{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:10:39Z","timestamp":1792455039517,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4-5","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.etp.2008.03.006","type":"journal-article","created":{"date-parts":[[2008,6,3]],"date-time":"2008-06-03T15:23:30Z","timestamp":1212506610000},"page":"373-380","source":"Crossref","is-referenced-by-count":85,"title":["Pathophysiological effects of Androctonus australis hector scorpion venom: Tissue damages and inflammatory response"],"prefix":"10.1016","volume":"60","author":[{"given":"Sonia","family":"Adi-Bessalem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djelila","family":"Hammoudi-Triki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Laraba-Djebari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2008.03.006_bib1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0041-0101(96)00206-1","article-title":"Both cardiogenic and non-cardiogenic factors are involved in the pathogenesis of pulmonary edema after scorpion envenoming","volume":"35","author":"Amaral","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hep.1840130226","article-title":"Effects of cytokines on the liver","volume":"13","author":"Andus","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2008.03.006_bib3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0041-0101(96)83697-X","article-title":"Inflammatory cytokines and scorpionic envenomation: analysis of serological levels in 46 Tunisian patients","volume":"34","author":"Barbouche","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0041-0101(02)00391-4","article-title":"Effect of Tityus serrulatus scorpion venom and its major toxin, TsTX-I, on the complement system in vivo","volume":"41","author":"Bertazzi","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib5","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.intimp.2005.02.007","article-title":"Activation of complement system and leukocyte recruitment by Tityus serrulatus scorpion venom","volume":"5","author":"Bertazzi","year":"2005","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.etp.2008.03.006_bib6","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0041-0101(98)00216-5","article-title":"Pharmacokinetics of the toxic fraction of Centruroides limpidus limpidus venom in experimentally envenomed rabbits and effects of immunotherapy with specific Fab\u20322","volume":"37","author":"Calderon-Aranda","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib7","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0041-0101(96)00219-X","article-title":"Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin Tityustoxin-I","volume":"35","author":"Corr\u00eaa","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0041-0101(98)00174-3","article-title":"Acute myocarditis following Tityus trinitatis envenoming: morphological and pathophysiological characteristics","volume":"37","author":"Daisley","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib9","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0041-0101(02)00145-9","article-title":"Sympathetic nervous system activation, antivenin administration and cardiovascular manifestations of scorpion envenomation","volume":"40","author":"De D\u00e0vila","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib10","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0041-0101(00)00225-7","article-title":"Evidence for the role of mast cells in the lung edema induced by Tityus serrulatus venom in rats","volume":"39","author":"De-Matos","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0041-0101(02)00331-8","article-title":"Relationship between plasmatic levels of various cytokines, tumour necrosis factor, enzymes, glucose and venom concentrations following Tityus scorpion sting","volume":"41","author":"D\u2019Suze","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib12","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.toxicon.2004.08.021","article-title":"Histopathological changes and inflammatory response induced by Tityus discrepans scorpion venom in rams","volume":"44","author":"D\u2019Suze","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF01966298","article-title":"Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration in vivo by indirect mechanisms","volume":"30","author":"Faccioli","year":"1990","journal-title":"Agents Actions"},{"key":"10.1016\/j.etp.2008.03.006_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0041-0101(96)00135-3","article-title":"Leukocyte response induced by Bothrops jararaca crude venom. In vivo and in vitro studies","volume":"35","author":"Farsky","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib15","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/0041-0101(93)90137-8","article-title":"Heparin or a PAF antagonist (BN-52021) prevents the acute pulmonary edema induced by Tityus serrulatus scorpion in the rat","volume":"31","author":"Freire-Maia","year":"1993","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0041-0101(02)00208-8","article-title":"Increased levels of IL-1\u03b2, IL-6, IL-8, IL-10 and TNF-\u03b1 in patients moderately or severely envenomed by Tityus serrulatus scorpion sting","volume":"41","author":"Fukahara","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0041-0101(75)90131-2","article-title":"Pharmacological studies of scorpion (Androctonus amoreuxi Aud. & Sav.) venom","volume":"13","author":"Ghazal","year":"1975","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/15563659209038636","article-title":"The cardiovascular system after scorpion envenomation. A review","volume":"30","author":"Gueron","year":"1992","journal-title":"J Toxicol Clin"},{"key":"10.1016\/j.etp.2008.03.006_bib19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0035-9203(03)00062-2","article-title":"Epidemiological data, clinical admission gradation and biological quantification by ELISA of scorpion envenomations in Algeria: effect of immunotherapy","volume":"98","author":"Hammoudi-Triki","year":"2004","journal-title":"J R Soc Trop Med Hyg"},{"issue":"3","key":"10.1016\/j.etp.2008.03.006_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.taap.2006.11.003","article-title":"Toxicokinetic and Toxicodynamic analyses of Androctonus australis hector venom in rats: optimization of antivenom","volume":"218","author":"Hammoudi-Triki","year":"2007","journal-title":"Ther Toxocol Appl Pharmacol"},{"key":"10.1016\/j.etp.2008.03.006_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/02724936.1993.11747642","article-title":"Reversible cardiomyopathy in patients with severe scorpion envenoming by Tityus serrulatus; evolution of enzymatic, electrocardiographic and echocardiographic alterations","volume":"13","author":"Hering","year":"1993","journal-title":"Ann Trop Paediatr"},{"key":"10.1016\/j.etp.2008.03.006_bib24","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0041-0101(95)00005-7","article-title":"Review article: the scorpion envenoming syndrome","volume":"33","author":"Ismail","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0041-0101(88)90215-2","article-title":"Are the toxicological effects of scorpion envenoming related to tissue venom concentration?","volume":"26","author":"Ismail","year":"1988","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0041-0101(80)90009-4","article-title":"Pharmacokinetrics of 125I-labelled venom from the scorpion Androctonus amoreuxi (Aud. and Sav.)","volume":"18","author":"Ismail","year":"1980","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V74.1.1.1","article-title":"The biology of interleukin-6","volume":"74","author":"Kishimoto","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.etp.2008.03.006_bib26","first-page":"254","article-title":"Utilisation de la Fraction toxique majoritaire isol\u00e9e \u00e0 partir du venin d\u2019 Androctonus australis hector d\u2019Alg\u00e9rie dans la valorisation du s\u00e9rum anti-scorpionique","volume":"62","author":"Laraba-Djebari","year":"1998","journal-title":"Arch Inst Pasteur Alg\u00e9rie"},{"key":"10.1016\/j.etp.2008.03.006_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00916097","article-title":"Host response to Bothrops asper snake. Analysis of edema formation, inflammatory cells and cytokine release in mouse model","volume":"17","author":"Lomonte","year":"1993","journal-title":"Inflammation"},{"key":"10.1016\/j.etp.2008.03.006_bib28","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0041-0101(98)00251-7","article-title":"Serum levels of cytokines in patients envenomed by Tityus serrulatus scorpion sting","volume":"37","author":"Magalhaes","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib29","first-page":"458","article-title":"Cytokines and nitric oxide in streptococcal toxic shock syndrome","volume":"104","author":"Martin","year":"1995","journal-title":"Med Clin"},{"key":"10.1016\/j.etp.2008.03.006_bib30","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0041-0101(98)00106-8","article-title":"Serum interleukin 1\u03b2, interleukin-6, nitric oxide and \u03b11-antitrypsin in scorpion envenomed children","volume":"36","author":"Meki","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1432-1327.1999.00625.x","article-title":"Scorpion toxins specific for sodium channels","volume":"264","author":"Possani","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.etp.2008.03.006_bib32","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/jlb.56.6.672","article-title":"Neutrophils, host defence, and inflammation: a double-edged sword","volume":"56","author":"Smith","year":"1994","journal-title":"J Leukocyte Biol"},{"key":"10.1016\/j.etp.2008.03.006_bib33","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0041-0101(88)90258-9","article-title":"Respiratory failure in children following envenomation by the scorpion Leiurus quinquestriatus: hemodynamic and neurological aspects","volume":"26","author":"Sofer","year":"1988","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib34","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0041-0101(95)00136-0","article-title":"Interleukin-6 release following scorpion sting in children","volume":"34","author":"Sofer","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.03.006_bib35","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0041-0101(00)00200-2","article-title":"Evidence for a direct action of Tityus serralutus on the cardiac muscle","volume":"39","author":"Teixeira","year":"2001","journal-title":"Toxicon"}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094029930800047X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094029930800047X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T03:32:50Z","timestamp":1588735970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094029930800047X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":35,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S094029930800047X"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2008.03.006","relation":{},"ISSN":["0940-2993"],"issn-type":[{"value":"0940-2993","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}