{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:46:29Z","timestamp":1792395989039,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","eu-focus.europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology Focus"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.euf.2019.12.002","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T23:34:09Z","timestamp":1577144049000},"page":"868-876","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Neurogenic Sexual Dysfunction Treatment: A Systematic Review"],"prefix":"10.1016","volume":"6","author":[{"given":"Giulio","family":"Del Popolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-4025","authenticated-orcid":false,"given":"Gianmartin","family":"Cito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-3218","authenticated-orcid":false,"given":"Luca","family":"Gemma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Natali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euf.2019.12.002_bib0005","first-page":"88","article-title":"The treatment of erectile dysfunction in patients with neurogenic disease","volume":"5","author":"Shridharani","year":"2016","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.euf.2019.12.002_bib0010","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.eururo.2015.07.071","article-title":"Summary of European Association of Urology (EAU) guidelines on neuro-urology","volume":"69","author":"Groen","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.euf.2019.12.002_bib0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1179\/2045772312Y.0000000025","article-title":"Impact of spinal cord injury on sexuality: broad-based clinical practice intervention and practical application","volume":"35","author":"Hess","year":"2012","journal-title":"J Spinal Cord Med"},{"key":"10.1016\/j.euf.2019.12.002_bib0020","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0079-6123(05)52030-2","article-title":"Female sexual function after spinal cord injury","volume":"152","author":"Sipski","year":"2006","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.euf.2019.12.002_bib0025","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/aja.2011.110","article-title":"Multiple sclerosis and sexual dysfunction","volume":"14","author":"Guo","year":"2012","journal-title":"Asian J Androl"},{"key":"10.1016\/j.euf.2019.12.002_bib0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/NRE-2000-15203","article-title":"Clinical assessment of sildenafil in the treatment of neurogenic male sexual dysfunction: after the hype","volume":"15","author":"Green","year":"2000","journal-title":"NeuroRehabilitation"},{"key":"10.1016\/j.euf.2019.12.002_bib0035","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1365-2605.2009.01033.x","article-title":"Sildenafil efficacy in erectile dysfunction secondary to spinal cord injury depends on the level of cord injuries","volume":"33","author":"Khorrami","year":"2010","journal-title":"Int J Androl"},{"key":"10.1016\/j.euf.2019.12.002_bib0040","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000020278","article-title":"Sildenafil in the treatment of sexual dysfunction in spinal cord-injured male patients","volume":"38","author":"Schmid","year":"2000","journal-title":"Eur Urol"},{"key":"10.1016\/j.euf.2019.12.002_bib0045","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ijir.2010.23","article-title":"Safety and efficacy of sildenafil citrate in the treatment of Parkinson-emergent erectile dysfunction: a double-blind, placebo-controlled, randomized study","volume":"22","author":"Safarinejad","year":"2010","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.euf.2019.12.002_bib0050","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1743-6109.2008.01106.x","article-title":"Efficacy and safety of medium and long-term tadalafil use in spinal cord patients with erectile dysfunction","volume":"6","author":"Lombardi","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.euf.2019.12.002_bib0055","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1743-6109.2006.00209.x","article-title":"Efficacy and safety of tadalafil across ethnic groups and various risk factors in men with erectile dysfunction: use of a novel noninferiority study design","volume":"3","author":"Morgentaler","year":"2006","journal-title":"J Sex Med"},{"key":"10.1016\/j.euf.2019.12.002_bib0060","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s40618-016-0557-y","article-title":"Effects of daily tadalafil on lower urinary tract symptoms in young men with multiple sclerosis and erectile dysfunction: a pilot study","volume":"40","author":"Francomano","year":"2017","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.euf.2019.12.002_bib0065","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/sj.sc.3101617","article-title":"Time\/duration effectiveness of sildenafil versus tadalafil in the treatment of erectile dysfunction in male spinal cord-injured patients","volume":"42","author":"Del Popolo","year":"2004","journal-title":"Spinal Cord"},{"key":"10.1016\/j.euf.2019.12.002_bib0070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/sj.ijir.3901600","article-title":"Erectile dysfunction in spinal cord-injured men: different treatment options","volume":"20","author":"Moemen","year":"2008","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.euf.2019.12.002_bib0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/sj.sc.3101950","article-title":"Phosphodiesterase inhibitors in the treatment of erectile dysfunction in spinal cord-injured men","volume":"45","author":"Soler","year":"2007","journal-title":"Spinal Cord"},{"key":"10.1016\/j.euf.2019.12.002_bib0080","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1111\/j.1743-6109.2009.01426.x","article-title":"Ten-year follow-up of sildenafil use in spinal cord-injured patients with erectile dysfunction","volume":"6","author":"Lombardi","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.euf.2019.12.002_bib0085","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/10790268.2008.11753647","article-title":"A placebo-controlled, multicenter, randomized, double-blind, flexible-dose, two-way crossover study to evaluate the efficacy and safety of sildenafil in men with traumatic spinal cord injury and erectile dysfunction","volume":"31","author":"Ergin","year":"2008","journal-title":"J Spinal Cord Med"},{"key":"10.1016\/j.euf.2019.12.002_bib0090","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1001\/archneur.64.11.nct70001","article-title":"Efficacy and safety of tadalafil in men with erectile dysfunction following spinal cord injury","volume":"64","author":"Giuliano","year":"2007","journal-title":"Arch Neurol"},{"key":"10.1016\/j.euf.2019.12.002_bib0095","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1212\/01.wnl.0000194260.43583.32","article-title":"Efficacy and safety of vardenafil in men with erectile dysfunction caused by spinal cord injury","volume":"66","author":"Giuliano","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.euf.2019.12.002_bib0100","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1111\/j.1442-2042.2006.01584.x","article-title":"Up-titration of vardenafil dose from 10 mg to20 mg improved erectile function in men with spinal cord injury","volume":"13","author":"Kimoto","year":"2006","journal-title":"Int J Urol"},{"key":"10.1016\/j.euf.2019.12.002_bib0105","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF02550868","article-title":"External vacuum device therapy for spinal cord injured males with erectile dysfunction","volume":"28","author":"Seckin","year":"1996","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.euf.2019.12.002_bib0110","first-page":"712","article-title":"Synergist erection system in the management of impotence secondary to spinal cord injury","volume":"70","author":"Zasler","year":"1989","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.euf.2019.12.002_bib0115","first-page":"731","article-title":"Intracavernous injection of prostaglandin E1 in spinal cord injured patients with erectile dysfunction. A preliminary report","volume":"33","author":"Tang","year":"1995","journal-title":"Paraplegia"},{"key":"10.1016\/j.euf.2019.12.002_bib0120","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-5347(17)40754-3","article-title":"Intracavernous injection of prostaglandin E1 for the treatment of erectile impotence","volume":"141","author":"Ishii","year":"1989","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2019.12.002_bib0125","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0022-5347(17)45825-3","article-title":"Intracavernous drug-induced erections in the management of male erectile dysfunction: experience with 100 patients","volume":"135","author":"Sidi","year":"1986","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2019.12.002_bib0130","first-page":"457","article-title":"Intracavernous pharmacotherapy for management of erectile dysfunction in spinal cord injury","volume":"27","author":"Lloyd","year":"1989","journal-title":"Paraplegia"},{"key":"10.1016\/j.euf.2019.12.002_bib0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0022-5347(17)36062-7","article-title":"Efficiency and side effects of intracavernous injections of moxisylyte in impotent patients: a dose-finding study versus placebo","volume":"149","author":"Costa","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2019.12.002_bib0140","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-9993(94)90028-0","article-title":"Experience with intracavernosal tri-mixture for the management of neurogenic erectile dysfunction","volume":"75","author":"Chao","year":"1994","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.euf.2019.12.002_bib0145","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1745-7262.2007.00269.x","article-title":"Outcome of implanting penile prosthesis for treating erectile dysfunction: experience with 42 cases","volume":"9","author":"Xuan","year":"2007","journal-title":"Asian J Androl"},{"key":"10.1016\/j.euf.2019.12.002_bib0150","first-page":"336","article-title":"Penile prostheses for the management of the neuropathic bladder and sexual dysfunction in spinal cord injury patients: long term follow up","volume":"32","author":"Kimoto","year":"1994","journal-title":"Paraplegia"},{"issue":"3 Pt 1","key":"10.1016\/j.euf.2019.12.002_bib0155","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0022-5347(05)00344-7","article-title":"Penile prosthetic surgery in neurologically impaired patients: long-term followup","volume":"175","author":"Zermann","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2019.12.002_bib0160","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0022-5347(17)55449-X","article-title":"Penile prosthesis: adjunct to treatment in patients with neurogenic bladder","volume":"124","author":"Smith","year":"1980","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2019.12.002_bib0165","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0090-4295(81)90260-0","article-title":"Management of neurogenic impotence with inflatable penile prosthesis","volume":"17","author":"Light","year":"1981","journal-title":"Urology"},{"key":"10.1016\/j.euf.2019.12.002_bib0170","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/10790268.2008.11753979","article-title":"Percutaneous perineal electrostimulation induces erection: clinical significance in patients with spinal cord injury and erectile dysfunction","volume":"31","author":"Shafik","year":"2008","journal-title":"J Spinal Cord Med"},{"key":"10.1016\/j.euf.2019.12.002_bib0175","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1076\/apab.107.3.248.4330","article-title":"Sacral anterior root stimulation for bladder control: clinical results","volume":"107","author":"van der Aa","year":"1999","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.euf.2019.12.002_bib0180","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000066725","article-title":"Dorsal rhizotomy with anterior sacral root stimulation for neurogenic bladder","volume":"76","author":"Vignes","year":"2001","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1016\/j.euf.2019.12.002_bib0185","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/sc.2013.137","article-title":"Two phase 3, multicenter, randomized, placebo-controlled clinical trials of fampridine-SR for treatment of spasticity in chronic spinal cord injury","volume":"52","author":"Cardenas","year":"2014","journal-title":"Spinal Cord"},{"key":"10.1016\/j.euf.2019.12.002_bib0190","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.parkreldis.2005.03.004","article-title":"The long-lasting improvement of sexual dysfunction in patients with advanced, fluctuating Parkinson\u2019s disease induced by pergolide: evidence from the results of an open, prospective, one-year trial","volume":"11","author":"Pohanka","year":"2005","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.euf.2019.12.002_bib0195","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1464-410X.2004.04565.x","article-title":"Apomorphine sublingual as primary or secondary treatment for erectile dysfunction in patients with spinal cord injury","volume":"93","author":"Strebel","year":"2004","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2019.12.002_bib0200","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1111\/j.1743-6109.2008.00948.x","article-title":"Sacral neuromodulation for lower urinary tract dysfunction and impact on erectile function","volume":"5","author":"Lombardi","year":"2008","journal-title":"J Sex Med"},{"key":"10.1016\/j.euf.2019.12.002_bib0205","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/sc.2010.176","article-title":"Clinical concomitant benefits on pelvic floor dysfunctions after sacral neuromodulation in patients with incomplete spinal cord injury","volume":"49","author":"Lombardi","year":"2011","journal-title":"Spinal Cord"},{"key":"10.1016\/j.euf.2019.12.002_bib0210","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.apmr.2017.09.001","article-title":"Randomized trial of clitoral vacuum suction versus vibratory stimulation in neurogenic female orgasmic dysfunction","volume":"99","author":"Alexander","year":"2018","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.euf.2019.12.002_bib0215","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1111\/j.1743-6109.2008.00812.x","article-title":"Clinical female sexual outcome after sacral neuromodulation implant for lower urinary tract symptom (LUTS)","volume":"5","author":"Lombardi","year":"2008","journal-title":"J Sex Med"},{"key":"10.1016\/j.euf.2019.12.002_bib0220","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/01.ju.0000113145.43174.24","article-title":"Efficacy of sildenafil in the treatment of female sexual dysfunction due to multiple sclerosis","volume":"171","author":"Dasgupta","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2019.12.002_bib0225","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0090-4295(00)00493-3","article-title":"Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury","volume":"55","author":"Sipski","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.euf.2019.12.002_bib0230","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/sc.2010.107","article-title":"Sildenafil in women with sexual arousal disorder following spinal cord injury","volume":"49","author":"Alexander","year":"2011","journal-title":"Spinal Cord"},{"key":"10.1016\/j.euf.2019.12.002_bib0235","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s00701-018-3557-1","article-title":"Effect of spinal anterior root stimulation and sacral deafferentation on bladder and sexual dysfunction in spinal cord injury","volume":"160","author":"Zaer","year":"2018","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.euf.2019.12.002_bib0240","first-page":"269","article-title":"Intracavernous pharmacotherapy for management of erectile dysfunction in multiple sclerosis patients","volume":"23","author":"Vidal","year":"1995","journal-title":"Rev Neurol"},{"key":"10.1016\/j.euf.2019.12.002_bib0245","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/BRS.0b013e3181695040","article-title":"Vardena\ufb01l Study Group. Vardena\ufb01l improves ejaculation success rates and self-con\ufb01dence in men with erectile dysfunction due to spinal cord injury","volume":"33","author":"Giuliano","year":"2008","journal-title":"Spine"}],"container-title":["European Urology Focus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456919303803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456919303803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:51:58Z","timestamp":1762498318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405456919303803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S2405456919303803"],"URL":"https:\/\/doi.org\/10.1016\/j.euf.2019.12.002","relation":{},"ISSN":["2405-4569"],"issn-type":[{"value":"2405-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurogenic Sexual Dysfunction Treatment: A Systematic Review","name":"articletitle","label":"Article Title"},{"value":"European Urology Focus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euf.2019.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Association of Urology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}