{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:45:35Z","timestamp":1791085535604,"version":"4.1.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Neuropsychopharmacology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.euroneuro.2012.01.008","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T05:00:51Z","timestamp":1330405251000},"page":"672-682","source":"Crossref","is-referenced-by-count":62,"title":["Hippocampus-specific deletion of tissue plasminogen activator \u201ctPA\u201d in adult mice impairs depression- and anxiety-like behaviors"],"prefix":"10.1016","volume":"22","author":[{"given":"Amine","family":"Bahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Dreyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euroneuro.2012.01.008_bb0005","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1254\/jjp.76.297","article-title":"Effect of 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl) amino]propoxy]-1,3-benzodioxole HCl (MKC-242), a novel 5-HT1A-receptor agonist, on aggressive behavior and marble burying behavior in mice","volume":"76","author":"Abe","year":"1998","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0040","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1601-183X.2007.00346.x","article-title":"Overexpression of plasminogen activators in the nucleus accumbens enhances cocaine-, amphetamine- and morphine-induced reward and behavioral sensitization","volume":"7","author":"Bahi","year":"2008","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0045","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbr.2011.09.024","article-title":"Involvement of tissue plasminogen activator \u201ctPA\u201d in ethanol-induced locomotor sensitization and conditioned-place preference","volume":"226","author":"Bahi","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0020","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1111\/j.1460-9568.2004.03771.x","article-title":"In vivo gene delivery of urokinase-type plasminogen activator with regulatable lentivirus induces behavioural changes in chronic cocaine administration","volume":"20","author":"Bahi","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0025","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/j.1460-9568.2004.03260.x","article-title":"CD81-induced behavioural changes during chronic cocaine administration: in vivo gene delivery with regulatable lentivirus","volume":"19","author":"Bahi","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0010","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1111\/j.1460-9568.2005.04157.x","article-title":"Silencing dopamine D3-receptors in the nucleus accumbens shell in vivo induces changes in cocaine-induced hyperlocomotion","volume":"21","author":"Bahi","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0035","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1471-4159.2004.02961.x","article-title":"In vivo gene silencing of CD81 by lentiviral expression of small interference RNAs suppresses cocaine-induced behaviour","volume":"92","author":"Bahi","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0030","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1111\/j.1471-4159.2006.04013.x","article-title":"Silencing urokinase in the ventral tegmental area in vivo induces changes in cocaine-induced hyperlocomotion","volume":"98","author":"Bahi","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00213-008-1164-1","article-title":"Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in rats","volume":"199","author":"Bahi","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0050","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1038\/sj.npp.1301668","article-title":"The role of tissue-type plasminogen activator system in amphetamine-induced conditional place preference extinction and reinstatement","volume":"33","author":"Bahi","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbr.2008.03.004","article-title":"Effects of urokinase-type plasminogen activator in the acquisition, expression and reinstatement of cocaine-induced conditioned-place preference","volume":"191","author":"Bahi","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0060","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.biopsych.2009.07.004","article-title":"Blockade of protein phosphatase 2B activity in the amygdala increases anxiety- and depression-like behaviors in mice","volume":"66","author":"Bahi","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0065","doi-asserted-by":"crossref","first-page":"e3248","DOI":"10.1371\/journal.pone.0003248","article-title":"Proteolysis of proBDNF is a key regulator in the formation of memory","volume":"3","author":"Barnes","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0070","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuroscience.2006.08.075","article-title":"Stress-induced spine loss in the medial amygdala is mediated by tissue-plasminogen activator","volume":"144","author":"Bennur","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0075","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0022-3565(25)20244-0","article-title":"Anxiolytic activity of steroid anesthetic alphaxalone","volume":"258","author":"Britton","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0080","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/BF02246029","article-title":"GABAmimetic agents display anxiolytic-like effects in the social interaction and elevated plus maze procedures","volume":"104","author":"Corbett","year":"1991","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0090","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/jcp.1041430222","article-title":"Tissue plasminogen activator messenger RNA levels increase in cultured human endothelial cells exposed to laminar shear stress","volume":"143","author":"Diamond","year":"1990","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0085","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1034\/j.1399-5618.2002.01203.x","article-title":"Antidepressants and neuroplasticity","volume":"4","author":"D'Sa","year":"2002","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(89)90811-X","article-title":"Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze","volume":"169","author":"Dunn","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0100","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/da.20378","article-title":"Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders","volume":"25","author":"Enoch","year":"2008","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0105","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00213-005-2190-x","article-title":"Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats","volume":"180","author":"Fernandez-Guasti","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0110","series-title":"The mouse brain in stereotaxic coordinates","author":"Franklin","year":"1996"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0115","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbr.2011.03.012","article-title":"Depressive-like behaviour of mice lacking cellular prion protein","volume":"227","author":"Gadotti","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0120","first-page":"407","article-title":"Animal model of anxiety: effect of acute diazepam treatment in the older adult genetically hypertensive rats of Koletsky type and in the older adult rats of Wistar strain","volume":"32","author":"Golda","year":"1989","journal-title":"Sb. Ved. Pr. Lek. Fak. Karlovy Univerzity Hradci Kralove"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0125","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1101\/lm.428307","article-title":"Mutation at the TrkB PLC {gamma}-docking site affects hippocampal LTP and associative learning in conscious mice","volume":"14","author":"Gruart","year":"2007","journal-title":"Learn. Mem."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0130","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.neuropharm.2011.02.009","article-title":"Characterization of 5-HT (1A\/1B)\u2212\/\u2212 mice: an animal model sensitive to anxiolytic treatments","volume":"61","author":"Guilloux","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0135","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s004210000299","article-title":"Acute psychological stress decreases plasma tissue plasminogen activator (tPA) and tissue plasminogen activator\/plasminogen activator inhibitor-1 (tPA\/PAI-1) complexes in cardiac patients","volume":"83","author":"Hevey","year":"2000","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0140","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.mehy.2008.09.009","article-title":"Is dysfunction of the tissue plasminogen activator (tPA)-plasmin pathway a link between major depression and cardiovascular disease?","volume":"72","author":"Hou","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/096368979200100108","article-title":"Tissue plasminogen activator expression in endothelial cells exposed to cyclic strain in vitro","volume":"1","author":"Iba","year":"1992","journal-title":"Cell Transplant."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0150","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbr.2011.03.029","article-title":"The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats","volume":"222","author":"Karakas","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"Suppl. 1","key":"10.1016\/j.euroneuro.2012.01.008_bb0155","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1399-5618.2007.00478.x","article-title":"Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology","volume":"9","author":"Kauer-Sant'Anna","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0160","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pnpbp.2006.06.024","article-title":"Low plasma BDNF is associated with suicidal behavior in major depression","volume":"31","author":"Kim","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0165","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.pnpbp.2005.04.010","article-title":"Serum brain-derived neurotrophic factor (BDNF) levels in patients with panic disorder: as a biological predictor of response to group cognitive behavioral therapy","volume":"29","author":"Kobayashi","year":"2005","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0170","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00213-004-2137-7","article-title":"Association of a functional BDNF polymorphism and anxiety-related personality traits","volume":"180","author":"Lang","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0175","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jad.2006.11.005","article-title":"Decreased plasma BDNF level in depressive patients","volume":"101","author":"Lee","year":"2007","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0180","doi-asserted-by":"crossref","first-page":"C387","DOI":"10.1152\/ajpcell.1993.265.2.C387","article-title":"Hyperosmotic stress stimulates tissue plasminogen activator expression by a PKC-independent pathway","volume":"265","author":"Levin","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0185","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neuron.2008.06.023","article-title":"TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment","volume":"59","author":"Li","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0190","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1124\/jpet.108.143610","article-title":"Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)","volume":"327","author":"Liang","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0195","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0200","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/mp.2011.36","article-title":"Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala","volume":"16","author":"Liu","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0205","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/neu.20250","article-title":"Activity-dependent release of tissue plasminogen activator from the dendritic spines of hippocampal neurons revealed by live-cell imaging","volume":"66","author":"Lochner","year":"2006","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0210","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.nbd.2007.12.010","article-title":"Protease-activated receptor-2 regulates trypsin expression in the brain and protects against seizures and epileptogenesis","volume":"30","author":"Lohman","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0215","doi-asserted-by":"crossref","first-page":"15239","DOI":"10.1073\/pnas.96.26.15239","article-title":"Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities","volume":"96","author":"Lyons","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0220","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jpsychires.2008.03.014","article-title":"Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine","volume":"43","author":"Matrisciano","year":"2009","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0225","doi-asserted-by":"crossref","first-page":"16345","DOI":"10.1073\/pnas.0407355101","article-title":"Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior","volume":"101","author":"Matys","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0230","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1160\/TH04-12-0838","article-title":"Tissue plasminogen activator in central nervous system physiology and pathology","volume":"93","author":"Melchor","year":"2005","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0235","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00406-011-0189-3","article-title":"BDNF serum levels, but not BDNF Val66Met genotype, are correlated with personality traits in healthy subjects","volume":"261","author":"Minelli","year":"2011","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0240","first-page":"679","article-title":"Stress at work alters serum brain-derived neurotrophic factor (BDNF) levels and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in healthy volunteers: BDNF and MHPG as possible biological markers of mental stress?","volume":"32","author":"Mitoma","year":"2008","journal-title":"'acol. Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0245","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.psychres.2008.08.005","article-title":"The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans","volume":"179","author":"Montag","year":"2010","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0250","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/BF00634451","article-title":"An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone","volume":"99","author":"Moser","year":"1989","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0255","doi-asserted-by":"crossref","first-page":"10131","DOI":"10.1523\/JNEUROSCI.1707-09.2009","article-title":"TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites","volume":"29","author":"Musumeci","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0260","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1254\/jphs.08R04FM","article-title":"Basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tPA)\u2014plasmin system via proteinase-activated receptor 1","volume":"108","author":"Nagai","year":"2008","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0265","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1476-5381.1991.tb12392.x","article-title":"Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents","volume":"104","author":"Njung'e","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0270","doi-asserted-by":"crossref","first-page":"R1053","DOI":"10.1152\/ajpregu.00776.2010","article-title":"The lighter side of BDNF","volume":"300","author":"Noble","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0275","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1073\/pnas.1017608108","article-title":"Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice","volume":"108","author":"Noel","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0280","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/bit.260380605","article-title":"Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism","volume":"38","author":"Nollert","year":"1991","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0285","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0028-3908(88)90077-9","article-title":"Influence of oestrogen on spontaneous and diazepam-induced exploration of rats in an elevated plus maze","volume":"27","author":"Nomikos","year":"1988","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0290","first-page":"237","article-title":"BDNF function and intracellular signaling in neurons","volume":"25","author":"Numakawa","year":"2010","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0295","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuroscience.2007.12.032","article-title":"A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders","volume":"152","author":"Olivier","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0300","doi-asserted-by":"crossref","first-page":"12288","DOI":"10.1523\/JNEUROSCI.2655-10.2010","article-title":"Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null, Drd1a\u2212\/\u2212 mice and in hippocampal siRNA silenced Drd1a mice","volume":"30","author":"Ortiz","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0305","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1126\/science.1100135","article-title":"Cleavage of proBDNF by tPA\/plasmin is essential for long-term hippocampal plasticity","volume":"306","author":"Pang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0310","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/bjc.1996.512","article-title":"Up-regulation of urokinase-type plasminogen activator in squamous cell carcinoma of human larynx","volume":"74","author":"Parolini","year":"1996","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0315","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nn998","article-title":"Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior","volume":"6","author":"Pawlak","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0320","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0325","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0049-3848(91)90123-E","article-title":"Diurnal patterns of serotonin, 5-hydroxyindoleacetic acid, tryptophan and fibrinolytic activity in blood of depressive patients and healthy volunteers","volume":"64","author":"Pietraszek","year":"1991","journal-title":"Thromb. Res."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0330","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neulet.2011.09.066","article-title":"Ameliorative effect of BDNF on prenatal ethanol and stress exposure-induced behavioral disorders","volume":"505","author":"Popova","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0335","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainres.2009.12.095","article-title":"Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA\u2212\/\u2212) mice","volume":"1326","author":"Pothakos","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0340","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/361453a0","article-title":"Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation","volume":"361","author":"Qian","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0345","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/BF02244657","article-title":"Effect of diazepam on cortical 5-HT release and behaviour in the guinea-pig on exposure to the elevated plus maze","volume":"110","author":"Rex","year":"1993","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0350","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1210\/mend.15.10.0706","article-title":"Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity","volume":"15","author":"Rios","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0355","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1476-5381.2011.01489.x","article-title":"Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors","volume":"164","author":"Sales","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0360","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuroscience.2011.02.055","article-title":"The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA","volume":"180","author":"Sartori","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0365","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1038\/npp.2010.114","article-title":"Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models","volume":"35","author":"Schmidt","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0370","doi-asserted-by":"crossref","first-page":"14118","DOI":"10.1073\/pnas.96.24.14118","article-title":"Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene","volume":"96","author":"Seeds","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0375","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1440-1819.2010.02074.x","article-title":"Plasma BDNF and tPA are associated with late-onset geriatric depression","volume":"64","author":"Shi","year":"2010","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0380","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.pnpbp.2008.06.003","article-title":"Potential antidepressant properties of cysteamine on hippocampal BDNF levels and behavioral despair in mice","volume":"32","author":"Shieh","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0385","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/s-0037-1614010","article-title":"Fluid shear stress increases the intra-cellular storage pool of tissue-type plasminogen activator in intact human conduit vessels","volume":"84","author":"Sjogren","year":"2000","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0390","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.psyneuen.2009.07.013","article-title":"Acute exercise ameliorates reduced brain-derived neurotrophic factor in patients with panic disorder","volume":"35","author":"Strohle","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0395","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/bst0300183","article-title":"Tissue plasminogen activator as a key effector in neurobiology and neuropathology","volume":"30","author":"Teesalu","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0400","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.mehy.2005.10.009","article-title":"The possible role of tissue-type plasminogen activator and the plasminogen system in the pathogenesis of major depression","volume":"66","author":"Tsai","year":"2006","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0405","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.mehy.2006.06.005","article-title":"The P11, tPA\/plasminogen system and brain-derived neurotrophic factor: Implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants","volume":"68","author":"Tsai","year":"2007","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0410","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.mehy.2006.09.043","article-title":"Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression","volume":"68","author":"Tsai","year":"2007","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0415","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.ATV.17.8.1512","article-title":"Shear stress as an inhibitor of vascular smooth muscle cell proliferation. Role of transforming growth factor-beta 1 and tissue-type plasminogen activator","volume":"17","author":"Ueba","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0420","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbr.2011.04.031","article-title":"Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice","volume":"223","author":"Umathe","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0425","first-page":"15","article-title":"5-Lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior","volume":"20","author":"Uz","year":"2002","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0430","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1083\/jcb.148.6.1295","article-title":"The tissue plasminogen activator (tPA)\/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate","volume":"148","author":"Wu","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0440","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.bbrc.2006.01.172","article-title":"Shear stress contributes to t-PA mRNA expression in human endothelial progenitor cells and nonthrombogenic potential of small diameter artificial vessels","volume":"342","author":"Yang","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0435","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/gps.2552","article-title":"Low serum BDNF may indicate the development of PSD in patients with acute ischemic stroke","volume":"26","author":"Yang","year":"2011","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0445","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF02253593","article-title":"Anxiolytic effect of carbamazepine in the elevated plus-maze: possible role of adenosine","volume":"106","author":"Zangrossi","year":"1992","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0450","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3109\/10253891003786415","article-title":"Involvement of tissue plasminogen activator in stress responsivity during acute cocaine withdrawal in mice","volume":"13","author":"Zhou","year":"2010","journal-title":"Stress"},{"key":"10.1016\/j.euroneuro.2012.01.008_bb0455","doi-asserted-by":"crossref","first-page":"923","DOI":"10.2174\/092986708783955455","article-title":"Fibrinolysis: the key to new pathogenetic mechanisms","volume":"15","author":"Zorio","year":"2008","journal-title":"Curr. Med. Chem."}],"container-title":["European Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X12000260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X12000260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T23:23:40Z","timestamp":1742599420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924977X12000260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":91,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0924977X12000260"],"URL":"https:\/\/doi.org\/10.1016\/j.euroneuro.2012.01.008","relation":{},"ISSN":["0924-977X"],"issn-type":[{"value":"0924-977X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}