{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:55:12Z","timestamp":1790344512530,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","eu-focus.europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology Focus"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.euf.2024.09.011","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T17:40:07Z","timestamp":1727286007000},"page":"301-311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preventing Infectious Complications Following Prostate Biopsy: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials of Alternative Approaches to Transrectal Biopsy with Empirical Antibiotic Prophylaxis Therapy"],"prefix":"10.1016","volume":"11","author":[{"given":"Kumar","family":"Madhavan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyank","family":"Bhargava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrut","family":"Phonde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonu","family":"Kumar Plash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneeth","family":"Kumar Kadlepla Mutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manupriya","family":"Madhavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devashish","family":"Kaushal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Jena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euf.2024.09.011_b0005","doi-asserted-by":"crossref","DOI":"10.1177\/17562872221105019","article-title":"Schema and cancer detection rates for transperineal prostate biopsy templates: a review","volume":"14","author":"Sidana","year":"2022","journal-title":"Ther Adv Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0010","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/JU.0000000000001399","article-title":"Nonantibiotic strategies for the prevention of infectious complications following prostate biopsy: a systematic review and meta-analysis","volume":"205","author":"Pradere","year":"2021","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/JU.0000000000003788","article-title":"Complications following transrectal and transperineal prostate biopsy: results of the ProBE-PC randomized clinical trial","volume":"211","author":"Mian","year":"2024","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.eururo.2023.12.015","article-title":"Transperineal versus transrectal magnetic resonance imaging-targeted and systematic prostate biopsy to prevent infectious complications: the PREVENT randomized trial","volume":"86","author":"Hu","year":"2024","journal-title":"Eur Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0025","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.euros.2021.06.009","article-title":"TREXIT is now: should we abandon the transrectal route for prostate biopsy?","volume":"31","author":"Grummet","year":"2021","journal-title":"Yes. Eur Urol Open Sci"},{"key":"10.1016\/j.euf.2024.09.011_b0030","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41391-020-0204-8","article-title":"\u201cTREXIT 2020\u201d: why the time to abandon transrectal prostate biopsy starts now","volume":"23","author":"Grummet","year":"2020","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.euf.2024.09.011_b0035","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/bju.15939","article-title":"A TREXIT catalyst: an updated review of NHS England prostate biopsy data during COVID-19","volume":"131","author":"Hayes","year":"2023","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2024.09.011_b0040","unstructured":"European Association of Urology. EAU guidelines on prostate cancer\u2014Uroweb. https:\/\/uroweb.org\/guidelines\/prostate-cancer."},{"key":"10.1016\/j.euf.2024.09.011_b0045","unstructured":"PRISMA. PRISMA statement. https:\/\/www.prisma-statement.org."},{"key":"10.1016\/j.euf.2024.09.011_b0050","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.juro.2012.09.121","article-title":"A prospective randomized trial of povidone-iodine prophylactic cleansing of the rectum before transrectal ultrasound guided prostate biopsy","volume":"189","author":"Abughosh","year":"2013","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0055","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11255-005-8440-3","article-title":"Prevention of pain and infective complications after transrectal prostate biopsy: a prospective study","volume":"38","author":"Akay","year":"2006","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.euf.2024.09.011_b0060","first-page":"28","article-title":"Bi\u00f3psia Prost\u00e1tica Transretal Ap\u00f3s Prepara\u00e7\u00e3o Profil\u00e1tica do Recto com Iodo-Povidona: Estudo Prospectivo Randomizado","volume":"35","author":"Cadilhe","year":"2018","journal-title":"Acta Urol Port"},{"key":"10.1016\/j.euf.2024.09.011_b0065","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5152\/tud.2019.19172","article-title":"Effect of rectal mucosa cleansing on acute prostatitis during prostate biopsy: a randomized prospective study","volume":"46","author":"Ergani","year":"2020","journal-title":"Turk J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0070","first-page":"225","article-title":"Role of povidone-iodine-soaked gauze in preventing infectious complications following trans rectal digital guided prostate biopsy","volume":"35","author":"Farooq","year":"2021","journal-title":"J Postgrad Med Inst"},{"key":"10.1016\/j.euf.2024.09.011_b0075","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5812\/iranjradiol.7561","article-title":"Decrease in infection rate following use of povidone-iodine during transrectal ultrasound guided biopsy of the prostate: a double blind randomized clinical trial","volume":"9","author":"Ghafoori","year":"2012","journal-title":"Iran J Radiol"},{"key":"10.1016\/j.euf.2024.09.011_b0080","first-page":"395","article-title":"Modified bowel preparation to reduce infection after prostate biopsy","volume":"29","author":"Huang","year":"2006","journal-title":"Chang Gung Med J"},{"key":"10.1016\/j.euf.2024.09.011_b0085","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/JU.0000000000002910","article-title":"Effectiveness of intrarectal povidone-iodine cleansing plus formalin disinfection of the needle tip in decreasing infectious complications after transrectal prostate biopsy: a randomized controlled trial","volume":"208","author":"Pontes-Junior","year":"2022","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0090","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000014854","article-title":"A prospective randomized trial of povidone-iodine suppository before transrectal ultrasonography-guided prostate biopsy","volume":"98","author":"Ryu","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.euf.2024.09.011_b0095","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00345-018-2221-y","article-title":"Antimicrobial lubricant reduces rectal bacteria at transrectal prostate biopsy: results from a prospective randomized trial","volume":"36","author":"Salomon","year":"2018","journal-title":"World J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0100","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4103\/iju.IJU_34_21","article-title":"Minimizing transrectal prostate biopsy-related infections; a prospective randomized trial of povidone-iodine intrarectal cleaning versus formalin needle disinfection","volume":"37","author":"Bajpai","year":"2021","journal-title":"Indian J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0105","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4081\/aiua.2014.4.284","article-title":"Transrectal versus transperineal 14-core prostate biopsy in detection of prostate cancer: a comparative evaluation at the same institution","volume":"86","author":"Cerruto","year":"2014","journal-title":"Arch Ital Urol Androl"},{"key":"10.1016\/j.euf.2024.09.011_b0110","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4111\/kju.2009.50.2.119","article-title":"The comparison between transperineal and transrectal ultrasound-guided prostate needle biopsy","volume":"50","author":"Chae","year":"2009","journal-title":"Korean J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0115","doi-asserted-by":"crossref","first-page":"16089","DOI":"10.1038\/srep16089","article-title":"Comparison between ultrasound guided transperineal and transrectal prostate biopsy: a prospective, randomized, and controlled trial","volume":"5","author":"Guo","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.euf.2024.09.011_b0120","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.urology.2007.09.029","article-title":"Optimal approach for prostate cancer detection as initial biopsy: prospective randomized study comparing transperineal versus transrectal systematic 12-core biopsy","volume":"71","author":"Hara","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.euf.2024.09.011_b0125","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.pcan.4500985","article-title":"A prospective randomized comparison of diagnostic efficacy between transperineal and transrectal 12-core prostate biopsy","volume":"11","author":"Takenaka","year":"2008","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.euf.2024.09.011_b0130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4103\/1119-3077.146991","article-title":"Transperineal versus transrectal prostate biopsy: our findings in a tertiary health institution","volume":"18","author":"Udeh","year":"2015","journal-title":"Niger J Clin Pract"},{"key":"10.1016\/j.euf.2024.09.011_b0135","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.euo.2019.08.007","article-title":"Complications and adverse events of three magnetic resonance imaging-based target biopsy techniques in the diagnosis of prostate cancer among men with prior negative biopsies: results from the FUTURE trial, a multicentre randomised controlled trial","volume":"2","author":"Wegelin","year":"2019","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.euf.2024.09.011_b0140","doi-asserted-by":"crossref","unstructured":"Ploussard G, Barret E, Fiard G, et al. Transperineal versus transrectal magnetic resonance imaging\u2013targeted biopsies for prostate cancer diagnosis: final results of the randomized PERFECT trial (CCAFU-PR1). Eur Urol Oncol. In press. https:\/\/doi.org\/10.1016\/j.euo.2024.01.019.","DOI":"10.1016\/j.euo.2024.01.019"},{"key":"10.1016\/j.euf.2024.09.011_b0145","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s11845-021-02723-y","article-title":"Effect of targeted prophylaxis with rectal swab on complications after prostate biopsy: prospective randomized study","volume":"191","author":"Benli","year":"2022","journal-title":"Ir J Med Sci"},{"key":"10.1016\/j.euf.2024.09.011_b0150","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4103\/aam.aam_48_18","article-title":"A prospective randomized comparative study of targeted versus empirical prophylactic antibiotics in the prevention of infective complications following transrectal ultrasound-guided prostate biopsy","volume":"18","author":"Doherty","year":"2019","journal-title":"Ann Afr Med"},{"key":"10.1016\/j.euf.2024.09.011_b0155","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1007\/s00345-018-2319-2","article-title":"Chemoprophylaxis during transrectal prostate needle biopsy: critical analysis through randomized clinical trial","volume":"36","author":"Elshal","year":"2018","journal-title":"World J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0160","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.prnil.2016.06.001","article-title":"Optimizing prophylactic antibiotic regimen in patients admitted for transrectal ultrasound-guided prostate biopsies: a prospective randomized study","volume":"4","author":"Fahmy","year":"2016","journal-title":"Prostate Int"},{"key":"10.1016\/j.euf.2024.09.011_b0165","first-page":"852","article-title":"Prevalence of antibiotic resistance in fecal flora before transrectal ultrasound-guided prostate biopsy and the clinical impact of targeted antibiotic prophylaxis","volume":"70","author":"Ozgur","year":"2017","journal-title":"Arch Esp Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0170","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/cid\/ciac913","article-title":"Rectal culture-based versus empirical antibiotic prophylaxis to prevent infectious complications in men undergoing transrectal prostate biopsy: a randomized, nonblinded multicenter trial","volume":"76","author":"Tops","year":"2023","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.euf.2024.09.011_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.juro.2015.02.1685","article-title":"MP48-11 Prospective randomized controlled study to assess the effect of perineal region cleansing with povidone iodine before transrectal needle biopsy of the prostate on infectious complications","volume":"193","author":"Taher","year":"2015","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0180","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/iju.13883","article-title":"Use of fosfomycin as targeted antibiotic prophylaxis before prostate biopsy: a prospective randomized study","volume":"26","author":"Van Besien","year":"2019","journal-title":"Int J Urol"},{"key":"10.1016\/j.euf.2024.09.011_b0185","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S1473-3099(22)00373-5","article-title":"Antibiotic prophylaxis versus no antibiotic prophylaxis in transperineal prostate biopsies (NORAPP): a randomised, open-label, non-inferiority trial","volume":"22","author":"Jacewicz","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.euf.2024.09.011_b0190","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5392107","article-title":"Prevalence, risk factors, and clinical relevance of fluoroquinolone-resistant organisms in rectal cultures: should we target antibiotic prophylaxis prior to prostate biopsy?","volume":"2016","author":"Van Besien","year":"2016","journal-title":"Adv Urol"}],"container-title":["European Urology Focus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456924001792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456924001792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T05:15:23Z","timestamp":1760073323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405456924001792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2405456924001792"],"URL":"https:\/\/doi.org\/10.1016\/j.euf.2024.09.011","relation":{},"ISSN":["2405-4569"],"issn-type":[{"value":"2405-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preventing Infectious Complications Following Prostate Biopsy: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials of Alternative Approaches to Transrectal Biopsy with Empirical Antibiotic Prophylaxis Therapy","name":"articletitle","label":"Article Title"},{"value":"European Urology Focus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euf.2024.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Association of Urology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}