{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:23:42Z","timestamp":1761513822468,"version":"3.40.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.etp.2016.05.005","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T20:41:29Z","timestamp":1464122489000},"page":"371-379","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["N -methyl- N -nitrosourea-induced schwannomas in male Sprague-Dawley rats with a literature review of inducible and spontaneous lesions"],"prefix":"10.1016","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-6201","authenticated-orcid":false,"given":"Katsuhiko","family":"Yoshizawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Yuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Emoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A.","family":"Elmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Airo","family":"Tsubura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2016.05.005_bib0005","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1177\/030098588702400603","article-title":"Morphology and classification of 96 primary cardiac neoplasms in Fischer 344 rats","volume":"24","author":"Alison","year":"1987","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0010","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1365-2990.1997.tb01312.x","article-title":"Human neoplastic Schwann cells: changes in the expression of neurotrophins and their low-affinity receptor p75","volume":"23","author":"Bonetti","year":"1997","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.etp.2016.05.005_bib0015","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/1097-0142(19900501)63:9<1737::AID-CNCR2820630914>3.0.CO;2-0","article-title":"Experimental model of tumors associated with neurofibromatosis","volume":"63","author":"Cardesa","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.etp.2016.05.005_bib0020","series-title":"Pathology of Tumours in Laboratory Animals, Vol. 1 \u2013 Tumours of the Rat","first-page":"699","article-title":"Tumours of the peripheral nervous system","author":"Cardesa","year":"1990"},{"key":"10.1016\/j.etp.2016.05.005_bib0025","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00401-011-0928-6","article-title":"Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms","volume":"123","author":"Carroll","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0030","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1158\/0008-5472.CAN-05-3780","article-title":"The interaction mode of premalignant schwannoma and immune effector cells during chemically induced carcinogenesis in the rat peripheral nervous system is strongly influenced by genetic background","volume":"66","author":"Gering","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.etp.2016.05.005_bib0035","first-page":"134","article-title":"Malignant peripheral nerve sheath tumors and spindle cell sarcomas: an immunohistochemical analysis of multiple markers","volume":"7","author":"Giangaspero","year":"1989","journal-title":"Appl. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0040","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1101\/gad.13.8.978","article-title":"Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring muntant NF2 protein","volume":"13","author":"Giovannini","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.etp.2016.05.005_bib0045","unstructured":"goRENI, INHAND draft paper of cardiovascular system. http:\/\/www.goreni.org\/ (January 2016)."},{"key":"10.1016\/j.etp.2016.05.005_bib0050","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/cr941192h","article-title":"A critical appraisal of the evolution of N-nitrosourea as anticancer drugs","volume":"97","author":"Gnewuch","year":"1997","journal-title":"Chem. Rev."},{"key":"10.1016\/j.etp.2016.05.005_bib0055","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/sj.neo.7900249","article-title":"Mouse models of neurofibromatosis 1 and 2","volume":"4","author":"Gutmann","year":"2002","journal-title":"Neoplasia"},{"key":"10.1016\/j.etp.2016.05.005_bib0060","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00305022","article-title":"Induction of heart tumors in Wistar rats after a single application of ethylmethansulphonate and dimethylnitrosamine","volume":"81","author":"Haas","year":"1974","journal-title":"Z. Krebsforsch."},{"key":"10.1016\/j.etp.2016.05.005_bib0065","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s00415-006-0347-0","article-title":"News on the genetics, epidemiology, medical care and translational research of Schwannomas","volume":"253","author":"Hanemann","year":"2006","journal-title":"J. Neurol."},{"key":"10.1016\/j.etp.2016.05.005_bib0070","first-page":"127","article-title":"Comparative pathology of cardiac neoplasms in humans and in laboratory rodents; a review","volume":"76","author":"Hoch-Ligeti","year":"1986","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.etp.2016.05.005_bib0075","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/BF00191444","article-title":"Frequent expression of 75kDa nerve growth factor receptor and phosphotyrosine in human peripheral nerve tumours: and immunohistochemical study on paraffin-embedded tissues","volume":"424","author":"Hoshi","year":"1994","journal-title":"Virchows Arch."},{"key":"10.1016\/j.etp.2016.05.005_bib0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1293\/tox.8.311","article-title":"A case of spontaneous cardiac malignant schwannoma in rat (F344\/DuCrj)","volume":"8","author":"Idogawa","year":"1995","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0085","doi-asserted-by":"crossref","first-page":"87S","DOI":"10.1177\/0192623312439125","article-title":"Proliferative and nonproliferative lesions of the rat and mouse central and peripheral nervous systems","volume":"40","author":"Kaufmann","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1293\/tox.2015-0057","article-title":"A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat","volume":"29","author":"Kinoshita","year":"2016","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0095","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ajmg.a.33189","article-title":"What\u2019s new in neurofibromatosis? Proceedings from the 2009 NF conference: new frontiers","volume":"152A","author":"Kissil","year":"2010","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.etp.2016.05.005_bib0100","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/NEN.0b013e31828ea4ac","article-title":"Chemically induced rat Schwann cell neoplasia as a model for early-stage human peripheral nerve sheath tumors: phenotypic characteristics and dysregulated gene expression","volume":"72","author":"Koelsch","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.etp.2016.05.005_bib0105","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/019262339001800124","article-title":"Characterization of N-nitrosourea-induced tumors of the nervous system; their prospective value for studies of neurocarcinogenesis and brain tumor therapy","volume":"18","author":"Koestner","year":"1990","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.pas.0000146044.90901.4c","article-title":"Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases","volume":"29","author":"Laskin","year":"2005","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0115","first-page":"M73","article-title":"Mouse models of neurofibromatosis","volume":"1471","author":"McClatchey","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.etp.2016.05.005_bib0120","series-title":"Pathology of the Fischer Rat","first-page":"179","article-title":"Spinal cord and peripheral nerves","author":"Mitsumori","year":"1990"},{"key":"10.1016\/j.etp.2016.05.005_bib0125","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1293\/tox.2015-0012","article-title":"A spontaneously occurring malignant pituicytoma in a male Sprague Dawley rat","volume":"28","author":"Moroki","year":"2015","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0130","unstructured":"National Toxicology Program (NTP). NTP technical report on the toxicology and carcinogenesis studies of acrylamide (CAS No. 79-06-1) in F344\/N rats and B6C3F1 mice (feed and drinking water study). NTP 2012:TR575:1-234. http:\/\/ntp.niehs.nih.gov\/ntp\/htdocs\/lt_rpts\/tr575_508.pdf (accessed January, 2016.)."},{"key":"10.1016\/j.etp.2016.05.005_bib0135","unstructured":"National Toxicology Program (NTP). NTP Historical Controls for NTP-2000 Diet. http:\/\/ntp\/niehs.nih.gov\/go\/763602 (accessed January, 2016.)."},{"key":"10.1016\/j.etp.2016.05.005_bib0140","first-page":"241","article-title":"genetics of susceptibility of rats to trigeminal schannomas induced by neonatal administration of N-ethyl-N-nitrosourea","volume":"74","author":"Naito","year":"1985","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.etp.2016.05.005_bib0145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/030098589102800208","article-title":"A retrospective survey of endocardial proliferative lesions in rats","volume":"28","author":"Novilla","year":"1991","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3835(93)90073-I","article-title":"Wechsler W. neu mutation and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats","volume":"70","author":"Ohgaki","year":"1993","journal-title":"Cancer Lett."},{"key":"10.1016\/j.etp.2016.05.005_bib0155","series-title":"Histology for Pathologists","first-page":"264","article-title":"Tumors of the peripheral nervous system","author":"Ortiz-Hidalgo","year":"2007"},{"key":"10.1016\/j.etp.2016.05.005_bib0160","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/019262339001800103","article-title":"Immunohistochemical characterization of rat central and peripheral nerve tumors induced by ethylnitrosourea","volume":"18","author":"Raju","year":"1990","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0165","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00401-012-0954-z","article-title":"Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems","volume":"123","author":"Rodriguez","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0170","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00000372-199802000-00018","article-title":"Neoplasms with neural differentiation: a review: part II: malignant neoplasms","volume":"20","author":"Sangueza","year":"1998","journal-title":"Am. J. Dermatopathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0175","first-page":"31","article-title":"Induction of heart tumors in rats using methylnitrosourea","volume":"115","author":"Schreiber","year":"1972","journal-title":"Zentralbl. Allg. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0180","first-page":"48","article-title":"The spectrum of extra neural tumors in rats following N-methyl-N-nitrosourea treatment","volume":"115","author":"Schreiber","year":"1972","journal-title":"Zentralbl. Allg. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0185","first-page":"282","article-title":"N-methyl nitrosourea induced endocardial schwannomas in rats \u2013 light and electron microscopic study","volume":"22","author":"Shankar","year":"1985","journal-title":"Ind. J. Cancer"},{"key":"10.1016\/j.etp.2016.05.005_bib0190","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1158\/0008-5472.CAN-03-4079","article-title":"Comparative pathology of nerve sheath tumors in mouse models and humans","volume":"64","author":"Stemmer-Rachamimov","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.etp.2016.05.005_bib0195","series-title":"World Cancer Report","first-page":"511","article-title":"Tumors of the nervous system","author":"Stewart","year":"2014"},{"key":"10.1016\/j.etp.2016.05.005_bib0200","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.etp.2013.11.003","article-title":"A liver schwannoma observed in a female Sprague-Dawley rat treated with MNU","volume":"66","author":"Teixeira-Guedes","year":"2014","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0205","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1439-0442.2005.00750.x","article-title":"Endocardial schwannomas in the Wistar rat","volume":"52","author":"Teredesai","year":"2005","journal-title":"J. Vet. Med. A"},{"key":"10.1016\/j.etp.2016.05.005_bib0210","first-page":"321","article-title":"Methylnitrosourea","volume":"Vol. 3","author":"Tsubura","year":"2014"},{"key":"10.1016\/j.etp.2016.05.005_bib0215","first-page":"3","article-title":"Von Recklinghausen\u2019s disease: experimental models and comparative aspects","volume":"58","author":"Turusov","year":"1996","journal-title":"Arkh. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0220","series-title":"Monographs on Pathology of Laboratory Animals Sponsored by the International Life Sciences Institute","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-3-642-83516-2_25","article-title":"Peripheral nerve sheath tumors, rat","author":"Walker","year":"1988"},{"key":"10.1016\/j.etp.2016.05.005_bib0225","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1177\/030098589102800601","article-title":"Intraocular and orbital malignant schwannoma in F344 rats","volume":"28","author":"Yoshitomi","year":"1991","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0230","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1293\/tox.9.107","article-title":"Malignant schwannoma of the intracranial trigeminal nerve in a 19-week old female Sprague-Dawley rat","volume":"9","author":"Yoshizawa","year":"1996","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0235","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1293\/tox.26.61","article-title":"Histopathological and immunohistochemical characterization of spontaneously occurring uterine deciduomas in young adult rats","volume":"26","author":"Yoshizawa","year":"2013","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.etp.2016.05.005_bib0240","series-title":"Recent Advances in Eye Research","first-page":"53","article-title":"N-Methyl-N-nitrosourea-induced retinal degeneration in rats: a reliable animal model of retinitis pigmentosa for the development of new therapeutic strategies","author":"Yoshizawa","year":"2015"},{"key":"10.1016\/j.etp.2016.05.005_bib0245","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0955-0674(96)80090-1","article-title":"Schwann cell differentiation","volume":"8","author":"Zorick","year":"1996","journal-title":"Curr. Opin. Cell Biol."}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299316300550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299316300550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:03:36Z","timestamp":1567958616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940299316300550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0940299316300550"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2016.05.005","relation":{},"ISSN":["0940-2993"],"issn-type":[{"type":"print","value":"0940-2993"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-methyl-N-nitrosourea-induced schwannomas in male Sprague-Dawley rats with a literature review of inducible and spontaneous lesions","name":"articletitle","label":"Article Title"},{"value":"Experimental and Toxicologic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etp.2016.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}