{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:54:38Z","timestamp":1791410078359,"version":"4.3.3"},"reference-count":48,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Neuropsychopharmacology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.euroneuro.2012.01.007","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T02:32:03Z","timestamp":1329791523000},"page":"632-640","source":"Crossref","is-referenced-by-count":26,"title":["Polymorphisms in AKR1C4 and HSD3B2 and differences in serum DHEAS and progesterone are associated with paranoid ideation during mania or hypomania in bipolar disorder"],"prefix":"10.1016","volume":"22","author":[{"given":"Anette G.M.","family":"Johansson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernilla","family":"Nikamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schalling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Land\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euroneuro.2012.01.007_bb0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0165-0327(02)00318-X","article-title":"Proposed multidimensional structure of mania: beyond the euphoric\u2013dysphoric dichotomy","volume":"73","author":"Akiskal","year":"2003","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0010","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1124\/jpet.110.173179","article-title":"Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin","volume":"335","author":"Bains","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0015","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1081\/ERC-200043715","article-title":"A role for the NGFI-B family in adrenal zonation and adrenocortical disease","volume":"30","author":"Bassett","year":"2004","journal-title":"Endocr. Res."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0025","first-page":"S36","article-title":"From neuroprogression to neuroprotection: implications for clinical care","volume":"193","author":"Berk","year":"2010","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0030","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/0024-3205(92)90563-5","article-title":"The effects of metabolic stress on plasma progesterone in healthy volunteers and schizophrenic patients","volume":"51","author":"Breier","year":"1992","journal-title":"Life Sci."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0040","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1399-5618.2009.00760.x","article-title":"The role of dopamine in bipolar disorder","volume":"11","author":"Cousins","year":"2009","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0045","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.neuropharm.2006.10.015","article-title":"Neurosteroid dehydroepiandrosterone sulfate enhances spontaneous glutamate release in rat prelimbic cortex through activation of dopamine D1 and sigma-1 receptor","volume":"52","author":"Dong","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0050","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/gepi.10252","article-title":"Pedigree disequilibrium tests for multilocus haplotypes","volume":"25","author":"Dudbridge","year":"2003","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0055","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/JCP.0b013e318166c4d5","article-title":"Antipsychotic-induced extrapyramidal side effects in bipolar disorder and schizophrenia: a systematic review","volume":"28","author":"Gao","year":"2008","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb8000","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/01.nmd.0000243763.81487.4d","article-title":"Course of illness in psychotic mania: is mood incongruence important?","volume":"195","author":"Gaudiano","year":"2007","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb8005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ajmg.b.30189","article-title":"Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia","volume":"136B","author":"Gelernter","year":"2005","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0060","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.biopsych.2006.04.023","article-title":"Nur77 gene knockout alters dopamine neuron biochemical activity and dopamine turnover","volume":"60","author":"Gilbert","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0065","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1176\/ajp.2007.164.2.236","article-title":"Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33","volume":"164","author":"Goes","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0075","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1210\/jc.2006-0227","article-title":"Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women","volume":"91","author":"Goodarzi","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0080","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10549-011-1772-z","article-title":"Polymorphism Thr160Thr in SRD5A1, involved in the progesterone metabolism, modifies postmenopausal breast cancer risk associated with menopausal hormone therapy","volume":"131","author":"Hein","year":"2011","journal-title":"Breast cancer research and treatment"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0085","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0006-8993(91)90384-8","article-title":"Changes in brain dopamine and acetylcholine release during and following stress are independent of the pituitary-adrenocortical axis","volume":"538","author":"Imperato","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0090","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jad.2011.04.009","article-title":"AKR1C4 gene variant associated with low euthymic serum progesterone and a history of mood irritability in males with bipolar disorder","volume":"133","author":"Johansson","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0095","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.biopsych.2006.08.012","article-title":"Dopamine beta-hydroxylase gene (DbetaH)-1021C\u2013>T influences self-reported paranoia during cocaine self-administration","volume":"61","author":"Kalayasiri","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0100","doi-asserted-by":"crossref","first-page":"R336","DOI":"10.1186\/bcr999","article-title":"Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study","volume":"7","author":"Lord","year":"2005","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0105","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jad.2006.11.013","article-title":"Plasma testosterone and dehydroepiandrosterone sulfate in male and female patients with dysthymic disorder","volume":"101","author":"Markianos","year":"2007","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00406-007-0790-7","article-title":"Bipolar I disorder with mood-incongruent psychotic symptoms: a comparative longitudinal study","volume":"259","author":"Marneros","year":"2009","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.npp.1300015","article-title":"Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents","volume":"28","author":"Marx","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0120","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/j.1530-0277.2010.01425.x","article-title":"Variation in genes encoding the neuroactive steroid synthetic enzymes 5alpha-reductase type 1 and 3alpha-reductase type 2 is associated with alcohol dependence","volume":"35","author":"Milivojevic","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0125","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1200\/JCO.2009.27.2153","article-title":"Chlordecone exposure and risk of prostate cancer","volume":"28","author":"Multigner","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0265","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/syn.20076","article-title":"Differences in the cellular distribution of D1 receptor mRNA in the hippocampus of bipolars and schizophrenics","volume":"54","author":"Pantazopoulos","year":"2004","journal-title":"Synapse"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0135","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mce.2003.11.006","article-title":"Structure\u2013function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins","volume":"215","author":"Penning","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0140","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0145","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.euroneuro.2005.07.007","article-title":"Alterations in DHEA metabolism in schizophrenia: two-month case\u2013control study","volume":"16","author":"Ritsner","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0150","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.1523\/JNEUROSCI.15-11-07189.1995","article-title":"Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion","volume":"15","author":"Roug\u00e9-Pont","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0155","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0006-3223(03)00165-3","article-title":"Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)","volume":"53","author":"Sachs","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0160","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1046\/j.1471-4159.1998.70062539.x","article-title":"Functional changes in rat nigral GABA(A) receptors induced by degeneration of the striatonigral GABAergic pathway: an electrophysiological study of receptors incorporated into Xenopus oocytes","volume":"70","author":"Sanna","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0165","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1176\/appi.ajp.159.6.968","article-title":"Syndromes and phenomenological subtypes underlying acute mania: a factor analytic study of 576 manic patients","volume":"159","author":"Sato","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0170","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1034\/j.1600-0447.2003.00194.x","article-title":"Long-term inter-episode stability of syndromes underlying mania","volume":"108","author":"Sato","year":"2003","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0175","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/sj.mp.4001782","article-title":"Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity","volume":"11","author":"Schule","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0185","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1176\/appi.ajp.162.11.2101","article-title":"Genotype-phenotype studies in bipolar disorder showing association between the DAOA\/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes","volume":"162","author":"Schulze","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0180","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1001\/archpsyc.63.12.1368","article-title":"What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics","volume":"63","author":"Schulze","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0195","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1158\/1055-9965.EPI-09-1018","article-title":"Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer","volume":"19","author":"Setlur","year":"2010","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"Suppl 20","key":"10.1016\/j.euroneuro.2012.01.007_bb0275","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0205","doi-asserted-by":"crossref","first-page":"10784","DOI":"10.1074\/jbc.M313308200","article-title":"Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action","volume":"279","author":"Steckelbroeck","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0210","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.pnpbp.2010.08.013","article-title":"SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders","volume":"34","author":"Steen","year":"2010","journal-title":"Prog. Neuropsychopharmacol Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0215","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.schres.2004.03.005","article-title":"Increased circulatory dehydroepiandrosterone and dehydroepiandrosterone-sulphate in first-episode schizophrenia: relationship to gender, aggression and symptomatology","volume":"71","author":"Strous","year":"2004","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0220","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF02253582","article-title":"D1 dopamine receptor binding in mood disorders measured by positron emission tomography","volume":"106","author":"Suhara","year":"1992","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0225","first-page":"3","article-title":"Evaluation of serum steroid hormones in schizophrenic patients","volume":"58","author":"Taherianfard","year":"2004","journal-title":"Indian J. Med. Sci."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0230","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/ijc.26162","article-title":"Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)","volume":"130","author":"Ter-Minassian","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1447-073x.2005.00098.x","article-title":"Topography and function of androgen-metabolizing enzymes in the central nervous system","volume":"80","author":"Tsuruo","year":"2005","journal-title":"Anat. Sci. Int."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0245","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0006-3223(01)01367-1","article-title":"A polymorphism in the dopamine beta-hydroxylase gene is associated with \u201cparanoid ideation\u201d in patients with major depression","volume":"51","author":"Wood","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0250","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.schres.2005.11.006","article-title":"Reduction of dopamine-related transcription factors Nurr1 and NGFI-B in the prefrontal cortex in schizophrenia and bipolar disorders","volume":"84","author":"Xing","year":"2006","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.euroneuro.2012.01.007_bb0255","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0303-7207(02)00041-2","article-title":"Steroidogenic enzyme gene expression in the human brain","volume":"190","author":"Yu","year":"2002","journal-title":"Mol. Cell. Endocrinol."}],"container-title":["European Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X12000259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X12000259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T01:18:26Z","timestamp":1561339106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924977X12000259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0924977X12000259"],"URL":"https:\/\/doi.org\/10.1016\/j.euroneuro.2012.01.007","relation":{},"ISSN":["0924-977X"],"issn-type":[{"value":"0924-977X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}