{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:50:11Z","timestamp":1787590211695,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.etp.2010.11.005","type":"journal-article","created":{"date-parts":[[2010,12,4]],"date-time":"2010-12-04T09:41:09Z","timestamp":1291455669000},"page":"503-508","source":"Crossref","is-referenced-by-count":284,"title":["Protective effect of sulforaphane against oxidative stress: Recent advances"],"prefix":"10.1016","volume":"64","author":[{"given":"Carlos Enrique","family":"Guerrero-Beltr\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariel","family":"Calder\u00f3n-Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Pedraza-Chaverri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda Irasema","family":"Chirino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2010.11.005_bib0005","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1021\/jf900549c","article-title":"Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential","volume":"57","author":"Angeloni","year":"2009","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.etp.2010.11.005_bib0010","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1271\/bbb.70545","article-title":"Protective effects of an extract of young radish (Raphanus sativus L.) cultivated with sulfur (sulfur-radish extract) and of sulforaphane on carbon tetrachloride-induced hepatotoxicity","volume":"72","author":"Baek","year":"2008","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.etp.2010.11.005_bib0015","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/glia.20793","article-title":"Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation","volume":"57","author":"Danilov","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.etp.2010.11.005_bib0020","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1167\/iovs.07-0960","article-title":"Demonstration by redox fluorometry that sulforaphane protects retinal pigment epithelial cells against oxidative stress","volume":"49","author":"del V Cano","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.etp.2010.11.005_bib0025","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0278-6915(99)00082-4","article-title":"Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes","volume":"37","author":"Fahey","year":"1999","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.etp.2010.11.005_bib0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0031-9422(00)00316-2","article-title":"The chemical diversity and distribution of glucosinolates and isothiocyanates among plants","volume":"56","author":"Fahey","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.etp.2010.11.005_bib0040","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.toxlet.2009.11.007","article-title":"Sulforaphane protects against cisplatin-induced nephrotoxicity","volume":"192","author":"Guerrero-Beltr\u00e1n","year":"2010","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.etp.2010.11.005_bib0045","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.toxlet.2010.08.009","article-title":"Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and \u03b3 glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1 cells","volume":"199","author":"Guerrero-Beltr\u00e1n","year":"2010","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.etp.2010.11.005_bib0050","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1124\/jpet.106.110866","article-title":"Protective effect of sulforaphane against dopaminergic cell death","volume":"321","author":"Han","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.etp.2010.11.005_bib0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00394-008-2009-8","article-title":"The cancer chemopreventive actions of phytochemicals derived from glucosinolates","volume":"47","author":"Hayes","year":"2008","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.etp.2010.11.005_bib0060","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1124\/jpet.103.064261","article-title":"In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat","volume":"310","author":"Hu","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.etp.2010.11.005_bib0065","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4049\/jimmunol.181.1.680","article-title":"The transcription factor Nrf2 is a therapeutic target against brain inflammation","volume":"181","author":"Innamorato","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.etp.2010.11.005_bib0070","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1081\/DMR-120000652","article-title":"Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE\/EpRE)","volume":"33","author":"Kong","year":"2001","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.etp.2010.11.005_bib0075","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1021\/jf980985s","article-title":"Variation of glucosinolates in vegetable crops of Brassica oleracea","volume":"47","author":"Kushad","year":"1999","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.etp.2010.11.005_bib0080","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.phrs.2008.09.003","article-title":"Dual roles of Nrf2 in cancer","volume":"58","author":"Lau","year":"2008","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.etp.2010.11.005_bib0085","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3945\/jn.110.121418","article-title":"Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation","volume":"140","author":"Lii","year":"2010","journal-title":"J Nutr"},{"key":"10.1016\/j.etp.2010.11.005_bib0090","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1152\/japplphysiol.00293.2009","article-title":"Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats","volume":"107","author":"Malaguti","year":"2009","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.etp.2010.11.005_bib0095","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1021\/jf010809a","article-title":"Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli sulforaphane and sulforaphane nitrile","volume":"49","author":"Matusheski","year":"2001","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.etp.2010.11.005_bib0105","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/jf0728146","article-title":"Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily","volume":"56","author":"Mukherjee","year":"2008","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.etp.2010.11.005_bib0110","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1017\/S0007114509992492","article-title":"Comparison of the protective effects of steamed and cooked broccolis on ischaemia\u2013reperfusion-induced cardiac injury","volume":"103","author":"Mukherjee","year":"2010","journal-title":"Br J Nutr"},{"key":"10.1016\/j.etp.2010.11.005_bib0115","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.phrs.2009.11.009","article-title":"Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels","volume":"61","author":"Piao","year":"2010","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.etp.2010.11.005_bib0120","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.brainres.2010.04.036","article-title":"Sulforaphane protects brains against hypoxic\u2013ischemic injury through induction of Nrf2-dependent phase 2 enzyme","volume":"1343","author":"Ping","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.etp.2010.11.005_bib0125","article-title":"The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer","author":"Razis","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.etp.2010.11.005_bib0130","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.clim.2008.10.007","article-title":"Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway","volume":"130","author":"Riedl","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1016\/j.etp.2010.11.005_bib0135","first-page":"501","article-title":"Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans","volume":"10","author":"Shapiro","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.etp.2010.11.005_bib0140","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.freeradbiomed.2010.01.021","article-title":"The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial\u2013mesenchymal transition and renal fibrosis","volume":"48","author":"Shin","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.etp.2010.11.005_bib0145","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1002\/jnr.21975","article-title":"Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures","volume":"87","author":"Siebert","year":"2009","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.etp.2010.11.005_bib0155","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1002\/jnr.22307","article-title":"Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation","volume":"88","author":"Soane","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.etp.2010.11.005_bib0165","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.taap.2008.11.007","article-title":"Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway","volume":"235","author":"Song","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.etp.2010.11.005_bib0170","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/j.1471-4159.2009.06394.x","article-title":"Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line","volume":"111","author":"Tarozzi","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.etp.2010.11.005_bib0180","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-1-4757-3230-6_14","article-title":"Brassica vegetables and cancer prevention epidemiology and mechanisms","volume":"472","author":"Van Poppel","year":"1999","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.etp.2010.11.005_bib0185","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/mnfr.200900197","article-title":"Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1\/2 Nrf-2 and the upregulation of detoxification enzymes","volume":"54","author":"Vauzour","year":"2010","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.etp.2010.11.005_bib0190","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1360-1385(02)02273-2","article-title":"Glucosinolate research in the Arabidopsis era","volume":"7","author":"Wittstock","year":"2002","journal-title":"Trends Plant Sci"},{"key":"10.1016\/j.etp.2010.11.005_bib0195","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1073\/pnas.0402004101","article-title":"Dietary approach to attenuate oxidative stress hypertension and inflammation in the cardiovascular system","volume":"101","author":"Wu","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.etp.2010.11.005_bib0200","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.2337\/db06-1003","article-title":"Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease","volume":"57","author":"Xue","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.etp.2010.11.005_bib0205","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/j.bcp.2008.02.029","article-title":"Sulforaphane protects kidneys against ischemia\u2013reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme","volume":"75","author":"Yoon","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.etp.2010.11.005_bib0210","doi-asserted-by":"crossref","first-page":"27545","DOI":"10.1074\/jbc.274.39.27545","article-title":"Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals","volume":"274","author":"Yu","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.etp.2010.11.005_bib0215","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.3748\/wjg.v16.i24.3002","article-title":"Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway","volume":"16","author":"Zhao","year":"2010","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.etp.2010.11.005_bib0220","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2005.09.065","article-title":"Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents","volume":"393","author":"Zhao","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.etp.2010.11.005_bib0225","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1161\/STROKEAHA.107.486506","article-title":"Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage","volume":"38","author":"Zhao","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.etp.2010.11.005_bib0230","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1523\/JNEUROSCI.1683-07.2007","article-title":"Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury","volume":"27","author":"Zhao","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.etp.2010.11.005_bib0235","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12012-008-9020-4","article-title":"Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress","volume":"8","author":"Zhu","year":"2008","journal-title":"Cardiovasc Toxicol"}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299310001831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299310001831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T20:07:34Z","timestamp":1712002054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940299310001831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0940299310001831"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2010.11.005","relation":{},"ISSN":["0940-2993"],"issn-type":[{"value":"0940-2993","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}