{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:19:07Z","timestamp":1761844747712},"reference-count":31,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental and Toxicologic Pathology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.etp.2017.03.007","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T20:46:20Z","timestamp":1491425180000},"page":"413-423","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of pancreatic islet cell tumors and renal tumors induced by a combined treatment of streptozotocin and nicotinamide in male SD rats"],"prefix":"10.1016","volume":"69","author":[{"given":"Yuki","family":"Kato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Masuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kae","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikinori","family":"Torii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Hishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Izawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Kuwamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoji","family":"Yamate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.etp.2017.03.007_bib0005","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1093\/carcin\/13.12.2329","article-title":"Sequential changes in glycogen content, expression of glucose transporters and enzymic patterns during development of clear\/acidophilic cell tumors in rat kidney","volume":"13","author":"Ahn","year":"1992","journal-title":"Carcinogenesis"},{"issue":"10","key":"10.1016\/j.etp.2017.03.007_bib0010","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/carcin\/5.10.1235","article-title":"Streptozotocin-induced liver tumors in the Syrian hamster","volume":"5","author":"Bell","year":"1984","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.etp.2017.03.007_bib0015","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/019262339302100409","article-title":"A quantitative cytochemical study on the pathogenesis of streptozotocin-induced epithelial tumors in rat kidney","volume":"21","author":"Chieco","year":"1993","journal-title":"Toxicol. Pathol."},{"issue":"2","key":"10.1016\/j.etp.2017.03.007_bib0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF01008039","article-title":"Ultrastructure of streptozotocin-induced renal tumours in mice","volume":"430","author":"Delahunt","year":"1997","journal-title":"Virchows Arch."},{"issue":"Suppl. (4)","key":"10.1016\/j.etp.2017.03.007_bib0025","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.1177\/0192623312438736","article-title":"Proliferative and nonproliferative lesions of the rat and mouse urinary system","volume":"40","author":"Frazier","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.etp.2017.03.007_bib0030","unstructured":"Giknis, M.L.A., Clifford, C.B., 2013. Compilation of Spontaneous Neoplastic Lesions and Survival in Crl:CD (SD) Rats From Control Groups."},{"key":"10.1016\/j.etp.2017.03.007_bib0035","series-title":"9. Liver and Pancreas, Histopathology of Preclinical Toxicity Studie","first-page":"501","author":"Greaves","year":"2012"},{"issue":"1","key":"10.1016\/j.etp.2017.03.007_bib0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jso.10142","article-title":"Review of the clinical, histological, and molecular aspects of pancreatic endocrine neoplasms","volume":"81","author":"Gumbs","year":"2002","journal-title":"J. Surg. Oncol."},{"issue":"2","key":"10.1016\/j.etp.2017.03.007_bib0045","first-page":"703","article-title":"Identification of a high-frequency model for renal carcinoma by the induction of renal tumors in the mouse with a single dose of streptozotocin","volume":"45","author":"Hard","year":"1985","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.etp.2017.03.007_bib0050","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00428976","article-title":"Autoradiographic study of the distribution and cellular uptake of (14C) \u2013 streptozotocin in the rat","volume":"12","author":"Karunanayake","year":"1976","journal-title":"Diabetologia"},{"issue":"2\u20133","key":"10.1016\/j.etp.2017.03.007_bib0055","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jcpa.2012.06.009","article-title":"The class A macrophage scavenger receptor CD204 is a useful immunohistochemical marker of canine histiocytic sarcoma","volume":"148","author":"Kato","year":"2013","journal-title":"J. Comp. Pathol."},{"issue":"7","key":"10.1016\/j.etp.2017.03.007_bib0060","first-page":"2144","article-title":"Tumorigenic action of streptozotocin on the pancreas and kidney in male Wistar rats","volume":"38","author":"Kazumi","year":"1978","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.etp.2017.03.007_bib0065","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1507\/endocrj1954.27.387","article-title":"Pancreatic islet cell tumors found in rats given alloxan and nicotinamide","volume":"27","author":"Kazumi","year":"1980","journal-title":"Endocrinol. Jpn."},{"key":"10.1016\/j.etp.2017.03.007_bib0070","series-title":"WHO Classification of Tumours of the Digestive System","article-title":"Neuroendocrine neoplasms of the pancreas","author":"Klimstra","year":"2010"},{"issue":"5","key":"10.1016\/j.etp.2017.03.007_bib0075","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/0192623312441407","article-title":"Immunohistochemical investigation of F344\/N rat islet cell tumors from national toxicology program studies","volume":"40","author":"Koivisto","year":"2012","journal-title":"Toxicol. Pathol."},{"issue":"2","key":"10.1016\/j.etp.2017.03.007_bib0080","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"issue":"14","key":"10.1016\/j.etp.2017.03.007_bib0085","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/0006-2952(81)90198-2","article-title":"(14C) Streptozotocin: its distribution and interaction with nucleic acids and proteins","volume":"30","author":"Masiello","year":"1981","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.etp.2017.03.007_bib0090","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/019262338401200311","article-title":"Streptozotocin-induced functioning islet cell tumor in the rat: high frequency of induction and biological properties of the tumor cells","volume":"12","author":"Masiello","year":"1984","journal-title":"Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.etp.2017.03.007_bib0095","first-page":"158","article-title":"Induction of malignant kidney tumors in rats with streptozotocin","volume":"34","author":"Mauer","year":"1974","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.etp.2017.03.007_bib0100","first-page":"77","article-title":"Neoplastic lesions in streptozotocin-treated rats","volume":"32","author":"Okawa","year":"1983","journal-title":"Jikken Dobutsu."},{"issue":"1","key":"10.1016\/j.etp.2017.03.007_bib0105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12022-013-9295-2","article-title":"Neuroendocrine tumors of the pancreas: current concepts and controversies","volume":"25","author":"Reid","year":"2014","journal-title":"Endocr. Pathol."},{"key":"10.1016\/j.etp.2017.03.007_bib0110","series-title":"Pathology of the Fischer Rat: Reference and Atlas","first-page":"545","article-title":"Endocrine pancreas","author":"Riley","year":"1990"},{"key":"10.1016\/j.etp.2017.03.007_bib0115","series-title":"Haschek and Rousseaux\u2019s Handbook of Toxicologic Pathology","first-page":"2392","article-title":"58. Endocrine system","author":"Rosol","year":"2013"},{"issue":"11","key":"10.1016\/j.etp.2017.03.007_bib0120","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.2337\/diab.43.11.1326","article-title":"STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells","volume":"43","author":"Schnedl","year":"1994","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.etp.2017.03.007_bib0125","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/030098588602300102","article-title":"Neoplasia and hyperplasia of pancreatic endocrine tissue in the rat: an immunocytochemical study","volume":"23","author":"Spencer","year":"1986","journal-title":"Vet. Pathol."},{"issue":"1","key":"10.1016\/j.etp.2017.03.007_bib0130","first-page":"1","article-title":"Morphological and microvascular changes of the adrenal glands in streptozotocin-induced long-term diabetic rats","volume":"114","author":"Sricharoenvej","year":"2009","journal-title":"Ital. J. Anat. Embryol."},{"issue":"2","key":"10.1016\/j.etp.2017.03.007_bib0135","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1440-1827.2001.01167.x","article-title":"Establishment and characterization of three new rat renal cell carcinoma cell lines from N-ethyl-N-hydroxyethylnitrosamine-induced basophilic cell tumors","volume":"51","author":"Tokuzen","year":"2001","journal-title":"Pathol. Int."},{"issue":"2\u20133","key":"10.1016\/j.etp.2017.03.007_bib0140","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tox.2011.10.001","article-title":"Decrease in urinary creatinine in acute kidney injury influences diagnostic value of urinary biomarker-to-creatinine ratio in rats","volume":"290","author":"Tonomura","year":"2011","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.etp.2017.03.007_bib0145","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF02215983","article-title":"Immunohistochemical and ultrastructural studies on rat islet cell tumours induced by streptozotocin and nicotinamide","volume":"390","author":"Yagihashi","year":"1981","journal-title":"Virchows Arch. A. Pathol. Anat. Histol."},{"issue":"4","key":"10.1016\/j.etp.2017.03.007_bib0150","first-page":"1845","article-title":"Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors","volume":"45","author":"Yamagami","year":"1985","journal-title":"Cancer Res."},{"issue":"18","key":"10.1016\/j.etp.2017.03.007_bib0155","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1200\/JCO.2007.15.4377","article-title":"One hundred years after carcinoid: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States","volume":"26","author":"Yao","year":"2008","journal-title":"J. Clin. Oncol."}],"container-title":["Experimental and Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299316302846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0940299316302846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T19:21:37Z","timestamp":1535916097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0940299316302846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0940299316302846"],"URL":"https:\/\/doi.org\/10.1016\/j.etp.2017.03.007","relation":{},"ISSN":["0940-2993"],"issn-type":[{"value":"0940-2993","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of pancreatic islet cell tumors and renal tumors induced by a combined treatment of streptozotocin and nicotinamide in male SD rats","name":"articletitle","label":"Article Title"},{"value":"Experimental and Toxicologic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.etp.2017.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}