{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:04:52Z","timestamp":1754399092168},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.etp.2011.11.003","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T09:38:55Z","timestamp":1327916335000},"page":"365-373","source":"Crossref","is-referenced-by-count":5,"title":["Involvement of monoamine oxidase-B in the acute neurotoxicity of MPTP in embryonic and newborn mice"],"prefix":"10.1016","volume":"65","author":[{"given":"Takafumi","family":"Sai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2011.11.003_bib0005","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/cdd.2009.217","article-title":"Paraquat and Parkinson's disease","volume":"7","author":"Berry","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.etp.2011.11.003_bib0010","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.reprotox.2006.01.007","article-title":"P-glycoprotein in the placenta: expression, localization, regulation and function","volume":"22","author":"Ceckova-Novotna","year":"2006","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.etp.2011.11.003_bib0015","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1471-4159.2008.05697.x","article-title":"Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum","volume":"107","author":"Chen","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.etp.2011.11.003_bib0020","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/0006-291X(85)91071-X","article-title":"Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes","volume":"128","author":"Chiba","year":"1985","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.etp.2011.11.003_bib0025","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1016\/S0021-9258(18)60674-X","article-title":"Energy-driven uptake of the neurotoxin 1-methyl-4-phenylpyridinium into chromaffin granules via the catecholamine transporter","volume":"263","author":"Daniels","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/j.etp.2011.11.003_bib0030","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1634\/stemcells.2008-0080","article-title":"Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor \u03b1 and noggin striatal infusions into the dopamine-depleted striatum","volume":"26","author":"de Chevigny","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.etp.2011.11.003_bib0035","doi-asserted-by":"crossref","first-page":"12535","DOI":"10.1523\/JNEUROSCI.1920-10.2010","article-title":"Pathogenic lysosomal depletion in Parkinson's disease","volume":"30","author":"Dehay","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.etp.2011.11.003_bib0040","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1476-5381.1993.tb13584.x","article-title":"Selective MPP+ uptake into synaptic dopamine vesicles: possible involvement in MPTP neurotoxicity","volume":"109","author":"Del Zompo","year":"1993","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.etp.2011.11.003_bib0045","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/glia.440050108","article-title":"Production and disposition of 1-methyl-4-phenylpyridinium in primary cultures of mouse astrocytes","volume":"5","author":"Di Monte","year":"1992","journal-title":"Glia"},{"key":"10.1016\/j.etp.2011.11.003_bib0050","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuroscience.2006.06.041","article-title":"Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain","volume":"142","author":"Fitzgerald","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.etp.2011.11.003_bib0235","series-title":"The mouse brain atlas","author":"Franklin","year":"1996"},{"key":"10.1016\/j.etp.2011.11.003_bib0060","doi-asserted-by":"crossref","first-page":"18754","DOI":"10.1073\/pnas.0704908104","article-title":"Selective inhibition of NF-\u03baB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease","volume":"104","author":"Ghosh","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.etp.2011.11.003_bib0065","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/01.jnen.0000235115.29440.ce","article-title":"Evidence of apoptosis in the subventricular zone and rostral migratory stream in the MPTP mouse model of Parkinson disease","volume":"65","author":"He","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.etp.2011.11.003_bib0070","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.neuro.2008.05.009","article-title":"Neural progenitor cells are protected against MPTP by MAO-B inhibitors","volume":"29","author":"He","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.etp.2011.11.003_bib0075","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.neuro.2008.02.007","article-title":"Neurotoxicity of MPTP to migrating neuroblasts: studies in acute and subacute mouse models of Parkinson's disease","volume":"29","author":"He","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.etp.2011.11.003_bib0080","doi-asserted-by":"crossref","unstructured":"Ito T, Suzuki K, Uchida K, Nakayama H. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuroblastic apoptosis in the subventricular zone is caused by 1-methy-4-phenylpiridinium (MPP(+)) converted from MPTP through MAO-B. Exp Toxicol Pathol, doi:10.1016\/j.etp.2011.01.013, in press.","DOI":"10.1016\/j.etp.2011.01.013"},{"key":"10.1016\/j.etp.2011.11.003_bib0085","doi-asserted-by":"crossref","unstructured":"Ito T, Suzuki K, Uchida K, Nakayama H. Different susceptibility to 1-methyl-4-phenylpyridium (MPP+)-induced nigro-striatal dopaminergic cell loss between C57BL\/6 and BALB\/c mice is not related to the difference of monoamine oxidase-B (MAO-B). Exp Toxicol Pathol, doi:10.1016\/j.etp.2011.07.004, in press.","DOI":"10.1016\/j.etp.2011.07.004"},{"key":"10.1016\/j.etp.2011.11.003_bib0090","series-title":"Atras of the developing mouse brain","author":"Jacobowitz","year":"1997"},{"key":"10.1016\/j.etp.2011.11.003_bib0095","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0014-2999(84)90740-4","article-title":"Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP","volume":"106","author":"Javitch","year":"1984","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.etp.2011.11.003_bib0100","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1353-8020(09)70829-6","article-title":"From the MPTP-treated primate to the treatment of motor complications in Parkinson's disease","volume":"15","author":"Jenner","year":"2009","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.etp.2011.11.003_bib0105","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1124\/jpet.110.166629","article-title":"Reduction of l-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease","volume":"333","author":"Johnston","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.etp.2011.11.003_bib0110","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.1073\/pnas.79.20.6385","article-title":"Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons","volume":"79","author":"Levitt","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.etp.2011.11.003_bib0115","doi-asserted-by":"crossref","first-page":"38581","DOI":"10.1074\/jbc.M005385200","article-title":"The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. a novel mechanism of toxicity","volume":"49","author":"Lotharius","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.etp.2011.11.003_bib0120","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1007\/s11064-007-9351-8","article-title":"Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced parkinsonism via activation of tyrosine kinase receptor signaling pathway","volume":"32","author":"Mandel","year":"2007","journal-title":"Neurochem Res"},{"key":"10.1016\/j.etp.2011.11.003_bib0125","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1111\/j.1471-4159.1990.tb03156.x","article-title":"Immunity of fetal mice to prenatal administration of the doparninergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin","volume":"55","author":"Melamed","year":"1990","journal-title":"J Neurochem"},{"key":"10.1016\/j.etp.2011.11.003_bib0130","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuropharm.2006.03.004","article-title":"Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism","volume":"51","author":"Mu\u00f1oz","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.etp.2011.11.003_bib0135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0161-813X(03)00095-0","article-title":"Monoamine oxidase expression during development and aging","volume":"25","author":"Nicotra","year":"2004","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.etp.2011.11.003_bib0140","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00702-005-0415-0","article-title":"Nitric oxide and MPP1-induced hydroxyl radical generation","volume":"113","author":"Obata","year":"2006","journal-title":"J Neural Transm"},{"key":"10.1016\/j.etp.2011.11.003_bib0145","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3940(92)90815-O","article-title":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase","volume":"148","author":"O\u2019Callaghan","year":"1992","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.etp.2011.11.003_bib0150","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1002\/jnr.22423","article-title":"Alzheimer's disease modifies progenitor cell expression of monoamine oxidase B in the subventricular zone","volume":"88","author":"Pugliese","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.etp.2011.11.003_bib0155","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1073\/pnas.84.22.8160","article-title":"Subcellular compartmentalization of 1-methyl-4-phenylpyridinium with catecholamines in adrenal medullary chromaffin vesicles may explain the lack of toxicity to adrenal chromaffin cells","volume":"84","author":"Reinhard","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.etp.2011.11.003_bib0160","doi-asserted-by":"crossref","unstructured":"Sai T, Uchida K, Nakayama H. Acute toxicity of MPTP and MPP+ in the brain of embryo and newborn mice. Exp Toxicol Pathol, doi:10.1016\/j.etp.2011.06.008, in press.","DOI":"10.1016\/j.etp.2011.06.008"},{"key":"10.1016\/j.etp.2011.11.003_bib0165","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF02335939","article-title":"The hypothalamus in MPTP-induced parkinsonism","volume":"11","author":"Sandyk","year":"1990","journal-title":"Ital J Neuro Sci"},{"key":"10.1016\/j.etp.2011.11.003_bib0170","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/sj.cdd.4402160","article-title":"Mitochondrial dysfunction in Parkinson's disease","volume":"14","author":"Schapira","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.etp.2011.11.003_bib0175","doi-asserted-by":"crossref","DOI":"10.1016\/0014-4886(87)90107-5","article-title":"Immunohistocemical localization of monoamine oxidase-B in the cat brain: clues to understanding n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity","volume":"97","author":"Schneider","year":"1987","journal-title":"Exp Neurol"},{"key":"10.1016\/j.etp.2011.11.003_bib0180","doi-asserted-by":"crossref","first-page":"14250","DOI":"10.1074\/jbc.M600922200","article-title":"In vivo complementation of complex I by the yeast Ndi1 enzyme. Possible application for treatment of Parkinson disease","volume":"281","author":"Seo","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.etp.2011.11.003_bib0185","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.neuro.2009.07.003","article-title":"MPTP-induced neuroblast apoptosis in the subventricular zone is not regulated by dopamine or other monoamine transporters","volume":"30","author":"Shibui","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.etp.2011.11.003_bib0190","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1042\/bj2350785","article-title":"Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases","volume":"235","author":"Singer","year":"1986","journal-title":"Biochem J"},{"key":"10.1016\/j.etp.2011.11.003_bib0195","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/glia.20233","article-title":"Glia cell number modulates sensitivity to MPTP in mice","volume":"52","author":"Smeyne","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.etp.2011.11.003_bib0200","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.expneurol.2009.11.018","article-title":"The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance","volume":"221","author":"Sonsalla","year":"2010","journal-title":"Exp Neurol"},{"key":"10.1016\/j.etp.2011.11.003_bib0205","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00418-008-0502-z","article-title":"Roles of gap junctions in glucose transport from glucose transporter 1-positive to -negative cells in the lateral wall of the rat cochlea","volume":"131","author":"Suzuki","year":"2009","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.etp.2011.11.003_bib0210","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1097\/00001756-200104170-00037","article-title":"Nuclear factor-kappaB activation is not involved in a MPTP model of Parkinson's disease","volume":"12","author":"Teismann","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.etp.2011.11.003_bib0215","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/cne.10093","article-title":"Developmental expression of monoamine oxidases A and B in the central and peripheral nervous system of the mouse","volume":"442","author":"Vitalis","year":"2002","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.etp.2011.11.003_bib0220","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF01243573","article-title":"Histochemical localisation of monoamine oxidase A and B in rat brain","volume":"74","author":"Willoughby","year":"1988","journal-title":"J Neural Transm"},{"key":"10.1016\/j.etp.2011.11.003_bib0225","first-page":"301","article-title":"Neuroprotective mechanism of modafinil on Parkinson disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"25","author":"Xiao","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.etp.2011.11.003_bib0230","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10072-008-0986-2","article-title":"Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson's disease","volume":"29","author":"Yokoyama","year":"2008","journal-title":"Neurol Sci"}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094029931100162X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094029931100162X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T16:34:37Z","timestamp":1713458077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094029931100162X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S094029931100162X"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2011.11.003","relation":{},"ISSN":["0940-2993"],"issn-type":[{"value":"0940-2993","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}