{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:06:34Z","timestamp":1769918794139,"version":"3.49.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"2-3","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.etp.2013.12.001","type":"journal-article","created":{"date-parts":[[2013,12,25]],"date-time":"2013-12-25T18:30:22Z","timestamp":1387996222000},"page":"147-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Activity of glycogen synthase and glycogen phosphorylase in normal and cirrhotic rat liver during glycogen synthesis from glucose or fructose"],"prefix":"10.1016","volume":"66","author":[{"given":"Natalia N.","family":"Bezborodkina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Yu.","family":"Chestnova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey V.","family":"Okovity","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris N.","family":"Kudryavtsev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2013.12.001_bib0005","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.2337\/diabetes.52.6.1333","article-title":"Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase","volume":"52","author":"Aiston","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.etp.2013.12.001_bib0010","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"Bechmann","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.etp.2013.12.001_bib0015","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1021\/bi0020372","article-title":"The amino-terminal tail of glycogen phosphorylase is a switch for controlling phosphorylase conformation, activation, and response to ligands","volume":"40","author":"Biorn","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.etp.2013.12.001_bib0020","series-title":"Oxford textbook of clinical hepatology","author":"Bircher","year":"1999"},{"key":"10.1016\/j.etp.2013.12.001_bib0025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and simple method for quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.etp.2013.12.001_bib0030","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00215303","article-title":"Synthesis of glycogen from fructose in the presence of elevated levels of glycogen phosphorylase in rat hepatocytes","volume":"30","author":"Ciudad","year":"1980","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.etp.2013.12.001_bib0035","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/ajcn\/76.5.911","article-title":"Fructose, weight gain, and the insulin resistance syndrome","volume":"76","author":"Elliott","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.etp.2013.12.001_bib0040","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/abbi.1994.1467","article-title":"Liver glycogen synthase, phosphorylase, and the glycogen concentration in rats given a glucose load orally: a 24-hour study","volume":"315","author":"Ercan","year":"1994","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.etp.2013.12.001_bib0045","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(03)00565-9","article-title":"Control of glycogen deposition","volume":"546","author":"Ferrer","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1016\/j.etp.2013.12.001_bib0050","first-page":"E900","article-title":"Kinetic analysis of glycogen sunthase and PDC in cirrhotic rat liver and skeletal muscle","volume":"267","author":"Giardina","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.etp.2013.12.001_bib0055","series-title":"Metabolic basis of inherited disease. Disorders of fructose metabolism","author":"Gitzelmann","year":"1989"},{"key":"10.1016\/j.etp.2013.12.001_bib0060","first-page":"607","article-title":"Cellular and molecular pathobiology, pharmacological intervention and biochemical assessment of liver fibrosis","volume":"vol. 1","author":"Gressner","year":"1999"},{"key":"10.1016\/j.etp.2013.12.001_bib0065","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/(SICI)1099-1492(199910)12:6<395::AID-NBM568>3.0.CO;2-M","article-title":"31P and 1H NMR spectroscopic studies of liver extracts of carbon tetrachloride-treated rats","volume":"12","author":"Harvey","year":"1999","journal-title":"NMR Biomed"},{"key":"10.1016\/j.etp.2013.12.001_bib0070","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/hep.1840090412","article-title":"Vitamin B6 repletion in cirrhosis with oral pyridoxine","volume":"9","author":"Henderson","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2013.12.001_bib0075","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF01799497","article-title":"Mechanisms of blood glucose homeostasis","volume":"13","author":"Hers","year":"1990","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.etp.2013.12.001_bib0080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/BF02256052","article-title":"Oxidative-stress-related changes in the livers of bile-duct-ligated rats","volume":"10","author":"Huang","year":"2003","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.etp.2013.12.001_bib0085","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00491759","article-title":"Histophotometric estimation of volume density of collage as an indication of fibrosis in rat liver","volume":"85","author":"James","year":"1986","journal-title":"Histochemistry"},{"key":"10.1016\/j.etp.2013.12.001_bib0090","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0168-8278(05)80147-3","article-title":"Splanchnic and peripheral glucose metabolism in cirrhosis","volume":"20","author":"Johansson","year":"1994","journal-title":"J Hepatol"},{"key":"10.1016\/j.etp.2013.12.001_bib0095","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4254\/wjh.v3.i5.99","article-title":"Insulin resistance and chronic liver disease","volume":"3","author":"Kawaguchi","year":"2011","journal-title":"World J Hepatol"},{"key":"10.1016\/j.etp.2013.12.001_bib0100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1034\/j.1600-0676.2003.00805.x","article-title":"Reduced hepatic glycogen stores in patients with liver cirrhosis","volume":"23","author":"Kr\u00e4henb\u00fchl","year":"2003","journal-title":"Liver Int"},{"key":"10.1016\/j.etp.2013.12.001_bib0105","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/hep.510240424","article-title":"Progressive decrease in tissue glycogen content in rats with long-term cholestasis","volume":"24","author":"Kr\u00e4henb\u00fchl","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2013.12.001_bib0110","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/hep.1840140638","article-title":"Decreased hepatic glycogen content and accelerated response to starvation in rats with carbon tetrachloride-induced cirrhosis","volume":"14","author":"Kr\u00e4henb\u00fchl","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2013.12.001_bib0115","first-page":"257","article-title":"Carbohydrate metabolism","volume":"vol. 1","author":"Kruszynska","year":"1999"},{"key":"10.1016\/j.etp.2013.12.001_bib0120","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1172\/JCI116263","article-title":"Metabolic handling of orally administrated glucose in cirrhosis","volume":"91","author":"Kruszynska","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.etp.2013.12.001_bib0125","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1017\/S0007114599000835","article-title":"Restoration of the glycogen-forming function of hepatocytes in rats with liver cirrhosis is facilitated by a high-carbohydrate diet","volume":"81","author":"Kudryavtseva","year":"1999","journal-title":"Br J Nutr"},{"key":"10.1016\/j.etp.2013.12.001_bib0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1078\/0940-2993-00155","article-title":"Glycogen-forming function of hepatocytes in cirrhotically altered rat liver after treatment with chorionic gonadotropin","volume":"53","author":"Kudryavtseva","year":"2001","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.etp.2013.12.001_bib0135","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1078\/0940-2993-00270","article-title":"Effects of the 2-ethylthiobenzimidazole hydrobromide (Bemithyl) on carbohydrate metabolism in cirrhotic rat liver","volume":"54","author":"Kudryavtseva","year":"2003","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.etp.2013.12.001_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0040-8166(98)80074-8","article-title":"Glycogen-forming function of hepatocytes in the rat regenerating cirrhotic liver after a partial-hepatectomy","volume":"30","author":"Kudryavtseva","year":"1998","journal-title":"Tissue Cell"},{"key":"10.1016\/j.etp.2013.12.001_bib0145","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1016\/S0021-9258(17)35834-9","article-title":"Active hepatic glycogen synthesis from gluconeogenic precursors despite high tissue levels of fructose 2,6-bisphosphate","volume":"261","author":"Kuwajima","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1016\/j.etp.2013.12.001_bib0150","series-title":"Methods of enzymatic analysis","first-page":"885","article-title":"Catalase","author":"Luck","year":"1971"},{"key":"10.1016\/j.etp.2013.12.001_bib0155","first-page":"E796","article-title":"Liver glycogen turnover in fed and fasted humans","volume":"266","author":"Magnusson","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.etp.2013.12.001_bib0160","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0168-8278(86)80488-3","article-title":"Splanchnic and leg exchange of free fatty acids in patients with liver cirrhosis","volume":"3","author":"Merli","year":"1986","journal-title":"J Hepatol"},{"key":"10.1016\/j.etp.2013.12.001_bib0165","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0167-4889(99)00130-5","article-title":"Regulatory role of glucose-6-phosphatase in the repletion of the liver glycogen during refeeding in fasted rats","volume":"1452","author":"Minassian","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.etp.2013.12.001_bib0170","first-page":"E505","article-title":"Metabolic effects of oral fructose in the liver of fasted rats","volume":"247","author":"Niewoehner","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1016\/j.etp.2013.12.001_bib0175","first-page":"E89","article-title":"Metabolic effects of oral glucose in the liver of fasted rats","volume":"246","author":"Niewoehner","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1016\/j.etp.2013.12.001_bib0180","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.2337\/diab.37.11.1559","article-title":"Relationship of hepatic glucose uptake to intrahepatic glucose concentration in fasted rats after glucose load","volume":"37","author":"Niewoehner","year":"1988","journal-title":"Diabetes"},{"key":"10.1016\/j.etp.2013.12.001_bib0280","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.etp.2013.12.001_bib0185","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0009-9120(88)80019-5","article-title":"Vitamin B6 status in cirrhotic patients in relation to apoenzyme of serum alanine aminotransferase","volume":"21","author":"Ohgi","year":"1988","journal-title":"Clin Biochem"},{"key":"10.1016\/j.etp.2013.12.001_bib0190","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/oxfordjournals.jbchem.a124937","article-title":"Contribution of peroxidation products to oxidative inactivation of rat liver microsomal glucose-6-phosphatase","volume":"118","author":"Ohyashiki","year":"1995","journal-title":"J Biochem"},{"key":"10.1016\/j.etp.2013.12.001_bib0195","series-title":"Histochemistry. Theoretical and applied","author":"Pearce","year":"1962"},{"key":"10.1016\/j.etp.2013.12.001_bib0200","first-page":"E529","article-title":"Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis","volume":"276","author":"Petersen","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.etp.2013.12.001_bib0205","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1096\/fj.04-2753fje","article-title":"The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation","volume":"19","author":"Planaguma","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.etp.2013.12.001_bib0210","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0016-5085(87)90433-1","article-title":"Aminopyrine N-demethilation by rats with liver cirrhosis","volume":"93","author":"Reichen","year":"1987","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etp.2013.12.001_bib0215","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0026-0495(97)90132-3","article-title":"Impaired nonoxidative glucose metabolism in patients with liver cirrhosis: effects of two insulin doses","volume":"46","author":"Riggio","year":"1997","journal-title":"Metabolism"},{"key":"10.1016\/j.etp.2013.12.001_bib0220","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1566524024605761","volume":"2","author":"Roach","year":"2002","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.etp.2013.12.001_bib0225","series-title":"Modern methods in biochemistry","first-page":"64","article-title":"Determination of lipid hydroperoxide with ammonium thiocyanate","author":"Romanova","year":"1977"},{"key":"10.1016\/j.etp.2013.12.001_bib0230","series-title":"Inborn errors of glycogen metabolism","author":"Rosenfeld","year":"1989"},{"key":"10.1016\/j.etp.2013.12.001_bib0235","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0026-0495(99)90265-2","article-title":"Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis","volume":"48","author":"Schneiter","year":"1999","journal-title":"Metabolism"},{"key":"10.1016\/j.etp.2013.12.001_bib0240","first-page":"261","article-title":"Hepatic key carbohydrate metabolizing enzymes in bening liver disease and hepatocellular carcinoma","volume":"99","author":"Shimamura","year":"1987","journal-title":"J Med Assoc Okayama"},{"key":"10.1016\/j.etp.2013.12.001_bib0250","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thyobarbituric acid test","volume":"866","author":"Uchigama","year":"1978","journal-title":"Anal Biochem"},{"key":"10.1016\/j.etp.2013.12.001_bib0255","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1139\/o92-081","article-title":"Particulate glycogen of mammalian liver: specificity in binding phosphorylase and glycogen synthase","volume":"70","author":"Vardanis","year":"1992","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.etp.2013.12.001_bib0260","series-title":"Methods of biochemical research","author":"Vilkova","year":"1982"},{"key":"10.1016\/j.etp.2013.12.001_bib0265","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1083\/jcb.42.1.68","article-title":"Correlated morphometric and biochemical studies on the cell. I. Morphometric model, stereologic methods and normal morphometric data for rat liver","volume":"42","author":"Weibel","year":"1969","journal-title":"J Cell Biol"},{"key":"10.1016\/j.etp.2013.12.001_bib0270","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1111\/j.1872-034X.2011.00868.x","article-title":"Impaired activities of cyclic adenosine monophosphate-responsive element binding protein, protein kinase A and calcium-independent phospholipase A2 are involved in deteriorated regeneration of cirrhotic liver after partial hepatectomy in rats","volume":"41","author":"Zhao","year":"2011","journal-title":"Hepatol Res"},{"key":"10.1016\/j.etp.2013.12.001_bib0275","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s12072-011-9256-0","article-title":"Protective effect of probucol on liver injury induced by carbon tetrachloride in rats","volume":"5","author":"Zhan","year":"2011","journal-title":"Hepatol Int"}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299313001346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299313001346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T09:08:28Z","timestamp":1746090508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940299313001346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":55,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0940299313001346"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2013.12.001","relation":{},"ISSN":["0940-2993"],"issn-type":[{"value":"0940-2993","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activity of glycogen synthase and glycogen phosphorylase in normal and cirrhotic rat liver during glycogen synthesis from glucose or fructose","name":"articletitle","label":"Article Title"},{"value":"Experimental and Toxicologic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etp.2013.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}