{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:02:33Z","timestamp":1780588953129,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.etap.2026.105045","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:54:41Z","timestamp":1779206081000},"page":"105045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Bisphenol A\u2013induced NF-\u03baB activation enhances proliferation and migration of renal cell carcinoma cells via SLC7A11 upregulation and redox remodeling"],"prefix":"10.1016","volume":"124","author":[{"given":"Qidi","family":"Zhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhisheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenbo","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2026.105045_bib1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.molliq.2018.05.029","article-title":"Health and environmental effects of persistent organic pollutants","volume":"263","author":"Alharbi","year":"2018","journal-title":"J. Mol. Liq."},{"issue":"3","key":"10.1016\/j.etap.2026.105045_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/tox.22519","article-title":"Bisphenol A is an exogenous toxin that promotes mitochondrial injury and death in tubular cells","volume":"33","author":"Bosch-Panadero","year":"2018","journal-title":"Environ. Toxicol."},{"issue":"2","key":"10.1016\/j.etap.2026.105045_bib3","first-page":"115","article-title":"Cancer statistics in China, 2015: cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.etap.2026.105045_bib4","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine\u2013glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"eLife"},{"issue":"5","key":"10.1016\/j.etap.2026.105045_bib5","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.etap.2026.105045_bib6","series-title":"Bisphenol A Exposure and Health Risks","article-title":"The Toxic effects BPA on fetuses, infants, and children","author":"Ellahi","year":"2017"},{"issue":"1","key":"10.1016\/j.etap.2026.105045_bib7","article-title":"Bisphenol A disrupts renal metabolism via MAPK-mediated steroid hormone dysregulation identified by transcriptomic and metabolomic analyses","volume":"15","author":"Gao","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.etap.2026.105045_bib8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The Complexity of NF-\u03baB Signaling in Inflammation and Cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol. Cancer"},{"issue":"8","key":"10.1016\/j.etap.2026.105045_bib9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"issue":"6","key":"10.1016\/j.etap.2026.105045_bib10","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The Nuclear Factor NF-kappaB Pathway in Inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.etap.2026.105045_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated ampk activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.etap.2026.105045_bib12","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/ki.2012.6","article-title":"Exposure to bisphenol A is associated with low-grade albuminuria in Chinese adults","volume":"81","author":"Li","year":"2012","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.etap.2026.105045_bib13","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1080\/15548627.2020.1739447","article-title":"Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death","volume":"17","author":"Li","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.etap.2026.105045_bib14","article-title":"Urinary Bisphenol A and its substitutes exposure increased the risk of renal tubular injury (N-Acetyl-\u03b2-d-Glucosaminidase) in the general Taiwanese population","volume":"13","author":"Lin","year":"2025","journal-title":"Front. Public Health"},{"key":"10.1016\/j.etap.2026.105045_bib15","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"issue":"10","key":"10.1016\/j.etap.2026.105045_bib16","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1681\/ASN.2013060604","article-title":"CKD and the Risk of Incident Cancer","volume":"25","author":"Lowrance","year":"2014","journal-title":"J. Am. Soc. Nephrol. JASN"},{"issue":"4","key":"10.1016\/j.etap.2026.105045_bib17","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1464-410X.2009.08376.x","article-title":"Comparison of rates and risk factors for developing chronic renal insufficiency, proteinuria and metabolic acidosis after radical or partial nephrectomy","volume":"104","author":"Malcolm","year":"2009","journal-title":"BJU Int."},{"key":"10.1016\/j.etap.2026.105045_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145401","article-title":"Associations of serum bisphenol A levels with incident chronic kidney disease risk","volume":"771","author":"Nie","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.etap.2026.105045_bib19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.envint.2013.12.007","article-title":"Bisphenol A and human chronic diseases: current evidences, possible mechanisms, and future perspectives","volume":"64","author":"Rezg","year":"2014","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.etap.2026.105045_bib20","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1089\/ars.2000.2.4-665","article-title":"Molecular cloning and expression of human xCT, the light chain of amino acid transport system x c \u00af","volume":"2","author":"Sato","year":"2000","journal-title":"Antioxid. Redox Signal."},{"issue":"7","key":"10.1016\/j.etap.2026.105045_bib21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nchembio.2079","article-title":"Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis","volume":"12","author":"Shimada","year":"2016","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.etap.2026.105045_bib22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1523-1755.2003.00060.x","article-title":"Renal cell carcinoma as a cause of end-stage renal disease in the United States: patient characteristics and survival","volume":"64","author":"Stiles","year":"2003","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.etap.2026.105045_bib23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.etap.2026.105045_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/cr.2010.177","article-title":"Non-canonical NF-\u03baB signaling pathway","volume":"21","author":"Sun","year":"2011","journal-title":"Cell Res."},{"issue":"16","key":"10.1016\/j.etap.2026.105045_bib25","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1038\/sj.onc.1201731","article-title":"Epidermal growth factor activation of NF-\u03baB Is mediated through I\u03baB\u03b1 degradation and intracellular free calcium","volume":"16","author":"Sun","year":"1998","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.etap.2026.105045_bib26","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer Journal Clinicians"},{"issue":"4","key":"10.1016\/j.etap.2026.105045_bib27","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ki.2012.422","article-title":"Bisphenol A exposure is associated with low-grade urinary albumin excretion in children of the United States","volume":"83","author":"Trasande","year":"2013","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.etap.2026.105045_bib28","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-\u03baB transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.etap.2026.105045_bib29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to bisphenol A (BPA)","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod. Toxicol."},{"issue":"8","key":"10.1016\/j.etap.2026.105045_bib30","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41401-023-01062-1","article-title":"Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-\u03baB P65-activated SLC7A11 transcription","volume":"44","author":"Wang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.etap.2026.105045_bib31","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.theriogenology.2019.09.045","article-title":"Maternal exposure to Bisphenol A during pregnancy interferes ovaries development of F1 female mice","volume":"142","author":"Wei","year":"2020","journal-title":"Theriogenology"},{"issue":"3","key":"10.1016\/j.etap.2026.105045_bib32","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.cell.2017.09.044","article-title":"PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals","volume":"171","author":"Wenzel","year":"2017","journal-title":"Cell"},{"issue":"1\u20132","key":"10.1016\/j.etap.2026.105045_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.etap.2026.105045_bib34","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.envpol.2017.11.027","article-title":"Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo","volume":"237","author":"Zhang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2026.105045_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137952","article-title":"Cardiovascular toxicity and mechanism of bisphenol A and emerging risk of bisphenol S","volume":"723","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668926001237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1382668926001237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:27:13Z","timestamp":1780586833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1382668926001237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":35,"alternative-id":["S1382668926001237"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2026.105045","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bisphenol A\u2013induced NF-\u03baB activation enhances proliferation and migration of renal cell carcinoma cells via SLC7A11 upregulation and redox remodeling","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2026.105045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105045"}}