{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:30:03Z","timestamp":1791570603934,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50 CA092629"],"award-info":[{"award-number":["P50 CA092629"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016945","name":"Sidney Kimmel Center for Prostate and Urologic Cancers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","eu-focus.europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology Focus"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.euf.2025.10.004","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:08:58Z","timestamp":1769202538000},"page":"201-207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Cancer Detection Between Transrectal and Transperineal Prostate Biopsy in an Active Surveillance Cohort"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-7261","authenticated-orcid":false,"given":"Sunny B.","family":"Nalavenkata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Tin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris D.","family":"Gaffney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Liso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Fainberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish I.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behfar","family":"Ehdaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euf.2025.10.004_b0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MOU.0000000000001083","article-title":"Transperineal vs. transrectal biopsy to reduce postinterventional sepsis","volume":"33","author":"Stangl-Kremser","year":"2023","journal-title":"Curr Opin Urol"},{"key":"10.1016\/j.euf.2025.10.004_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.urology.2022.04.013","article-title":"Transperineal prostate biopsy is associated with lower tissue core pathogen burden relative to transrectal biopsy: mechanistic underpinnings for lower infection risk in the transperineal approach","volume":"165","author":"Werneburg","year":"2022","journal-title":"Urology"},{"key":"10.1016\/j.euf.2025.10.004_b0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.eururo.2023.12.015","article-title":"Transperineal versus transrectal magnetic resonance imaging-targeted and systematic prostate biopsy to prevent infectious complications: the PREVENT randomized trial","volume":"86","author":"Hu","year":"2024","journal-title":"Eur Urol"},{"key":"10.1016\/j.euf.2025.10.004_b0020","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1464-410X.2009.08938.x","article-title":"\u2018Prostatic evasive anterior tumours\u2019: the role of magnetic resonance imaging","volume":"105","author":"Lawrentschuk","year":"2010","journal-title":"BJU Int"},{"issue":"Suppl 1","key":"10.1016\/j.euf.2025.10.004_b0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/bju.15124","article-title":"Detection of clinically significant cancer in the anterior prostate by transperineal biopsy","volume":"126","author":"Cowan","year":"2020","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2025.10.004_b0030","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1046\/j.1464-410X.2002.02796.x","article-title":"Anterior prostate cancer: is it more difficult to diagnose?","volume":"89","author":"Bott","year":"2002","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2025.10.004_b0035","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.juro.2012.05.006","article-title":"Location and pathological characteristics of cancers in radical prostatectomy specimens identified by transperineal biopsy compared to transrectal biopsy","volume":"188","author":"Hossack","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2025.10.004_b0040","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1464-410X.2012.10972.x","article-title":"High detection rate of significant prostate tumours in anterior zones using transperineal ultrasound-guided template saturation biopsy","volume":"110","author":"Mabjeesh","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2025.10.004_b0045","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.euo.2020.12.012","article-title":"Magnetic resonance imaging\/ultrasound fusion-guided transperineal versus magnetic resonance imaging\/ultrasound fusion-guided transrectal prostate biopsy\u2014a systematic review","volume":"4","author":"Rai","year":"2021","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.euf.2025.10.004_b0050","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4081\/aiua.2017.1.55","article-title":"A retrospective comparison between transrectal and transperineal prostate biopsy in the detection of prostate cancer","volume":"89","author":"Di Franco","year":"2017","journal-title":"Arch Ital Urol Androl"},{"key":"10.1016\/j.euf.2025.10.004_b0055","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.urology.2010.08.048","article-title":"Trans-rectal versus trans-perineal saturation rebiopsy of the prostate: is there a difference in cancer detection rate?","volume":"77","author":"Abdollah","year":"2011","journal-title":"Urology"},{"key":"10.1016\/j.euf.2025.10.004_b0060","doi-asserted-by":"crossref","first-page":"16089","DOI":"10.1038\/srep16089","article-title":"Comparison between ultrasound guided transperineal and transrectal prostate biopsy: a prospective, randomized, and controlled trial","volume":"5","author":"Guo","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.euf.2025.10.004_b0065","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.pcan.4500985","article-title":"A prospective randomized comparison of diagnostic efficacy between transperineal and transrectal 12-core prostate biopsy","volume":"11","author":"Takenaka","year":"2008","journal-title":"Prostate Cancer Prostat Dis"},{"key":"10.1016\/j.euf.2025.10.004_b0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.urology.2007.09.029","article-title":"Optimal approach for prostate cancer detection as initial biopsy: prospective randomized study comparing transperineal versus transrectal systematic 12-core biopsy","volume":"71","author":"Hara","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.euf.2025.10.004_b0075","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/bju.14017","article-title":"Prospective comparison of transperineal magnetic resonance imaging\/ultrasonography fusion biopsy and transrectal systematic biopsy in biopsy-naive patients","volume":"121","author":"Borkowetz","year":"2018","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2025.10.004_b0080","doi-asserted-by":"crossref","first-page":"191.e9","DOI":"10.1016\/j.urolonc.2022.01.004","article-title":"Comparisons of efficacy and complications between transrectal and transperineal prostate biopsy with or without antibiotic prophylaxis","volume":"40","author":"He","year":"2022","journal-title":"Urol Oncol"},{"key":"10.1016\/j.euf.2025.10.004_b0085","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/j.1464-410X.2009.08954.x","article-title":"Detection rate and factors predictive the presence of prostate cancer in patients undergoing ultrasonography-guided transperineal saturation biopsies of the prostate","volume":"105","author":"Novara","year":"2010","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2025.10.004_b0090","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12894-019-0539-4","article-title":"Comparisons of cancer detection rate and complications between transrectal and transperineal prostate biopsy approaches \u2013 a single center preliminary study","volume":"19","author":"Huang","year":"2019","journal-title":"BMC Urol"},{"key":"10.1016\/j.euf.2025.10.004_b0095","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4081\/aiua.2014.4.284","article-title":"Transrectal versus transperineal 14-core prostate biopsy in detection of prostate cancer: a comparative evaluation at the same institution","volume":"86","author":"Cerruto","year":"2014","journal-title":"Arch Ital Urol Androl"},{"key":"10.1016\/j.euf.2025.10.004_b0100","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.euo.2023.08.001","article-title":"Is there an impact of transperineal versus transrectal magnetic resonance imaging\u2013targeted biopsy in clinically significant prostate cancer detection rate? A systematic review and meta-analysis","volume":"6","author":"Uleri","year":"2023","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.euf.2025.10.004_b0105","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.euo.2024.01.019","article-title":"Transperineal versus transrectal magnetic resonance imaging-targeted biopsies for prostate cancer diagnosis: final results of the randomized PERFECT trial (CCAFU-PR1)","volume":"7","author":"Ploussard","year":"2024","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.euf.2025.10.004_b0110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/JU.0000000000003979","article-title":"Clinically significant prostate cancer detection following transrectal and transperineal biopsy: results of the Prostate Biopsy Efficacy and Complications randomized clinical trial","volume":"212","author":"Mian","year":"2024","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2025.10.004_b0115","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1470-2045(25)00100-7","article-title":"Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection (TRANSLATE): a multicentre, randomised, controlled trial","volume":"26","author":"Bryant","year":"2025","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.euf.2025.10.004_b0120","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/pcan.2015.29","article-title":"Improved detection of anterior fibromuscular stroma and transition zone prostate cancer using biparametric and multiparametric MRI with MRI-targeted biopsy and MRI-US fusion guidance","volume":"18","author":"Radtke","year":"2015","journal-title":"Prostate Cancer Prostat Dis"},{"key":"10.1016\/j.euf.2025.10.004_b0125","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/pros.24288","article-title":"Comparison of transperineal and transrectal targeted prostate biopsy using Mahalanobis distance matching within propensity score caliper method: a multicenter study of Turkish Urooncology Association","volume":"82","author":"Koparal","year":"2022","journal-title":"Prostate"},{"key":"10.1016\/j.euf.2025.10.004_b0130","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41391-022-00641-3","article-title":"The transition from transrectal to transperineal prostate biopsy without antibiotic prophylaxis: cancer detection rates and complication rates","volume":"26","author":"Hogenhout","year":"2023","journal-title":"Prostate Cancer Prostat Dis"},{"key":"10.1016\/j.euf.2025.10.004_b0135","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1097\/JU.0000000000001523","article-title":"Transperineal prostate biopsy improves the detection of clinically significant prostate cancer among men on active surveillance","volume":"205","author":"Meyer","year":"2021","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2025.10.004_b0140","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/aja.2011.130","article-title":"The results of transperineal versus transrectal prostate biopsy: a systematic review and meta-analysis","volume":"14","author":"Shen","year":"2012","journal-title":"Asian J Androl"},{"key":"10.1016\/j.euf.2025.10.004_b0145","doi-asserted-by":"crossref","first-page":"13457","DOI":"10.1038\/s41598-023-40371-7","article-title":"Transperineal vs transrectal magnetic resonance and ultrasound image fusion prostate biopsy: a pair-matched comparison","volume":"13","author":"Kaneko","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.euf.2025.10.004_b0150","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/cam4.1300","article-title":"Mechanism underlying the negative effect of prostate volume on the outcome of extensive transperineal ultrasound-guided template prostate biopsy","volume":"7","author":"Demura","year":"2018","journal-title":"Cancer Med"},{"key":"10.1016\/j.euf.2025.10.004_b0155","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/bju.13649","article-title":"Lesion volume predicts prostate cancer risk and aggressiveness: validation of its value alone and matched with prostate imaging reporting and data system score","volume":"120","author":"Martorana","year":"2017","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2025.10.004_b0160","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/bju.15997","article-title":"Standardized prostate cancer incidence and mortality rates following initial non-malignant biopsy result","volume":"132","author":"Stroomberg","year":"2023","journal-title":"BJU Int"}],"container-title":["European Urology Focus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456925002901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456925002901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:59:54Z","timestamp":1773745194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405456925002901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2405456925002901"],"URL":"https:\/\/doi.org\/10.1016\/j.euf.2025.10.004","relation":{},"ISSN":["2405-4569"],"issn-type":[{"value":"2405-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of Cancer Detection Between Transrectal and Transperineal Prostate Biopsy in an Active Surveillance Cohort","name":"articletitle","label":"Article Title"},{"value":"European Urology Focus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euf.2025.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of European Association of Urology.","name":"copyright","label":"Copyright"}]}}