{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:41:01Z","timestamp":1789443661899,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["europeanneuropsychopharmacology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Neuropsychopharmacology"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.euroneuro.2012.06.008","type":"journal-article","created":{"date-parts":[[2012,7,7]],"date-time":"2012-07-07T06:36:48Z","timestamp":1341643008000},"page":"721-727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["P50 sensory gating is a trait marker of the bipolar spectrum"],"prefix":"10.1016","volume":"23","author":[{"given":"Jos\u00e9 A.","family":"Cabranes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Anc\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"S\u00e1nchez-Morla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A.","family":"Garc\u00eda-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rodr\u00edguez-Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Barabash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euroneuro.2012.06.008_bib1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0165-1781(90)90099-Q","article-title":"Sensory physiology and catecholamines in schizophrenia and mania","volume":"31","author":"Adler","year":"1990","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib2","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1176\/ajp.150.12.1856","article-title":"Normalization of auditory physiology by cigarette smoking in schizophrenic patients","volume":"150","author":"Adler","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3109\/15622975.2011.552192","article-title":"Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder","volume":"12","author":"Ancin","year":"2011","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.schres.2006.08.009","article-title":"Genetic and environmental influences on sensory gating of mid-latency auditory evoked responses: a twin study","volume":"89","author":"Anokhin","year":"2007","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jad.2010.11.020","article-title":"Differences between bipolar I and bipolar II disorders in clinical features, comorbidity, and family history","volume":"131","author":"Baek","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0006-3223(87)90188-0","article-title":"Neurophysiological assessment of sensory gating in psychiatric inpatients: comparison between schizophrenia and other diagnoses","volume":"22","author":"Baker","year":"1987","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1600-0447.2010.01638.x","article-title":"Meta-analytic review of neurocognition in bipolar II disorder","volume":"123","author":"Bora","year":"2011","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/155005949102200109","article-title":"Replication and extension of P50 findings in schizophrenia","volume":"22","author":"Boutros","year":"1991","journal-title":"Clin. Electroencephalogr."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1001\/archpsyc.1990.01810140081011","article-title":"Sensorimotor gating and schizophrenia. Human and animal model studies","volume":"47","author":"Braff","year":"1990","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.schres.2004.01.004","article-title":"Meta-analysis of the P300 and P50 waveforms in schizophrenia","volume":"70","author":"Bramon","year":"2004","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib11","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.pnpbp.2011.02.020","article-title":"Differential pattern of semantic memory organization between bipolar I and II disorders","volume":"35","author":"Chang","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib12","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1469-8986.2010.01168.x","article-title":"Probing the relative contribution of the first and second responses to sensory gating indices: a meta-analysis","volume":"48","author":"Chang","year":"2011","journal-title":"Psychophysiology"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.psychres.2010.12.009","article-title":"Differential sensory gating functions between smokers and non-smokers among drug-naive first episode schizophrenic patients","volume":"188","author":"Chen","year":"2011","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib14","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3940(01)02454-5","article-title":"Enhancement of auditory sensory gating and stimulus-bound gamma band (40Hz) oscillations in heavy tobacco smokers","volume":"317","author":"Crawford","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.psychres.2004.05.009","article-title":"Suppression of P50 evoked potential component, schizotypal beliefs and smoking","volume":"128","author":"Croft","year":"2004","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib17","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1111\/j.1469-8986.2011.01262.x","article-title":"An evaluation of P50 paired-click methodologies","volume":"48","author":"Dalecki","year":"2011","journal-title":"Psychophysiology"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib18","first-page":"989","article-title":"Neurophysiological studies of sensory gating in mania: comparison with schizophrenia","volume":"18","author":"Franks","year":"1983","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib19","first-page":"537","article-title":"Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients","volume":"18","author":"Freedman","year":"1983","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib20","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: etymology and strategic intentions","volume":"160","author":"Gottesman","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neulet.2009.03.077","article-title":"Regional brain gray matter abnormalities in patients with bipolar II disorder: a comparison study with bipolar I patients and healthy controls","volume":"456","author":"Ha","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/ajmg.b.30653","article-title":"Further evidence for shared genetic effects between psychotic bipolar disorder and P50 suppression: a combined twin and family study","volume":"147B","author":"Hall","year":"2008","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0165-0327(99)00154-8","article-title":"MRI-based measurements of temporal lobe and ventricular structures in patients with bipolar I and bipolar II disorders","volume":"60","author":"Hauser","year":"2000","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.schres.2008.11.016","article-title":"Neuroleptic effects on P50 sensory gating in patients with first-episode never-medicated schizophrenia","volume":"108","author":"Hong","year":"2009","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib25","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1176\/appi.ajp.2010.09091335","article-title":"Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression","volume":"167","author":"Huang","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib26","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1017\/S0033291710002606","article-title":"Differences in temperament and character dimensions in patients with bipolar I or II or major depressive disorder and general population subjects","volume":"41","author":"Jylha","year":"2011","journal-title":"Psychol. Med."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib27","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/FPC.0b013e32833caa2b","article-title":"The ALDH2 and DRD2\/ANKK1 genes interacted in bipolar II but not bipolar I disorder","volume":"20","author":"Lee","year":"2010","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/15622975.2010.505298","article-title":"The COMT and DRD3 genes interacted in bipolar I but not bipolar II disorder","volume":"12","author":"Lee","year":"2011","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib29","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/archpsyc.59.12.1085","article-title":"Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia","volume":"59","author":"Leonard","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.psychres.2008.04.001","article-title":"Diminished P50, N100 and P200 auditory sensory gating in bipolar I disorder","volume":"167","author":"Lijffijt","year":"2009","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jad.2010.05.026","article-title":"Differences in white matter abnormalities between bipolar I and II disorders","volume":"127","author":"Liu","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.psychres.2003.04.001","article-title":"P50 inhibitory gating deficit is correlated with the negative symptomatology of schizophrenia","volume":"136","author":"Louchart-de la Chapelle","year":"2005","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib33","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1177\/070674370404901202","article-title":"Neurobiological findings in bipolar II disorder compared with findings in bipolar I disorder","volume":"49","author":"McGrath","year":"2004","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0920-9964(91)90007-E","article-title":"Gating of auditory response in schizophrenics and normal controls. Effects of recording site and stimulation interval on the P50 wave","volume":"4","author":"Nagamoto","year":"1991","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib35","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/schbul\/10.2.300","article-title":"A heuristic vulnerability\/stress model of schizophrenic episodes","volume":"10","author":"Nuechterlein","year":"1984","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.schres.2010.03.004","article-title":"Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the consortium on genetics of schizophrenia","volume":"119","author":"Olincy","year":"2010","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1176\/appi.ajp.162.1.43","article-title":"Diminished suppression of the P50 auditory evoked potential in bipolar disorder subjects with a history of psychosis","volume":"162","author":"Olincy","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib38","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.psychres.2007.02.009","article-title":"P50 sensory gating ratios in schizophrenics and controls: a review and data analysis","volume":"158","author":"Patterson","year":"2008","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib39","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1399-5618.2009.00734.x","article-title":"An initial report of a new biological marker for bipolar disorder: P85 evoked brain potential","volume":"11","author":"Patterson","year":"2009","journal-title":"Bipolar. Disord."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijpsycho.2007.10.006","article-title":"Test-retest reliability of P50, N100 and P200 auditory sensory gating in healthy subjects","volume":"67","author":"Rentzsch","year":"2008","journal-title":"Int. J. Psychophysiol."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jad.2010.05.014","article-title":"Functional impairment in bipolar II disorder: is it as disabling as bipolar I?","volume":"127","author":"Rosa","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib42","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1600-0447.2007.01141.x","article-title":"P50 sensory gating deficit is a common marker of vulnerability to bipolar disorder and schizophrenia","volume":"117","author":"Sanchez-Morla","year":"2008","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.schres.2010.01.010","article-title":"P50 gating in deficit and nondeficit schizophrenia","volume":"119","author":"Santos","year":"2010","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib44","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.schres.2010.05.026","article-title":"More evidence to support the role of S2 in P50 studies","volume":"122","author":"Shan","year":"2010","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib45","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1176\/appi.ajp.2010.09071059","article-title":"Cognitive abilities and 50- and 100-msec paired-click processes in schizophrenia","volume":"167","author":"Smith","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib46","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1017\/S0033291711000018","article-title":"Are bipolar II patients cognitively impaired? A systematic review","volume":"41","author":"Sole","year":"2011","journal-title":"Psychol. Med."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/archpsyc.55.1.41","article-title":"Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study","volume":"55","author":"van Gorp","year":"1998","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib48","first-page":"1","article-title":"Input dysfunction in schizophrenia","volume":"72","author":"Venables","year":"1964","journal-title":"Prog. Exp. Pers. Res."},{"key":"10.1016\/j.euroneuro.2012.06.008_bib49","series-title":"Progress in Experimental Personality Research","article-title":"Input dysfunction in schizophrenia","author":"Venables","year":"1967"},{"key":"10.1016\/j.euroneuro.2012.06.008_bib50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ajmg.b.30239","article-title":"Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder","volume":"141B","author":"Xu","year":"2006","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."}],"container-title":["European Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X12001605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X12001605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T13:56:55Z","timestamp":1561903015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924977X12001605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0924977X12001605"],"URL":"https:\/\/doi.org\/10.1016\/j.euroneuro.2012.06.008","relation":{},"ISSN":["0924-977X"],"issn-type":[{"value":"0924-977X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P50 sensory gating is a trait marker of the bipolar spectrum","name":"articletitle","label":"Article Title"},{"value":"European Neuropsychopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euroneuro.2012.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. and ECNP. All rights reserved.","name":"copyright","label":"Copyright"}]}}