{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:49:51Z","timestamp":1786988991614,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003946","name":"European Society for Sexual Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","eu-focus.europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology Focus"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.euf.2021.04.012","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T19:33:42Z","timestamp":1620156822000},"page":"814-828","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Single-cell Transcriptomics Uncover a Novel Role of Myeloid Cells and T-lymphocytes in the Fibrotic Microenvironment in Peyronie\u2019s Disease"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-2534","authenticated-orcid":false,"given":"Uros","family":"Milenkovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Boeckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diether","family":"Lambrechts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekin\u2019s","family":"Janky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Hatzichristodoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"van Renterghem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gevaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Cellek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinity J.","family":"Bivalacqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"De Ridder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Albersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euf.2021.04.012_bib0005","doi-asserted-by":"crossref","first-page":"280","DOI":"10.21037\/tau.2016.04.05","article-title":"Peyronie\u2019s disease: a literature review on epidemiology, genetics, pathophysiology, diagnosis and work-up","volume":"5","author":"Al-Thakafi","year":"2016","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.euf.2021.04.012_bib0010","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1111\/j.1743-6109.2008.00895.x","article-title":"The chronology of depression and distress in men with Peyronie\u2019s disease","volume":"5","author":"Nelson","year":"2008","journal-title":"J Sex Med"},{"key":"10.1016\/j.euf.2021.04.012_bib0015","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.sxmr.2017.01.006","article-title":"Contemporary review of grafting techniques for the surgical treatment of Peyronie\u2019s disease","volume":"5","author":"Hatzichristodoulou","year":"2017","journal-title":"Sex Med Rev"},{"key":"10.1016\/j.euf.2021.04.012_bib0020","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.eururo.2018.07.005","article-title":"Clinical efficacy of injection and mechanical therapy for Peyronie\u2019s disease: a systematic review of the literature","volume":"74","author":"Russo","year":"2018","journal-title":"Eur Urol"},{"key":"10.1016\/j.euf.2021.04.012_bib0025","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0022-5347(01)65361-8","article-title":"Schlossberg SM. Proposal: trauma as the cause of the Peyronie\u2019s lesion","volume":"157","author":"Devine","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2021.04.012_bib0030","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/bju.14638","article-title":"Simvastatin and the Rho-kinase inhibitor Y-27632 prevent myofibroblast transformation in Peyronie\u2019s disease-derived fibroblasts via inhibition of YAP\/TAZ nuclear translocation","volume":"123","author":"Milenkovic","year":"2019","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2021.04.012_bib0035","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.sxmr.2019.02.004","article-title":"Pathophysiology and future therapeutic perspectives for resolving fibrosis in Peyronie\u2019s disease","volume":"7","author":"Milenkovic","year":"2019","journal-title":"Sex Med Rev"},{"key":"10.1016\/j.euf.2021.04.012_bib0040","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.eururo.2018.10.014","article-title":"Antifibrotic synergy between phosphodiesterase type 5 inhibitors and selective oestrogen receptor modulators in Peyronie\u2019s disease models","volume":"75","author":"Ilg","year":"2019","journal-title":"Eur Urol"},{"key":"10.1016\/j.euf.2021.04.012_bib0045","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ncpuro0201","article-title":"Mechanisms of disease: new insights into the cellular and molecular pathology of Peyronie\u2019s disease","volume":"2","author":"Gonzalez-Cadavid","year":"2005","journal-title":"Nat Clin Pract Urol"},{"key":"10.1016\/j.euf.2021.04.012_bib0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41585-018-0109-7","article-title":"The mechanisms and potential of stem cell therapy for penile fibrosis","volume":"16","author":"Milenkovic","year":"2019","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.euf.2021.04.012_bib0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41584-019-0324-5","article-title":"Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases","volume":"16","author":"Hinz","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.euf.2021.04.012_bib0060","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The myofibroblast: one function, multiple origins","volume":"170","author":"Hinz","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.euf.2021.04.012_bib0065","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0022-5347(01)65360-6","article-title":"The microscopic pathology of Peyronie\u2019s disease","volume":"157","author":"Davis","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2021.04.012_bib0070","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0022-5347(01)66582-0","article-title":"The immunological features of Peyronie\u2019s disease","volume":"155","author":"Ralph","year":"1996","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2021.04.012_bib0075","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0090-4295(01)01578-3","article-title":"Gene expression profiles in the Peyronie\u2019s disease plaque","volume":"59","author":"Magee","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.euf.2021.04.012_bib0080","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1164\/rccm.200709-1446OC","article-title":"Treatment of idiopathic pulmonary fibrosis with etanercept: an exploratory, placebo-controlled trial","volume":"178","author":"Raghu","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.euf.2021.04.012_bib0085","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1002\/art.39289","article-title":"Dissecting the heterogeneity of skin gene expression patterns in systemic sclerosis","volume":"67","author":"Assassi","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.euf.2021.04.012_bib0090","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1136\/thoraxjnl-2012-202943","article-title":"Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis","volume":"68","author":"Yang","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.euf.2021.04.012_bib0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012106","article-title":"Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury","volume":"5","author":"Pendergrass","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.euf.2021.04.012_bib0100","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41584-019-0322-7","article-title":"Shared and distinct mechanisms of fibrosis","volume":"15","author":"Distler","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.euf.2021.04.012_bib0105","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.18295\/2075-0528.1676","article-title":"The role of damage-associated molecular patterns (DAMPs) in human diseases part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine","volume":"15","author":"Land","year":"2015","journal-title":"Sultan Qaboos Univ Med J"},{"key":"10.1016\/j.euf.2021.04.012_bib0110","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.3389\/fimmu.2019.02035","article-title":"Human monocyte subsets and phenotypes in major chronic inflammatory diseases","volume":"10","author":"Kapellos","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.euf.2021.04.012_bib0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/imm.12888","article-title":"Human dendritic cell subsets: an update","volume":"154","author":"Collin","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.euf.2021.04.012_bib0120","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1038\/s41467-018-04985-0","article-title":"Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway","volume":"9","author":"Tang-Huau","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.euf.2021.04.012_bib0125","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/jid.2008.194","article-title":"Psoriasis is characterized by accumulation of immunostimulatory and Th1\/Th17 cell-polarizing myeloid dendritic cells","volume":"129","author":"Zaba","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.euf.2021.04.012_bib0130","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.kint.2016.10.030","article-title":"Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes","volume":"91","author":"Liao","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.euf.2021.04.012_bib0135","series-title":"Biology of myelomonocytic cells","article-title":"Dendritic cells: location, function, and clinical implications","author":"Castell-Rodr\u00edguez","year":"2017"},{"key":"10.1016\/j.euf.2021.04.012_bib0140","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/ki.2008.189","article-title":"Macrophages and dendritic cells: what is the difference?","volume":"74","author":"Ferenbach","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.euf.2021.04.012_bib0145","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.euf.2021.04.012_bib0150","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1038\/s41598-019-43578-9","article-title":"Differences in the molecular signatures of mucosal-associated invariant T cells and conventional T cells","volume":"9","author":"Park","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.euf.2021.04.012_bib0155","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41577-019-0191-y","article-title":"Mucosal-associated invariant T cells and disease","volume":"19","author":"Toubal","year":"2019","journal-title":"Nat Rev Immunol"}],"container-title":["European Urology Focus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456921001188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456921001188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:53:04Z","timestamp":1762498384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405456921001188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S2405456921001188"],"URL":"https:\/\/doi.org\/10.1016\/j.euf.2021.04.012","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740095780.793595287","asserted-by":"object"}]},"ISSN":["2405-4569"],"issn-type":[{"value":"2405-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell Transcriptomics Uncover a Novel Role of Myeloid Cells and T-lymphocytes in the Fibrotic Microenvironment in Peyronie\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"European Urology Focus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euf.2021.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 European Association of Urology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}