{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:45:30Z","timestamp":1791661530634,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["euoncology.europeanurology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Urology Oncology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.euo.2019.08.008","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T17:28:13Z","timestamp":1567790893000},"page":"648-656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Prebiopsy IMPROD Biparametric Magnetic Resonance Imaging Combined with Prostate-Specific Antigen Density in the Diagnosis of Prostate Cancer: An External Validation Study"],"prefix":"10.1016","volume":"3","author":[{"given":"Juha","family":"Knaapila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Jambor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana Montoya","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Ettala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8849-4604","authenticated-orcid":false,"given":"Pekka","family":"Taimen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Verho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5376-8270","authenticated-orcid":false,"given":"Aida","family":"Kiviniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-2455","authenticated-orcid":false,"given":"Tapio","family":"Pahikkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Merisaari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Lamminen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-1105","authenticated-orcid":false,"given":"Jani","family":"Saunavaara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu J.","family":"Aronen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-7471","authenticated-orcid":false,"given":"Kari T.","family":"Syv\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Bostr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euo.2019.08.008_bib0005","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1001\/jama.2017.1704","article-title":"Association between radiation therapy, surgery, or observation for localized prostate cancer and patient-reported outcomes after 3 years","volume":"317","author":"Barocas","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.euo.2019.08.008_bib0010","series-title":"EAU-ESTRO-ESUR-SIOG guidelines on prostate cancer 2018","author":"Mottet","year":"2018"},{"key":"10.1016\/j.euo.2019.08.008_bib0015","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.eururo.2015.06.046","article-title":"A contemporary prostate cancer grading system: a validated alternative to the Gleason score","volume":"69","author":"Epstein","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.euo.2019.08.008_bib0020","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.humpath.2018.01.027","article-title":"New prostate cancer grade grouping system predicts survival after radical prostatectomy","volume":"75","author":"Erickson","year":"2018","journal-title":"Hum Pathol"},{"key":"10.1016\/j.euo.2019.08.008_bib0025","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.eururo.2012.04.024","article-title":"Individualized estimation of the benefit of radical prostatectomy from the Scandinavian Prostate Cancer group randomized trial","volume":"62","author":"Vickers","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.euo.2019.08.008_bib0030","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","article-title":"Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study","volume":"389","author":"Ahmed","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.euo.2019.08.008_bib0035","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s00330-013-2795-0","article-title":"Influence of imaging and histological factors on prostate cancer detection and localisation on multiparametric MRI: a prospective study","volume":"23","author":"Bratan","year":"2013","journal-title":"Eur Radiol"},{"key":"10.1016\/j.euo.2019.08.008_bib0040","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1056\/NEJMoa1801993","article-title":"MRI-targeted or standard biopsy for prostate-cancer diagnosis","volume":"378","author":"Kasivisvanathan","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.euo.2019.08.008_bib0045","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/jmri.24682","article-title":"Prebiopsy multiparametric 3T prostate MRI in patients with elevated PSA, normal digital rectal examination, and no previous biopsy","volume":"41","author":"Jambor","year":"2015","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.euo.2019.08.008_bib0050","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1470-2045(18)30569-2","article-title":"Use of prostate systematic and targeted biopsy on the basis of multiparametric MRI in biopsy-naive patients (MRI-FIRST): a prospective, multicentre, paired diagnostic study","volume":"20","author":"Rouvi\u00e8re","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.euo.2019.08.008_bib0055","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.eururo.2018.11.023","volume":"75","author":"van der Leest","year":"2019","journal-title":"Eur Urol"},{"key":"10.1016\/j.euo.2019.08.008_bib0060","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.eururo.2017.02.026","article-title":"What is the negative predictive value of multiparametric magnetic resonance imaging in excluding prostate cancer at biopsy? A systematic review and meta-analysis from the European Association of Urology Prostate Cancer guidelines Panel","volume":"72","author":"Moldovan","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.euo.2019.08.008_bib0065","article-title":"Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer","volume":"2019","author":"Drost","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.euo.2019.08.008_bib0070","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.0219","article-title":"Assessment of the diagnostic accuracy of biparametric magnetic resonance imaging for prostate cancer in biopsy-naive men: the Biparametric MRI for Detection of Prostate Cancer (BIDOC) study","volume":"1","author":"Boesen","year":"2018","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.euo.2019.08.008_bib0075","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/jmri.25641","article-title":"Novel biparametric MRI and targeted biopsy improves risk stratification in men with a clinical suspicion of prostate cancer (IMPROD trial)","volume":"46","author":"Jambor","year":"2017","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.euo.2019.08.008_bib0080","article-title":"Biparametric versus multiparametric MRI in the diagnosis of prostate cancer","volume":"5","author":"Thestrup","year":"2016","journal-title":"Acta Radiol Open"},{"key":"10.1016\/j.euo.2019.08.008_bib0085","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/bju.12639","article-title":"Diagnostic value of biparametric magnetic resonance imaging (MRI) as an adjunct to prostate-specific antigen (PSA)-based detection of prostate cancer in men without prior biopsies","volume":"115","author":"Rais-Bahrami","year":"2015","journal-title":"BJU Int"},{"key":"10.1016\/j.euo.2019.08.008_bib0090","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.euo.2018.09.001","article-title":"Prebiopsy biparametric magnetic resonance imaging combined with prostate-specific antigen density in detecting and ruling out Gleason 7\u201310 prostate cancer in biopsy-na\u00efve men","volume":"2","author":"Boesen","year":"2019","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.euo.2019.08.008_bib0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.eururo.2015.08.052","article-title":"PI-RADS prostate imaging-reporting and data system: 2015, version 2","volume":"69","author":"Weinreb","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.euo.2019.08.008_bib0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/bju.13465","article-title":"Combination of Prostate Imaging Reporting and Data System (PI-RADS) score and prostate-specific antigen (PSA) density predicts biopsy outcome in prostate biopsy na\u00efve patients","volume":"119","author":"Washino","year":"2017","journal-title":"BJU Int"},{"key":"10.1016\/j.euo.2019.08.008_bib0105","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.juro.2017.03.130","article-title":"The value of PSA density in combination with PI-RADS\u2122 for the accuracy of prostate cancer prediction","volume":"198","author":"Distler","year":"2017","journal-title":"J Urol"},{"key":"10.1016\/j.euo.2019.08.008_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002813","article-title":"Validation of IMPROD biparametric MRI in men with clinically suspected prostate cancer: a prospective multi-institutional trial","volume":"16","author":"Jambor","year":"2019","journal-title":"PLoS Med"},{"key":"10.1016\/j.euo.2019.08.008_bib0115","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/PAS.0000000000000530","article-title":"The 2014 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma: definition of grading patterns and proposal for a new grading system","volume":"40","author":"Epstein","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.euo.2019.08.008_bib0120","article-title":"DTComPair: comparison of binary diagnostic tests in a paired study design","author":"Stock","year":"2019","journal-title":"R package version"},{"key":"10.1016\/j.euo.2019.08.008_bib0125","doi-asserted-by":"crossref","first-page":"i6","DOI":"10.1136\/bmj.i6","article-title":"Net benefit approaches to the evaluation of prediction models, molecular markers, and diagnostic tests","volume":"352","author":"Vickers","year":"2016","journal-title":"Br Med J"},{"key":"10.1016\/j.euo.2019.08.008_bib0130","author":"R Computing Team"},{"key":"10.1016\/j.euo.2019.08.008_bib0135","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.urology.2017.04.015","article-title":"Re-examining prostate-specific antigen (PSA) density: defining the optimal PSA range and patients for using PSA density to predict prostate cancer using extended template biopsy","volume":"105","author":"Jue","year":"2017","journal-title":"Urology"},{"key":"10.1016\/j.euo.2019.08.008_bib0140","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41391-017-0024-7","article-title":"Prostate-specific antigen (PSA) density in the diagnostic algorithm of prostate cancer","volume":"21","author":"Nordstr\u00f6m","year":"2018","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.euo.2019.08.008_bib0145","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1056\/NEJMoa031918","article-title":"Prevalence of prostate cancer among men with a prostate-specific antigen level \u22644.0\u202fng per milliliter","volume":"350","author":"Thompson","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.euo.2019.08.008_bib0150","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.urology.2018.06.011","article-title":"Cognitive versus software fusion for MRI targeted biopsy: experience before and after implementation of fusion","volume":"119","author":"Monda","year":"2018","journal-title":"Urology"},{"key":"10.1016\/j.euo.2019.08.008_bib0155","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.eururo.2018.11.040","article-title":"The FUTURE trial: a multicenter randomised controlled trial on target biopsy techniques based on magnetic resonance imaging in the diagnosis of prostate cancer in patients with prior negative biopsies","volume":"75","author":"Wegelin","year":"2019","journal-title":"Eur Urol"}],"container-title":["European Urology Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2588931119301348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2588931119301348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:46:04Z","timestamp":1762875964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2588931119301348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S2588931119301348"],"URL":"https:\/\/doi.org\/10.1016\/j.euo.2019.08.008","relation":{},"ISSN":["2588-9311"],"issn-type":[{"value":"2588-9311","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prebiopsy IMPROD Biparametric Magnetic Resonance Imaging Combined with Prostate-Specific Antigen Density in the Diagnosis of Prostate Cancer: An External Validation Study","name":"articletitle","label":"Article Title"},{"value":"European Urology Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euo.2019.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Association of Urology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}