{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:09:32Z","timestamp":1771945772320,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.etp.2008.12.009","type":"journal-article","created":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T10:03:43Z","timestamp":1233569023000},"page":"27-34","source":"Crossref","is-referenced-by-count":23,"title":["Protective effects of Chlorpromazine and Verapamil against cadmium-induced kidney damage in vivo"],"prefix":"10.1016","volume":"62","author":[{"given":"Bin","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Fa","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Hua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2008.12.009_bib1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/0748233706071736","article-title":"Plasma lipid peroxidation and erythrocyte antioxidant enzymes status in workers exposed to cadmium","volume":"22","author":"Babu","year":"2006","journal-title":"Toxicol Ind Health"},{"key":"10.1016\/j.etp.2008.12.009_bib2","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.etp.2008.12.009_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0041-008X(05)80018-3","article-title":"Differences in cadmium and mercury uptakes by hepatocytes: role of calcium channels","volume":"110","author":"Blazka","year":"1991","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.etp.2008.12.009_bib4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00204-003-0451-1","article-title":"Changes in the structure and function of the kidney of rats chronically exposed to cadmium. I. Biochemical and histopathological studies","volume":"77","author":"Brz\u00f3ska","year":"2003","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.etp.2008.12.009_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0009-2797(95)03685-7","article-title":"Inhibition of ATPase activity in rat synaptic plasma membranes by simultaneous exposure to metals","volume":"100","author":"Carfagna","year":"1996","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.etp.2008.12.009_bib6","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0022-3565(24)35156-0","article-title":"Effects of treatment with haloperidol, chlorpromazine, and clozapine on protein kinase C (PKC) and phosphoinositide-specific phospholipase C (PI-PLC) activity and on mRNA and protein expression of PKC and PLC isozymes in rat brain","volume":"291","author":"Dwivedi","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.etp.2008.12.009_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/taap.1999.8785","article-title":"The antagonistic effect of chlorpromazine on cadmium toxicity","volume":"161","author":"El-Ashmawy","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.etp.2008.12.009_bib8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/taap.1996.8060","article-title":"The effect of cadmium on cytosolic free calcium, protein kinase C, and collagen synthesis in rat osteosarcoma (ROS 17\/2.8) cells","volume":"143","author":"Gregoryj","year":"1997","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.etp.2008.12.009_bib9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0009-8981(73)90466-X","article-title":"Determination of serum creatinine by a direct colorimetric method","volume":"43","author":"Heineg\u00e5rd","year":"1973","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.etp.2008.12.009_bib10","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1179\/oeh.2007.13.2.202","article-title":"Cadmium-induced cancers in animals and in humans","volume":"13","author":"Huff","year":"2007","journal-title":"Int J Occup Environ Health"},{"key":"10.1016\/j.etp.2008.12.009_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/toxsci\/61.2.295","article-title":"Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species","volume":"61","author":"Joseph","year":"2001","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.etp.2008.12.009_bib12","first-page":"130","article-title":"A modified spectroscopic assay of superoxide dismutase","volume":"21","author":"Kakkar","year":"1984","journal-title":"Indian J Biochem Biophys"},{"key":"10.1016\/j.etp.2008.12.009_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0009-8981(78)90081-5","article-title":"Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method","volume":"90","author":"Kei","year":"1978","journal-title":"Clin Chem Acta"},{"key":"10.1016\/j.etp.2008.12.009_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0041-0101(02)00313-6","article-title":"Oxidative stress associated hepatic and renal toxicity induced by ricin in mice","volume":"41","author":"Kumar","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.etp.2008.12.009_bib15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.tox.2005.03.012","article-title":"Role of mitogen activated protein kinases and protein kinase C in cadmium-induced apoptosis of primary epithelial lung cells","volume":"211","author":"L\u00e5g","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.etp.2008.12.009_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.etp.2008.12.009_bib17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tox.2004.03.014","article-title":"Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells","volume":"200","author":"Miyahara","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.etp.2008.12.009_bib18","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1177\/0960327107073810","article-title":"Effects of diallyl tetrasulfide on cadmium-induced oxidative damage in the liver of rats","volume":"26","author":"Murugavel","year":"2007","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.etp.2008.12.009_bib19","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.1371\/journal.pone.0000545","article-title":"Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel","volume":"2","author":"Ol\u00e1h","year":"2007","journal-title":"PLOS One"},{"key":"10.1016\/j.etp.2008.12.009_bib20","series-title":"Handbook of experimental pharmacology","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/978-3-642-70856-5_6","article-title":"The nephropathy of chronic cadmium poisoning","author":"Piscator","year":"1986"},{"key":"10.1016\/j.etp.2008.12.009_bib21","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase purification assay","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.etp.2008.12.009_bib22","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1152\/ajprenal.00066.2002","article-title":"Cd-MT causes endocytosis of brush-border transporters in rat renal proximal tubules","volume":"283","author":"Sabolic","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.etp.2008.12.009_bib23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuint.2004.08.001","article-title":"Early and delayed glutamate effects in rat primary cortical neurons changes in the subcellular distribution of protein kinase C isoforms and in intracellular calcium concentration","volume":"46","author":"Siniscalchi","year":"2005","journal-title":"Neurochem Int"},{"key":"10.1016\/j.etp.2008.12.009_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0300-483X(97)00057-7","article-title":"Cadmium uptake by a human hepatic cell line (WRL-68 cells)","volume":"120","author":"Souza","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.etp.2008.12.009_bib25","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00774-004-0505-3","article-title":"Both mercury and cadmium directly influence calcium homeostasis resulting from the suppression of scale bone cells: the scale is a good model for the evaluation of heavy metals in bone metabolism","volume":"22","author":"Suzuki","year":"2004","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.etp.2008.12.009_bib26","first-page":"451","article-title":"The effect of antisense oligonucleotide treatment of plasma membrane Ca2+-ATPase in PC12 cells","volume":"9","author":"Szemraj","year":"2004","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.etp.2008.12.009_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0300-483X(00)00144-X","article-title":"The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures","volume":"145","author":"Szuster-Ciesielska","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.etp.2008.12.009_bib28","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1016\/S0021-9258(18)50638-4","article-title":"Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids","volume":"254","author":"Takai","year":"1979","journal-title":"J Biol Chem"},{"key":"10.1016\/j.etp.2008.12.009_bib29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/15287390151101583","article-title":"Renal cortical mitochondrial dysfunction upon cadmium metallothionein administration to Sprague-Dawley rats","volume":"63","author":"Tang","year":"2001","journal-title":"J Toxicol Environ Health"},{"key":"10.1016\/j.etp.2008.12.009_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tox.2006.10.011","article-title":"Chronic exposure of mice to environmentally relevant, low doses of cadmium leads to early renal damage, not predicted by blood or urine cadmium levels","volume":"229","author":"Thijssen","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.etp.2008.12.009_bib31","series-title":"Oxford textbook of clinical nephrology","first-page":"1175","article-title":"Heavy metals and the kidney","author":"Wedeen","year":"1998"},{"key":"10.1016\/j.etp.2008.12.009_bib32","first-page":"1","article-title":"The role of loop 6\/7 in folding and functional performance of Na+\u2013K+-ATPase","volume":"20","author":"Xu","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.etp.2008.12.009_bib33","first-page":"19","article-title":"Changes in tissue metals after cadmium intoxication and intervention with chlorpromazine in male rats","volume":"13","author":"Yang","year":"2000","journal-title":"Biomed Environ Sci"}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299308001863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299308001863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T10:19:39Z","timestamp":1738923579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940299308001863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0940299308001863"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2008.12.009","relation":{},"ISSN":["0940-2993"],"issn-type":[{"value":"0940-2993","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}