{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:58:53Z","timestamp":1762498733129,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007113","name":"Sexual Medicine Society of North America Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007113","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","eu-focus.europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology Focus"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.euf.2022.10.003","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T01:44:08Z","timestamp":1666230248000},"page":"60-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Androgen Receptor Signaling is Similar in Human Corpus Cavernosum in Men with Different Serum Testosterone Levels"],"prefix":"10.1016","volume":"9","author":[{"given":"Kajal","family":"Khodamoradi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Dullea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ramsoomair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roei","family":"Golan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjith","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.euf.2022.10.003_b0005","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1210\/me.2008-0089","article-title":"Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions","volume":"22","author":"Smith","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.euf.2022.10.003_b0010","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1210\/er.2007-0019","article-title":"Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex","volume":"28","author":"Heemers","year":"2007","journal-title":"Endocr Rev"},{"key":"10.1016\/j.euf.2022.10.003_b0015","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.eururo.2004.01.005","article-title":"Hormonal supplementation and erectile dysfunction","volume":"45","author":"Aversa","year":"2004","journal-title":"Eur Urol"},{"key":"10.1016\/j.euf.2022.10.003_b0020","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0090-4295(00)00667-1","article-title":"Effect of testosterone on the number of NADPH diaphorase-stained nerve fibers in the rat corpus cavernosum and dorsal nerve","volume":"56","author":"Baba","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.euf.2022.10.003_b0025","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s00345-003-0371-y","article-title":"Androgen and estrogen receptors in the human corpus cavernosum penis: immunohistochemical and cell culture results","volume":"21","author":"Schultheiss","year":"2003","journal-title":"World J Urol"},{"key":"10.1016\/j.euf.2022.10.003_b0030","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3390\/cancers9040032","article-title":"The androgen receptor and VEGF: mechanisms of androgen-regulated angiogenesis in prostate cancer","volume":"9","author":"Eisermann","year":"2017","journal-title":"Cancers"},{"key":"10.1016\/j.euf.2022.10.003_b0035","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fendo.2019.00225","article-title":"Androgen deficiency and phosphodiesterase type 5 expression changes in aging male: therapeutic implications","volume":"10","author":"Aversa","year":"2019","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.euf.2022.10.003_b0040","doi-asserted-by":"crossref","first-page":"890186","DOI":"10.3389\/fcell.2022.890186","article-title":"The nuclear translocation of heme oxygenase-1 in human diseases","volume":"10","author":"Yang","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.euf.2022.10.003_b0045","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/S0140-6736(13)61126-5","article-title":"Male hypogonadism","volume":"383","author":"Basaria","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.euf.2022.10.003_b0050","doi-asserted-by":"crossref","first-page":"M76","DOI":"10.1093\/gerona\/57.2.M76","article-title":"Andropause: clinical implications of the decline in serum testosterone levels with aging in men","volume":"57","author":"Matsumoto","year":"2002","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.euf.2022.10.003_b0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/13685530601051155","article-title":"Testosterone and erectile physiology","volume":"9","author":"Guay","year":"2006","journal-title":"Aging Male"},{"key":"10.1016\/j.euf.2022.10.003_b0060","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1210\/endo.136.4.7534702","article-title":"Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat","volume":"136","author":"Lugg","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.euf.2022.10.003_b0065","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/j.1939-4640.1997.tb02435.x","article-title":"Androgenic maintenance of the rat erectile response via a non-nitric-oxide-dependent pathway","volume":"18","author":"Reilly","year":"1997","journal-title":"J Androl"},{"key":"10.1016\/j.euf.2022.10.003_b0070","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/j.1939-4640.2003.tb02686.x","article-title":"Effects of medical or surgical castration on erectile function in an animal model","volume":"24","author":"Traish","year":"2003","journal-title":"J Androl"},{"key":"10.1016\/j.euf.2022.10.003_b0075","first-page":"1502","article-title":"Mechanism of androgen in improving erectile dysfunction in castrated rats by regulating androgen receptor\/vascular endothelial growth factor","volume":"99","author":"Jiao","year":"2019","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.euf.2022.10.003_b0080","first-page":"232","article-title":"Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate","volume":"22","author":"Huggins","year":"1972","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.euf.2022.10.003_b0085","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/sj.bjc.6690445","article-title":"Endogenous sex hormones and prostate cancer: a quantitative review of prospective studies","volume":"80","author":"Eaton","year":"1999","journal-title":"Br J Cancer"},{"key":"10.1016\/j.euf.2022.10.003_b0090","first-page":"169","article-title":"A prospective, population-based study of androstenedione, estrogens, and prostatic cancer","volume":"50","author":"Barrett-Connor","year":"1990","journal-title":"Cancer Res"},{"key":"10.1016\/j.euf.2022.10.003_b0095","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1158\/1055-9965.EPI-04-0715","article-title":"Serum testosterone and the risk of prostate cancer: potential implications for testosterone therapy","volume":"14","author":"Parsons","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.euf.2022.10.003_b0100","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/jnci\/djm323","article-title":"Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies","volume":"100","author":"Endogenous Hormones and Prostate Cancer Collaborative Group","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.euf.2022.10.003_b0105","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.eururo.2012.06.027","article-title":"Goodbye androgen hypothesis, hello saturation model","volume":"62","author":"Morgentaler","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.euf.2022.10.003_b0110","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4103\/1008-682X.173935","article-title":"Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation","volume":"19","author":"Alves-Lopes","year":"2017","journal-title":"Asian J Androl"},{"key":"10.1016\/j.euf.2022.10.003_b0115","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/bph.12700","article-title":"Gas what: NO is not the only answer to sexual function","volume":"172","author":"Yetik-Anacak","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.euf.2022.10.003_b0120","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.nurpra.2016.11.016","article-title":"Comparison of testosterone replacement therapy medications in the treatment of hypogonadism","volume":"13","author":"Luthy","year":"2017","journal-title":"J Nurse Pract"},{"key":"10.1016\/j.euf.2022.10.003_b0125","doi-asserted-by":"crossref","first-page":"834","DOI":"10.21037\/tau.2016.07.10","article-title":"Pharmacology of testosterone replacement therapy preparations","volume":"5","author":"Shoskes","year":"2016","journal-title":"Transl Androl Urol"}],"container-title":["European Urology Focus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456922002310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456922002310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:53:59Z","timestamp":1762498439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405456922002310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S2405456922002310"],"URL":"https:\/\/doi.org\/10.1016\/j.euf.2022.10.003","relation":{},"ISSN":["2405-4569"],"issn-type":[{"type":"print","value":"2405-4569"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Androgen Receptor Signaling is Similar in Human Corpus Cavernosum in Men with Different Serum Testosterone Levels","name":"articletitle","label":"Article Title"},{"value":"European Urology Focus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euf.2022.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 European Association of Urology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}