{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:50:08Z","timestamp":1786989008416,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","europeanneuropsychopharmacology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Neuropsychopharmacology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.euroneuro.2015.06.014","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T23:34:41Z","timestamp":1435880081000},"page":"126-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Mirtazapine in pregnancy and lactation \u2013 A systematic review"],"prefix":"10.1016","volume":"26","author":[{"given":"Mirte","family":"Smit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koert M.","family":"Dolman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Honig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.euroneuro.2015.06.014_bib1","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1176\/appi.ajp.161.12.2325","article-title":"Mirtazapine and breast-feeding","volume":"161","author":"Aichhorn","year":"2004","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.euroneuro.2015.06.014_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1527-3458.2001.tb00198.x","article-title":"A review of the pharmacological and clinical profile of mirtazapine","volume":"7","author":"Antilla","year":"2001","journal-title":"CNS Drug Rev."},{"issue":"4","key":"10.1016\/j.euroneuro.2015.06.014_bib3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/089033402237904","article-title":"Studying drugs in human milk: time to unify the approach","volume":"18","author":"Begg","year":"2002","journal-title":"J. Hum. Lact."},{"issue":"4","key":"10.1016\/j.euroneuro.2015.06.014_bib4","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/01.AOG.0000116689.75396.5f","article-title":"Prevalence of depression during pregnancy: systematic review","volume":"103","author":"Bennett","year":"2004","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.euroneuro.2015.06.014_bib5","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/JCP.0b013e318173aa2e","article-title":"A new look at the neonate\u2019s clinical presentation after in utero exposure to antidepressants in late pregnancy","volume":"28","author":"Boucher","year":"2009","journal-title":"J. Clin. Psychopharmacol."},{"issue":"6","key":"10.1016\/j.euroneuro.2015.06.014_bib6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3109\/10253890.2011.623250","article-title":"Maternal pregnancy-specific anxiety is associated with child executive function at 6\u20139 years age","volume":"14","author":"Buss","year":"2011","journal-title":"Stress"},{"key":"10.1016\/j.euroneuro.2015.06.014_bib7","unstructured":"Cupitt D., Kennedy D., 2011. MotherSafe TIS, Sydney, Australia (OTIS Abstracts)."},{"issue":"1","key":"10.1016\/j.euroneuro.2015.06.014_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00737-011-0251-1","article-title":"Untreated prenatal maternal depression and the potential risks to offspring: a review","volume":"15","author":"Davalos","year":"2012","journal-title":"Arch. Womens Ment. Health"},{"issue":"8","key":"10.1016\/j.euroneuro.2015.06.014_bib9","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.4088\/JCP.v67n0817","article-title":"Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes","volume":"67","author":"Djulus","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.euroneuro.2015.06.014_bib10","series-title":"Prenatal Exposure to Mirtazapine and Birth Outcomes","author":"Djulus","year":"2006"},{"issue":"4","key":"10.1016\/j.euroneuro.2015.06.014_bib11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/070674370905400405","article-title":"Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study","volume":"54","author":"Einarson","year":"2009","journal-title":"Can. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.euroneuro.2015.06.014_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/da.20598","article-title":"Adverse effects of antidepressant use in pregnancy: an evaluation of fetal growth andpreterm birth","volume":"27","author":"Einarson","year":"2010","journal-title":"Depress. Anxiety"},{"issue":"9","key":"10.1016\/j.euroneuro.2015.06.014_bib13","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1080\/00048670903107583","article-title":"Serotonin discontinuation syndrome following in utero exposure to antidepressant medication: prospective controlled study","volume":"43","author":"Galbally","year":"2009","journal-title":"Aust. N. Z. J. Psychiatry"},{"issue":"5","key":"10.1016\/j.euroneuro.2015.06.014_bib14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/00048674.2010.549995","article-title":"Developmental outcomes of children exposed to antidepressants in pregnancy","volume":"45","author":"Galbally","year":"2011","journal-title":"Aust. N. Z. J. Psychiatry"},{"issue":"5 Pt 1","key":"10.1016\/j.euroneuro.2015.06.014_bib15","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/01.AOG.0000183597.31630.db","article-title":"Perinatal depression: a systematic review of prevalence and incidence","volume":"106","author":"Gavin","year":"2005","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.euroneuro.2015.06.014_bib16","first-page":"1","article-title":"Perinatal depression: prevalence, screening accuracy, and screening outcomes","volume":"119","author":"Gaynes","year":"2005","journal-title":"Evid. Rep. Technol. Assess."},{"issue":"2","key":"10.1016\/j.euroneuro.2015.06.014_bib17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2165\/00002018-200730020-00002","article-title":"Use of contemporary antidepressants during breastfeeding: a proposal for a specific safety index","volume":"30","author":"Gentile","year":"2007","journal-title":"Drug Saf."},{"key":"10.1016\/j.euroneuro.2015.06.014_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4088\/JCP.12r07967","article-title":"The effect of prenatal antidepressant exposure on neonatal adaptation: a systematic review and meta-analysis","volume":"74","author":"Grigoriadis","year":"2013","journal-title":"J. Clin. Psychiatry"},{"issue":"10","key":"10.1016\/j.euroneuro.2015.06.014_bib19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1001\/archgenpsychiatry.2010.111","article-title":"A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction","volume":"67","author":"Grote","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"issue":"4","key":"10.1016\/j.euroneuro.2015.06.014_bib20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s00404-005-0007-0","article-title":"Mirtazapine use in resistant hyperemesis gravidarum: report of three cases and review of the literature","volume":"272","author":"Guclu","year":"2005","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.euroneuro.2015.06.014_bib21","article-title":"Use of mirtazapine and olanzapine in treatment of major depressive disorder with psychotic features developed during pregnancy: a case report","author":"Gule\u00e7","year":"2011","journal-title":"Klin. Psikofarmakol. B\u00fcl.-Bull. Clin. Psychopharmacol."},{"issue":"4","key":"10.1016\/j.euroneuro.2015.06.014_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/JCP.0b013e318295fe12","article-title":"Atypical antipsychotic drugs and pregnancy outcome: a prospective, cohort study","volume":"33","author":"Habermann","year":"2013","journal-title":"J. Clin. Psychopharmacol."},{"issue":"6","key":"10.1016\/j.euroneuro.2015.06.014_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1089\/bfm.2010.0011","article-title":"Discontinuation syndrome in newborns whose mothers took antidepressants while pregnant or breastfeeding","volume":"5","author":"Hale","year":"2010","journal-title":"Breastfeed. Med."},{"issue":"1","key":"10.1016\/j.euroneuro.2015.06.014_bib24","first-page":"159","article-title":"Mirtazapine: a newer antidepressant","volume":"59","author":"Hartmann","year":"1999","journal-title":"Am. Fam. Physician"},{"issue":"8","key":"10.1016\/j.euroneuro.2015.06.014_bib25","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/pds.1570","article-title":"Maternal use of selective serotonin re-uptake inhibitors and persistent pulmonary hypertension of the newborn","volume":"17","author":"K\u00e4ll\u00e9n","year":"2008","journal-title":"Pharmacoepidemiol. Drug Saf."},{"issue":"5","key":"10.1016\/j.euroneuro.2015.06.014_bib26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/tera.10095","article-title":"Mirtazapine use in two pregnant women: is it safe?","volume":"66","author":"Kesim","year":"2002","journal-title":"Teratology"},{"issue":"8","key":"10.1016\/j.euroneuro.2015.06.014_bib27","first-page":"8","article-title":"Prenatal antidepressant exposure and risk of spontaneous abortion \u2013 a population-based study","volume":"28","author":"Kjaersgaard","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.euroneuro.2015.06.014_bib28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1176\/ajp.2007.164.2.348a","article-title":"Mirtazapine and breastfeeding: maternal and infant plasma levels","volume":"164","author":"Klier","year":"2007","journal-title":"Am. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.euroneuro.2015.06.014_bib29","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1365-2125.2006.02773.x","article-title":"Transfer of the antidepressant mirtazapine into breast milk","volume":"63","author":"Kristensen","year":"2007","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.euroneuro.2015.06.014_bib30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/jcp.0b013e31815ac4d2","article-title":"Delivery outcome in relation to maternal use of some recently introduced antidepressants","volume":"27","author":"Lennestal","year":"2007","journal-title":"J. Clin. Psychopharmacol."},{"issue":"Suppl 1","key":"10.1016\/j.euroneuro.2015.06.014_bib31","first-page":"S53","article-title":"Antidepressant drug exposure during pregnancy. CZTIS small prospective study","volume":"32","author":"Manakova","year":"2011","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.euroneuro.2015.06.014_bib32","first-page":"13","article-title":"Effects of maternal psychotropic drug dosage on birth outcomes","volume":"10","author":"Michielsen","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"11","key":"10.1016\/j.euroneuro.2015.06.014_bib33","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1176\/appi.ajp.2012.11111721","article-title":"Neurodevelopmwent of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression","volume":"169","author":"Nulman","year":"2012","journal-title":"Am. J. Psychiatry"},{"issue":"5","key":"10.1016\/j.euroneuro.2015.06.014_bib34","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/00004714-200010000-00006","article-title":"Mirtazapine effects on alertness and sleep in patients as recorded by interactive telecommunication during treatment with different dosing regimens","volume":"20","author":"Radhakishun","year":"2000","journal-title":"J. Clin. Psychopharmacol."},{"issue":"1","key":"10.1016\/j.euroneuro.2015.06.014_bib35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bpobgyn.2013.09.005","article-title":"The use of antidepressant medication in pregnancy","volume":"p28","author":"Ray","year":"2014","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"3","key":"10.1016\/j.euroneuro.2015.06.014_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00404-003-0502-0","article-title":"Mirtazapine (Remergil) for treatment resistant hyperemesis gravidarum: rescue of a twin pregnancy","volume":"268","author":"Rohde","year":"2003","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.euroneuro.2015.06.014_bib37","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s007370170014","article-title":"Mirtazapine: treatment of depression, anxiety, and hyperemesis gravidarum in the pregnant patient. A report of 7 cases","volume":"3","author":"Saks","year":"2001","journal-title":"Arch. Womens Ment. Health"},{"issue":"4","key":"10.1016\/j.euroneuro.2015.06.014_bib38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1586\/eem.12.33","article-title":"Neurobehavioral risk is associated with gestational exposure to stress hormones","volume":"7","author":"Sandman","year":"2012","journal-title":"Expert Rev. Endocrinol. Metab."},{"key":"10.1016\/j.euroneuro.2015.06.014_bib39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00404-007-0406-5","article-title":"Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine","volume":"277","author":"Schwarzer","year":"2008","journal-title":"Arch. Gynecol. Obstet."},{"issue":"2","key":"10.1016\/j.euroneuro.2015.06.014_bib40","first-page":"e188","article-title":"Neonatal recurrent prolonged hypothermia associated with maternal mirtazapine treatment during pregnancy","volume":"15","author":"Sokolover","year":"2008","journal-title":"Can. J. Clin. Pharmacol. Summer"},{"issue":"2","key":"10.1016\/j.euroneuro.2015.06.014_bib41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/JCP.0b013e318199f17e","article-title":"High mirtazapine plasma levels in infant after breast feeding: case report and review of literature","volume":"29","author":"Tonn","year":"2009","journal-title":"J. Clin. Psychopharmacol."},{"issue":"11","key":"10.1016\/j.euroneuro.2015.06.014_bib42","first-page":"978","article-title":"Antidepressants in pregnancy: a systematic review","volume":"44","author":"Udechuku","year":"2010","journal-title":"Aust. N. Z. J. Psychiatry"},{"issue":"11","key":"10.1016\/j.euroneuro.2015.06.014_bib43","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3109\/14767058.2013.766697","article-title":"Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases","volume":"26","author":"Uguz","year":"2013","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"1","key":"10.1016\/j.euroneuro.2015.06.014_bib44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.genhosppsych.2013.07.016","article-title":"Low-dose mirtazapine in treatment of major depression developed following severe nausea and vomiting during pregnancy: two cases","volume":"36","author":"Uguz","year":"2014","journal-title":"Gen. Hosp. Psychiatry"},{"issue":"1","key":"10.1016\/j.euroneuro.2015.06.014_bib45","first-page":"90","article-title":"Side effects of treatment with benzodiazepines","volume":"22","author":"Uzun","year":"2010","journal-title":"Psychiatr. Danub."},{"key":"10.1016\/j.euroneuro.2015.06.014_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006528.pub2","article-title":"Mirtazapine versus other antidepressive agents for depression","author":"Watanabe","year":"2011","journal-title":"Cochrane Database Syst Rev."},{"issue":"6","key":"10.1016\/j.euroneuro.2015.06.014_bib47","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1176\/appi.ajp.161.6.1066","article-title":"Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants","volume":"161","author":"Weissman","year":"2004","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.euroneuro.2015.06.014_bib48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.reprotox.2004.07.004","article-title":"Newer antidepressants in pregnancy: prospective outcome of a case series","volume":"19","author":"Yaris","year":"2004","journal-title":"Reprod. Toxicol."},{"issue":"3","key":"10.1016\/j.euroneuro.2015.06.014_bib49","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.pnpbp.2004.01.010","article-title":"Use of polypharmacotherapy in pregnancy: a prospective outcome in a case","volume":"28","author":"Yaris","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.euroneuro.2015.06.014_bib50","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pnpbp.2004.11.020","article-title":"Psychotropic drugs in pregnancy: a case-control study","volume":"29","author":"Yaris","year":"2005","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"}],"container-title":["European Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X15001844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X15001844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T01:59:33Z","timestamp":1537495173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924977X15001844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0924977X15001844"],"URL":"https:\/\/doi.org\/10.1016\/j.euroneuro.2015.06.014","relation":{},"ISSN":["0924-977X"],"issn-type":[{"value":"0924-977X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mirtazapine in pregnancy and lactation \u2013 A systematic review","name":"articletitle","label":"Article Title"},{"value":"European Neuropsychopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euroneuro.2015.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. and ECNP. All rights reserved.","name":"copyright","label":"Copyright"}]}}