{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T18:24:24Z","timestamp":1747160664736,"version":"3.40.5"},"reference-count":14,"publisher":"Elsevier BV","issue":"9-10","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Guangzhou Health Bureau of China","award":["2008-Zdi-07"],"award-info":[{"award-number":["2008-Zdi-07"]}]},{"name":"Guangdong Science and Technology Bureau of China","award":["2009B030801054"],"award-info":[{"award-number":["2009B030801054"]}]},{"name":"Sun Yat-sen University Clinical Research 5010 Program","award":["2007003"],"award-info":[{"award-number":["2007003"]}]},{"name":"Project of Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnosis"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.etp.2014.07.001","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T16:45:10Z","timestamp":1406565910000},"page":"423-428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of long-term impact of immunosuppressants at therapeutic doses on hepatic function and histological changes in unilateral nephrectomized rats"],"prefix":"10.1016","volume":"66","author":[{"given":"Yehui","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaxin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaoyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banglao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuzhou","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-2671","authenticated-orcid":false,"given":"Zhiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2014.07.001_bib0005","doi-asserted-by":"crossref","first-page":"690382","DOI":"10.1155\/2013\/690382","article-title":"Long-term impact of immunosuppressants at therapeutic doses on male reproductive system in unilateral nephrectomized rats: a comparative study","volume":"2013","author":"Chen","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.etp.2014.07.001_bib0010","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/01.TP.0000074310.40484.94","article-title":"Dyslipidemia in renal transplant recipients treated with a sirolimus and cyclosporine-based immunosuppressive regimen: incidence, risk factors, progression, and prognosis","volume":"76","author":"Chueh","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.etp.2014.07.001_bib0015","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1097\/00007890-199904150-00017","article-title":"Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group","volume":"67","author":"Groth","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.etp.2014.07.001_bib0020","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/00007890-199311000-00008","article-title":"Increased susceptibility for CsA-induced hepatotoxicity in kidney graft recipients with chronic viral hepatitis C","volume":"56","author":"Horina","year":"1993","journal-title":"Transplantation"},{"key":"10.1016\/j.etp.2014.07.001_bib0025","first-page":"1195","article-title":"The value of serial serum trough cyclosporine levels in human renal transplantation","volume":"16","author":"Kahan","year":"1984","journal-title":"Transplant Proc"},{"key":"10.1016\/j.etp.2014.07.001_bib0030","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1097\/00007890-200004150-00009","article-title":"Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients","volume":"69","author":"Kreis","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.etp.2014.07.001_bib0035","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2165\/00002018-200528020-00006","article-title":"Benefit-risk assessment of sirolimus in renal transplantation","volume":"28","author":"Kuypers","year":"2005","journal-title":"Drug Saf"},{"key":"10.1016\/j.etp.2014.07.001_bib0040","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00007890-198701000-00009","article-title":"Hepatobiliary and pancreatic complications of cyclosporine therapy in 466 renal transplant recipients","volume":"43","author":"Lorber","year":"1987","journal-title":"Transplantation"},{"key":"10.1016\/j.etp.2014.07.001_bib0045","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.nut.2005.04.002","article-title":"Comparing rat's to human's age: how old is my rat in people years?","volume":"21","author":"Quinn","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.etp.2014.07.001_bib0050","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.proghi.2004.04.001","article-title":"Cyclosporine A and adverse effects on organs: histochemical studies","volume":"39","author":"Rezzani","year":"2004","journal-title":"Prog Histochem Cytochem"},{"key":"10.1016\/j.etp.2014.07.001_bib0055","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0022-5347(17)43479-3","article-title":"Effect of cyclosporine A on male reproduction in rats","volume":"138","author":"Seethalakshmi","year":"1987","journal-title":"J Urol"},{"key":"10.1016\/j.etp.2014.07.001_bib0060","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1097\/01.tp.0000219703.39149.85","article-title":"Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials","volume":"81","author":"Webster","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.etp.2014.07.001_bib0065","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2165\/00002018-199512050-00006","article-title":"A risk-benefit assessment of tacrolimus in transplantation","volume":"12","author":"Winkler","year":"1995","journal-title":"Drug Saf"},{"key":"10.1016\/j.etp.2014.07.001_bib0070","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/S0041-1345(00)01411-1","article-title":"Rescue therapy with tacrolimus in renal graft patients with cyclosporine A-induced hepatotoxicity: a preliminary study","volume":"32","author":"Yuan","year":"2000","journal-title":"Transplant Proc"}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299314000918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299314000918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T04:14:32Z","timestamp":1565669672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940299314000918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":14,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0940299314000918"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2014.07.001","relation":{},"ISSN":["0940-2993"],"issn-type":[{"type":"print","value":"0940-2993"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of long-term impact of immunosuppressants at therapeutic doses on hepatic function and histological changes in unilateral nephrectomized rats","name":"articletitle","label":"Article Title"},{"value":"Experimental and Toxicologic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etp.2014.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier GmbH. Published by Elsevier GmbH All rights reserved.","name":"copyright","label":"Copyright"}]}}