{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:00:48Z","timestamp":1784718048081,"version":"3.55.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"publisher","award":["16CR2003A"],"award-info":[{"award-number":["16CR2003A"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","eu-focus.europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology Focus"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.euf.2018.09.016","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:42:50Z","timestamp":1539045770000},"page":"284-291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["HOXA9, PCDH17, POU4F2, and ONECUT2 as a Urinary Biomarker Combination for the Detection of Bladder Cancer in Chinese Patients with Hematuria"],"prefix":"10.1016","volume":"6","author":[{"given":"Yishuo","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Perschon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Lilly","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jishan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-8752","authenticated-orcid":false,"given":"Jianfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euf.2018.09.016_bib0005","first-page":"87","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.euf.2018.09.016_bib0010","first-page":"115","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.euf.2018.09.016_bib0015","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0022-5347(05)67916-5","article-title":"A prospective analysis of 1,930 patients with hematuria to evaluate current diagnostic practice","volume":"163","author":"Khadra","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2018.09.016_bib0020","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0090-4295(01)00919-0","article-title":"Evaluation of asymptomatic microscopic hematuria in adults: the American Urological Association best practice policy\u2014part I: definition, detection, prevalence, and etiology","volume":"57","author":"Grossfeld","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.euf.2018.09.016_bib0025","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S0090-4295(01)00920-7","article-title":"Evaluation of asymptomatic microscopic hematuria in adults: the American Urological Association best practice policy\u2014part II: patient evaluation, cytology, voided markers, imaging, cystoscopy, nephrology evaluation, and follow-up","volume":"57","author":"Grossfeld","year":"2001","journal-title":"Urology"},{"issue":"66","key":"10.1016\/j.euf.2018.09.016_bib0030","first-page":"e25","article-title":"Prospective analysis of sensitivity and specificity of urinary cytology and other urinary biomarkers for bladder cancer","volume":"33","author":"Yafi","year":"2015","journal-title":"Urol Oncol"},{"key":"10.1016\/j.euf.2018.09.016_bib0035","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.euf.2018.09.016_bib0040","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nm.2305","article-title":"Cancer epigenetics reaches mainstream oncology","volume":"17","author":"Rodriguez-Paredes","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.euf.2018.09.016_bib0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1755-8794-4-45","article-title":"Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine","volume":"4","author":"Chen","year":"2011","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.euf.2018.09.016_bib0050","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.eururo.2012.01.011","article-title":"Genome-wide analysis of CpG island methylation in bladder cancer identified TBX2, TBX3, GATA2, and ZIC4 as pTa-specific prognostic markers","volume":"61","author":"Kandimalla","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.euf.2018.09.016_bib0055","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.mayocp.2012.04.013","article-title":"A noninvasive multianalyte urine-based diagnostic assay for urothelial cancer of the bladder in the evaluation of hematuria","volume":"87","author":"Karnes","year":"2012","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.euf.2018.09.016_bib0060","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1464-410X.2011.10428.x","article-title":"A methylation assay for the detection of non-muscle-invasive bladder cancer (NMIBC) recurrences in voided urine","volume":"109","author":"Zuiverloon","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2018.09.016_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137003","article-title":"Methylation of HOXA9 and ISL1 predicts patient outcome in high-grade non-invasive bladder cancer","volume":"10","author":"Kitchen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.euf.2018.09.016_bib0070","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.juro.2015.08.085","article-title":"Evaluation of an epigenetic profile for the detection of bladder cancer in patients with hematuria","volume":"195","author":"van Kessel","year":"2016","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2018.09.016_bib0075","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1186\/s12885-016-2748-5","article-title":"Promoter hypermethylation of HS3ST2, SEPTIN9 and SLIT2 combined with FGFR3 mutations as a sensitive\/specific urinary assay for diagnosis and surveillance in patients with low or high-risk non-muscle-invasive bladder cancer","volume":"16","author":"Roperch","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.euf.2018.09.016_bib0080","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.18632\/oncotarget.6666","article-title":"An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.euf.2018.09.016_bib0085","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.juro.2016.12.096","article-title":"FGFR3, TERT and OTX1 as a urinary biomarker combination for surveillance of patients with bladder cancer in a large prospective multicenter study","volume":"197","author":"Beukers","year":"2017","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2018.09.016_bib0090","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.juro.2016.09.118","article-title":"Validation of a DNA methylation-mutation urine assay to select patients with hematuria for cystoscopy","volume":"197","author":"van Kessel","year":"2017","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2018.09.016_bib0095","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.tranon.2017.01.001","article-title":"Epigenome-wide DNA methylation profiling identifies differential methylation biomarkers in high-grade bladder cancer","volume":"10","author":"Olkhov-Mitsel","year":"2017","journal-title":"Transl Oncol"},{"key":"10.1016\/j.euf.2018.09.016_bib0100","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.juro.2016.12.010","article-title":"Performance characteristics of a multigene urine biomarker test for monitoring for recurrent urothelial carcinoma in a multicenter study","volume":"197","author":"Kavalieris","year":"2017","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2018.09.016_bib0105","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.1158\/1078-0432.CCR-10-2659","article-title":"Comprehensive genome methylation analysis in bladder cancer: identification and validation of novel methylated genes and application of these as urinary tumor markers","volume":"17","author":"Reinert","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.euf.2018.09.016_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046297","article-title":"Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation","volume":"7","author":"Reinert","year":"2012","journal-title":"PLoS One"}],"container-title":["European Urology Focus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240545691830289X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240545691830289X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:49:11Z","timestamp":1762498151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240545691830289X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S240545691830289X"],"URL":"https:\/\/doi.org\/10.1016\/j.euf.2018.09.016","relation":{},"ISSN":["2405-4569"],"issn-type":[{"value":"2405-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HOXA9, PCDH17, POU4F2, and ONECUT2 as a Urinary Biomarker Combination for the Detection of Bladder Cancer in Chinese Patients with Hematuria","name":"articletitle","label":"Article Title"},{"value":"European Urology Focus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euf.2018.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}