An Update","volume":"9","author":"Morelli","year":"2020","journal-title":"Antioxid. -Basel"},{"issue":"4","key":"10.1016\/j.etap.2026.105032_bib50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.14797\/mdcvj.293","article-title":"Aspirin in the Modern Era of Cardiovascular Disease Prevention","volume":"17","author":"Murphy","year":"2021","journal-title":"Methodist Debakey Cardiovasc J."},{"issue":"2","key":"10.1016\/j.etap.2026.105032_bib51","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/105072501300042703","article-title":"Amiodarone stimulates interleukin-6 production in cultured human thyrocytes, exerting cytotoxic effects on thyroid follicles in suspension culture","volume":"11","author":"Nakajima","year":"2001","journal-title":"Thyroid"},{"issue":"2","key":"10.1016\/j.etap.2026.105032_bib52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.15386\/mpr-1130","article-title":"Influence of concomitant medication on plasma concentration of amiodarone in patients with atrial fibrillation - a pilot study","volume":"92","author":"Neag","year":"2019","journal-title":"Med Pharm. Rep."},{"issue":"12","key":"10.1016\/j.etap.2026.105032_bib53","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1016\/j.cell.2025.03.037","article-title":"Fate and state transitions during human blood vessel organoid development","volume":"188","author":"Nikolova","year":"2025","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib54","first-page":"247","article-title":"Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and cisplatin in vitro","volume":"23","author":"Nuver","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.etap.2026.105032_bib55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.yjmcc.2017.06.008","article-title":"Suppression of autophagic flux contributes to cardiomyocyte death by activation of necroptotic pathways","volume":"108","author":"Ogasawara","year":"2017","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.etap.2026.105032_bib56","first-page":"5","article-title":"Lipopolysaccharide-induced redistribution of myocardial connexin43 is associated with increased macrophage infiltration in both normotensive and spontaneously hypertensive rats","volume":"69","author":"Okruhlicova","year":"2018","journal-title":"J. Physiol. Pharm."},{"issue":"7","key":"10.1016\/j.etap.2026.105032_bib57","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/anae.14610","article-title":"J. Adverse side-effects of dexamethasone in surgical patients - an abridged Cochrane systematic review","volume":"74","author":"Polderman","year":"2019","journal-title":"Anaesthesia"},{"issue":"2","key":"10.1016\/j.etap.2026.105032_bib58","first-page":"1959","article-title":"Cyanidin ameliorates cisplatin-induced cardiotoxicity via inhibition of ROS-mediated apoptosis","volume":"15","author":"Qian","year":"2018","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.etap.2026.105032_bib59","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev-med-051019-102940","article-title":"Aspirin in the Prevention of Cardiovascular Disease and Cancer","volume":"72","author":"Ricciotti","year":"2021","journal-title":"Annu Rev. Med"},{"key":"10.1016\/j.etap.2026.105032_bib60","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.biomaterials.2017.07.021","article-title":"Inspiration from heart development: Biomimetic development of functional human cardiac organoids","volume":"142","author":"Richards","year":"2017","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.etap.2026.105032_bib61","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1365-2249.2000.01373.x","article-title":"Differential anti-inflammatory and anti-oxidative effects of dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation","volume":"122","author":"Rocks\u00e9n","year":"2000","journal-title":"Clin. Exp. Immunol."},{"issue":"18","key":"10.1016\/j.etap.2026.105032_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26185702","article-title":"Joint Cardioprotective Effect of Vitamin C and Other Antioxidants against Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention","volume":"26","author":"Rodrigo","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib63","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s40261-016-0455-2","article-title":"Pharmacokinetic Drug-Drug Interactions Between Vonoprazan and Low-Dose Aspirin or Nonsteroidal Anti-inflammatory Drugs: A Phase 2, Open-Label, Study in Healthy Japanese Men","volume":"37","author":"Sakurai","year":"2017","journal-title":"Clin. Drug Invest."},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib64","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1476-5381.2009.00344.x","article-title":"The signal transduction cascade regulating the expression of the gap junction protein connexin43 by \u03b2-adrenoceptors","volume":"158","author":"Salameh","year":"2009","journal-title":"Brit J. Pharm."},{"issue":"13","key":"10.1016\/j.etap.2026.105032_bib65","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s40265-023-01923-3","article-title":"Recent Advances in Antiarrhythmic Drug Therapy","volume":"83","author":"Saljic","year":"2023","journal-title":"Drugs"},{"key":"10.1016\/j.etap.2026.105032_bib66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.semcdb.2022.10.001","article-title":"Microfluidic organoids-on-a-chip: The future of human models","volume":"144","author":"Saorin","year":"2023","journal-title":"Semin Cell Dev. Biol."},{"issue":"25","key":"10.1016\/j.etap.2026.105032_bib67","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1016\/j.cell.2023.10.030","article-title":"Multi-chamber cardioids unravel human heart development and cardiac defects","volume":"186","author":"Schmidt","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib68","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1186\/s13256-022-03644-9","article-title":"Methotrexate-induced acute cardiotoxicity requiring veno-arterial extracorporeal membrane oxygenation support: a case report","volume":"16","author":"Shah","year":"2022","journal-title":"J. Med Case Rep."},{"issue":"5","key":"10.1016\/j.etap.2026.105032_bib69","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jaccao.2024.07.012","article-title":"Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Preclinical Cardiotoxicity Screening in Cardio-Oncology","volume":"6","author":"Shead","year":"2024","journal-title":"Jacc-Cardiooncol"},{"key":"10.1016\/j.etap.2026.105032_bib70","doi-asserted-by":"crossref","DOI":"10.1039\/D5MD00167F","article-title":"NLRP3 inflammasome: structure, mechanism, drug-induced organ toxicity, therapeutic strategies, and future perspectives","author":"Singh","year":"2025","journal-title":"RSC Med Chem."},{"issue":"4","key":"10.1016\/j.etap.2026.105032_bib71","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1463-1326.2006.00616.x","article-title":"PPARgamma agonists: safety issues in heart failure","volume":"9","author":"Tang","year":"2007","journal-title":"Diabetes Obes. Metab."},{"issue":"7","key":"10.1016\/j.etap.2026.105032_bib72","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3390\/pharmaceutics14071313","article-title":"Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation","volume":"14","author":"Tang","year":"2022","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib73","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41392-022-01024-9","article-title":"Human organoids in basic research and clinical applications","volume":"7","author":"Tang","year":"2022","journal-title":"Signal Transduct. Tar."},{"issue":"6","key":"10.1016\/j.etap.2026.105032_bib74","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/j.1365-2125.2004.02082.x","article-title":"Population pharmacokinetics of total and unbound plasma cisplatin in adult patients","volume":"57","author":"Urien","year":"2004","journal-title":"Brit J. Clin. Pharm."},{"issue":"9","key":"10.1016\/j.etap.2026.105032_bib75","doi-asserted-by":"crossref","first-page":"H1453","DOI":"10.1152\/ajpheart.00554.2015","article-title":"Drug-induced mitochondrial dysfunction and cardiotoxicity","volume":"309","author":"Varga","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.etap.2026.105032_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112322","article-title":"Vascular cells improve functionality of human cardiac organoids","volume":"42","author":"Voges","year":"2023","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib77","doi-asserted-by":"crossref","first-page":"164","DOI":"10.18632\/aging.204466","article-title":"Doxorubicin induced ROS-dependent HIF1\u03b1 activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis","volume":"15","author":"Wen","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.etap.2026.105032_bib78","doi-asserted-by":"crossref","unstructured":"Wheless L., Guennoun R., Michalski-Mcneely B., Gonzalez K.M., Weiss R., Zhang S., Yao L., Madden C., Chen H.C., Triozzi J.L., Tao R., Wilson O., Wells Q.S., Hung A., Bibee K., Hartman R.I., Xu Y. No Increased Risk of Major Adverse Cardiovascular Events following Nicotinamide Exposure. medRxiv, 2024.","DOI":"10.1101\/2024.09.16.24313743"},{"issue":"5","key":"10.1016\/j.etap.2026.105032_bib79","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1001\/jamadermatol.2025.0001","article-title":"Risk of Major Adverse Cardiovascular Events Following Nicotinamide Exposure","volume":"161","author":"Wheless","year":"2025","journal-title":"JAMA Dermatol."},{"issue":"8-10","key":"10.1016\/j.etap.2026.105032_bib80","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/01902148.2016.1243742","article-title":"Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin","volume":"42","author":"Williamson","year":"2016","journal-title":"Exp. Lung Res"},{"key":"10.1016\/j.etap.2026.105032_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154331","article-title":"Icariin exhibits protective effects on cisplatin-induced cardiotoxicity via ROS-mediated oxidative stress injury and","volume":"104","author":"Xia","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.etap.2026.105032_bib82","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/464508","article-title":"Wenxin-Keli Regulates the Calcium\/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction","volume":"2013","author":"Xing","year":"2013","journal-title":"Evid. Based Complement Altern. Med"},{"key":"10.1016\/j.etap.2026.105032_bib83","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.882027","article-title":"The Roles of Cardiac Fibroblasts and Endothelial Cells in Myocarditis","volume":"9","author":"Xuan","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"5","key":"10.1016\/j.etap.2026.105032_bib84","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1365-2133.2006.07474.x","article-title":"Bleomycin and the skin","volume":"155","author":"Yamamoto","year":"2006","journal-title":"Br. J. Dermatol."},{"issue":"8","key":"10.1016\/j.etap.2026.105032_bib85","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13631","article-title":"Generation of human vascularized and chambered cardiac organoids for cardiac disease modelling and drug evaluation","volume":"57","author":"Yang","year":"2024","journal-title":"Cell Prolif."},{"key":"10.1016\/j.etap.2026.105032_bib86","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.12659\/MSM.912999","article-title":"Renal Function and Plasma Methotrexate Concentrations Predict Toxicities in Adults Receiving High-Dose Methotrexate","volume":"24","author":"Yang","year":"2018","journal-title":"Med Sci. Monit."},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib87","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11357-022-00705-1","article-title":"The efficacy and safety of \u03b2-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial","volume":"45","author":"Yi","year":"2023","journal-title":"Geroscience"},{"issue":"8","key":"10.1016\/j.etap.2026.105032_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15082107","article-title":"Cardiomyocyte-Targeting Peptide to Deliver Amiodarone","volume":"15","author":"Zahid","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.etap.2026.105032_bib89","article-title":"Stoichiometric optimization of Gata4, Hand2, Mef2c, and Tbx5 expression for contractile cardiomyocyte reprogramming","volume":"9","author":"Zhang","year":"2019","journal-title":"Sci. Rep. -Uk"},{"issue":"3","key":"10.1016\/j.etap.2026.105032_bib90","first-page":"406","article-title":"Amiodarone promotes heat-induced apoptosis, inflammation and oxidative stress in mouse HL1 atrial myocytes","volume":"41","author":"Zhao","year":"2021","journal-title":"Nan Fang. Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.etap.2026.105032_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108171","article-title":"Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids","volume":"179","author":"Zhou","year":"2023","journal-title":"Environ. Int"}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668926001109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668926001109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T09:28:39Z","timestamp":1783157319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668926001109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":91,"alternative-id":["S1382668926001109"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2026.105032","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardio-Vessel Organoids (CVO) generated from pluripotent stem cell for modelling the cardiovascular system in vitro and revealing the cardiovascular toxicity of drugs","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2026.105032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105032"}}