{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:58:33Z","timestamp":1781661513719,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Neuropsychopharmacology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.euroneuro.2018.12.006","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T19:12:32Z","timestamp":1544728352000},"page":"211-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Leptin gene polymorphisms are associated with weight gain during lithium augmentation in patients with major depression"],"prefix":"10.1016","volume":"29","author":[{"given":"Sandra K.","family":"Bopp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Heilbronner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schlattmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"M\u00fchleisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Bschor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Steinacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Stamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Merkl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Herms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2978-0982","authenticated-orcid":false,"given":"Stephan","family":"K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Sterzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Hellweg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Cichon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Undine E.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6624-2975","authenticated-orcid":false,"given":"Thomas G.","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazda","family":"Adli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Ricken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.euroneuro.2018.12.006_bib0001","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000065414","article-title":"Weight gain and serum leptin levels in patients on lithium treatment","volume":"46","author":"Atmaca","year":"2002","journal-title":"Neuropsychobiology"},{"issue":"1","key":"10.1016\/j.euroneuro.2018.12.006_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0278-5846(99)00085-8","article-title":"Endocrine effects of lithium carbonate in healthy premenopausal women: relationship with body weight regulation","volume":"24","author":"Baptista","year":"2000","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"7-8","key":"10.1016\/j.euroneuro.2018.12.006_bib0003","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.clinbiochem.2008.11.001","article-title":"Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients","volume":"42","author":"Ben Ali","year":"2009","journal-title":"Clin. Biochem."},{"issue":"2","key":"10.1016\/j.euroneuro.2018.12.006_bib0004","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.pnpbp.2012.03.001","article-title":"Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain","volume":"38","author":"Brandl","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.euroneuro.2018.12.006_bib0005","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s40265-014-0220-x","article-title":"Lithium in the treatment of major depressive disorder","volume":"74","author":"Bschor","year":"2014","journal-title":"Drugs"},{"issue":"6","key":"10.1016\/j.euroneuro.2018.12.006_bib0006","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/YPG.0b013e3283328e06","article-title":"Leptin gene -2548 G\/A variants predict risperidone-associated weight gain in children and adolescents","volume":"19","author":"Calarge","year":"2009","journal-title":"Psychiatr. Genet."},{"issue":"3","key":"10.1016\/j.euroneuro.2018.12.006_bib0007","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cellsig.2014.12.012","article-title":"Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes","volume":"27","author":"Chen","year":"2015","journal-title":"Cell Signal."},{"issue":"20","key":"10.1016\/j.euroneuro.2018.12.006_bib0008","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1073\/pnas.1601355113","article-title":"PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome","volume":"113","author":"Chen","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.euroneuro.2018.12.006_bib0009","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1038\/sj.ijo.0803657","article-title":"Obesity and polymorphisms in genes regulating human adipose tissue","volume":"31","author":"Dahlman","year":"2007","journal-title":"Int. J. Obes. (Lond.)"},{"issue":"2","key":"10.1016\/j.euroneuro.2018.12.006_bib0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/21623945.2014.975538","article-title":"Genetic variants in leptin: determinants of obesity and leptin levels in south Indian population","volume":"4","author":"Dasgupta","year":"2014","journal-title":"Adipocyte"},{"issue":"1","key":"10.1016\/j.euroneuro.2018.12.006_bib0011","doi-asserted-by":"crossref","first-page":"57","DOI":"10.64719\/pb.4131","article-title":"Leptin and leptin receptor gene polymorphisms and increases in body mass index (BMI) from olanzapine treatment in persons with schizophrenia","volume":"40","author":"Ellingrod","year":"2007","journal-title":"Psychopharmacol. Bull."},{"issue":"6","key":"10.1016\/j.euroneuro.2018.12.006_bib0012","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ijo.2010.217","article-title":"Phenotypic and genetic variation in leptin as determinants of weight regain","volume":"35","author":"Erez","year":"2011","journal-title":"Int. J. Obes. (Lond.)"},{"issue":"1","key":"10.1016\/j.euroneuro.2018.12.006_bib0013","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.gene.2013.05.064","article-title":"Association between Leptin gene polymorphisms and plasma leptin level in three consanguineous families with obesity","volume":"527","author":"Fourati","year":"2013","journal-title":"Gene"},{"issue":"9","key":"10.1016\/j.euroneuro.2018.12.006_bib0014","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1210\/jcem.86.9.7792","article-title":"Expression of leptin (Ob) and leptin receptor (Ob-R) in human fibroblasts: regulation of leptin secretion by insulin","volume":"86","author":"Glasow","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.euroneuro.2018.12.006_bib0015","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J Neurol Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.euroneuro.2018.12.006_bib0016","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00213-004-2038-9","article-title":"Plasma levels of leptin and endogenous immune modulators during treatment with carbamazepine or lithium","volume":"179","author":"Himmerich","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"issue":"7","key":"10.1016\/j.euroneuro.2018.12.006_bib0017","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1055\/s-2002-33466","article-title":"A polymorphism in the leptin promoter region (-2548G\/A) influences gene expression and adipose tissue secretion of leptin","volume":"34","author":"Hoffstedt","year":"2002","journal-title":"Horm. Metab. Res."},{"issue":"10","key":"10.1016\/j.euroneuro.2018.12.006_bib0018","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00439-014-1462-0","article-title":"Population and genomic lessons from genetic analysis of two Indian populations","volume":"133","author":"Juyal","year":"2014","journal-title":"Hum. Genet."},{"issue":"16","key":"10.1016\/j.euroneuro.2018.12.006_bib0019","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","article-title":"A molecular mechanism for the effect of lithium on development","volume":"93","author":"Klein","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.euroneuro.2018.12.006_bib0020","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.eurpsy.2014.08.006","article-title":"Association study of the HTR2C, leptin and adiponectin genes and serum marker analyzes in clozapine treated long-term patients with schizophrenia","volume":"30","author":"Klemettil\u00e4","year":"2015","journal-title":"Eur. Psychiatry"},{"issue":"7","key":"10.1016\/j.euroneuro.2018.12.006_bib0021","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.euroneuro.2012.08.010","article-title":"Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels","volume":"23","author":"Kloiber","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"7","key":"10.1016\/j.euroneuro.2018.12.006_bib0024","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2217\/pgs.11.45","article-title":"Pharmacogenetics of leptin in antipsychotic-associated weight gain and obesity-related complications","volume":"12","author":"Lee","year":"2011","journal-title":"Pharmacogenomics"},{"issue":"2","key":"10.1016\/j.euroneuro.2018.12.006_bib0025","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.biopsych.2006.02.027","article-title":"Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder","volume":"61","author":"Li","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.euroneuro.2018.12.006_bib0026","first-page":"1002","article-title":"No gene is an island: the flip-flop phenomenon","volume":"80","author":"Lin","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.euroneuro.2018.12.006_bib0027","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/0269881105057515","article-title":"Lithium: a review of its metabolic adverse effects","volume":"20","author":"Livingstone","year":"2006","journal-title":"J. Psychopharmacol."},{"issue":"34","key":"10.1016\/j.euroneuro.2018.12.006_bib0028","doi-asserted-by":"crossref","first-page":"35503","DOI":"10.1074\/jbc.M402937200","article-title":"Wnt10b inhibits development of white and brown adipose tissues","volume":"279","author":"Longo","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.euroneuro.2018.12.006_bib0029","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/BF00403921","article-title":"Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM","volume":"39","author":"Malmstr\u00f6m","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.euroneuro.2018.12.006_bib0030","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/173218","article-title":"Polymorphism in LEP and LEPR may modify leptin levels and represent risk factors for thyroid cancer","volume":"2015","author":"Marcello","year":"2015","journal-title":"Int. J. Endocrinol."},{"issue":"7","key":"10.1016\/j.euroneuro.2018.12.006_bib0031","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00018-013-1378-1","article-title":"Wnt and lithium: a common destiny in the therapy of nervous system pathologies","volume":"71","author":"Meffre","year":"2014","journal-title":"Cell Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.euroneuro.2018.12.006_bib0032","doi-asserted-by":"crossref","first-page":"E1247","DOI":"10.1152\/ajpendo.00274.2009","article-title":"Recent advances in understanding leptin signaling and leptin resistance","volume":"297","author":"Morris","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.euroneuro.2018.12.006_bib0033","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1086\/383251","article-title":"A simple correction for multiple testing for SNPs in linkage disequilibrium with each other","volume":"74","author":"Nyholt","year":"2004","journal-title":"Am. J. Hum. Genet."},{"issue":"12","key":"10.1016\/j.euroneuro.2018.12.006_bib0034","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","article-title":"Population structure and eigenanalysis","volume":"2","author":"Patterson","year":"2006","journal-title":"PLOS Genet."},{"issue":"6","key":"10.1016\/j.euroneuro.2018.12.006_bib0035","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/JCP.0b013e3181fae248","article-title":"Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatment","volume":"30","author":"Perez-Iglesias","year":"2010","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.euroneuro.2018.12.006_bib0037","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.psyneuen.2016.04.013","article-title":"Leptin serum concentrations are associated with weight gain during lithium augmentation","volume":"71","author":"Ricken","year":"2016","journal-title":"Psychoneuroendocrinology"},{"issue":"5481","key":"10.1016\/j.euroneuro.2018.12.006_bib0038","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.289.5481.950","article-title":"Inhibition of adipogenesis by Wnt signalling","volume":"289","author":"Ross","year":"2000","journal-title":"Science"},{"issue":"Suppl 20","key":"10.1016\/j.euroneuro.2018.12.006_bib0039","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.euroneuro.2018.12.006_bib0041","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neulet.2014.02.005","article-title":"Lithium decreases plasma adiponectin levels in bipolar depression","volume":"564","author":"Soeiro-de-Souza","year":"2014","journal-title":"Neurosci. Lett."},{"issue":"8","key":"10.1016\/j.euroneuro.2018.12.006_bib0042","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2217\/14622416.9.8.1055","article-title":"Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes","volume":"9","author":"Srivastava","year":"2008","journal-title":"Pharmacogenomics"},{"issue":"4","key":"10.1016\/j.euroneuro.2018.12.006_bib0043","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/01213011-200504000-00002","article-title":"Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis","volume":"15","author":"Templeman","year":"2005","journal-title":"Pharmacogenet. Genom."},{"issue":"1","key":"10.1016\/j.euroneuro.2018.12.006_bib0046","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3109\/15622970109039980","article-title":"50 Years with lithium treatment in affective disorders: present problems and priorities","volume":"2","author":"Vestergaard","year":"2001","journal-title":"World J. Biol. Psychiatry"},{"issue":"10","key":"10.1016\/j.euroneuro.2018.12.006_bib0047","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2337\/diab.45.10.1435","article-title":"Insulin and cortisol promote leptin production in cultured human fat cells","volume":"45","author":"Wabitsch","year":"1996","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.euroneuro.2018.12.006_bib0048","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/oby.2011.148","article-title":"Genetic polymorphisms in adipokine genes and the risk of obesity: a systematic review and meta-analysis","volume":"20","author":"Yu","year":"2012","journal-title":"Obes. (Silver Spring)"},{"issue":"2","key":"10.1016\/j.euroneuro.2018.12.006_bib0049","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/01.ypg.0000057881.80011.45","article-title":"Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients","volume":"13","author":"Zill","year":"2003","journal-title":"Psychiatr. Genet."}],"container-title":["European Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X18319916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924977X18319916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:36:26Z","timestamp":1775306186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924977X18319916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0924977X18319916"],"URL":"https:\/\/doi.org\/10.1016\/j.euroneuro.2018.12.006","relation":{},"ISSN":["0924-977X"],"issn-type":[{"value":"0924-977X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leptin gene polymorphisms are associated with weight gain during lithium augmentation in patients with major depression","name":"articletitle","label":"Article Title"},{"value":"European Neuropsychopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.euroneuro.2018.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}