{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T13:29:06Z","timestamp":1794576546032,"version":"4.9.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","europeanneuropsychopharmacology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Neuropsychopharmacology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.euroneuro.2014.12.002","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T23:42:22Z","timestamp":1419032542000},"page":"413-424","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["The atypical antipsychotic clozapine selectively inhibits interleukin 8 (IL-8)-induced neutrophil chemotaxis"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9485-1276","authenticated-orcid":false,"given":"Marta","family":"Capannolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-082X","authenticated-orcid":false,"given":"Irene","family":"Fasciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Aloisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierangelo","family":"Bellio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Celenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Cinque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Cifone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Scarselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Maggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euroneuro.2014.12.002_bib1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.devcel.2012.02.003","article-title":"LTB4 is a signal-relay molecule during neutrophil chemotaxis","volume":"22","author":"Afonso","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib2","first-page":"417","article-title":"Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C","volume":"1","author":"Allen","year":"2002","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuropharm.2010.10.018","article-title":"Differential induction of adenylyl cyclase supersensitivity by antiparkinson drugs acting as agonists at dopamine D 1\/D 2\/D 3 receptors vs D 2\/D 3 receptors only: parallel observations from co-transfected human and native cerebral receptors","volume":"60","author":"Aloisi","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib4","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.4049\/jimmunol.163.12.6810","article-title":"Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice","volume":"163","author":"Byrum","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.immuni.2010.07.018","article-title":"Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis","volume":"33","author":"Chou","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/hup.917","article-title":"Haematological toxicity of drugs used in psychiatry","volume":"23","author":"Flanagan","year":"2008","journal-title":"Hum. Psychopharmacol"},{"issue":"6","key":"10.1016\/j.euroneuro.2014.12.002_bib7","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.4049\/jimmunol.178.6.3874","article-title":"The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine","volume":"178","author":"Fumagalli","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1517\/17425255.4.6.721","article-title":"Utilization of membrane vesicle preparations to study drug-ABC transporter interactions","volume":"4","author":"Glavinas","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1189\/jlb.1003479","article-title":"Synergy between proinflammatory ligands of G protein-coupled receptors in neutrophil activation and migration","volume":"76","author":"Gouwy","year":"2004","journal-title":"J. Leukoc. Biol."},{"issue":"4","key":"10.1016\/j.euroneuro.2014.12.002_bib10","article-title":"Effects of clozapine on neutrophils\u05f3 chemotaxis","volume":"6","author":"Guaraldi","year":"1996","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib11","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1073\/pnas.91.17.8156","article-title":"Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity","volume":"91","author":"Guidot","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib12","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.4049\/jimmunol.155.3.1428","volume":"155","author":"Hammond","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib13","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.1840701","article-title":"Structure and functional expression of a human interleukin-8 receptor","volume":"253","author":"Holmes","year":"1991","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.euroneuro.2014.12.002_bib14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/00048670601109980","article-title":"Prolongation of clozapine-induced neutropenia with olanzapine","volume":"41","author":"Jagadheesan","year":"2007","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1124\/jpet.110.173948","article-title":"Functional selectivity and biased receptor signaling.","volume":"336","author":"Kenakin","year":"2011","journal-title":"J. Pharmacol. Exp. Ther"},{"issue":"1","key":"10.1016\/j.euroneuro.2014.12.002_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jchromb.2006.05.031","article-title":"Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach.","volume":"843","author":"Kirchherr","year":"2006","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"1","key":"10.1016\/j.euroneuro.2014.12.002_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.109.002014","article-title":"Xenobiotic, bile acid, and cholesterol transporters: function and regulation","volume":"62","author":"Klaassen","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib18","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1124\/dmd.113.054304","article-title":"Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4","volume":"42","author":"K\u00f6ck","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/JCP.0b013e3181e6a082","article-title":"Clozapine is cytotoxic to primary cultures of human bone marrow mesenchymal stromal cells","volume":"30","author":"Lahdelma","year":"2010","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib21","doi-asserted-by":"crossref","first-page":"13438","DOI":"10.1016\/S0021-9258(18)77365-1","article-title":"The mechanism of leukotriene B4 export from human polymorphonuclear leukocytes","volume":"265","author":"Lam","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.euroneuro.2014.12.002_bib22","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1111\/j.1471-4159.2007.04896.x","article-title":"G protein-coupled receptor oligomerization provides the framework for signal discrimination","volume":"103","author":"Maggio","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev-med-050911-161504","article-title":"Update on typical and atypical antipsychotic drugs","volume":"64","author":"Meltzer","year":"2013","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib24","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1152\/ajplung.00233.2002","article-title":"Pathophysiological roles of interleukin-8\/IL8 in pulmonary diseases","volume":"284","author":"Mukaida","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib25","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1126\/science.1891716","article-title":"Cloning of complementary DNA encoding a functional human interleukin-8 receptor","volume":"253","author":"Murphy","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib26","first-page":"83","article-title":"Interleukin-3, interleukin-8, fMLP and C5a enhance the release of leukotrienes from neutrophils of patients with atopic dermatitis","volume":"73","author":"Neuber","year":"1991","journal-title":"Immunology"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/hup.1181","article-title":"Haematological toxicity of clozapine and some other drugs used in psychiatry","volume":"26","author":"Nooijen","year":"2011","journal-title":"Hum. Psychopharmacol"},{"issue":"4","key":"10.1016\/j.euroneuro.2014.12.002_bib28","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1471-4159.2007.04660.x","article-title":"Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation","volume":"102","author":"Novi","year":"2007","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.euroneuro.2014.12.002_bib29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0893-133X(98)00048-7","article-title":"Mixed agonist-antagonist properties of clozapine at different human cloned muscarinic receptor subtypes expressed in Chinese hamster ovary cells","volume":"20","author":"Olianas","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib30","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/sj.tpj.6500179","article-title":"Potential clozapine target sites on peripheral hematopoietic cells and stromal cells of the bone marrow","volume":"3","author":"Pereira","year":"2003","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib31","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.4049\/jimmunol.1201114","article-title":"The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions","volume":"189","author":"Raghuwanshi","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib32","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1124\/mol.63.5.1094","article-title":"Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5","volume":"63","author":"Reid","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/jpet.107.131342","article-title":"ATP-Dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4)","volume":"324","author":"Rius","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib34","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tips.2008.01.006","article-title":"Multidrug resistance protein 4 (MRP4\/ ABCC4): a versatile efflux transporter for drugs and signalling molecules","volume":"29","author":"Russel","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0014-2999(00)00272-7","article-title":"Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments","volume":"397","author":"Scarselli","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib36","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1038\/npp.2014.38","article-title":"Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a \u03b2arrestin2-independent activation of Akt","volume":"39","author":"Schmid","year":"2014","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.euroneuro.2014.12.002_bib37","doi-asserted-by":"crossref","first-page":"e61193","DOI":"10.1371\/journal.pone.0061193","article-title":"The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge","volume":"8","author":"Schymeinsky","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejphar.2012.02.018","article-title":"MRP4 and CFTR in the regulation of cAMP and \u03b2-adrenergic contraction in cardiac myocytes","volume":"681","author":"Sellers","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib39","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1126\/science.287.5455.1037","article-title":"Polarization of chemoattractant receptor signaling during neutrophil chemotaxis","volume":"287","author":"Servant","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.euroneuro.2014.12.002_bib40","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1021\/tx700128c","article-title":"Disproportionation of clozapine radical: a link between one-electron oxidation of clozapine and formation of its nitrenium cation","volume":"20","author":"Sikora","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1203\/00006450-199507000-00003","article-title":"Comparative differences and combined effects of interleukin-8, leukotriene B4, and platelet-activating factor on neutrophil chemotaxis of the newborn","volume":"38","author":"Tan","year":"1995","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1192\/bjp.bp.108.051979","article-title":"Reasons for discontinuing clozapine: matched, case-control comparison with risperidone long-acting injection","volume":"194","author":"Taylor","year":"2009","journal-title":"Br. J. Psychiatry."},{"issue":"2","key":"10.1016\/j.euroneuro.2014.12.002_bib43","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/1523-1747.ep12464458","article-title":"Recombinant human interleukin-8 is a potent activator of canine neutrophil aggregation, migration, and leukotriene B4 biosynthesis","volume":"96","author":"Thomsen","year":"1991","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib44","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1124\/mol.111.071134","article-title":"Inactivation of multidrug resistance proteins (MRPs) disrupts both cellular extrusion and intracellular degradation of cAMP","volume":"80","author":"Xie","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib45","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1742-7843.2008.00298.x","article-title":"Antipsychotic drugs inhibit the function of breast cancer resistance protein","volume":"103","author":"Wang","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib46","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1021\/cn400121z","article-title":"Classics in chemical neuroscience: clozapine","volume":"4","author":"Wenthur","year":"2013","journal-title":"ACS Chem. Neurosci"},{"issue":"31","key":"10.1016\/j.euroneuro.2014.12.002_bib47","doi-asserted-by":"crossref","first-page":"28663","DOI":"10.1074\/jbc.M413475200","article-title":"The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities","volume":"280","author":"Wilson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib48","doi-asserted-by":"crossref","first-page":"27935","DOI":"10.1074\/jbc.M703255200","article-title":"Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation","volume":"282","author":"Wise","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.euroneuro.2014.12.002_bib49","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.2144\/03356ss04","article-title":"Hematopoietic cells from mice that are deficient in both Bcrp1\/Abcg2 and Mdr1a\/1b develop normally but are sensitized to mitoxantrone","volume":"35","author":"Zhou","year":"2003","journal-title":"Biotechniques"}],"container-title":["European Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X14003368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X14003368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T20:30:50Z","timestamp":1690749050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924977X14003368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0924977X14003368"],"URL":"https:\/\/doi.org\/10.1016\/j.euroneuro.2014.12.002","relation":{},"ISSN":["0924-977X"],"issn-type":[{"value":"0924-977X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The atypical antipsychotic clozapine selectively inhibits interleukin 8 (IL-8)-induced neutrophil chemotaxis","name":"articletitle","label":"Article Title"},{"value":"European Neuropsychopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euroneuro.2014.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. and ECNP. All rights reserved.","name":"copyright","label":"Copyright"}]}}