{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:58:31Z","timestamp":1771808311659,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.etp.2011.11.004","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T03:13:40Z","timestamp":1325042020000},"page":"351-356","source":"Crossref","is-referenced-by-count":5,"title":["Phenotypic characteristics and proliferative activity of hyperplastic ductule cells in cholangiofibrosis induced by thioacetamide in rats"],"prefix":"10.1016","volume":"65","author":[{"given":"Masaki","family":"Hata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Yamanegi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ohyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Nakasho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2011.11.004_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1007082515548","article-title":"Cholangiocarcinoma and liver cirrhosis in relation to changes due to thioacetamide","volume":"208","author":"Al-Bader","year":"2000","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.etp.2011.11.004_bib0010","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/labinvest.3700699","article-title":"The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthease 1","volume":"88","author":"Butler","year":"2008","journal-title":"Lab Invest"},{"key":"10.1016\/j.etp.2011.11.004_bib0015","first-page":"5752","article-title":"Phenotypic characterization of metaplastic intestinal glands and ductular heptocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan","volume":"51","author":"Elmore","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/j.etp.2011.11.004_bib0020","first-page":"1220","article-title":"Sequential appearance of intestinal mucosal cell types in the right and caudate liver lobes of furan-treated rats","volume":"16","author":"Elmore","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2011.11.004_bib0025","first-page":"254","article-title":"\u201cIntestinal-type\u201d of adenocarcinoma preferentially induced in right\/caudate liver lobes of rats treated with furan","volume":"53","author":"Elmore","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.etp.2011.11.004_bib0030","first-page":"142","article-title":"Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylaminofluorene, and 3\u2032-methyl-4-dimethylaminoazobenzene","volume":"16","author":"Farber","year":"1956","journal-title":"Cancer Res"},{"key":"10.1016\/j.etp.2011.11.004_bib0035","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/hep.23880","article-title":"Age dependence of oval cell responses and bile duct carcinomas in male F344 rats fed a cyclic choline-deficient, ethionine-supplemented diet","volume":"52","author":"Guest","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2011.11.004_bib0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1440-1746.2001.02364.x","article-title":"Subcellular redistribution of protein kinase C isozymes is associated with rat liver cirrhotic changes induced by carbon tetrachloride or thioacetamide","volume":"16","author":"Jeong","year":"2001","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.etp.2011.11.004_bib0045","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/01926230590922901","article-title":"Persistence of liver cirrhosis in association with proliferation of nonparenchymal cells and altered location of \u03b1-smooth muscle actin-positive cells","volume":"33","author":"Kang","year":"2005","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.etp.2011.11.004_bib0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-5926-9-9","article-title":"Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation","volume":"9","author":"Limaye","year":"2010","journal-title":"Comp Hepatol"},{"key":"10.1016\/j.etp.2011.11.004_bib0055","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0168-8278(02)00011-9","article-title":"Reproducible production of thioacetamide-induced macronodular cirrhosis in the rat with no mortality","volume":"36","author":"Li","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.etp.2011.11.004_bib0060","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/labinvest.2009.15","article-title":"Expression of stem cell factor and its receptor c-kit during the development of intrahepatic cholangiocarcinoma","volume":"89","author":"Mansuroglu","year":"2009","journal-title":"Lab Invest"},{"key":"10.1016\/j.etp.2011.11.004_bib0065","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/hep.20600","article-title":"Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury","volume":"41","author":"Michalopoulos","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2011.11.004_bib0070","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/hep.20178","article-title":"2-Acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: confocal and electron microscopic studies","volume":"39","author":"Paku","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2011.11.004_bib0075","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/hep.20858","article-title":"Immunohistochemical analysis of cytokeratin 7 expression in resting and proliferating biliary structures of rat liver","volume":"42","author":"Paku","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2011.11.004_bib0080","first-page":"192","article-title":"Progressive microscopic alterations in the livers of rats fed the hepatic carcinogens 3\u2032-methyl-4-dimethylaminoazobenzene and 4\u2032-fluoro-4-dimethylaminoazobenzene","volume":"12","author":"Price","year":"1952","journal-title":"Cancer Res"},{"key":"10.1016\/j.etp.2011.11.004_bib0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0232-1513(84)80063-8","article-title":"Histogenesis of cholangiomas and cholangiocarcinomas in thioacetamide fed rats","volume":"26","author":"Praet","year":"1984","journal-title":"Exp Pathol"},{"key":"10.1016\/j.etp.2011.11.004_bib0090","first-page":"353","article-title":"Reversible and irreversible changes in experimental cirrhosis","volume":"47","author":"Quinn","year":"1965","journal-title":"Am J Pathol"},{"key":"10.1016\/j.etp.2011.11.004_bib0095","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/hep.510290524","article-title":"Overexpression of c-NEU and c-MET during rat liver cholangiocarcinogenesis: a link between biliary intestinal metaplasia and mucin-producing cholangiocarcinoma","volume":"29","author":"Radaeva","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2011.11.004_bib0100","first-page":"129","article-title":"Appearance of ductular hepatocytes in rat liver after bile duct ligation and subsequent zone 3 necrosis by carbon tetrachloride","volume":"140","author":"Sirica","year":"1992","journal-title":"Am J Pathol"},{"key":"10.1016\/j.etp.2011.11.004_bib0105","first-page":"375","article-title":"Ductular Hepatocytes. Evidence for a bile ductular cell origin in furan-treated rats","volume":"145","author":"Sirica","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1016\/j.etp.2011.11.004_bib0110","first-page":"354","article-title":"Intestinal metaplasia as a common option of oval cells in relation to cholangiofibrosis in liver of rats exposed to 2-acetylaminofluorene","volume":"52","author":"Tatematsu","year":"1985","journal-title":"Lab Invest"},{"key":"10.1016\/j.etp.2011.11.004_bib0115","first-page":"249","article-title":"Cholangiofibrosis induced by short-term feeding of 3\u2032-methyl-4-(dimethylamino)azobenzene: an electron microscopic observation","volume":"65","author":"Terao","year":"1974","journal-title":"Gann"},{"key":"10.1016\/j.etp.2011.11.004_bib0120","first-page":"1702","article-title":"Participation of small intraportal stem cells in the restitutive response of the liver to periportal necrosis induced by allyl alcohol","volume":"21","author":"Yavorkovsky","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2011.11.004_bib0125","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/carcin\/bgh037","article-title":"Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma","volume":"25","author":"Yeh","year":"2004","journal-title":"Carcinogenesis"}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299311001631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299311001631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T13:20:45Z","timestamp":1543324845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940299311001631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0940299311001631"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2011.11.004","relation":{},"ISSN":["0940-2993"],"issn-type":[{"value":"0940-2993","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}