{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:49:23Z","timestamp":1762112963803},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Contemporary ionic-based membrane models are computationally expensive and are not intended to match the properties of a given experimental preparation. The aim of this work was to use measured restitution properties of electrically remodelled atrial tissue to develop a simplified membrane model based on the Fenton\u2013Karma (FK) equations amenable to large-scale simulation of chronic atrial fibrillation (CAF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Two membrane models, the FK-CAF and FK-CNTRL parameter sets, were developed to match action potential duration (APD) and conduction velocity (CV) restitution properties of rapid-pacing-induced electrically remodelled sheep atria and healthy atria, respectively. The models were tested by inducing reentry in a two-dimensional anisotropic monodomain and comparing the resulting cycle lengths (CL) with measured CLs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Parameters for the FK models were obtained that reproduced APD and CV restitution properties measured in the CAF and healthy sheep atria. Using the FK-CAF parameters, reentry was sustained in a 2.5 by 2.5\u2009cm sheet with a CL = 91.0 \u00b1 3.0\u2009ms. Reentry (CL = 113.2 \u00b1 5.2\u2009ms) could only be sustained in the FK-CNTRL model after the tissue was first activated at a fast rate (136.5\u2009ms).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The FK-CAF model is shown to approximate the restitution properties of remodelled sheep atria and can be used to simulate reentry with short CLs similar to those measured during AF episodes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.eupc.2005.04.010","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T20:49:16Z","timestamp":1123102156000},"page":"S135-S145","source":"Crossref","is-referenced-by-count":15,"title":["A membrane model of electrically remodelled atrial myocardium derived from in vivo measurements*"],"prefix":"10.1093","volume":"7","author":[{"given":"Amy M.","family":"Goodman","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Duke University P.O. 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