{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:50:01Z","timestamp":1793278201912,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,30]],"date-time":"2017-07-30T00:00:00Z","timestamp":1501372800000},"content-version":"am","delay-in-days":363,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Office of Research and DevelopmentOffice of Research and Development"},{"name":"Veterans Affairs Career Development Award","award":["1IK2BX001275"],"award-info":[{"award-number":["1IK2BX001275"]}]},{"name":"Veterans Affairs Merit Award","award":["1I01BX001146"],"award-info":[{"award-number":["1I01BX001146"]}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Neuropsychopharmacology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.euroneuro.2016.05.003","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T04:38:09Z","timestamp":1463978289000},"page":"1310-1319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Disinhibition of the extracellular-signal-regulated kinase restores the amplification of circadian rhythms by lithium in cells from bipolar disorder patients"],"prefix":"10.1016","volume":"26","author":[{"given":"Michael J.","family":"McCarthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Landgraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa J.","family":"Le Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.euroneuro.2016.05.003_bib1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/jclp.20608","article-title":"Objective assessment of circadian activity and sleep patterns in individuals at behavioural risk of hypomania","volume":"65","author":"Ankers","year":"2009","journal-title":"J. Clin. Psychol."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnins.2011.00035","article-title":"Elk-1 a transcription factor with multiple facets in the brain","volume":"5","author":"Besnard","year":"2011","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib3","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.neuroscience.2006.12.037","article-title":"c-Jun N-terminal kinase inhibitor SP600125 modulates the period of mammalian circadian rhythms","volume":"145","author":"Chansard","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib4","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1523\/JNEUROSCI.23-07-03085.2003","article-title":"Circadian and photic regulation of phosphorylation of ERK1\/2 and Elk-1 in the suprachiasmatic nuclei of the Syrian hamster","volume":"23","author":"Coogan","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib5","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/jcs.00384","article-title":"GSK-3: tricks of the trade for a multi-tasking kinase","volume":"116","author":"Doble","year":"2003","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib6","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1046\/j.1471-4159.2001.00300.x","article-title":"Reduced activation and expression of ERK1\/2 MAP kinase in the post-mortem brain of depressed suicide subjects","volume":"77","author":"Dwivedi","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib7","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1017\/S1461145709990575","article-title":"Aberrant extracellular signal-regulated kinase (ERK)1\/2 signalling in suicide brain: role of ERK kinase 1 (MEK1)","volume":"12","author":"Dwivedi","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib8","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1046\/j.1460-9568.2003.02592.x","article-title":"The ERK\/MAP kinase pathway couples light to immediate-early gene expression in the suprachiasmatic nucleus","volume":"17","author":"Dziema","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib9","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.4088\/JCP.13m08506","article-title":"The relationship between affective state and the rhythmicity of activity in bipolar disorder","volume":"75","author":"Gonzalez","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib10","doi-asserted-by":"crossref","first-page":"25166","DOI":"10.1074\/jbc.M212726200","article-title":"p38 mitogen-activated protein kinase regulates oscillation of chick pineal circadian clock","volume":"278","author":"Hayashi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib11","doi-asserted-by":"crossref","first-page":"29397","DOI":"10.1074\/jbc.M503526200","article-title":"A role for glycogen synthase kinase-3beta in the mammalian circadian clock","volume":"280","author":"Iitaka","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/0748730411419775","article-title":"Valproic acid phase shifts the rhythmic expression of Period2::Luciferase","volume":"26","author":"Johansson","year":"2011","journal-title":"J. Biol. Rhythm."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1399-5618.2005.00187.x","article-title":"Actigraphic assessment of circadian activity and sleep patterns in bipolar disorder","volume":"7","author":"Jones","year":"2005","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib14","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1460-9568.2005.03950.x","article-title":"Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock","volume":"21","author":"Kim","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pnpbp.2011.11.014","article-title":"The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity","volume":"37","author":"Kim","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib16","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/j.bbadis.2013.06.010","article-title":"Egr1 regulates lithium-induced transcription of the Period 2 (PER2) gene","volume":"1832","author":"Kim","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib17","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","article-title":"A molecular mechanism for the effect of lithium on development","volume":"93","author":"Klein","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib18","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.bbamcr.2006.12.002","article-title":"Regulation of MAP kinases by MAP kinase phosphatases","volume":"1773","author":"Kondoh","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2199-11-60","article-title":"Determination of reference genes for circadian studies in different tissues and mouse strains","volume":"11","author":"Kosir","year":"2010","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/sj.mp.4001807","article-title":"The association of DUSP6 gene with schizophrenia and bipolar disorder: its possible role in the development of bipolar disorder","volume":"11","author":"Lee","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib21","doi-asserted-by":"crossref","first-page":"e33292","DOI":"10.1371\/journal.pone.0033292","article-title":"Lithium impacts on the amplitude and period of the molecular circadian clockwork","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2007.02.047","article-title":"Intercellular coupling confers robustness against mutations in the SCN circadian clock network","volume":"129","author":"Liu","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib23","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2012.02.039","article-title":"CNVs: harbingers of a rare variant revolution in psychiatric genetics","volume":"148","author":"Malhotra","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib24","article-title":"Calcium channel genes associated with bipolar disorder modulate lithium\u05f3s amplification of circadian rhythms","author":"McCarthy","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib25","doi-asserted-by":"crossref","first-page":"e318","DOI":"10.1038\/tp.2013.90","article-title":"Genetic and clinical factors predict lithium\u05f3s effects on PER2 gene expression rhythms in cells from bipolar disorder patients","volume":"3","author":"McCarthy","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jad.2014.04.034","article-title":"Associations between circadian activity rhythms and functional brain abnormalities among euthymic bipolar patients: a preliminary study","volume":"164","author":"McKenna","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib27","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.tibs.2011.03.006","article-title":"The Ras\u2013ERK and PI3K\u2013mTOR pathways: cross-talk and compensation","volume":"36","author":"Mendoza","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib28","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1242\/jcs.035048","article-title":"Ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner","volume":"121","author":"Meng","year":"2008","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib29","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1038\/ncomms4339","article-title":"Genome-wide association study reveals two new risk loci for bipolar disorder","volume":"5","author":"Muhleisen","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib30","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1001\/jamapsychiatry.2014.176","article-title":"Identification of pathways for bipolar disorder: a meta-analysis","volume":"71","author":"Nurnberger","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib31","doi-asserted-by":"crossref","first-page":"17748","DOI":"10.1074\/jbc.274.25.17748","article-title":"Circadian regulation of cAMP response element-mediated gene expression in the suprachiasmatic nuclei","volume":"274","author":"Obrietan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib32","doi-asserted-by":"crossref","first-page":"e1002694","DOI":"10.1371\/journal.pgen.1002694","article-title":"ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes","volume":"8","author":"Odrowaz","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib33","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ng.943","article-title":"Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4","volume":"43","author":"PGC-BD","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib34","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1471-244X-13-213","article-title":"Systematic review of genome-wide gene expression studies of bipolar disorder","volume":"13","author":"Seifuddin","year":"2013","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib36","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/mp.2009.43","article-title":"Genome-wide association study of bipolar disorder in European American and African American individuals","volume":"14","author":"Smith","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.euroneuro.2016.05.003_bib37","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1074-5521(03)00170-4","article-title":"Cell-active dual specificity phosphatase inhibitors identified by high-content screening","volume":"10","author":"Vogt","year":"2003","journal-title":"Chem. Biol."},{"key":"10.1016\/j.euroneuro.2016.05.003_bib38","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jad.2009.10.017","article-title":"Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia","volume":"124","author":"Yuan","year":"2010","journal-title":"J. Affect. Disord."}],"container-title":["European Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X1630044X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X1630044X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T10:33:57Z","timestamp":1689935637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924977X1630044X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0924977X1630044X"],"URL":"https:\/\/doi.org\/10.1016\/j.euroneuro.2016.05.003","relation":{},"ISSN":["0924-977X"],"issn-type":[{"value":"0924-977X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disinhibition of the extracellular-signal-regulated kinase restores the amplification of circadian rhythms by lithium in cells from bipolar disorder patients","name":"articletitle","label":"Article Title"},{"value":"European Neuropsychopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euroneuro.2016.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}