{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:08:41Z","timestamp":1785535721006,"version":"3.56.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","europeanneuropsychopharmacology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Neuropsychopharmacology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.euroneuro.2015.04.026","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T01:47:45Z","timestamp":1430790465000},"page":"1248-1259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evidence against a critical role of CB1 receptors in adaptation of the hypothalamic\u2013pituitary\u2013adrenal axis and other consequences of daily repeated stress"],"prefix":"10.1016","volume":"25","author":[{"given":"Cristina","family":"Rabasa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Pastor-Ciurana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Delgado-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"G\u00f3mez-Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Gagliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda S.","family":"Garc\u00eda-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Manzanares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9524-3635","authenticated-orcid":false,"given":"Antonio","family":"Armario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euroneuro.2015.04.026_bib1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.yhbeh.2013.03.017","article-title":"Monoacylglycerol lipase inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity n male CD1 mice","volume":"63","author":"Aliczki","year":"2013","journal-title":"Horm. Behav."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jpsychires.2009.07.008","article-title":"Susceptibility to stress in transgenic mice overexpressing TrkC, a model of panic disorder","volume":"44","author":"Amador-Arjona","year":"2010","journal-title":"J. Psychiatry Res."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000180003","article-title":"Effect of acute and chronic psychogenic stress on corticoadrenal and pituitary-thyroid hormones in male rats","volume":"20","author":"Armario","year":"1984","journal-title":"Horm. Res."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib5","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tips.2010.04.005","article-title":"Activation of the hypothalamic\u2013pituitary\u2013adrenal axis by addictive drugs: different pathways, common outcome","volume":"31","author":"Armario","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10571-012-9814-6","article-title":"What can we know from pituitary\u2013adrenal hormones about the nature and consequences of exposure to emotional stressors?","volume":"32","author":"Armario","year":"2012","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1471-4159.2007.05149.x","article-title":"BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice","volume":"105","author":"Aso","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib8","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1210\/en.2010-0101","article-title":"Regulation of the hypothalamic\u2013pituitary\u2013adrenal axis circadian rhythm by endocannabinoids is sexually diergic","volume":"151","author":"Atkinson","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib9","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.euroneuro.2014.07.005","article-title":"Role of the basolateral am\u00edgdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress","volume":"24","author":"Bedse","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/10253890290027895","article-title":"C-fos mRNA induction after acute and chronic audiogenic stress: possible role of the orbitofrontal cortex in habituation","volume":"5","author":"Campeau","year":"2002","journal-title":"Stress"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuroscience.2010.01.062","article-title":"Facilitation of endocannabinoid effects in the ventral hippocampus modulates anxiety-like behaviors depending on previous stress experience","volume":"167","author":"Campos","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib12","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1172\/JCI17725","article-title":"The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis","volume":"112","author":"Cota","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib13","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1210\/en.2005-1649","article-title":"Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic\u2013pituitary\u2013adrenal axis function","volume":"148","author":"Cota","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib14","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1523\/JNEUROSCI.23-12-04850.2003","article-title":"Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism","volume":"23","author":"Di","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib15","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1210\/endo-124-6-2978","article-title":"Dissociation between changes in plasma bioactive and immunoreactiveadrenocorticotropin after hemorrhage in awake dogs","volume":"124","author":"Engeland","year":"1989","journal-title":"Endocrinology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib16","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1210\/en.2010-0285","article-title":"Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling","volume":"151","author":"Evanson","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/00008877-200509000-00016","article-title":"Differential response to acute and repeated stress in cannabinoid CB1 receptor knockout newborn and adult mice","volume":"16","author":"Fride","year":"2005","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib18","doi-asserted-by":"crossref","first-page":"11078","DOI":"10.1523\/JNEUROSCI.1223-09.2009","article-title":"Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance","volume":"29","author":"Ganon-Elazar","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib19","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/j.1460-9568.2004.03293.x","article-title":"Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice","volume":"19","author":"Haller","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib20","series-title":"Generalized Estimating Equations","author":"Hardin","year":"2003"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib21","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.psyneuen.2012.04.017","article-title":"Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice","volume":"37","author":"Hartmann","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib22","doi-asserted-by":"crossref","first-page":"9406","DOI":"10.1073\/pnas.0914661107","article-title":"Endogenous cannabinoid signaling is essential for stress adaptation","volume":"107","author":"Hill","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib23","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1093\/cercor\/bhq280","article-title":"Alterations in corticolimbic dendritic morphology and emotional behavior in cannabinoid CB1 receptor-deficient mice parallel the effects of chronic stress","volume":"21","author":"Hill","year":"2011","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib24","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1523\/JNEUROSCI.0496-11.2011","article-title":"Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response","volume":"31","author":"Hill","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuroscience.2011.12.030","article-title":"Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic\u2013pituitary\u2013adrenal axis","volume":"204","author":"Hill","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib26","series-title":"Comparative Cytoarchitectonic Atlas of the C57BL6 and 129Sv Mouse Brains","author":"Hof","year":"2000"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1601-183X.2008.00463.x","article-title":"Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling","volume":"8","author":"Kamprath","year":"2009","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib28","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/0006-8993(93)90665-A","article-title":"Regulation of the hypothalamic pituitary adrenal axis during chronic stress: responses to repeated intraperitoneal hypertonic saline injection","volume":"630","author":"Kiss","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib29","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1126\/science.283.5400.401","article-title":"Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice","volume":"283","author":"Ledent","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib30","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1365-2826.1992.tb00220.x","article-title":"Repeated immobilization stress alters tyrosine hydroxylase, corticotropin-releasing hormone and corticosteroid receptor messenger ribonucleic acid levels in rat brain","volume":"4","author":"Mamalaki","year":"1992","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0006-8993(99)01756-4","article-title":"Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of delta(9)-tetrahydrocannabinol in rats","volume":"839","author":"Manzanares","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib32","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuroscience.2003.10.016","article-title":"The hypothalamic\u2013pituitary\u2013adrenal and glucose responses to daily repeated immobilisation stress in rats: individual differences","volume":"123","author":"Marquez","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib33","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature00839","article-title":"The endogenous cannabinoid system controls extinction of aversive memories","volume":"418","author":"Marsicano","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0736-5748(98)00030-6","article-title":"Anterior pituitary response to stress: time-related changes and adaptation","volume":"16","author":"Marti","year":"1998","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0306-4530(93)90056-Q","article-title":"Effect of regularity of exposure to chronic immobilization stress on the circadian pattern of pituitary adrenal hormones, growth hormone, and thyroid stimulating hormone in the adult male rat","volume":"18","author":"Marti","year":"1993","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib36","series-title":"Generalized, Linear, and Mixed Models","author":"McCulloch","year":"2001"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib37","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1111\/j.1460-9568.2008.06266.x","article-title":"Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation","volume":"27","author":"Patel","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib38","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1210\/en.2004-0638","article-title":"Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic\u2013pituitary\u2013adrenal axis","volume":"145","author":"Patel","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib39","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1460-9568.2005.03916.x","article-title":"Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling","volume":"21","author":"Patel","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib40","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbr.2010.10.001","article-title":"Adaptation of the hypothalamic\u2013pituitary\u2013adrenal axis and glucose to repeated immobilization or restraint stress is not influenced by associative signals","volume":"217","author":"Rabasa","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib41","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3109\/10253890.2013.824964","article-title":"Adaptation of the pituitary\u2013adrenal axis to daily repeated forced swim exposure in rats is dependent on the temperature of water","volume":"16","author":"Rabasa","year":"2013","journal-title":"Stress"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11064-009-0030-9","article-title":"Cannabinoids and their interactions with diazepam on modulation of serum corticosterone concentration in male mice","volume":"35","author":"Saber-Tehrani","year":"2010","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib43","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.psyneuen.2009.10.002","article-title":"High susceptibility to chronic social stress is associated with a depression-like phenotype","volume":"35","author":"Schmidt","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib44","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.psyneuen.2007.09.008","article-title":"Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice","volume":"33","author":"Steiner","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib45","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0079-6123(08)00433-0","article-title":"Role of the endocannabinoid system in regulation of the hypothalamic\u2013pituitary\u2013adrenocortical axis","volume":"170","author":"Steiner","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib46","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.neuropharm.2004.01.003","article-title":"Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors","volume":"46","author":"Uriguen","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib47","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1046\/j.1365-2826.2003.00986.x","article-title":"Genetic selection for coping style predicts stressor susceptibility","volume":"15","author":"Veenema","year":"2003","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib48","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000087034","article-title":"Stress symptoms induced by repeated morphine withdrawal in comparison to other chronic stress models in mice","volume":"81","author":"Zelena","year":"2005","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.euroneuro.2015.04.026_bib49","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1152\/ajpendo.00219.2003","article-title":"Role of hypothalamic inputs in maintaining pituitary\u2013adrenal responsiveness in repeated restraint","volume":"285","author":"Zelena","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.euroneuro.2015.04.026_bib50","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1073\/pnas.96.10.5780","article-title":"Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice","volume":"96","author":"Zimmer","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["European Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X15001467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X15001467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T11:18:44Z","timestamp":1566645524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924977X15001467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0924977X15001467"],"URL":"https:\/\/doi.org\/10.1016\/j.euroneuro.2015.04.026","relation":{},"ISSN":["0924-977X"],"issn-type":[{"value":"0924-977X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence against a critical role of CB1 receptors in adaptation of the hypothalamic\u2013pituitary\u2013adrenal axis and other consequences of daily repeated stress","name":"articletitle","label":"Article Title"},{"value":"European Neuropsychopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euroneuro.2015.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. and ECNP. All rights reserved.","name":"copyright","label":"Copyright"}]}}