{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:31:02Z","timestamp":1793421062883,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003705","name":"Korea Institute of Toxicology","doi-asserted-by":"publisher","award":["KK\\u22122602\\u201301"],"award-info":[{"award-number":["KK\\u22122602\\u201301"]}],"id":[{"id":"10.13039\/501100003705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003562","name":"Korea Ministry of Environment","doi-asserted-by":"publisher","award":["2480000070"],"award-info":[{"award-number":["2480000070"]}],"id":[{"id":"10.13039\/501100003562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003654","name":"Korea Environmental Industry and Technology Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003081","name":"Ministry of Education, Ethiopia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology and Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.etap.2026.105100","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:44:13Z","timestamp":1784097853000},"page":"105100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Developmental neurotoxicity of short-chain phthalates in human neurospheres"],"prefix":"10.1016","volume":"126","author":[{"given":"Soontag","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixian","family":"Quah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Seong","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onju","family":"Ham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Yang","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyojin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-6423","authenticated-orcid":false,"given":"Seung-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook-Joon","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etap.2026.105100_bib1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/cells13070648","article-title":"Mitochondrial permeability transition, cell death and neurodegeneration","volume":"13","author":"Baev","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.etap.2026.105100_bib2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1515\/reveh-2020-0162","article-title":"Health effects associated with phthalate activity on nuclear receptors","volume":"37","author":"Begum","year":"2022","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.etap.2026.105100_bib3","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1016\/j.fct.2010.08.004","article-title":"Usage pattern of personal care products in California households","volume":"48","author":"Bennett","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2026.105100_bib4","doi-asserted-by":"crossref","first-page":"C828","DOI":"10.1152\/ajpcell.00066.2006","article-title":"Formation of actin-ADF\/cofilin rods transiently retards decline of mitochondrial potential and ATP in stressed neurons","volume":"291","author":"Bernstein","year":"2006","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.etap.2026.105100_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.fct.2012.11.014","article-title":"Usage patterns of personal care products: important factors for exposure assessment","volume":"55","author":"Biesterbos","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2026.105100_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137035","article-title":"Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals","volume":"311","author":"Blum","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2026.105100_bib7","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.etap.2026.105100_bib8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cbi.2006.04.014","article-title":"Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism","volume":"163","author":"Depeint","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.etap.2026.105100_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fct.2017.03.057","article-title":"Di-n-butyl phthalate exposure negatively influences structural and functional neuroplasticity via Rho-GTPase signaling pathways","volume":"105","author":"Ding","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2026.105100_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138510","article-title":"Insight into the health risk implicated in mitochondrial toxicity of dibutyl phthalate exposure on zebrafish (Danio rerio) cells","volume":"326","author":"Fan","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.etap.2026.105100_bib11","doi-asserted-by":"crossref","first-page":"14442","DOI":"10.1021\/es4042034","article-title":"A survey of phthalates and parabens in personal care products from the United States and its implications for human exposure","volume":"47","author":"Guo","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2026.105100_bib12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1289\/ehp.10788","article-title":"Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations","volume":"116","author":"H\u00f6gberg","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2026.105100_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109231","article-title":"Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates","volume":"184","author":"Henriksen","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.etap.2026.105100_bib14","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.cell.2014.06.024","article-title":"Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells","volume":"158","author":"Homem","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.etap.2026.105100_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.scitotenv.2018.08.149","article-title":"Personal care products use and phthalate exposure levels among pregnant women","volume":"648","author":"Hsieh","year":"2019","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.etap.2026.105100_bib16","article-title":"Phthalate levels in cord blood are associated with preterm delivery and fetal growth parameters in Chinese women","volume":"9","author":"Huang","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.etap.2026.105100_bib17","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1021\/es0628755","article-title":"Systemic uptake of diethyl phthalate, dibutyl phthalate, and butyl paraben following whole-body topical application and reproductive and thyroid hormone levels in humans","volume":"41","author":"Janjua","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.etap.2026.105100_bib18","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.etap.2026.105100_bib19","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1523\/JNEUROSCI.0321-21.2021","article-title":"The axonal glycolytic pathway contributes to sensory axon extension and growth cone dynamics","volume":"41","author":"Ketschek","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.etap.2026.105100_bib20","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1136\/jech-2015-206315","article-title":"Association of diethylhexyl phthalate with obesity-related markers and body mass change from birth to 3 months of age","volume":"70","author":"Kim","year":"2016","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.etap.2026.105100_bib21","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.etap.2026.105100_bib22","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1289\/ehp.1003178","article-title":"Prenatal exposure to phthalates and infant development at 6 months: prospective mothers and children\u2019s environmental health (MOCEH) study","volume":"119","author":"Kim","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2026.105100_bib23","doi-asserted-by":"crossref","first-page":"A440","DOI":"10.1289\/ehp.108-a440b","article-title":"Human exposure estimates for phthalates","volume":"108","author":"Kohn","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2026.105100_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/15287394.2021.1973631","article-title":"Di-n-butyl phthalate disrupts neuron maturation in primary rat embryo neurons and male C57BL\/6 mice","volume":"85","author":"Lee","year":"2022","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.etap.2026.105100_bib25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.fct.2019.04.040","article-title":"Dibutyl phthalate impairs neural progenitor cell proliferation and hippocampal neurogenesis","volume":"129","author":"Lee","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.etap.2026.105100_bib26","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jpedsurg.2009.02.048","article-title":"Properties of secondary and tertiary human enteric nervous system neurospheres","volume":"44","author":"Lindley","year":"2009","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.etap.2026.105100_bib27","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.bbabio.2014.03.010","article-title":"The H+-ATP synthase: a gate to ROS-mediated cell death or cell survival","volume":"1837","author":"Mart\u00ednez-Reyes","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.etap.2026.105100_bib28","article-title":"Establishment of an a priori protocol for the implementation and interpretation of an in-vitro testing battery for the assessment of developmental neurotoxicity","volume":"17","author":"Masjosthusmann","year":"2020","journal-title":"EFSA Support. Publ."},{"key":"10.1016\/j.etap.2026.105100_bib29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neuro.2010.12.009","article-title":"Endocrine disruptors and childhood social impairment","volume":"32","author":"Miodovnik","year":"2011","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.etap.2026.105100_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101674","article-title":"Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement","volume":"37","author":"Nolfi-Donegan","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.etap.2026.105100_bib31","series-title":"OECD Series on Testing and Assessment","doi-asserted-by":"crossref","DOI":"10.1787\/e1f1244b-en","article-title":"Guidance document on the validation and international acceptance of new or updated test methods for hazard assessment","author":"OECD","year":"2005"},{"key":"10.1016\/j.etap.2026.105100_bib32","unstructured":"OECD, 2023. Initial Recommendations on Evaluation of Data from the Developmental Neurotoxicity (DNT) In-Vitro Testing Battery."},{"key":"10.1016\/j.etap.2026.105100_bib33","first-page":"40","article-title":"Scientific opinion on the relevance of dissimilar mode of action and its appropriate application for cumulative risk assessment of pesticides residues in food","volume":"11","author":"Panel","year":"2013","journal-title":"EFSA J."},{"key":"10.1016\/j.etap.2026.105100_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105408","article-title":"Phthalate exposure and neurodevelopment: a systematic review and meta-analysis of human epidemiological evidence","volume":"137","author":"Radke","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.etap.2026.105100_bib35","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g: profiler, GSEA","volume":"14","author":"Reimand","year":"2019","journal-title":"Cytoscape Enrich. Nat. Protoc."},{"key":"10.1016\/j.etap.2026.105100_bib36","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/carcin\/bgi315","article-title":"Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H + -ATP synthase","volume":"27","author":"Santamar\u00eda","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.etap.2026.105100_bib37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2605.2005.00567.x","article-title":"Human exposure to phthalates via consumer products","volume":"29","author":"Schettler","year":"2006","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.etap.2026.105100_bib38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/npp.2009.115","article-title":"Normal development of brain circuits","volume":"35","author":"Tau","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.etap.2026.105100_bib39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.etap.2026.105100_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.126249","article-title":"Phthalates in the environment: characteristics, fate and transport, and advanced wastewater treatment technologies","volume":"344","author":"Tuan Tran","year":"2022","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.etap.2026.105100_bib41","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3390\/healthcare9050603","article-title":"Phthalates and their impacts on human health","volume":"9","author":"Wang","year":"2021","journal-title":"Healthcare"},{"key":"10.1016\/j.etap.2026.105100_bib42","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1289\/ehp.1103705","article-title":"Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age","volume":"120","author":"Whyatt","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.etap.2026.105100_bib43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.envpol.2018.01.035","article-title":"DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development","volume":"236","author":"Yin","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2026.105100_bib44","doi-asserted-by":"crossref","first-page":"11731","DOI":"10.1074\/jbc.M412898200","article-title":"Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function","volume":"280","author":"Yu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.etap.2026.105100_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118106","article-title":"Phthalate metabolites: characterization, toxicities, global distribution, and exposure assessment","volume":"291","author":"Zhang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.etap.2026.105100_bib46","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13374","article-title":"Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation","volume":"5","author":"Zheng","year":"2016","journal-title":"eLife"}],"container-title":["Environmental Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138266892600178X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138266892600178X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:59:12Z","timestamp":1793419152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138266892600178X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":46,"alternative-id":["S138266892600178X"],"URL":"https:\/\/doi.org\/10.1016\/j.etap.2026.105100","relation":{},"ISSN":["1382-6689"],"issn-type":[{"value":"1382-6689","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental neurotoxicity of short-chain phthalates in human neurospheres","name":"articletitle","label":"Article Title"},{"value":"Environmental Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etap.2026.105100","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105100"}}