{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:45:34Z","timestamp":1792154734046,"version":"4.4.0"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","eu-focus.europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology Focus"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.euf.2026.09.007","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:49:58Z","timestamp":1792151398000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Active Surveillance for Intermediate-risk Prostate Cancer: Implications of AI-enabled Pattern Quantification"],"prefix":"10.1016","author":[{"given":"Gesa","family":"Mittmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick C.N.","family":"van den Bergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samson W.","family":"Fine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-5919","authenticated-orcid":false,"given":"Titus J.","family":"Brinker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euf.2026.09.007_b0005","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1056\/NEJMoa2406050","article-title":"Results after four years of screening for prostate cancer with PSA and MRI","volume":"391","author":"Hugosson","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.euf.2026.09.007_b0010","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa2214122","article-title":"Fifteen-year outcomes after monitoring, surgery, or radiotherapy for prostate cancer","volume":"388","author":"Hamdy","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.euf.2026.09.007_b0015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.eururo.2021.12.007","article-title":"Systematic review of active surveillance for clinically localised prostate cancer to develop recommendations regarding inclusion of intermediate-risk disease, biopsy characteristics at inclusion and monitoring, and surveillance repeat biopsy strategy","volume":"81","author":"Willemse","year":"2022","journal-title":"Eur Urol"},{"key":"10.1016\/j.euf.2026.09.007_b0020","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/bju.16884","article-title":"Quantification of prostate cancer Gleason pattern 4 to predict oncological outcome","volume":"136","author":"Olivier","year":"2025","journal-title":"BJU Int"},{"key":"10.1016\/j.euf.2026.09.007_b0025","doi-asserted-by":"crossref","unstructured":"Pickersgill NA, Fletcher SA, Aiken N, et al. Total Gleason Pattern 4 length outperforms grade group and clinical models in predicting oncologic outcomes in grade Group 2\u20134 prostate cancer. medRxiv, https:\/\/doi.org\/10.64898\/2026.02.27.26347289.","DOI":"10.64898\/2026.02.27.26347289"},{"key":"10.1016\/j.euf.2026.09.007_b0030","doi-asserted-by":"crossref","DOI":"10.1097\/01.JU.0001191468.48904.a0.08","article-title":"IP31-08 re-evaluating active surveillance eligibility in prostate cancer based on Gleason Pattern 4 quantification","volume":"215","author":"Fletcher","year":"2026","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2026.09.007_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.clgc.2024.102204","article-title":"Quantification of Gleason Pattern 4 metrics identifies pathologic progression in patients with grade Group 2 prostate cancer on active surveillance","volume":"22","author":"Perera","year":"2024","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.euf.2026.09.007_b0040","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41391-022-00600-y","article-title":"Oncological outcomes of cribriform histology pattern in prostate cancer patients: a systematic review and meta-analysis","volume":"26","author":"Russo","year":"2023","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.euf.2026.09.007_b0045","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/JU.0000000000004919","article-title":"Whole-slide telepathology grading of prostate cancer in biopsies using International Society of Urological Pathology criteria: interobserver and intraobserver concordance and implications for active surveillance","volume":"215","author":"Lucia","year":"2026","journal-title":"J Urol"},{"key":"10.1016\/j.euf.2026.09.007_b0050","doi-asserted-by":"crossref","first-page":"8959","DOI":"10.1038\/s41467-025-64712-4","article-title":"Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer","volume":"16","author":"Mittmann","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.euf.2026.09.007_b0055","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.euros.2026.03.016","article-title":"Finding holes: pathologist-level performance using AI for cribriform morphology detection in prostate cancer","volume":"87","author":"Szolnoky","year":"2026","journal-title":"Eur Urol Open Sci"},{"key":"10.1016\/j.euf.2026.09.007_b0060","doi-asserted-by":"crossref","unstructured":"Buzoianu MM, Yu R, Assel M, et al. Comparing Gleason Pattern 4 measurement approaches on prostate biopsy using machine learning: a proof-of-principle study. medRxiv, https:\/\/doi.org\/10.64898\/2026.04.23.26351615.","DOI":"10.64898\/2026.04.23.26351615"}],"container-title":["European Urology Focus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456926002208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405456926002208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:50:00Z","timestamp":1792151400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405456926002208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":12,"alternative-id":["S2405456926002208"],"URL":"https:\/\/doi.org\/10.1016\/j.euf.2026.09.007","relation":{},"ISSN":["2405-4569"],"issn-type":[{"value":"2405-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Active Surveillance for Intermediate-risk Prostate Cancer: Implications of AI-enabled Pattern Quantification","name":"articletitle","label":"Article Title"},{"value":"European Urology Focus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euf.2026.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology.","name":"copyright","label":"Copyright"}]}}