{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:44:15Z","timestamp":1788871455119,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["2238017"],"award-info":[{"award-number":["2238017"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["23658265"],"award-info":[{"award-number":["23658265"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["26292152"],"award-info":[{"award-number":["26292152"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["24780288"],"award-info":[{"award-number":["24780288"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.etp.2014.09.008","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T22:31:43Z","timestamp":1414017103000},"page":"53-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Immunohistochemical characterization of glial fibrillary acidic protein (GFAP)-expressing cells in a rat liver cirrhosis model induced by repeated injections of thioacetamide (TAA)"],"prefix":"10.1016","volume":"67","author":[{"given":"Anusha Hemamali","family":"Tennakoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Izawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavindra Kumara","family":"Wijesundera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisa","family":"Katou-Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossain M.","family":"Golbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Kuwamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoji","family":"Yamate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2014.09.008_bib0005","doi-asserted-by":"crossref","first-page":"G245","DOI":"10.1152\/ajpgi.2000.279.2.G245","article-title":"Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis","volume":"279","author":"Arthur","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.etp.2014.09.008_bib0010","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12072-007-9031-4","article-title":"Thy1-positive bone marrow stem cells express liver-specific genes in vitro and can mature into hepatocytes in vivo","volume":"2","author":"Bae","year":"2008","journal-title":"Hepatol Int"},{"key":"10.1016\/j.etp.2014.09.008_bib0015","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1136\/gut.2003.020263","article-title":"Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications","volume":"53","author":"Benvegn\u00f9","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.etp.2014.09.008_bib0020","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1042\/bj20030557","article-title":"TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP","volume":"374","author":"Bernardo","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.etp.2014.09.008_bib0025","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0167-4838(99)00279-4","article-title":"Tissue inhibitors of metalloproteinases: evolution, structure and function","volume":"1477","author":"Brew","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.etp.2014.09.008_bib0030","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(01)00260-4","article-title":"Hepatic stellate cell\/myofibroblast subpopulations in fibrotic human and rat livers","volume":"36","author":"Cassiman","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.etp.2014.09.008_bib0035","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.exer.2009.02.022","article-title":"Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury","volume":"89","author":"Chaurasia","year":"2009","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.etp.2014.09.008_bib0040","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.transproceed.2008.06.052","article-title":"Hepatic stellate cell activation and hepatic fibrosis induced by ischemia\/reperfusion injury","volume":"40","author":"Cheng","year":"2008","journal-title":"Transplant Proc"},{"key":"10.1016\/j.etp.2014.09.008_bib0045","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1053\/j.gastro.2007.02.033","article-title":"Gene expression profiles during hepatic stellate cell activation in culture and in vivo","volume":"132","author":"De Minicis","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etp.2014.09.008_bib0050","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1097\/01.LAB.0000101911.53973.90","article-title":"Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis","volume":"83","author":"Desmouli\u00e8re","year":"2003","journal-title":"Lab Invest"},{"key":"10.1016\/j.etp.2014.09.008_bib0055","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.2353\/ajpath.2007.070273","article-title":"Thy-1 is expressed in hepatic myofibroblasts and not oval cells in stem cell-mediated liver regeneration","volume":"171","author":"Dezso","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.etp.2014.09.008_bib0060","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.etp.2014.09.008_bib0065","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0165-5728(85)80073-4","article-title":"Extra-neural glial fibrillary acidic protein (GFAP) immunoreactivity in perisinusoidal stellate cells of rat liver","volume":"8","author":"Gard","year":"1985","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.etp.2014.09.008_bib0070","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1126\/science.277.5323.225","article-title":"Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5","volume":"277","author":"Giannelli","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.etp.2014.09.008_bib0075","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1055\/s-2007-991517","article-title":"Hepatic fibrogenesis","volume":"27","author":"Guo","year":"2007","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.etp.2014.09.008_bib0080","first-page":"135","article-title":"Hepatic fibrosis and cirrhosis: the (myo)fibroblastic cell subpopulations involved","volume":"38","author":"Guyot","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.etp.2014.09.008_bib0085","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/CS20060242","article-title":"Liver fibrosis: cellular mechanisms of progression and resolution","volume":"112","author":"Henderson","year":"2007","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.etp.2014.09.008_bib0090","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.etp.2014.09.008_bib0095","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jhep.2006.04.014","article-title":"Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis","volume":"45","author":"Kisseleva","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.etp.2014.09.008_bib0100","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0016-5085(99)70407-5","article-title":"Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential","volume":"117","author":"Knittel","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etp.2014.09.008_bib0105","first-page":"193","article-title":"GFAP expression in the liver as an early marker of stellate cells activation","volume":"110","author":"Morini","year":"2005","journal-title":"Ital J Anat Embryol"},{"key":"10.1016\/j.etp.2014.09.008_bib0110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0232-1513(88)80155-5","article-title":"Thioacetamide-induced cirrhosis-like liver lesions in rats\u2014usefulness and reliability of this animal model","volume":"34","author":"M\u00fcller","year":"1988","journal-title":"Exp Pathol"},{"key":"10.1016\/j.etp.2014.09.008_bib0115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/hep.1840140211","article-title":"Immunohistochemical detection of transforming growth factor-beta 1 in fibrotic liver diseases","volume":"14","author":"Nagy","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2014.09.008_bib0120","doi-asserted-by":"crossref","first-page":"430138","DOI":"10.1155\/2012\/430138","article-title":"Nestin protein is phosphorylated in adult neural stem\/progenitor cells and not endothelial progenitor cells","volume":"2012","author":"Namiki","year":"2012","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.etp.2014.09.008_bib0125","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/hep.510290232","article-title":"Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells","volume":"29","author":"Niki","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2014.09.008_bib0130","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/hep.510240220","article-title":"Population of hepatic macrophages and response of perfused liver to platelet-activating factor during production of thioacetamide-induced cirrhosis in rats","volume":"24","author":"Noda","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2014.09.008_bib0135","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/hep.1840150621","article-title":"Changes of hepatic fatty acid metabolism produced by chronic thioacetamide administration in rats","volume":"15","author":"Nozu","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2014.09.008_bib0140","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1023\/A:1003851821487","article-title":"Expression of TNF-alpha and immunohistochemical distribution of hepatic macrophage surface markers in carbon tetrachloride-induced chronic liver injury in rats","volume":"31","author":"Orfila","year":"1999","journal-title":"Histochem J"},{"key":"10.1016\/j.etp.2014.09.008_bib0145","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/hep.20425","article-title":"Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats","volume":"40","author":"Parsons","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2014.09.008_bib0150","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.etp.2014.09.008_bib0155","doi-asserted-by":"crossref","first-page":"C485","DOI":"10.1152\/ajpcell.1991.260.3.C485","article-title":"Mitogenic signals for platelet-derived growth factor isoforms in liver fat-storing cells","volume":"260","author":"Pinzani","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1016\/j.etp.2014.09.008_bib0160","first-page":"785","article-title":"Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis","volume":"148","author":"Pinzani","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.etp.2014.09.008_bib0165","doi-asserted-by":"crossref","first-page":"d808","DOI":"10.2741\/reeves","article-title":"Activation of hepatic stellate cells\u2014a key issue in liver fibrosis","volume":"7","author":"Reeves","year":"2002","journal-title":"Front Biosci"},{"key":"10.1016\/j.etp.2014.09.008_bib0170","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1096\/fj.05-5460rev","article-title":"Thy-1 as a regulator of cell\u2013cell and cell\u2013matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis","volume":"20","author":"Rege","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.etp.2014.09.008_bib0175","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1053\/j.gastro.2006.01.036","article-title":"The bone marrow functionally contributes to liver fibrosis","volume":"130","author":"Russo","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.etp.2014.09.008_bib0180","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/labinvest.2008.91","article-title":"Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice","volume":"88","author":"Salguero Palacios","year":"2008","journal-title":"Lab Invest"},{"key":"10.1016\/j.etp.2014.09.008_bib0185","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/labinvest.3700349","article-title":"Role for hedgehog signaling in hepatic stellate cell activation and viability","volume":"85","author":"Sicklick","year":"2005","journal-title":"Lab Invest"},{"key":"10.1016\/j.etp.2014.09.008_bib0190","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2131\/jts.27.165","article-title":"Combination of fixation using PLP fixative and embedding in paraffin by the AMeX method is useful for histochemical studies in assessment of immunotoxicity","volume":"27","author":"Suzuki","year":"2002","journal-title":"J Toxicol Sci"},{"key":"10.1016\/j.etp.2014.09.008_bib0195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/jhep.2002.30083","article-title":"Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injury","volume":"35","author":"Tahashi","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.etp.2014.09.008_bib0200","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.etp.2013.05.008","article-title":"Characterization of glial fibrillary acidic protein (GFAP)-expressing hepatic stellate cells and myofibroblasts in thioacetamide (TAA)-induced rat liver injury","volume":"65","author":"Tennakoon","year":"2013","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.etp.2014.09.008_bib0205","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1513\/pats.200601-004TK","article-title":"Epithelial origin of myofibroblasts during fibrosis in the lung","volume":"3","author":"Willis","year":"2006","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.etp.2014.09.008_bib0210","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.etp.2014.09.008_bib0215","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.etp.2014.09.008_bib0220","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/j.ejca.2007.10.021","article-title":"Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells","volume":"43","author":"Yamate","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.etp.2014.09.008_bib0225","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.etp.2012.07.005","article-title":"Thy-1 expression, a possible marker of early myofibroblast development, in renal tubulointerstitial fibrosis induced in rats by cisplatin","volume":"65","author":"Yuasa","year":"2013","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.etp.2014.09.008_bib0230","doi-asserted-by":"crossref","first-page":"23337","DOI":"10.1074\/jbc.M700194200","article-title":"Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition","volume":"282","author":"Zeisberg","year":"2007","journal-title":"J Biol Chem"}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299314001225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299314001225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T10:41:38Z","timestamp":1565952098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940299314001225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0940299314001225"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2014.09.008","relation":{},"ISSN":["0940-2993"],"issn-type":[{"value":"0940-2993","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunohistochemical characterization of glial fibrillary acidic protein (GFAP)-expressing cells in a rat liver cirrhosis model induced by repeated injections of thioacetamide (TAA)","name":"articletitle","label":"Article Title"},{"value":"Experimental and Toxicologic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etp.2014.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}