{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:49:48Z","timestamp":1786988988413,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"crossref","award":["2014YSN24"],"award-info":[{"award-number":["2014YSN24"]}],"id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81574078"],"award-info":[{"award-number":["81574078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81072646"],"award-info":[{"award-number":["81072646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.etp.2017.01.003","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T18:30:17Z","timestamp":1485196217000},"page":"193-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Hepatotoxicity induced by radix Sophorae tonkinensis in mice and increased serum cholinesterase as a potential supplemental biomarker for liver injury"],"prefix":"10.1016","volume":"69","author":[{"given":"Liping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingmin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaochao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruomin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zean","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.etp.2017.01.003_bib0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.33549\/physiolres.933028","article-title":"Betaine increases the butyrylcholinesterase activity in rat plasma","volume":"65","author":"\u0160i\u0161kov\u00e1","year":"2016","journal-title":"Physiol. Res."},{"key":"10.1016\/j.etp.2017.01.003_bib0010","series-title":"Guide for Acute Toxicity of Chinese Traditional Medicine and Natural Medicine (in Chinese)","author":"Anon","year":"2005"},{"key":"10.1016\/j.etp.2017.01.003_bib0015","series-title":"Guide for Long-term Toxicity of Chinese Traditional Medicine and Natural Medicine (in Chinese)","author":"Anon","year":"2005"},{"key":"10.1016\/j.etp.2017.01.003_bib0020","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj2600625","article-title":"Comparison of butyrylcholinesterase and acetylcholinesterase","volume":"260","author":"Chatonnet","year":"1989","journal-title":"Biochem. J."},{"issue":"18","key":"10.1016\/j.etp.2017.01.003_bib0025","first-page":"293","article-title":"Rat subacute hepatotoxicity induced by Sophorae tonkinensis Radix et Rhizoma (in Chinese)","volume":"19","author":"Chen","year":"2013","journal-title":"Chin. J. Exp. Trad. Med. Formulae"},{"key":"10.1016\/j.etp.2017.01.003_bib0030","first-page":"25","volume":"vol. 1","author":"Commission","year":"2010"},{"issue":"3","key":"10.1016\/j.etp.2017.01.003_bib0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1179\/016164110X12759951866876","article-title":"Neuroprotection and underlying mechanisms of oxymatrine in cerebral ischemia of rats","volume":"33","author":"Cui","year":"2013","journal-title":"Neurol. Res."},{"key":"10.1016\/j.etp.2017.01.003_bib0040","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-015-4916-6","article-title":"Blood cholinesterase activity levels of farmers in winter and hot season of Mae Taeng District, Chiang Mai Province, Thailand","author":"Hongsibsong","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.etp.2017.01.003_bib0045","first-page":"111","article-title":"Globus pallidus lesion and generalized torsion dystonia due to Shandougen poisoning in two patients (in Chinese)","volume":"2","author":"Huang","year":"2009","journal-title":"Adv. Drug React. J."},{"issue":"3","key":"10.1016\/j.etp.2017.01.003_bib0050","first-page":"157","article-title":"The inhibitory effects of oxymartrine on central nervous system in mice (in Chinese)","volume":"22","author":"Jiang","year":"2000","journal-title":"J. Ningxia Med. College"},{"issue":"5","key":"10.1016\/j.etp.2017.01.003_bib0055","first-page":"413","article-title":"Effects of synthetic(\u2212)-huperzine A on cholinesterase activities and mouse water maze performance","volume":"19","author":"Jing","year":"1998","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.etp.2017.01.003_bib0060","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.yrtph.2015.05.003","article-title":"Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice","volume":"72","author":"Kandhare","year":"2015","journal-title":"Regul. Toxicol. Pharmacol.: RTP"},{"issue":"2","key":"10.1016\/j.etp.2017.01.003_bib0065","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1177\/0300060513517485","article-title":"Fatty liver and serum cholinesterase are independently correlated with HbA1c levels: cross-sectional analysis of 5384 people","volume":"42","author":"Katoh","year":"2014","journal-title":"J. Int. Med. Res."},{"issue":"1","key":"10.1016\/j.etp.2017.01.003_bib0070","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0254-6272(16)30009-7","article-title":"Effect of modified fasting therapy on body weight, fat and muscle mass, and blood chemistry in patients with obesity","volume":"36","author":"Kim","year":"2016","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.etp.2017.01.003_bib0075","series-title":"Casarett & Doull\u2019s Toxicology-The Basic Science of Poisons","first-page":"153","author":"Klaassen","year":"2013"},{"issue":"13","key":"10.1016\/j.etp.2017.01.003_bib0080","first-page":"1821","article-title":"Mechanism studies on hepatotoxicity of rats induced by Sophorae Tonkinensis Radix et Rhizoma in rat (in Chinese)","volume":"36","author":"Li","year":"2011","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.etp.2017.01.003_bib0085","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuro.2012.09.009","article-title":"Cytisine confers neuronal protection against excitotoxic injury by down-regulating GluN2B-containing NMDA receptors","volume":"34","author":"Li","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.etp.2017.01.003_bib0090","first-page":"55","article-title":"Simultaneous determination of contents of matrine and oxymatrine in sophora tonkinensis gagnep. by HPLC (in Chinese)","volume":"1","author":"Li","year":"2014","journal-title":"Pharm. J. Chin. People\u2019s Liberation Army"},{"key":"10.1016\/j.etp.2017.01.003_bib0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.reprotox.2014.05.015","article-title":"Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos\/larvae","volume":"47","author":"Lu","year":"2014","journal-title":"Reprod. Toxicol."},{"issue":"18","key":"10.1016\/j.etp.2017.01.003_bib0100","first-page":"170","article-title":"Influence of hepatic injury caused by Sophorae tonkinensis Radix et Rhizoma on cytochrome P450 enzymes in rats (in Chinese)","volume":"20","author":"Qiao","year":"2014","journal-title":"Chin. J. Exp. Trad. Med. Formulae"},{"issue":"3","key":"10.1016\/j.etp.2017.01.003_bib0105","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s00244-009-9403-y","article-title":"Toxic effect and biochemical study of chlorfluazuron, oxymatrine, and spinosad on honey bees (Apis mellifera)","volume":"58","author":"Rabea","year":"2010","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"1","key":"10.1016\/j.etp.2017.01.003_bib0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.7869\/tg.158","article-title":"Serum cholinesterase is an excellent biomarker of liver cirrhosis","volume":"35","author":"Ramachandran","year":"2014","journal-title":"Trop. Gastroenterol."},{"issue":"3","key":"10.1016\/j.etp.2017.01.003_bib0115","first-page":"385","article-title":"Study on early change features of microRNA in the peripheral blood of Sophorae tonkinensis radix et rhizoma induced liver injury rats (in Chinese)","volume":"33","author":"Sheng","year":"2013","journal-title":"Chin. J. Integr. Tradit. Western Med."},{"issue":"1","key":"10.1016\/j.etp.2017.01.003_bib0120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2478\/v10102-010-0004-4","article-title":"Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats","volume":"3","author":"Simeonova","year":"2010","journal-title":"Interdiscip. Toxicol."},{"key":"10.1016\/j.etp.2017.01.003_bib0125","first-page":"1","article-title":"Synthesis of some tetrahydropyrimidine-5-carboxylates, determination of their metal chelating effects and inhibition profiles against acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase","author":"Sujayev","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.etp.2017.01.003_bib0130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jpba.2013.05.003","article-title":"Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS\/MS method","volume":"83","author":"Tang","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.etp.2017.01.003_bib0135","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5214\/ans.0972.7531.2008.150403","article-title":"Acetylcholinesterase:a versatile enzyme of nervous system","volume":"15","author":"Tripathi","year":"2008","journal-title":"Ann. Neurosci."},{"issue":"3","key":"10.1016\/j.etp.2017.01.003_bib0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000073056","article-title":"Movement disorders possibly induced by traditional Chinese herbs","volume":"50","author":"Wang","year":"2003","journal-title":"Eur. Neurol."},{"issue":"8","key":"10.1016\/j.etp.2017.01.003_bib0145","first-page":"2036","article-title":"An experience of cure of a cluster of acute subprosttrate sophora root toxication (Reports of 56 cases) (in Chinese)","volume":"24","author":"Wang","year":"2009","journal-title":"West China Med. J."},{"issue":"1","key":"10.1016\/j.etp.2017.01.003_bib0150","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jep.2012.08.028","article-title":"Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract of Fructus Psoraleae","volume":"144","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.etp.2017.01.003_bib0155","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jep.2015.11.005","article-title":"Evaluation of kudzu root extract-induced hepatotoxicity","volume":"176","author":"Wang","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.etp.2017.01.003_bib0160","first-page":"912","article-title":"Analysis of chemical constituents of effective part of anti-butyrylcholinesterase of sophora tonkinensis by UPLC-Q-TOF-MS (in Chinese)","volume":"17","author":"Wang","year":"2015","journal-title":"Mod. Chin. Med."},{"issue":"9","key":"10.1016\/j.etp.2017.01.003_bib0165","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1172\/JCI102667","article-title":"Plasma cholinesterase activity in liver disease: its valuve as a diagnostic test of liver function compared with flocculation tests and plasma protein determinations","volume":"31","author":"Wilson","year":"1952","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.etp.2017.01.003_bib0170","doi-asserted-by":"crossref","first-page":"e1611","DOI":"10.7717\/peerj.1611","article-title":"Chronic unpredicted mild stress-induced depression alter saxagliptin pharmacokinetics and CYP450 activity in GK rats","volume":"4","author":"Xia","year":"2016","journal-title":"Peer J."},{"issue":"2","key":"10.1016\/j.etp.2017.01.003_bib0175","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pharep.2014.10.016","article-title":"Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2\/STAT3 signaling","volume":"67","author":"Yang","year":"2015","journal-title":"Pharmacol. Rep.: PR"},{"issue":"11","key":"10.1016\/j.etp.2017.01.003_bib0180","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1007\/s005350200154","article-title":"Accurate prediction of fulminant hepatic failure in severe acute viral hepatitis: multicenter study","volume":"37","author":"Yoshiba","year":"2002","journal-title":"J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.etp.2017.01.003_bib0185","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S1995-7645(14)60062-6","article-title":"Effect of matrine on transforming growth factor \u03b21 and hepatocyte growth factor in rat liver fibrosis model","volume":"7","author":"Yu","year":"2014","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"14","key":"10.1016\/j.etp.2017.01.003_bib0190","first-page":"31","article-title":"Simultaneous determination of matrine and oxymatrine in sophora tonkinesis gapnep. by HPLC (in chinese)","volume":"17","author":"Yuan","year":"2008","journal-title":"China Pharm."},{"issue":"5","key":"10.1016\/j.etp.2017.01.003_bib0195","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ejps.2011.09.020","article-title":"Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice","volume":"44","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.etp.2017.01.003_bib0200","first-page":"1222","article-title":"Study on the hepatotoxicity induced by matrine and oxymatrine (in chinese)","volume":"29","author":"Zhang","year":"2011","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"10.1016\/j.etp.2017.01.003_bib0205","series-title":"The Toxicology Foundation","first-page":"82","author":"Zhou","year":"2000"},{"key":"10.1016\/j.etp.2017.01.003_bib0210","doi-asserted-by":"crossref","first-page":"905715","DOI":"10.1155\/2013\/905715","article-title":"The effects of high-dose qinggan huoxue recipe on acute liver failure induced by d-galactosamine in rats","volume":"2013","author":"Zhu","year":"2013","journal-title":"Evid.-Based Complementary Altern. Med.: eCAM"},{"key":"10.1016\/j.etp.2017.01.003_bib0215","doi-asserted-by":"crossref","first-page":"880","DOI":"10.12659\/MSM.895552","article-title":"Protective role of grape seed proanthocyanidins against ccl4 induced acute liver injury in mice","volume":"22","author":"Zou","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.etp.2017.01.003_bib0220","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.talanta.2015.04.056","article-title":"HPLC-UV method validation for the identification and quantification of bioactive amines in commercial eggs","volume":"142","author":"de Figueiredo","year":"2015","journal-title":"Talanta"}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299317300246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299317300246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T02:46:35Z","timestamp":1601433995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940299317300246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0940299317300246"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2017.01.003","relation":{},"ISSN":["0940-2993"],"issn-type":[{"value":"0940-2993","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatotoxicity induced by radix Sophorae tonkinensis in mice and increased serum cholinesterase as a potential supplemental biomarker for liver injury","name":"articletitle","label":"Article Title"},{"value":"Experimental and Toxicologic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etp.2017.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}