{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:55:46Z","timestamp":1791269746075,"version":"4.1.0"},"reference-count":4,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.etp.2005.05.018","type":"journal-article","created":{"date-parts":[[2005,8,18]],"date-time":"2005-08-18T11:37:07Z","timestamp":1124365027000},"page":"183-188","source":"Crossref","is-referenced-by-count":29,"special_numbering":"S1","title":["In vitro studies: What is their role in toxicology?"],"prefix":"10.1016","volume":"57","author":[{"given":"Robert B.","family":"Devlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Frampton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Ghio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2005.05.018_bib1","first-page":"L960","article-title":"Effects of aqueous extracts of PM10 filters from the Utah Valley on human airway epithelial cells","volume":"21","author":"Frampton","year":"1999","journal-title":"Am J Physiol: Lung Cell Mol Physiol"},{"key":"10.1016\/j.etp.2005.05.018_bib2","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1164\/ajrccm.164.4.2011089","article-title":"Inflammatory lung injury after bronchial instillation of air pollution particles","volume":"164","author":"Ghio","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.etp.2005.05.018_bib3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2105\/AJPH.79.5.623","article-title":"Respiratory hospital admissions associated with community air pollution and a steel mill, Utah Valley","volume":"79","author":"Pope III","year":"1989","journal-title":"Am J Public Health"},{"key":"10.1016\/j.etp.2005.05.018_bib4","first-page":"L483","article-title":"Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM","volume":"281","author":"Wu","year":"2001","journal-title":"Am J Physiol: Lung Cell Mol Physiol"}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299305000461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299305000461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T17:23:52Z","timestamp":1548264232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940299305000461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":4,"alternative-id":["S0940299305000461"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2005.05.018","relation":{},"ISSN":["0940-2993"],"issn-type":[{"value":"0940-2993","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}